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The map label for this gene is pyrB

Identifier: 138894676

GI number: 138894676

Start: 1071874

End: 1072800

Strand: Direct

Name: pyrB

Synonym: GTNG_1006

Alternate gene names: 138894676

Gene position: 1071874-1072800 (Clockwise)

Preceding gene: 138894675

Following gene: 138894677

Centisome position: 30.19

GC content: 53.29

Gene sequence:

>927_bases
ATGGCCCATCTACTCACGTTAAGTGAACTGTCGCTTTCCGAAATCAACCGTTTGCTCGATGAAGCGGAGACGTTCCGCAA
CGGGCGTCCGTGGCATCCAGCGACGCCGATGTATGTAGCGAACTTGTTTTTTGAACCGAGCACGCGCACGAAATGCAGCT
TCGAGATGGCGGAGCGGAAACTGGGGCTTCATGTCATTCCATTTGACCCGGAACGCTCAAGTGTGCAAAAAGGAGAGACG
CTGTACGATACGGTCAAGACGCTTGAAGCGATCGGGGTTGACGCTGTGGTTATCCGCCATCACGAAGATGCCTATTTCGA
AGCGCTCCGTCATTCGGTTGGTGTTTCGATCATTAACGCCGGCGACGGCTGTGGACACCATCCGACCCAATCGCTGCTTG
ACTTGCTGACAATTCGTCAAGAGTTTGGAACGTTTGCTGGGTTGACGGTCGTGATCATCGGTGACATTCGCCATAGCCGC
GTCGCCCGCTCCAATGCGGAAGTGTTGACAAGATTGGGGGCAAACGTCTTGTTTTCCGGACCGCCGGAATGGGAAGATGA
CATGAACCTGCACGGGACTTATGTCGAGATCGATGAAGCCATCGCTCGCGCTGATGTCGTCATGCTTTTGCGCATCCAGC
ACGAACGTCACGCTGAAAAAATGGGATTAACCAAAGAAGAGTACCACCAACAATACGGGCTGACGCTCGAGCGGGCACAG
TTGATGAAACCGGGCGCCATCATTCTGCACCCGGCGCCGGTCAATCGTGGGGTCGAAATCGCGAGTCAGCTTGTCGAAGC
GAAACCGTCACGCATTTTTAAACAAATGGAAAATGGCGTCTATGTGCGGATGGCGGTCTTAAAACGGGCAATAGAAGGGA
GAATGCAGCATGGCCATGTGGTTGAAAAATGGCATGTCGTTCAATGA

Upstream 100 bases:

>100_bases
ATGGGGCGGAGTCTACCCTCTGCTCCGCCATGCCTCAATCGTCACACCTTGCCTTGCCGGCAAGGTGTTTTTTTATCAAA
AAGAAAAGGGAGAGAGACTG

Downstream 100 bases:

>100_bases
AAACGGGCAATTGGTGCGAACTCATATCAAAATAGAGCACGGAAACATTGCAGCGATCCATCATGAACAGCTGTTTGAAG
CAAATGGAGAAGACGTGATC

Product: aspartate carbamoyltransferase catalytic subunit

Products: NA

Alternate protein names: Aspartate transcarbamylase; ATCase

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MAHLLTLSELSLSEINRLLDEAETFRNGRPWHPATPMYVANLFFEPSTRTKCSFEMAERKLGLHVIPFDPERSSVQKGET
LYDTVKTLEAIGVDAVVIRHHEDAYFEALRHSVGVSIINAGDGCGHHPTQSLLDLLTIRQEFGTFAGLTVVIIGDIRHSR
VARSNAEVLTRLGANVLFSGPPEWEDDMNLHGTYVEIDEAIARADVVMLLRIQHERHAEKMGLTKEEYHQQYGLTLERAQ
LMKPGAIILHPAPVNRGVEIASQLVEAKPSRIFKQMENGVYVRMAVLKRAIEGRMQHGHVVEKWHVVQ

Sequences:

>Translated_308_residues
MAHLLTLSELSLSEINRLLDEAETFRNGRPWHPATPMYVANLFFEPSTRTKCSFEMAERKLGLHVIPFDPERSSVQKGET
LYDTVKTLEAIGVDAVVIRHHEDAYFEALRHSVGVSIINAGDGCGHHPTQSLLDLLTIRQEFGTFAGLTVVIIGDIRHSR
VARSNAEVLTRLGANVLFSGPPEWEDDMNLHGTYVEIDEAIARADVVMLLRIQHERHAEKMGLTKEEYHQQYGLTLERAQ
LMKPGAIILHPAPVNRGVEIASQLVEAKPSRIFKQMENGVYVRMAVLKRAIEGRMQHGHVVEKWHVVQ
>Mature_307_residues
AHLLTLSELSLSEINRLLDEAETFRNGRPWHPATPMYVANLFFEPSTRTKCSFEMAERKLGLHVIPFDPERSSVQKGETL
YDTVKTLEAIGVDAVVIRHHEDAYFEALRHSVGVSIINAGDGCGHHPTQSLLDLLTIRQEFGTFAGLTVVIIGDIRHSRV
ARSNAEVLTRLGANVLFSGPPEWEDDMNLHGTYVEIDEAIARADVVMLLRIQHERHAEKMGLTKEEYHQQYGLTLERAQL
MKPGAIILHPAPVNRGVEIASQLVEAKPSRIFKQMENGVYVRMAVLKRAIEGRMQHGHVVEKWHVVQ

Specific function: Pyrimidine biosynthesis; second step. [C]

COG id: COG0540

COG function: function code F; Aspartate carbamoyltransferase, catalytic chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family

Homologues:

Organism=Homo sapiens, GI18105007, Length=302, Percent_Identity=34.4370860927152, Blast_Score=162, Evalue=4e-40,
Organism=Escherichia coli, GI2367364, Length=305, Percent_Identity=33.1147540983607, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1786469, Length=332, Percent_Identity=25.3012048192771, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790703, Length=329, Percent_Identity=25.2279635258359, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI193204318, Length=320, Percent_Identity=34.375, Blast_Score=148, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6322331, Length=303, Percent_Identity=33.3333333333333, Blast_Score=141, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24642586, Length=310, Percent_Identity=34.1935483870968, Blast_Score=154, Evalue=9e-38,

Paralogues:

None

Copy number: 2080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 14328 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): PYRB_GEOTN (A4IM30)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001125129.1
- ProteinModelPortal:   A4IM30
- SMR:   A4IM30
- STRING:   A4IM30
- GeneID:   4965949
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_1006
- NMPDR:   fig|420246.5.peg.975
- eggNOG:   COG0540
- HOGENOM:   HBG579429
- OMA:   MNRGLEI
- ProtClustDB:   PRK00856
- BioCyc:   GTHE420246:GTNG_1006-MONOMER
- HAMAP:   MF_00001
- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002082
- PRINTS:   PR00100
- PRINTS:   PR00101
- TIGRFAMs:   TIGR00670

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N; SSF53671 Asp/Orn_carbamoyltranf

EC number: =2.1.3.2

Molecular weight: Translated: 34702; Mature: 34571

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHLLTLSELSLSEINRLLDEAETFRNGRPWHPATPMYVANLFFEPSTRTKCSFEMAERK
CCCEEEHHHCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHEEECCCCCCCHHHHHHHHH
LGLHVIPFDPERSSVQKGETLYDTVKTLEAIGVDAVVIRHHEDAYFEALRHSVGVSIINA
CCCEEECCCCCHHHHHCCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCEEEEEC
GDGCGHHPTQSLLDLLTIRQEFGTFAGLTVVIIGDIRHSRVARSNAEVLTRLGANVLFSG
CCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCEEECC
PPEWEDDMNLHGTYVEIDEAIARADVVMLLRIQHERHAEKMGLTKEEYHQQYGLTLERAQ
CCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHH
LMKPGAIILHPAPVNRGVEIASQLVEAKPSRIFKQMENGVYVRMAVLKRAIEGRMQHGHV
HCCCCEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHCCEEEHHHHHHHHHHHHHHCCCE
VEKWHVVQ
ECCEEECC
>Mature Secondary Structure 
AHLLTLSELSLSEINRLLDEAETFRNGRPWHPATPMYVANLFFEPSTRTKCSFEMAERK
CCEEEHHHCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHEEECCCCCCCHHHHHHHHH
LGLHVIPFDPERSSVQKGETLYDTVKTLEAIGVDAVVIRHHEDAYFEALRHSVGVSIINA
CCCEEECCCCCHHHHHCCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCEEEEEC
GDGCGHHPTQSLLDLLTIRQEFGTFAGLTVVIIGDIRHSRVARSNAEVLTRLGANVLFSG
CCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCEEECC
PPEWEDDMNLHGTYVEIDEAIARADVVMLLRIQHERHAEKMGLTKEEYHQQYGLTLERAQ
CCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHH
LMKPGAIILHPAPVNRGVEIASQLVEAKPSRIFKQMENGVYVRMAVLKRAIEGRMQHGHV
HCCCCEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHCCEEEHHHHHHHHHHHHHHCCCE
VEKWHVVQ
ECCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA