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The map label for this gene is aceA [H]

Identifier: 138894257

GI number: 138894257

Start: 645691

End: 646977

Strand: Direct

Name: aceA [H]

Synonym: GTNG_0583

Alternate gene names: 138894257

Gene position: 645691-646977 (Clockwise)

Preceding gene: 138894255

Following gene: 138894258

Centisome position: 18.19

GC content: 52.84

Gene sequence:

>1287_bases
ATGGCGTCATTTGCTGAACGTGTCCGACAATTGGAGGAAAGTTGGAAAAATGAAGAGCGCTGGAAAGGGGTCGTCCGTCC
GTACAGCGCCGAAGATGTTATTAAACTGCGCGGCTCGCTTGATATTGAGCATACGCTCGCTCGACGCGGAGCTGAAAAGT
TATGGAAGCTGTTAAATACGGAAGATTACGTTCATGCGCTCGGTGCGTTGACCGGAAATCAAGCCGTGCAACAAGTGAAA
GCTGGATTGAAGGCCATTTACTTAAGCGGCTGGCAGGTAGCGGCCGATGCCAACCTCGCAGGACATATGTATCCGGATCA
AAGCTTGTATCCGTCCAACAGCGTTCCGCATGTAGTCAAACGTATTAACCAAGCGTTGCAACGTGCAGATCAAATCCAAT
ATTTAGAAGGTAGTGGAGATGTTGACTATTTTGTGCCGATCGTTGCTGACGCGGAAGCTGGATTCGGCGGCCAGCTGAAC
GTGTTTGAGCTCATGAAAGCGATGATCGAAGCCGGGGCGGCCGGCGTCCATTTCGAAGATCAGCTGTCGTCGGAGAAAAA
ATGCGGCCATTTAGGTGGGAAAGTGCTCTTGCCGACGCAAACGGCGGTGCGCAACTTGATCGCAGCGCGGCTTGCTGCTG
ACGTCATGGGTGTCCCGACTGTGCTCATCGCTCGCACCGATGCGAATGCTGCTGACTTGATCACAAGCGACATTGACCCG
CGCGATCAACAGTTTATTACCGGCGAACGGACGACGGAAGGGTTTTATCGCACACGGGCAGGCCTCGACCAAGCGATCGC
TCGCGGACTTGCTTACGCGCCGTATGCCGACCTTATTTGGTGTGAAACGAGCGAACCAAATTTGGATGAAGCACGCCGAT
TCGCGGAAGCGATTCACGAGCAATTTCCAGGTAAGCTGCTCGCGTACAACTGCTCGCCGTCATTTAACTGGAAGAAAAAA
TTGGACGACGAAACGATCGCCAAATTCCAGCAAGAGCTCGGTAAAATGGGATACAAGTTCCAATTCGTCACTCTCGCCGG
CTTCCATGCGCTCAACTACAGCATGTTTGAGTTGGCACGCGGCTACAAAGATCGCGGCATGGCAGCATACGCCGAACTGC
AGCAAGCCGAATTTGCCGCTGAAAAGTACGGCTACACGGCAACGCGCCATCAGCGTGAAGTTGGTACTGGCTATTTCGAT
GAAGTCGCTCAAGTCATCTCCGGCGGCCAGTCGTCCACAGTCGCCTTAAAAGGGTCAACTGAGGAGGAACAGTTTACAAC
TGCTTAA

Upstream 100 bases:

>100_bases
AAAAGTTTCAAAAAAACACTTGCATTTTTTTCTAACTGTTATATAATAAAAACCGTAAACATAACAATGTAATATAACAA
TAGGGATGGGGGAAGGAAAA

Downstream 100 bases:

>100_bases
TGTAAATCAACAATGGATGTAGATGAAGGCCCGGTCTCTCCGGGCTTTTTTTAGTGCATAAAAGGAAAAAGATGGCGCAC
CCTATAGGCATAGGGAGGCG

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MASFAERVRQLEESWKNEERWKGVVRPYSAEDVIKLRGSLDIEHTLARRGAEKLWKLLNTEDYVHALGALTGNQAVQQVK
AGLKAIYLSGWQVAADANLAGHMYPDQSLYPSNSVPHVVKRINQALQRADQIQYLEGSGDVDYFVPIVADAEAGFGGQLN
VFELMKAMIEAGAAGVHFEDQLSSEKKCGHLGGKVLLPTQTAVRNLIAARLAADVMGVPTVLIARTDANAADLITSDIDP
RDQQFITGERTTEGFYRTRAGLDQAIARGLAYAPYADLIWCETSEPNLDEARRFAEAIHEQFPGKLLAYNCSPSFNWKKK
LDDETIAKFQQELGKMGYKFQFVTLAGFHALNYSMFELARGYKDRGMAAYAELQQAEFAAEKYGYTATRHQREVGTGYFD
EVAQVISGGQSSTVALKGSTEEEQFTTA

Sequences:

>Translated_428_residues
MASFAERVRQLEESWKNEERWKGVVRPYSAEDVIKLRGSLDIEHTLARRGAEKLWKLLNTEDYVHALGALTGNQAVQQVK
AGLKAIYLSGWQVAADANLAGHMYPDQSLYPSNSVPHVVKRINQALQRADQIQYLEGSGDVDYFVPIVADAEAGFGGQLN
VFELMKAMIEAGAAGVHFEDQLSSEKKCGHLGGKVLLPTQTAVRNLIAARLAADVMGVPTVLIARTDANAADLITSDIDP
RDQQFITGERTTEGFYRTRAGLDQAIARGLAYAPYADLIWCETSEPNLDEARRFAEAIHEQFPGKLLAYNCSPSFNWKKK
LDDETIAKFQQELGKMGYKFQFVTLAGFHALNYSMFELARGYKDRGMAAYAELQQAEFAAEKYGYTATRHQREVGTGYFD
EVAQVISGGQSSTVALKGSTEEEQFTTA
>Mature_427_residues
ASFAERVRQLEESWKNEERWKGVVRPYSAEDVIKLRGSLDIEHTLARRGAEKLWKLLNTEDYVHALGALTGNQAVQQVKA
GLKAIYLSGWQVAADANLAGHMYPDQSLYPSNSVPHVVKRINQALQRADQIQYLEGSGDVDYFVPIVADAEAGFGGQLNV
FELMKAMIEAGAAGVHFEDQLSSEKKCGHLGGKVLLPTQTAVRNLIAARLAADVMGVPTVLIARTDANAADLITSDIDPR
DQQFITGERTTEGFYRTRAGLDQAIARGLAYAPYADLIWCETSEPNLDEARRFAEAIHEQFPGKLLAYNCSPSFNWKKKL
DDETIAKFQQELGKMGYKFQFVTLAGFHALNYSMFELARGYKDRGMAAYAELQQAEFAAEKYGYTATRHQREVGTGYFDE
VAQVISGGQSSTVALKGSTEEEQFTTA

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=435, Percent_Identity=67.5862068965517, Blast_Score=612, Evalue=1e-176,
Organism=Escherichia coli, GI1786525, Length=263, Percent_Identity=28.8973384030418, Blast_Score=83, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71982926, Length=435, Percent_Identity=64.1379310344827, Blast_Score=573, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI17561814, Length=435, Percent_Identity=64.1379310344827, Blast_Score=573, Evalue=1e-164,
Organism=Saccharomyces cerevisiae, GI6325263, Length=251, Percent_Identity=41.4342629482072, Blast_Score=180, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6320908, Length=307, Percent_Identity=36.8078175895765, Blast_Score=176, Evalue=6e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 47360; Mature: 47229

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASFAERVRQLEESWKNEERWKGVVRPYSAEDVIKLRGSLDIEHTLARRGAEKLWKLLNT
CCHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
EDYVHALGALTGNQAVQQVKAGLKAIYLSGWQVAADANLAGHMYPDQSLYPSNSVPHVVK
HHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEEECCCCCCCCCCCCCCCCCCCCCHHHH
RINQALQRADQIQYLEGSGDVDYFVPIVADAEAGFGGQLNVFELMKAMIEAGAAGVHFED
HHHHHHHHHHHEEEECCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCHH
QLSSEKKCGHLGGKVLLPTQTAVRNLIAARLAADVMGVPTVLIARTDANAADLITSDIDP
HHCCHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHCCCCC
RDQQFITGERTTEGFYRTRAGLDQAIARGLAYAPYADLIWCETSEPNLDEARRFAEAIHE
CCCCEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHH
QFPGKLLAYNCSPSFNWKKKLDDETIAKFQQELGKMGYKFQFVTLAGFHALNYSMFELAR
HCCCCEEEEECCCCCCHHHHCCHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHC
GYKDRGMAAYAELQQAEFAAEKYGYTATRHQREVGTGYFDEVAQVISGGQSSTVALKGST
CHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEECCC
EEEQFTTA
CCHHCCCC
>Mature Secondary Structure 
ASFAERVRQLEESWKNEERWKGVVRPYSAEDVIKLRGSLDIEHTLARRGAEKLWKLLNT
CHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
EDYVHALGALTGNQAVQQVKAGLKAIYLSGWQVAADANLAGHMYPDQSLYPSNSVPHVVK
HHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEEECCCCCCCCCCCCCCCCCCCCCHHHH
RINQALQRADQIQYLEGSGDVDYFVPIVADAEAGFGGQLNVFELMKAMIEAGAAGVHFED
HHHHHHHHHHHEEEECCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCHH
QLSSEKKCGHLGGKVLLPTQTAVRNLIAARLAADVMGVPTVLIARTDANAADLITSDIDP
HHCCHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHCCCCC
RDQQFITGERTTEGFYRTRAGLDQAIARGLAYAPYADLIWCETSEPNLDEARRFAEAIHE
CCCCEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHH
QFPGKLLAYNCSPSFNWKKKLDDETIAKFQQELGKMGYKFQFVTLAGFHALNYSMFELAR
HCCCCEEEEECCCCCCHHHHCCHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHC
GYKDRGMAAYAELQQAEFAAEKYGYTATRHQREVGTGYFDEVAQVISGGQSSTVALKGST
CHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEECCC
EEEQFTTA
CCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]