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The map label for this gene is pgcA [H]

Identifier: 138894187

GI number: 138894187

Start: 575712

End: 577469

Strand: Direct

Name: pgcA [H]

Synonym: GTNG_0513

Alternate gene names: 138894187

Gene position: 575712-577469 (Clockwise)

Preceding gene: 138894186

Following gene: 138894189

Centisome position: 16.22

GC content: 48.63

Gene sequence:

>1758_bases
ATGGAGTGGAGACAAAAATATGAACAATGGCTTCGCGAACCGCAGTTGGATCCAGAGCTGAAGCAGCTTCTGGAGCAACA
CCGTGACGATGAGCGGTGGCTCGAAGATTGTTTTTACAAAAACTTGGAATTTGGCACCGGCGGTATGCGCGGTGAAATTG
GACCGGGGACGAACCGAATGAACATTTATACGGTTCGGAAAGCCTCGGAGGGTTTGGCACGATACATACAATCGTTTGGC
AATGAGGCGAAACAGCGTGGAGTCGTCATTGCCTACGACTCCCGGCATAAATCGCCGGAATTCGCCATGGAAGCGGCGAA
AACGTTAGCTACAAACGGCATTCAAACATACGTGTTTGATGAATTGCGGCCGACGCCGGAGCTGTCGTTTGCCGTTCGTC
ATTTGGGAGCATTTTCTGGCATTGTCATTACCGCCAGCCATAACCCACCGGAATATAACGGCTACAAAGTATATGGTGAA
GACGGAGGGCAGCTGCCGCCGGATACTGCTGATGAAGTGATCCGCTACGTCAATGAAGTCGAGAACGAGCTCGCCATTCA
TGTCGAGGATGAAGAAACGTTAAAAGAAAAAGGGCTGATCCGCATCATTGGCCAAGAAATTGATGAGGCGTATGTGAATG
CCGTAAAAACCATCTCGCTTCATCCGGAACTGGCTCAAGAGACGGATATTCGCATCGTGTTTACGCCGCTTCACGGCACG
TCAAACAAACCGGTGCGCCGTGTGCTAGCTGAACTTGGCTACCAAAACGTTTTTGTCGTTCAGGAGCAAGAACAGCCGGA
TCCGAATTTTTCAACTGTTGCCTCACCAAACCCAGAAGAGCATGCAGCTTTTGCCTTAGCGATTGAGCTTGGCAAGCAAG
TAAATGCCGACTTGCTCATTGCCACCGACCCGGACGCAGACCGGCTCGGCATTGCTGTAAAAAATGAGCAAGGAGAGTAT
GTCGTTTTAACCGGTAACCAAACGGGTGGGCTGCTGCTTCATTATTTATTGTCTCAGCGGAAAGAAAAAGGTTTACTGCC
ACAAAATGGCGTCGTCTTAAAAACGATCGTGACATCCGAGTTTGGCCGGGCGATTGCTGACTCGTTCGGTTTGGAGACGA
TCGATACGCTGACCGGATTTAAATTCATTGGTGAAAAAATCAAGGAATATGAACAAACGGGTCAGTATACGTTCCAGTTT
GGCTATGAGGAAAGTTACGGATATTTAATCGGGGATTTTGCACGCGATAAAGATGCGGTACAGGCAGCTGTTCTTGCAGC
GGAAGTGTGTGCGTTTTACAAACAGCAGGGGCTGTCTCTGTATGAAGCGCTTCTTCAATTGTTTGACAAATACGGGTATT
ACCGTGAAGGGCAACAGTCGCTCACGTTAAAAGGCAAGGAAGGAGCGGAAACGATCGCTGCTATTTTATCGTCATTCCGC
GAGCAACCGCCGGTTGAGGCAGCTGGGAAAAAAGTGACAGTGATCGAGGATTACAAAACGAAGGAGCGGACGAATACGTT
AACTGGGGAGAAAACTGCCATCACACTTCCAACTTCGAACGTCTTGAAATACGTATTAGAGGATGGCTCTTGGTTTTGTC
TGCGTCCATCAGGGACGGAGCCGAAAATGAAAGCGTACTTTGGTGTCAAAGGAACATCACTGCAAGATAGTGAAGAAAAA
TTGGCGAACCTTACTGATGCTGTCATGCAACGAGTGCATGACGTCTTGCGTACCGTTTCGCCTTCTTATGCTCAATAA

Upstream 100 bases:

>100_bases
GTGTCCATATTTTCCAGGACATCCTTTTTCTTTTAGCAGGTATATTGTATGATGGCAACGAATACATAAACAGGAGAAAT
AAAGATTGGAGGTAACAGCA

Downstream 100 bases:

