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The map label for this gene is pyrP [H]

Identifier: 138894675

GI number: 138894675

Start: 1070411

End: 1071712

Strand: Direct

Name: pyrP [H]

Synonym: GTNG_1005

Alternate gene names: 138894675

Gene position: 1070411-1071712 (Clockwise)

Preceding gene: 138894674

Following gene: 138894676

Centisome position: 30.15

GC content: 55.15

Gene sequence:

>1302_bases
GTGAACAAACCGATACTGGATATTCAAGACCGCCCGACAGTTGGGCAATGGGTGACGTTAAGCTTGCAGCATTTATTCGC
CATGTTTGGGGCAACGATTTTAGTGCCGTATTTGGTTGGGTTAGACCCCTCGATCGCCCTGCTCACAAGCGGGCTTGGGA
CGCTCGCGTTTTTGCTTATCACGAAATGGCAAGTACCGGCCTATCTCGGCTCATCGTTCGCCTACATCGCGCCGATCATT
GCGGCGAAAACAGCCGGTGGCCCGGGTGCGGCCATGATCGGCAGCTTCCTTGCCGGGCTCGTGTACGGCATCGTCGCCCT
CATCATTAAAAAGGCCGGATATCGTTGGGTGATGAAACTGTTGCCACCGGTCGTCGTCGGTCCGGTCATCATTGTCATCG
GTCTCGGTTTAGCCGGCACGGCGGTGGGAATGGCGATGAACGGCCCGGACGGCAACTACAGTCTGCTCCATTTTTCGGTC
GCGTTAGTGACGCTTGCCGCCACGGTCATTTGCTCGGTACTGGCGCGCGGCATGCTGAGCTTAATCCCAGTGCTTGTCGG
CATCGTCGTCGGTTACGTCTATGCCCTCGCAGTCGGGCTCGTTGACTTATCGAACGTAGCGAAAGCAAAGTGGATAGAAA
TGCCGGATTTCCTTCTCCCGTTCGCTGACTATCCGGTGCGCATCACCGCGGAGATTGTCATGCTCATGGTGCCAGTCGCC
ATTGTCACCTTGTCGGAGCATATCGGCCATCAGCTCGTGTTAAGCAAAGTCGTCGGCCGCGACTTAATCCAGAAGCCAGG
ATTGCACCGGTCGATTTTAGGGGACGGAACAGCGACGATGATTTCTGCTTTGCTTGGCGGTCCGCCGAAAACGACGTACG
GGGAAAACATTGGTGTGCTCGCGATCACGCGTGTCTACAGCGTCTACGTGCTTGCCGGCGCAGCGGTAATTGCCATCGTG
TTCGGTTTTGTCGGCAAAGTGACGGCGCTGATTGGCTCGATTCCGACACCGGTCATGGGCGGCGTCTCGATTTTACTGTT
CGGTATTATCGCCTCGTCCGGTTTGCGTATGCTTGTGGATAGCCGCGTGGATTTTGGCCAGACGCGCAACTTAATCATCG
CCTCGGTCATTTTAGTCATCGGAATTGGCGGGGCGGTGCTAAAAATTAGTGAGAGCTTTCAAATCACTGGAATGGCGTTG
TCAGCCATTGTCGGTGTCCTGCTCAACTTAGTGTTGCCAGGACGGCCGCAAGTAGCGGAAAACTTATTTGAAGAAGAAAA
AAGCAACGACCATGTCGCCTAA

Upstream 100 bases:

>100_bases
GGCTGTTTCTGCACCCTCTTTGTGCCTTCGCGGGCCAAGAGGTTTTTTTTGTGCACACTAAAAGATAAATTCGCTTAGAT
AGCGAAAGGAGTGAAGGAAA

Downstream 100 bases:

>100_bases
ATCAAATAAAAACACCTTTTAATTAAGTCCAGCGAGGCTTAAAAAGGTGGGAACGAAGCGCATGGGGCGGAGTCTACCCT
CTGCTCCGCCATGCCTCAAT

Product: Uracil permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MNKPILDIQDRPTVGQWVTLSLQHLFAMFGATILVPYLVGLDPSIALLTSGLGTLAFLLITKWQVPAYLGSSFAYIAPII
AAKTAGGPGAAMIGSFLAGLVYGIVALIIKKAGYRWVMKLLPPVVVGPVIIVIGLGLAGTAVGMAMNGPDGNYSLLHFSV
ALVTLAATVICSVLARGMLSLIPVLVGIVVGYVYALAVGLVDLSNVAKAKWIEMPDFLLPFADYPVRITAEIVMLMVPVA
IVTLSEHIGHQLVLSKVVGRDLIQKPGLHRSILGDGTATMISALLGGPPKTTYGENIGVLAITRVYSVYVLAGAAVIAIV
FGFVGKVTALIGSIPTPVMGGVSILLFGIIASSGLRMLVDSRVDFGQTRNLIIASVILVIGIGGAVLKISESFQITGMAL
SAIVGVLLNLVLPGRPQVAENLFEEEKSNDHVA

Sequences:

>Translated_433_residues
MNKPILDIQDRPTVGQWVTLSLQHLFAMFGATILVPYLVGLDPSIALLTSGLGTLAFLLITKWQVPAYLGSSFAYIAPII
AAKTAGGPGAAMIGSFLAGLVYGIVALIIKKAGYRWVMKLLPPVVVGPVIIVIGLGLAGTAVGMAMNGPDGNYSLLHFSV
ALVTLAATVICSVLARGMLSLIPVLVGIVVGYVYALAVGLVDLSNVAKAKWIEMPDFLLPFADYPVRITAEIVMLMVPVA
IVTLSEHIGHQLVLSKVVGRDLIQKPGLHRSILGDGTATMISALLGGPPKTTYGENIGVLAITRVYSVYVLAGAAVIAIV
FGFVGKVTALIGSIPTPVMGGVSILLFGIIASSGLRMLVDSRVDFGQTRNLIIASVILVIGIGGAVLKISESFQITGMAL
SAIVGVLLNLVLPGRPQVAENLFEEEKSNDHVA
>Mature_433_residues
MNKPILDIQDRPTVGQWVTLSLQHLFAMFGATILVPYLVGLDPSIALLTSGLGTLAFLLITKWQVPAYLGSSFAYIAPII
AAKTAGGPGAAMIGSFLAGLVYGIVALIIKKAGYRWVMKLLPPVVVGPVIIVIGLGLAGTAVGMAMNGPDGNYSLLHFSV
ALVTLAATVICSVLARGMLSLIPVLVGIVVGYVYALAVGLVDLSNVAKAKWIEMPDFLLPFADYPVRITAEIVMLMVPVA
IVTLSEHIGHQLVLSKVVGRDLIQKPGLHRSILGDGTATMISALLGGPPKTTYGENIGVLAITRVYSVYVLAGAAVIAIV
FGFVGKVTALIGSIPTPVMGGVSILLFGIIASSGLRMLVDSRVDFGQTRNLIIASVILVIGIGGAVLKISESFQITGMAL
SAIVGVLLNLVLPGRPQVAENLFEEEKSNDHVA

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680143, Length=234, Percent_Identity=30.7692307692308, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI44680145, Length=234, Percent_Identity=30.7692307692308, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI44680148, Length=509, Percent_Identity=23.5756385068762, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI40316845, Length=509, Percent_Identity=23.5756385068762, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1788843, Length=439, Percent_Identity=43.7357630979499, Blast_Score=350, Evalue=8e-98,
Organism=Escherichia coli, GI87081818, Length=420, Percent_Identity=39.2857142857143, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI87082181, Length=460, Percent_Identity=28.4782608695652, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1790087, Length=453, Percent_Identity=26.2693156732892, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87082178, Length=459, Percent_Identity=25.7080610021786, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17558856, Length=219, Percent_Identity=27.3972602739726, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17542260, Length=217, Percent_Identity=25.3456221198157, Blast_Score=68, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17541904, Length=248, Percent_Identity=25.4032258064516, Blast_Score=68, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17542262, Length=176, Percent_Identity=26.7045454545455, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21356175, Length=240, Percent_Identity=27.5, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 45163; Mature: 45163

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHCCCCCCC
>Mature Secondary Structure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HHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8206848 [H]