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The map label for this gene is yfhQ [H]

Identifier: 138894142

GI number: 138894142

Start: 524536

End: 525642

Strand: Direct

Name: yfhQ [H]

Synonym: GTNG_0468

Alternate gene names: 138894142

Gene position: 524536-525642 (Clockwise)

Preceding gene: 138894141

Following gene: 138894144

Centisome position: 14.77

GC content: 52.66

Gene sequence:

>1107_bases
ATGAATATGACAACGTGGACAAAACGGTTTCCTGCCCGCGAGTTTCAGCGCGATTTGCTTGATTGGTTTGCCCGTGAGCG
CCGCGATTTACCGTGGCGCCAAGACCGCGATCCGTATAAGGTTTGGGTATCGGAAGTCATGTTGCAGCAGACGCGCGTCG
AGACAGTGATTCCGTATTTTGAAAAGTTTATCAGGCAATTTCCGACGCTAGAGGCGCTCGCTGACGCCGATGAAGACGAA
GTGCTGAAAGCGTGGGAAGGGCTCGGCTATTACTCGCGTGTGCGCAACTTGCATGCAGCGGTAAAAGAAGTAAAAGAGCG
CTACGGAGGAAAAGTGCCGGATAATCCGGATGAGTTTTCGAAGTTGAAAGGAGTCGGTCCGTATACGGTCGGGGCTGTAT
TGAGCCTCGCCTACGGCGTGCCAGAGCCAGCGGTCGATGGTAACGTCATGCGTGTGTTGTCTCGTTTGTTTTTGGTGACG
GATGACATTGCTAAGGCGTCAACACGAAAGCGGTTTGAACAGATTGTCCGTGAAATTATGGCGTATGAACAGCCTGGGGC
ATTTAATGAAGCGTTGATTGAGCTGGGTGCTCTTGTTTGTACGCCGCGCCGCCCATCGTGCCTTCTTTGCCCGGTGCAAG
CTCATTGCCGAGCGTTCGCGGAAGGGGTGCCGGAGGAACTGCCGGTGAAAACGAAAAAAACAGCGGTGAAACAAGTGCCC
CTTGCGGTCGCGGTGCTGACTGACCAAGAAGGGCGCATTCTGATTCGCAAACGTGATCATACCGGTCTGCTGGCAAACTT
GTGGGAATTTCCAAGCTGTGAAATGAAGGGCGAAGGTGAGAAAGAGAATTTGGAAAGGGCGTTTTTGAACGAGCAAGGTC
TCGACGTCAAGCTTGGTGAACCTATCGTTTCGTTTGATCATGTTTTTTCCCACTTAGTGTGGAAGCTGACGGTGTTTTAT
GGACGATTGCTTGATGGCGAGCGGCTGGAGGAACCGTATCGATTGGTGTCAGAGAGGGAGCTAGAGACATACGCATTTCC
TGTATCACATCAGCGCGTTTGGCGGGAATATCAAGAGCACGCAGGCGAAGCGCGCCGCCTGCGTTAA

Upstream 100 bases:

>100_bases
TGTAGTGGATCACCCAGCCGTTTGTCTTCCTGCATGCTGCAAGTCATGTTGGGGGTTTTTTGGTATAATGGGATGGACAA
TAGACACCATGGGGGACATA

Downstream 100 bases:

>100_bases
TCGGGAACTGGCATCGTGCCATGCGTGTACGTCGCTTCGCGGCGCCCAAGGCCACCGCGCGCTTCAATTTCTTCAATAAT
TTCCCGATGAATCGTTTGCC

Product: A/G-specific adenine DNA glycosylase

Products: Adenine [C]

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MNMTTWTKRFPAREFQRDLLDWFARERRDLPWRQDRDPYKVWVSEVMLQQTRVETVIPYFEKFIRQFPTLEALADADEDE
VLKAWEGLGYYSRVRNLHAAVKEVKERYGGKVPDNPDEFSKLKGVGPYTVGAVLSLAYGVPEPAVDGNVMRVLSRLFLVT
DDIAKASTRKRFEQIVREIMAYEQPGAFNEALIELGALVCTPRRPSCLLCPVQAHCRAFAEGVPEELPVKTKKTAVKQVP
LAVAVLTDQEGRILIRKRDHTGLLANLWEFPSCEMKGEGEKENLERAFLNEQGLDVKLGEPIVSFDHVFSHLVWKLTVFY
GRLLDGERLEEPYRLVSERELETYAFPVSHQRVWREYQEHAGEARRLR

Sequences:

>Translated_368_residues
MNMTTWTKRFPAREFQRDLLDWFARERRDLPWRQDRDPYKVWVSEVMLQQTRVETVIPYFEKFIRQFPTLEALADADEDE
VLKAWEGLGYYSRVRNLHAAVKEVKERYGGKVPDNPDEFSKLKGVGPYTVGAVLSLAYGVPEPAVDGNVMRVLSRLFLVT
DDIAKASTRKRFEQIVREIMAYEQPGAFNEALIELGALVCTPRRPSCLLCPVQAHCRAFAEGVPEELPVKTKKTAVKQVP
LAVAVLTDQEGRILIRKRDHTGLLANLWEFPSCEMKGEGEKENLERAFLNEQGLDVKLGEPIVSFDHVFSHLVWKLTVFY
GRLLDGERLEEPYRLVSERELETYAFPVSHQRVWREYQEHAGEARRLR
>Mature_368_residues
MNMTTWTKRFPAREFQRDLLDWFARERRDLPWRQDRDPYKVWVSEVMLQQTRVETVIPYFEKFIRQFPTLEALADADEDE
VLKAWEGLGYYSRVRNLHAAVKEVKERYGGKVPDNPDEFSKLKGVGPYTVGAVLSLAYGVPEPAVDGNVMRVLSRLFLVT
DDIAKASTRKRFEQIVREIMAYEQPGAFNEALIELGALVCTPRRPSCLLCPVQAHCRAFAEGVPEELPVKTKKTAVKQVP
LAVAVLTDQEGRILIRKRDHTGLLANLWEFPSCEMKGEGEKENLERAFLNEQGLDVKLGEPIVSFDHVFSHLVWKLTVFY
GRLLDGERLEEPYRLVSERELETYAFPVSHQRVWREYQEHAGEARRLR

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI190358497, Length=413, Percent_Identity=35.8353510895884, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI115298648, Length=413, Percent_Identity=35.8353510895884, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI6912520, Length=413, Percent_Identity=35.8353510895884, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI115298654, Length=413, Percent_Identity=35.8353510895884, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI115298652, Length=413, Percent_Identity=35.8353510895884, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI115298650, Length=413, Percent_Identity=35.8353510895884, Blast_Score=209, Evalue=3e-54,
Organism=Escherichia coli, GI1789331, Length=302, Percent_Identity=39.7350993377483, Blast_Score=222, Evalue=3e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.- [C]

Molecular weight: Translated: 42582; Mature: 42582

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMTTWTKRFPAREFQRDLLDWFARERRDLPWRQDRDPYKVWVSEVMLQQTRVETVIPYF
CCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EKFIRQFPTLEALADADEDEVLKAWEGLGYYSRVRNLHAAVKEVKERYGGKVPDNPDEFS
HHHHHHCCCHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
KLKGVGPYTVGAVLSLAYGVPEPAVDGNVMRVLSRLFLVTDDIAKASTRKRFEQIVREIM
HHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYEQPGAFNEALIELGALVCTPRRPSCLLCPVQAHCRAFAEGVPEELPVKTKKTAVKQVP
HCCCCCCHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHCCCCCCCCCHHHHHHHHCC
LAVAVLTDQEGRILIRKRDHTGLLANLWEFPSCEMKGEGEKENLERAFLNEQGLDVKLGE
EEEEEEECCCCEEEEEECCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCEECCC
PIVSFDHVFSHLVWKLTVFYGRLLDGERLEEPYRLVSERELETYAFPVSHQRVWREYQEH
CHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
AGEARRLR
HHHHHCCC
>Mature Secondary Structure
MNMTTWTKRFPAREFQRDLLDWFARERRDLPWRQDRDPYKVWVSEVMLQQTRVETVIPYF
CCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EKFIRQFPTLEALADADEDEVLKAWEGLGYYSRVRNLHAAVKEVKERYGGKVPDNPDEFS
HHHHHHCCCHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
KLKGVGPYTVGAVLSLAYGVPEPAVDGNVMRVLSRLFLVTDDIAKASTRKRFEQIVREIM
HHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYEQPGAFNEALIELGALVCTPRRPSCLLCPVQAHCRAFAEGVPEELPVKTKKTAVKQVP
HCCCCCCHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHCCCCCCCCCHHHHHHHHCC
LAVAVLTDQEGRILIRKRDHTGLLANLWEFPSCEMKGEGEKENLERAFLNEQGLDVKLGE
EEEEEEECCCCEEEEEECCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCEECCC
PIVSFDHVFSHLVWKLTVFYGRLLDGERLEEPYRLVSERELETYAFPVSHQRVWREYQEH
CHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
AGEARRLR
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Guanine-adenine mispair [C]

Specific reaction: Catalyzes the excision of adenine from a guanine-adenine mispair [C]

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]