>100_bases
TCAATGAACAATCAACGGCGGGGAATTGGACGAAACCAATTCCCCGTTGCTTTTACGAGTAAAAATATGCGTACTGCTCG
ACTCCCATTTTTTGTTCACT

Product: phosphoglucomutase

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 585; Mature: 585

Protein sequence:

>585_residues
MEWRQKYEQWLREPQLDPELKQLLEQHRDDERWLEDCFYKNLEFGTGGMRGEIGPGTNRMNIYTVRKASEGLARYIQSFG
NEAKQRGVVIAYDSRHKSPEFAMEAAKTLATNGIQTYVFDELRPTPELSFAVRHLGAFSGIVITASHNPPEYNGYKVYGE
DGGQLPPDTADEVIRYVNEVENELAIHVEDEETLKEKGLIRIIGQEIDEAYVNAVKTISLHPELAQETDIRIVFTPLHGT
SNKPVRRVLAELGYQNVFVVQEQEQPDPNFSTVASPNPEEHAAFALAIELGKQVNADLLIATDPDADRLGIAVKNEQGEY
VVLTGNQTGGLLLHYLLSQRKEKGLLPQNGVVLKTIVTSEFGRAIADSFGLETIDTLTGFKFIGEKIKEYEQTGQYTFQF
GYEESYGYLIGDFARDKDAVQAAVLAAEVCAFYKQQGLSLYEALLQLFDKYGYYREGQQSLTLKGKEGAETIAAILSSFR
EQPPVEAAGKKVTVIEDYKTKERTNTLTGEKTAITLPTSNVLKYVLEDGSWFCLRPSGTEPKMKAYFGVKGTSLQDSEEK
LANLTDAVMQRVHDVLRTVSPSYAQ

Sequences:

>Translated_585_residues
MEWRQKYEQWLREPQLDPELKQLLEQHRDDERWLEDCFYKNLEFGTGGMRGEIGPGTNRMNIYTVRKASEGLARYIQSFG
NEAKQRGVVIAYDSRHKSPEFAMEAAKTLATNGIQTYVFDELRPTPELSFAVRHLGAFSGIVITASHNPPEYNGYKVYGE
DGGQLPPDTADEVIRYVNEVENELAIHVEDEETLKEKGLIRIIGQEIDEAYVNAVKTISLHPELAQETDIRIVFTPLHGT
SNKPVRRVLAELGYQNVFVVQEQEQPDPNFSTVASPNPEEHAAFALAIELGKQVNADLLIATDPDADRLGIAVKNEQGEY
VVLTGNQTGGLLLHYLLSQRKEKGLLPQNGVVLKTIVTSEFGRAIADSFGLETIDTLTGFKFIGEKIKEYEQTGQYTFQF
GYEESYGYLIGDFARDKDAVQAAVLAAEVCAFYKQQGLSLYEALLQLFDKYGYYREGQQSLTLKGKEGAETIAAILSSFR
EQPPVEAAGKKVTVIEDYKTKERTNTLTGEKTAITLPTSNVLKYVLEDGSWFCLRPSGTEPKMKAYFGVKGTSLQDSEEK
LANLTDAVMQRVHDVLRTVSPSYAQ
>Mature_585_residues
MEWRQKYEQWLREPQLDPELKQLLEQHRDDERWLEDCFYKNLEFGTGGMRGEIGPGTNRMNIYTVRKASEGLARYIQSFG
NEAKQRGVVIAYDSRHKSPEFAMEAAKTLATNGIQTYVFDELRPTPELSFAVRHLGAFSGIVITASHNPPEYNGYKVYGE
DGGQLPPDTADEVIRYVNEVENELAIHVEDEETLKEKGLIRIIGQEIDEAYVNAVKTISLHPELAQETDIRIVFTPLHGT
SNKPVRRVLAELGYQNVFVVQEQEQPDPNFSTVASPNPEEHAAFALAIELGKQVNADLLIATDPDADRLGIAVKNEQGEY
VVLTGNQTGGLLLHYLLSQRKEKGLLPQNGVVLKTIVTSEFGRAIADSFGLETIDTLTGFKFIGEKIKEYEQTGQYTFQF
GYEESYGYLIGDFARDKDAVQAAVLAAEVCAFYKQQGLSLYEALLQLFDKYGYYREGQQSLTLKGKEGAETIAAILSSFR
EQPPVEAAGKKVTVIEDYKTKERTNTLTGEKTAITLPTSNVLKYVLEDGSWFCLRPSGTEPKMKAYFGVKGTSLQDSEEK
LANLTDAVMQRVHDVLRTVSPSYAQ

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=557, Percent_Identity=33.0341113105925, Blast_Score=297, Evalue=2e-80,
Organism=Homo sapiens, GI31377548, Length=585, Percent_Identity=31.1111111111111, Blast_Score=276, Evalue=6e-74,
Organism=Escherichia coli, GI1786904, Length=533, Percent_Identity=24.577861163227, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI1789566, Length=403, Percent_Identity=25.8064516129032, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71993870, Length=578, Percent_Identity=31.6608996539792, Blast_Score=250, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI71993878, Length=313, Percent_Identity=32.9073482428115, Blast_Score=162, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6323934, Length=593, Percent_Identity=31.3659359190556, Blast_Score=229, Evalue=1e-60,
Organism=Drosophila melanogaster, GI20129809, Length=587, Percent_Identity=30.3236797274276, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24651977, Length=544, Percent_Identity=29.9632352941176, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24653722, Length=586, Percent_Identity=27.3037542662116, Blast_Score=214, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 65523; Mature: 65523

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEWRQKYEQWLREPQLDPELKQLLEQHRDDERWLEDCFYKNLEFGTGGMRGEIGPGTNRM
CCHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCE
NIYTVRKASEGLARYIQSFGNEAKQRGVVIAYDSRHKSPEFAMEAAKTLATNGIQTYVFD
EEEEEHHHHHHHHHHHHHHCCHHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEC
ELRPTPELSFAVRHLGAFSGIVITASHNPPEYNGYKVYGEDGGQLPPDTADEVIRYVNEV
CCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHH
ENELAIHVEDEETLKEKGLIRIIGQEIDEAYVNAVKTISLHPELAQETDIRIVFTPLHGT
CCCEEEEECCHHHHHHCCHHEEHHHHHHHHHHHHHHEEECCCCHHCCCCCEEEEEECCCC
SNKPVRRVLAELGYQNVFVVQEQEQPDPNFSTVASPNPEEHAAFALAIELGKQVNADLLI
CCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHEEHHCCCCCCCEEE
ATDPDADRLGIAVKNEQGEYVVLTGNQTGGLLLHYLLSQRKEKGLLPQNGVVLKTIVTSE
EECCCCCCEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHH
FGRAIADSFGLETIDTLTGFKFIGEKIKEYEQTGQYTFQFGYEESYGYLIGDFARDKDAV
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEECHHCCHHHH
QAAVLAAEVCAFYKQQGLSLYEALLQLFDKYGYYREGQQSLTLKGKEGAETIAAILSSFR
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHH
EQPPVEAAGKKVTVIEDYKTKERTNTLTGEKTAITLPTSNVLKYVLEDGSWFCLRPSGTE
CCCCHHHCCCEEEEEECCCCHHHHCCCCCCCEEEECCHHHHHHHHHCCCCEEEECCCCCC
PKMKAYFGVKGTSLQDSEEKLANLTDAVMQRVHDVLRTVSPSYAQ
CCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEWRQKYEQWLREPQLDPELKQLLEQHRDDERWLEDCFYKNLEFGTGGMRGEIGPGTNRM
CCHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCE
NIYTVRKASEGLARYIQSFGNEAKQRGVVIAYDSRHKSPEFAMEAAKTLATNGIQTYVFD
EEEEEHHHHHHHHHHHHHHCCHHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEC
ELRPTPELSFAVRHLGAFSGIVITASHNPPEYNGYKVYGEDGGQLPPDTADEVIRYVNEV
CCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHH
ENELAIHVEDEETLKEKGLIRIIGQEIDEAYVNAVKTISLHPELAQETDIRIVFTPLHGT
CCCEEEEECCHHHHHHCCHHEEHHHHHHHHHHHHHHEEECCCCHHCCCCCEEEEEECCCC
SNKPVRRVLAELGYQNVFVVQEQEQPDPNFSTVASPNPEEHAAFALAIELGKQVNADLLI
CCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHEEHHCCCCCCCEEE
ATDPDADRLGIAVKNEQGEYVVLTGNQTGGLLLHYLLSQRKEKGLLPQNGVVLKTIVTSE
EECCCCCCEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHH
FGRAIADSFGLETIDTLTGFKFIGEKIKEYEQTGQYTFQFGYEESYGYLIGDFARDKDAV
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEECHHCCHHHH
QAAVLAAEVCAFYKQQGLSLYEALLQLFDKYGYYREGQQSLTLKGKEGAETIAAILSSFR
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHH
EQPPVEAAGKKVTVIEDYKTKERTNTLTGEKTAITLPTSNVLKYVLEDGSWFCLRPSGTE
CCCCHHHCCCEEEEEECCCCHHHHCCCCCCCEEEECCHHHHHHHHHCCCCEEEECCCCCC
PKMKAYFGVKGTSLQDSEEKLANLTDAVMQRVHDVLRTVSPSYAQ
CCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]