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The map label for this gene is manC [C]

Identifier: 138894009

GI number: 138894009

Start: 381290

End: 382333

Strand: Direct

Name: manC [C]

Synonym: GTNG_0335

Alternate gene names: 138894009

Gene position: 381290-382333 (Clockwise)

Preceding gene: 138894003

Following gene: 138894010

Centisome position: 10.74

GC content: 50.29

Gene sequence:

>1044_bases
ATGAAAGCATTGTTGCTGGCTGGAGGATTAGGTACACGTCTTCGTCCATTGACCGAAAACATCCCCAAACCGATGGCCCC
AATTGCAAATCGGCCGTGGCTTGAGCACCTCATTATTCATCTTCGCGATCAAGGAGTCAATGAATTTGTCATCGCTGCTC
ACCATTGTTCAGAAGTGATCCGCCGTTATTTCGGCGACGGGAAGAGTTGGAACGTCAACATTACATACGCGCTTGAACCA
TTCCCGCTTGGAACGGCCGGGGCAATTAAAAATGCCGAACGTTGGCTTGATGAACGATTCCTCGTGTTTAACGCCGATAT
TGTACATTTGCCGCAATTGATTCCTCTGCTTGATTTTCACCGACAGCACGGTGGCATCGCGACGATTGTTTTAACGGAAG
TCGACGATCCGTCCTCCTATGGAGTAGTTGAACAAGATGACCAAGGACAAATTTTGCGCTTTATCGAGAAGCCGCGCCGT
GAGGAAGCGCCGTCCAACCGGATCAATGCCGGTATGTATATTTTGGAACCGGACGTAATGCGCTACATTCCGGCTGAGCA
GGAAGTGTCGATCGAACGTGAAACATTCCCGCGCTTAATCGAAGAAAACACTGGTGTTTATGGCATTGTCAGCAGCGGAT
ATTGGCGCGATATGGGAACGCCGGCCCGTTATCGCCAAGTGCATTGGGATGCCTTGAACCGAGAGTTTCCGCTCCCGATC
AAAGGGCGTGAGATTCAGCCGGGCGTGTTTGTCGGTGAAAATGTCAAAATTAGTTCGGGTGTGCTGTTTGTACCCCCTGT
ACTAATTGGTCATAATGTGAAAATCGGGCATCAAGCAGTCATCGGCCCGTATGCCGTCATCGGTGACGATTGTCAAATCG
GCTCCCGCGTCCATTGCGCGCATACGATTGTCTGGGATCGTTCCCTCATTCGTGATCGCAGCCGTTTGCAAAACAGCATT
TTTGGCTACCGGACGGTGACACCGGCTGGAGAAGTATTCGAAGATTCGATTATTAATCAGTTTAAGGAGGCGGTGCAAGC
ATGA

Upstream 100 bases:

>100_bases
AGCTGAGTGCTAGCAATCTATGAATCACTTTCATTTTCTCGTTCATCCGTCAAGATGATTGTCTGTTTTTTGCGAAAAAA
TCATATGGAGGGATGACGAA

Downstream 100 bases:

>100_bases
CCCGAATTGCGTACGTCAGTACATATCCGCCGCGTAGGTGCGGATTGGCTACGTTTACGGAACATCTTCGTCAAAGCATT
GATAGCGTCCGCGGAAAGGT

Product: nucleoside-diphosphate-sugar pyrophosphorylase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MKALLLAGGLGTRLRPLTENIPKPMAPIANRPWLEHLIIHLRDQGVNEFVIAAHHCSEVIRRYFGDGKSWNVNITYALEP
FPLGTAGAIKNAERWLDERFLVFNADIVHLPQLIPLLDFHRQHGGIATIVLTEVDDPSSYGVVEQDDQGQILRFIEKPRR
EEAPSNRINAGMYILEPDVMRYIPAEQEVSIERETFPRLIEENTGVYGIVSSGYWRDMGTPARYRQVHWDALNREFPLPI
KGREIQPGVFVGENVKISSGVLFVPPVLIGHNVKIGHQAVIGPYAVIGDDCQIGSRVHCAHTIVWDRSLIRDRSRLQNSI
FGYRTVTPAGEVFEDSIINQFKEAVQA

Sequences:

>Translated_347_residues
MKALLLAGGLGTRLRPLTENIPKPMAPIANRPWLEHLIIHLRDQGVNEFVIAAHHCSEVIRRYFGDGKSWNVNITYALEP
FPLGTAGAIKNAERWLDERFLVFNADIVHLPQLIPLLDFHRQHGGIATIVLTEVDDPSSYGVVEQDDQGQILRFIEKPRR
EEAPSNRINAGMYILEPDVMRYIPAEQEVSIERETFPRLIEENTGVYGIVSSGYWRDMGTPARYRQVHWDALNREFPLPI
KGREIQPGVFVGENVKISSGVLFVPPVLIGHNVKIGHQAVIGPYAVIGDDCQIGSRVHCAHTIVWDRSLIRDRSRLQNSI
FGYRTVTPAGEVFEDSIINQFKEAVQA
>Mature_347_residues
MKALLLAGGLGTRLRPLTENIPKPMAPIANRPWLEHLIIHLRDQGVNEFVIAAHHCSEVIRRYFGDGKSWNVNITYALEP
FPLGTAGAIKNAERWLDERFLVFNADIVHLPQLIPLLDFHRQHGGIATIVLTEVDDPSSYGVVEQDDQGQILRFIEKPRR
EEAPSNRINAGMYILEPDVMRYIPAEQEVSIERETFPRLIEENTGVYGIVSSGYWRDMGTPARYRQVHWDALNREFPLPI
KGREIQPGVFVGENVKISSGVLFVPPVLIGHNVKIGHQAVIGPYAVIGDDCQIGSRVHCAHTIVWDRSLIRDRSRLQNSI
FGYRTVTPAGEVFEDSIINQFKEAVQA

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=330, Percent_Identity=35.7575757575758, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI11761619, Length=330, Percent_Identity=35.7575757575758, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI31881779, Length=366, Percent_Identity=23.7704918032787, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI45447090, Length=366, Percent_Identity=23.7704918032787, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI1788351, Length=227, Percent_Identity=29.5154185022026, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1790224, Length=185, Percent_Identity=31.3513513513514, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI133931050, Length=329, Percent_Identity=34.6504559270517, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17509979, Length=345, Percent_Identity=27.536231884058, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17509981, Length=332, Percent_Identity=26.8072289156627, Blast_Score=95, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6320148, Length=337, Percent_Identity=37.9821958456973, Blast_Score=197, Evalue=1e-51,
Organism=Drosophila melanogaster, GI21355443, Length=331, Percent_Identity=34.1389728096677, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24644084, Length=331, Percent_Identity=34.1389728096677, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24653912, Length=370, Percent_Identity=28.1081081081081, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 39149; Mature: 39149

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALLLAGGLGTRLRPLTENIPKPMAPIANRPWLEHLIIHLRDQGVNEFVIAAHHCSEVI
CCEEEEECCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEHHHHHHHH
RRYFGDGKSWNVNITYALEPFPLGTAGAIKNAERWLDERFLVFNADIVHLPQLIPLLDFH
HHHHCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHCEEEEEECCHHHHHHHHHHHHHH
RQHGGIATIVLTEVDDPSSYGVVEQDDQGQILRFIEKPRREEAPSNRINAGMYILEPDVM
HHCCCEEEEEEEECCCCCCCCCEEECCCCHHHHHHHCCHHHCCCCCCCCCCEEEECCHHH
RYIPAEQEVSIERETFPRLIEENTGVYGIVSSGYWRDMGTPARYRQVHWDALNREFPLPI
HHCCCCHHCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
KGREIQPGVFVGENVKISSGVLFVPPVLIGHNVKIGHQAVIGPYAVIGDDCQIGSRVHCA
CCCCCCCCEEECCCEEECCCEEEECCEEECCCEEECCEEEECCEEEECCCCCCCCEEEEE
HTIVWDRSLIRDRSRLQNSIFGYRTVTPAGEVFEDSIINQFKEAVQA
EHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKALLLAGGLGTRLRPLTENIPKPMAPIANRPWLEHLIIHLRDQGVNEFVIAAHHCSEVI
CCEEEEECCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEHHHHHHHH
RRYFGDGKSWNVNITYALEPFPLGTAGAIKNAERWLDERFLVFNADIVHLPQLIPLLDFH
HHHHCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHCEEEEEECCHHHHHHHHHHHHHH
RQHGGIATIVLTEVDDPSSYGVVEQDDQGQILRFIEKPRREEAPSNRINAGMYILEPDVM
HHCCCEEEEEEEECCCCCCCCCEEECCCCHHHHHHHCCHHHCCCCCCCCCCEEEECCHHH
RYIPAEQEVSIERETFPRLIEENTGVYGIVSSGYWRDMGTPARYRQVHWDALNREFPLPI
HHCCCCHHCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
KGREIQPGVFVGENVKISSGVLFVPPVLIGHNVKIGHQAVIGPYAVIGDDCQIGSRVHCA
CCCCCCCCEEECCCEEECCCEEEECCEEECCCEEECCEEEECCEEEECCCCCCCCEEEEE
HTIVWDRSLIRDRSRLQNSIFGYRTVTPAGEVFEDSIINQFKEAVQA
EHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA