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The map label for this gene is thiN [H]

Identifier: 138894700

GI number: 138894700

Start: 1101910

End: 1102557

Strand: Direct

Name: thiN [H]

Synonym: GTNG_1032

Alternate gene names: 138894700

Gene position: 1101910-1102557 (Clockwise)

Preceding gene: 138894699

Following gene: 138894702

Centisome position: 31.04

GC content: 52.62

Gene sequence:

>648_bases
ATGATCATCCATATCGTCGGCGGCGGACCACGCGAGCTTCTCCCTGACTTGCGCTTTTATGATGGTGAAGATGTGTGCTG
GGTCGGCGTCGATCGCGGTACAATGACGTTGCTTGAGGCAGGTTTTCGGCCGGTGCGGGCGTTTGGCGACTTCGATTCGC
TGCCGGCCGAGGACGTTGTCAAGCTGCAGCAGGCATTTCCAGACCTTGACGTATGGCCGGCAGAAAAAGACAAAACCGAT
ATGGAGATCGCCCTGGATTGGGCGGTTGAACAAACGGCTCGCTGCATTCGCCTGTTCGGTGCGACCGGCGGGCGGCTTGA
TCATTTGTTTGGGAACGTCGAGCTGTTGCTGAAATACGCTGACCGTCCGATTGAAATCGTCGACCGGCAAAACGTGTTGA
CCGTTCATTTGCCTGGTACGTATACGGTCATGTATGACGCGCGGTACTGCTACGTATCGTACATCCCGGTTTCCGAAACA
GTGGCTGAATTCACGCTCACCGGATTTAAATATCCGTTAACTAACTGTCATATTTCCCGTGGCTCCACACTATGTATTAG
TAACGAACTTATCCAGTCTTCCGGTACTTTTTCGTTTTCCGAAGGCATATTAATGATGATAAGGAGCAGCGACTCCAGCT
GCCTGTAG

Upstream 100 bases:

>100_bases
TTCTAAGGAGGGCAATGGTCAGTCAAACATCGATTTACAGGATGAAAAAGGCACATAACCAACCAGTCATTGCCCTTGCA
AAAGGCAAAGGGGGGAGAGA

Downstream 100 bases:

>100_bases
TTGCGATTGGTCAATTCGGGAATATACTGAATAAGGAAATGATGGGAAGCTCGTTACGATGGGTGTGAGGAGGGAATCGG
GATGAAGTTTTATACCATTA

Product: thiamin pyrophosphokinase

Products: NA

Alternate protein names: TPK; Thiamine diphosphokinase [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MIIHIVGGGPRELLPDLRFYDGEDVCWVGVDRGTMTLLEAGFRPVRAFGDFDSLPAEDVVKLQQAFPDLDVWPAEKDKTD
MEIALDWAVEQTARCIRLFGATGGRLDHLFGNVELLLKYADRPIEIVDRQNVLTVHLPGTYTVMYDARYCYVSYIPVSET
VAEFTLTGFKYPLTNCHISRGSTLCISNELIQSSGTFSFSEGILMMIRSSDSSCL

Sequences:

>Translated_215_residues
MIIHIVGGGPRELLPDLRFYDGEDVCWVGVDRGTMTLLEAGFRPVRAFGDFDSLPAEDVVKLQQAFPDLDVWPAEKDKTD
MEIALDWAVEQTARCIRLFGATGGRLDHLFGNVELLLKYADRPIEIVDRQNVLTVHLPGTYTVMYDARYCYVSYIPVSET
VAEFTLTGFKYPLTNCHISRGSTLCISNELIQSSGTFSFSEGILMMIRSSDSSCL
>Mature_215_residues
MIIHIVGGGPRELLPDLRFYDGEDVCWVGVDRGTMTLLEAGFRPVRAFGDFDSLPAEDVVKLQQAFPDLDVWPAEKDKTD
MEIALDWAVEQTARCIRLFGATGGRLDHLFGNVELLLKYADRPIEIVDRQNVLTVHLPGTYTVMYDARYCYVSYIPVSET
VAEFTLTGFKYPLTNCHISRGSTLCISNELIQSSGTFSFSEGILMMIRSSDSSCL

Specific function: Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate [H]

COG id: COG1564

COG function: function code H; Thiamine pyrophosphokinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiamine pyrophosphokinase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006282
- InterPro:   IPR007373
- InterPro:   IPR007371 [H]

Pfam domain/function: PF04263 TPK_catalytic [H]

EC number: =2.7.6.2 [H]

Molecular weight: Translated: 24047; Mature: 24047

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIHIVGGGPRELLPDLRFYDGEDVCWVGVDRGTMTLLEAGFRPVRAFGDFDSLPAEDVV
CEEEEECCCHHHHCCCCEEECCCCEEEEEECCCHHHHHHHCCCEEECCCCCCCCCHHHHH
KLQQAFPDLDVWPAEKDKTDMEIALDWAVEQTARCIRLFGATGGRLDHLFGNVELLLKYA
HHHHHCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCHHHHHCCHHHEEECC
DRPIEIVDRQNVLTVHLPGTYTVMYDARYCYVSYIPVSETVAEFTLTGFKYPLTNCHISR
CCCEEEECCCCEEEEECCCEEEEEEECEEEEEEEEEHHHHHHHHHHCCCCCCCCEEEECC
GSTLCISNELIQSSGTFSFSEGILMMIRSSDSSCL
CCEEEEEHHHHHCCCCEEECCCEEEEEECCCCCCC
>Mature Secondary Structure
MIIHIVGGGPRELLPDLRFYDGEDVCWVGVDRGTMTLLEAGFRPVRAFGDFDSLPAEDVV
CEEEEECCCHHHHCCCCEEECCCCEEEEEECCCHHHHHHHCCCEEECCCCCCCCCHHHHH
KLQQAFPDLDVWPAEKDKTDMEIALDWAVEQTARCIRLFGATGGRLDHLFGNVELLLKYA
HHHHHCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCHHHHHCCHHHEEECC
DRPIEIVDRQNVLTVHLPGTYTVMYDARYCYVSYIPVSETVAEFTLTGFKYPLTNCHISR
CCCEEEECCCCEEEEECCCEEEEEEECEEEEEEEEEHHHHHHHHHHCCCCCCCCEEEECC
GSTLCISNELIQSSGTFSFSEGILMMIRSSDSSCL
CCEEEEEHHHHHCCCCEEECCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]