Click here to switch to the map view.

The map label for this gene is prpE

Identifier: 138894384

GI number: 138894384

Start: 789922

End: 790659

Strand: Reverse

Name: prpE

Synonym: GTNG_0712

Alternate gene names: 138894384

Gene position: 790659-789922 (Counterclockwise)

Preceding gene: 138894385

Following gene: 138894379

Centisome position: 22.27

GC content: 53.39

Gene sequence:

>738_bases
ATGCACATCGACATCATCGGTGACATTCATGGTTGTTATCGCGAATTTACCGCATTAACGGAAAAACTCGGTTATGTATG
GGACAAAGGGATACCGATTCATCCAGACGGTCGGAAGCTCGGTTTTGTCGGTGATTTGACGGACCGCGGTCCTGAGTCGC
TGAAAATGATTGACATCGTCTGCGCCCTTGTCGACCGCAAGCTTGCCCACTATGTGCCCGGCAACCATTGCAATAAATTA
TACCGCTTTTTTTTAGGGCGAAATGTACAAGTCACCCACGGGCTCGAGACGACGGTCGCTGAGTACCGTGCTTTGCCTCC
GAGCGAACAAGAGATGATCCGCCGCAAGTTCATTCGTCTATATGAAGGAGCACCGCTCTATGCTGTTTTAGATGAGGGAC
GCCTCGTCATCGCCCACGCCGGCATTCGCCACGATTATATCGGCCGGATGGATAAAAAAGTGAAGACGTTTGTCCTTTAC
GGCGACATCACGGGCGAAACGAACCCGGACGGTACACCTGTGCGCCGCGACTGGGCAAAACGGTATCGCGGCGATGCGTG
GATTGTGTACGGCCACACTCCGGTGGAAAAACCGCGCTTTGTCGGTCGAACCGTCAACATCGACACAGGCTGTGTATTTG
GCGGTGCGCTGACTGCGTTGCGTTATCCGGAGATGACGACGGTCTCTGTCCCATCGTCGATGCCGCACGTACCCGAAAAG
TTCCGTACATTTTCTTGA

Upstream 100 bases:

>100_bases
GTAAGCGGCTTTGCTTTTTTGCCTAACTCAAAATGTCTGTTCCTTCCGTCGGACGGGCACGCTGTTAGTAACTACACCCA
ACAGGAAAGGAGCACACAAC

Downstream 100 bases:

>100_bases
CCTGATTTTCACTTGCGCGCCGCCTCAATGAGGCGCGCCATATCATCGGGAAGCGGAGCGGTAAACGTATACAGCTGTCT
GGCAAACGGGTGAAAAAAAG

Product: bis(5'-nucleosyl)-tetraphosphatase PrpE

Products: NA

Alternate protein names: Ap4A hydrolase; Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase; Diadenosine tetraphosphatase

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MHIDIIGDIHGCYREFTALTEKLGYVWDKGIPIHPDGRKLGFVGDLTDRGPESLKMIDIVCALVDRKLAHYVPGNHCNKL
YRFFLGRNVQVTHGLETTVAEYRALPPSEQEMIRRKFIRLYEGAPLYAVLDEGRLVIAHAGIRHDYIGRMDKKVKTFVLY
GDITGETNPDGTPVRRDWAKRYRGDAWIVYGHTPVEKPRFVGRTVNIDTGCVFGGALTALRYPEMTTVSVPSSMPHVPEK
FRTFS

Sequences:

>Translated_245_residues
MHIDIIGDIHGCYREFTALTEKLGYVWDKGIPIHPDGRKLGFVGDLTDRGPESLKMIDIVCALVDRKLAHYVPGNHCNKL
YRFFLGRNVQVTHGLETTVAEYRALPPSEQEMIRRKFIRLYEGAPLYAVLDEGRLVIAHAGIRHDYIGRMDKKVKTFVLY
GDITGETNPDGTPVRRDWAKRYRGDAWIVYGHTPVEKPRFVGRTVNIDTGCVFGGALTALRYPEMTTVSVPSSMPHVPEK
FRTFS
>Mature_245_residues
MHIDIIGDIHGCYREFTALTEKLGYVWDKGIPIHPDGRKLGFVGDLTDRGPESLKMIDIVCALVDRKLAHYVPGNHCNKL
YRFFLGRNVQVTHGLETTVAEYRALPPSEQEMIRRKFIRLYEGAPLYAVLDEGRLVIAHAGIRHDYIGRMDKKVKTFVLY
GDITGETNPDGTPVRRDWAKRYRGDAWIVYGHTPVEKPRFVGRTVNIDTGCVFGGALTALRYPEMTTVSVPSSMPHVPEK
FRTFS

Specific function: Asymmetrically hydrolyzes Ap4p to yield AMP and ATP

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prpE family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PRPE_GEOTN (A4IL88)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001124837.1
- ProteinModelPortal:   A4IL88
- SMR:   A4IL88
- STRING:   A4IL88
- GeneID:   4965655
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_0712
- NMPDR:   fig|420246.5.peg.691
- eggNOG:   COG0639
- HOGENOM:   HBG724457
- OMA:   HCNKLYR
- PhylomeDB:   A4IL88
- ProtClustDB:   PRK13625
- BioCyc:   GTHE420246:GTNG_0712-MONOMER
- HAMAP:   MF_01443
- InterPro:   IPR004843

Pfam domain/function: PF00149 Metallophos

EC number: =3.6.1.17

Molecular weight: Translated: 27791; Mature: 27791

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIDIIGDIHGCYREFTALTEKLGYVWDKGIPIHPDGRKLGFVGDLTDRGPESLKMIDIV
CEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHH
CALVDRKLAHYVPGNHCNKLYRFFLGRNVQVTHGLETTVAEYRALPPSEQEMIRRKFIRL
HHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHH
YEGAPLYAVLDEGRLVIAHAGIRHDYIGRMDKKVKTFVLYGDITGETNPDGTPVRRDWAK
HCCCCEEEEECCCCEEEEECCCCHHHHHHHCCCEEEEEEEEEECCCCCCCCCCCHHHHHH
RYRGDAWIVYGHTPVEKPRFVGRTVNIDTGCVFGGALTALRYPEMTTVSVPSSMPHVPEK
HHCCCEEEEECCCCCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCHH
FRTFS
HCCCC
>Mature Secondary Structure
MHIDIIGDIHGCYREFTALTEKLGYVWDKGIPIHPDGRKLGFVGDLTDRGPESLKMIDIV
CEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHH
CALVDRKLAHYVPGNHCNKLYRFFLGRNVQVTHGLETTVAEYRALPPSEQEMIRRKFIRL
HHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHH
YEGAPLYAVLDEGRLVIAHAGIRHDYIGRMDKKVKTFVLYGDITGETNPDGTPVRRDWAK
HCCCCEEEEECCCCEEEEECCCCHHHHHHHCCCEEEEEEEEEECCCCCCCCCCCHHHHHH
RYRGDAWIVYGHTPVEKPRFVGRTVNIDTGCVFGGALTALRYPEMTTVSVPSSMPHVPEK
HHCCCEEEEECCCCCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCHH
FRTFS
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA