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The map label for this gene is lspA

Identifier: 138894672

GI number: 138894672

Start: 1068134

End: 1068616

Strand: Direct

Name: lspA

Synonym: GTNG_1002

Alternate gene names: 138894672

Gene position: 1068134-1068616 (Clockwise)

Preceding gene: 138894671

Following gene: 138894673

Centisome position: 30.09

GC content: 51.55

Gene sequence:

>483_bases
GTGGGGGGATTTCGCGCGGTGATCTATTATTTGCTCGCAGCGGCGGTGATCGCTCTGGATCAATGGACAAAATGGCTTGT
TGTCCGCTATATGCAGCTCGGGGAGAGCATCCCGATGATCGACAATGTCCTCTACATTACATCGCACCGCAATCGCGGTG
CAGCGTGGGGCATGTTGCAAGGACAGTTTTGGCTGTTTTATTTAGTGACAGTCATCGTTGTAGCTGGGATCATCATCTAC
ATCCGCCGCTTGCGGCCTTCAGAACGATTGGCCGGCATAGGCCTTGGCCTGATGCTCGGCGGGGCGATCGGCAATTTTAT
TGACCGTGTGTTCCGGAAAGAAGTGGTCGACTTTATCCATACGTACATCGGCACATACAGCTTTCCGGTGTTCAATATCG
CTGACTCAGCGCTGACTGTCGGCGTCATCTTGCTGTTTATCCATATGTTTTTTTTCGCAACACCAGAGAAAGGGAATGAG
TAG

Upstream 100 bases:

>100_bases
GGCATAACAAAAGCGGCAGGCTGCCTTCCTGGCGGCCTTGCCGCTTCGTTTGTTTGCCATGGCCAAGTATGGTACAATGC
TGAAAGGATAAATCGGAAAC

Downstream 100 bases:

>100_bases
ATGGATACGATCACATTTCACATCGAAGAGGAATATGACGGCGAGCGGATCGATAAAGTGATCGCTGCGCTAAATGATGA
ATGGTCGCGTTCGCAAGTGC

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 160; Mature: 159

Protein sequence:

>160_residues
MGGFRAVIYYLLAAAVIALDQWTKWLVVRYMQLGESIPMIDNVLYITSHRNRGAAWGMLQGQFWLFYLVTVIVVAGIIIY
IRRLRPSERLAGIGLGLMLGGAIGNFIDRVFRKEVVDFIHTYIGTYSFPVFNIADSALTVGVILLFIHMFFFATPEKGNE

Sequences:

>Translated_160_residues
MGGFRAVIYYLLAAAVIALDQWTKWLVVRYMQLGESIPMIDNVLYITSHRNRGAAWGMLQGQFWLFYLVTVIVVAGIIIY
IRRLRPSERLAGIGLGLMLGGAIGNFIDRVFRKEVVDFIHTYIGTYSFPVFNIADSALTVGVILLFIHMFFFATPEKGNE
>Mature_159_residues
GGFRAVIYYLLAAAVIALDQWTKWLVVRYMQLGESIPMIDNVLYITSHRNRGAAWGMLQGQFWLFYLVTVIVVAGIIIYI
RRLRPSERLAGIGLGLMLGGAIGNFIDRVFRKEVVDFIHTYIGTYSFPVFNIADSALTVGVILLFIHMFFFATPEKGNE

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=150, Percent_Identity=30.6666666666667, Blast_Score=80, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_GEOTN (A4IM26)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001125125.1
- STRING:   A4IM26
- MEROPS:   A08.001
- GeneID:   4965945
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_1002
- NMPDR:   fig|420246.5.peg.971
- eggNOG:   COG0597
- HOGENOM:   HBG724422
- OMA:   LARRYVI
- PhylomeDB:   A4IM26
- ProtClustDB:   PRK00376
- BioCyc:   GTHE420246:GTNG_1002-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 18100; Mature: 17969

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 108-108 ACT_SITE 135-135

Signals:

None

Transmembrane regions:

HASH(0xe05c2f0)-; HASH(0xc6c5998)-; HASH(0xd8be85c)-; HASH(0xce860b8)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGFRAVIYYLLAAAVIALDQWTKWLVVRYMQLGESIPMIDNVLYITSHRNRGAAWGMLQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEEECCCCCCCCCCHHH
GQFWLFYLVTVIVVAGIIIYIRRLRPSERLAGIGLGLMLGGAIGNFIDRVFRKEVVDFIH
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TYIGTYSFPVFNIADSALTVGVILLFIHMFFFATPEKGNE
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
>Mature Secondary Structure 
GGFRAVIYYLLAAAVIALDQWTKWLVVRYMQLGESIPMIDNVLYITSHRNRGAAWGMLQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEEECCCCCCCCCCHHH
GQFWLFYLVTVIVVAGIIIYIRRLRPSERLAGIGLGLMLGGAIGNFIDRVFRKEVVDFIH
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TYIGTYSFPVFNIADSALTVGVILLFIHMFFFATPEKGNE
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA