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The map label for this gene is ykuU [H]

Identifier: 138894584

GI number: 138894584

Start: 988093

End: 988656

Strand: Direct

Name: ykuU [H]

Synonym: GTNG_0914

Alternate gene names: 138894584

Gene position: 988093-988656 (Clockwise)

Preceding gene: 138894583

Following gene: 138894585

Centisome position: 27.83

GC content: 50.53

Gene sequence:

>564_bases
ATGGCAGAGCGCTTAGTCGGAAAACAAGCTCCACGTTTTGAAATGGAGGCTGTCCTGCCGAATGGAGAGTTTGGCCGTGT
CAGCCTTGAGGAAAACATGAAAAATGGCAAATGGACGGTGCTGTTCTTCTATCCACTCGACTTTACATTCGTTTGCCCGA
CGGAAATTACAGCGATATCTGACCGCTATCATGAATTTGAAGACTTAAATGCAGTCGTGATCGGTGTATCGACTGACTCT
GTTTACTCGCATAAAGCATGGATGAACGTACCGCGAAACCAAAACGGCATCGGTCAAATTAAATACCCGCTCGCTGCTGA
TCGGACGCAGCAAGTTTCGCGTGATTACGGCGTGCTCATTGAAGAAGAGGGGGTCGCACTGCGCGGTTTGTTCATCATCG
ATCCGGACGGTGAGTTGAAATATGCCGTCATTCACCATAACAATATCGGCCGCGATGTCGATGAAGTATTGCGCGTGCTG
CAAGCGTTGCAAACCGGCGGCCTCTGCCCTGCAAACTGGAAGCCAGGACAACCGACGTTGACGCTGCAAGGAGAGTCGCA
TTGA

Upstream 100 bases:

>100_bases
TGCATCCCCTAAACGATGAAAGAAATGGTTTACGGTGTTGCAATGAATGATGTCAGTGATTGGTATGACATCACTATTTT
TAGCAATGGAGGGCTTACAT

Downstream 100 bases:

>100_bases
GCATGGAAAAGGTCTAACGGGGAGTTAGGCCTTTCTTTTTCCATATGGAGGGATGAGGTGTGAAACTGCGTGAACCAATG
CCGGAACTGACCGGAGCAAC

Product: 2-cys peroxiredoxin

Products: an alcohol; H2O; NAD [C]

Alternate protein names: NA

Number of amino acids: Translated: 187; Mature: 186

Protein sequence:

>187_residues
MAERLVGKQAPRFEMEAVLPNGEFGRVSLEENMKNGKWTVLFFYPLDFTFVCPTEITAISDRYHEFEDLNAVVIGVSTDS
VYSHKAWMNVPRNQNGIGQIKYPLAADRTQQVSRDYGVLIEEEGVALRGLFIIDPDGELKYAVIHHNNIGRDVDEVLRVL
QALQTGGLCPANWKPGQPTLTLQGESH

Sequences:

>Translated_187_residues
MAERLVGKQAPRFEMEAVLPNGEFGRVSLEENMKNGKWTVLFFYPLDFTFVCPTEITAISDRYHEFEDLNAVVIGVSTDS
VYSHKAWMNVPRNQNGIGQIKYPLAADRTQQVSRDYGVLIEEEGVALRGLFIIDPDGELKYAVIHHNNIGRDVDEVLRVL
QALQTGGLCPANWKPGQPTLTLQGESH
>Mature_186_residues
AERLVGKQAPRFEMEAVLPNGEFGRVSLEENMKNGKWTVLFFYPLDFTFVCPTEITAISDRYHEFEDLNAVVIGVSTDSV
YSHKAWMNVPRNQNGIGQIKYPLAADRTQQVSRDYGVLIEEEGVALRGLFIIDPDGELKYAVIHHNNIGRDVDEVLRVLQ
ALQTGGLCPANWKPGQPTLTLQGESH

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI5802974, Length=179, Percent_Identity=52.5139664804469, Blast_Score=193, Evalue=8e-50,
Organism=Homo sapiens, GI32483377, Length=177, Percent_Identity=53.1073446327684, Blast_Score=193, Evalue=9e-50,
Organism=Homo sapiens, GI4505591, Length=179, Percent_Identity=49.7206703910614, Blast_Score=188, Evalue=2e-48,
Organism=Homo sapiens, GI32455266, Length=179, Percent_Identity=49.7206703910614, Blast_Score=188, Evalue=2e-48,
Organism=Homo sapiens, GI32455264, Length=179, Percent_Identity=49.7206703910614, Blast_Score=188, Evalue=2e-48,
Organism=Homo sapiens, GI32189392, Length=179, Percent_Identity=50.8379888268156, Blast_Score=181, Evalue=5e-46,
Organism=Homo sapiens, GI5453549, Length=184, Percent_Identity=48.3695652173913, Blast_Score=179, Evalue=2e-45,
Organism=Homo sapiens, GI4758638, Length=191, Percent_Identity=31.413612565445, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI33188454, Length=82, Percent_Identity=53.6585365853659, Blast_Score=88, Evalue=4e-18,
Organism=Escherichia coli, GI1786822, Length=181, Percent_Identity=38.6740331491713, Blast_Score=138, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI32565831, Length=184, Percent_Identity=53.804347826087, Blast_Score=202, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI193204376, Length=184, Percent_Identity=53.804347826087, Blast_Score=202, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI17554494, Length=174, Percent_Identity=46.551724137931, Blast_Score=166, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI25153706, Length=195, Percent_Identity=26.6666666666667, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323613, Length=179, Percent_Identity=52.5139664804469, Blast_Score=177, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6320661, Length=179, Percent_Identity=50.8379888268156, Blast_Score=176, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6319407, Length=193, Percent_Identity=27.979274611399, Blast_Score=96, Evalue=3e-21,
Organism=Drosophila melanogaster, GI17738015, Length=187, Percent_Identity=50.8021390374332, Blast_Score=186, Evalue=8e-48,
Organism=Drosophila melanogaster, GI17157991, Length=177, Percent_Identity=51.9774011299435, Blast_Score=183, Evalue=5e-47,
Organism=Drosophila melanogaster, GI24641739, Length=177, Percent_Identity=51.9774011299435, Blast_Score=183, Evalue=5e-47,
Organism=Drosophila melanogaster, GI24656348, Length=183, Percent_Identity=49.1803278688525, Blast_Score=182, Evalue=1e-46,
Organism=Drosophila melanogaster, GI17864676, Length=183, Percent_Identity=49.1803278688525, Blast_Score=182, Evalue=1e-46,
Organism=Drosophila melanogaster, GI21357347, Length=181, Percent_Identity=43.646408839779, Blast_Score=165, Evalue=1e-41,
Organism=Drosophila melanogaster, GI17975518, Length=190, Percent_Identity=33.1578947368421, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24581278, Length=187, Percent_Identity=30.4812834224599, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24652434, Length=190, Percent_Identity=33.1578947368421, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24652436, Length=190, Percent_Identity=33.1578947368421, Blast_Score=100, Evalue=6e-22,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: 1.6.4.- [C]

Molecular weight: Translated: 20988; Mature: 20857

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAERLVGKQAPRFEMEAVLPNGEFGRVSLEENMKNGKWTVLFFYPLDFTFVCPTEITAIS
CCCCCCCCCCCCEEEEEECCCCCCCEEEHHHCCCCCCEEEEEEECCCEEEECCCCEEEHH
DRYHEFEDLNAVVIGVSTDSVYSHKAWMNVPRNQNGIGQIKYPLAADRTQQVSRDYGVLI
HHHHHHCCCCEEEEEECCCCCCCCHHEEECCCCCCCCCEEEECCCCCHHHHHHHCCCEEE
EEEGVALRGLFIIDPDGELKYAVIHHNNIGRDVDEVLRVLQALQTGGLCPANWKPGQPTL
ECCCEEEEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEE
TLQGESH
EEECCCC
>Mature Secondary Structure 
AERLVGKQAPRFEMEAVLPNGEFGRVSLEENMKNGKWTVLFFYPLDFTFVCPTEITAIS
CCCCCCCCCCCEEEEEECCCCCCCEEEHHHCCCCCCEEEEEEECCCEEEECCCCEEEHH
DRYHEFEDLNAVVIGVSTDSVYSHKAWMNVPRNQNGIGQIKYPLAADRTQQVSRDYGVLI
HHHHHHCCCCEEEEEECCCCCCCCHHEEECCCCCCCCCEEEECCCCCHHHHHHHCCCEEE
EEEGVALRGLFIIDPDGELKYAVIHHNNIGRDVDEVLRVLQALQTGGLCPANWKPGQPTL
ECCCEEEEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEE
TLQGESH
EEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ROOH; Proton; NADH [C]

Specific reaction: ROOH + Proton + NADH = an alcohol + H2O + NAD [C]

General reaction: Oxidoreductases; Acting on NADH or NADPH; With a disulfide as acceptor [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]