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The map label for this gene is nudG [H]

Identifier: 138894003

GI number: 138894003

Start: 373523

End: 373924

Strand: Direct

Name: nudG [H]

Synonym: GTNG_0329

Alternate gene names: 138894003

Gene position: 373523-373924 (Clockwise)

Preceding gene: 138894001

Following gene: 138894009

Centisome position: 10.52

GC content: 56.72

Gene sequence:

>402_bases
ATGAAACGGGTTATCCACGTGGTCGGGGCAGCCATCTGCAATGAACAGGGGGACGTCTTATGCGCGTTGCGTGGGCCGCA
GATGTCGTTGCCGAACGTTTGGGAGTTTCCAGGCGGCAAAGTGGAAGAAGGAGAGAGTTCGGAAGCGGCCTTAGTTCGAG
AAATTCGTGAGGAACTTGGCTGTACCATTTCGGTCGGCAAGCTGTTAGCTGATGTGTTCCATAAGTATGAACACGCCATC
GTTCATTTGCAGACATATGAAGCTCGCCTCATCGATGGGGAGCCGCGGGCACGGGAGCATGCCGAGCTCCGGTGGGTGCC
GCTCTCTCAGCTTCGTACCCTGGCATGGGCGCCCGCTGATCTCCCTACCGTTGAGGCACTGTTGGCAAAGAGCTGTTCAT
AG

Upstream 100 bases:

>100_bases
ACATTTGTTATAGCACAATGTTTGAATAAATTCCACTATTTTGGAAAACGAAACGTTTTTTGCTAAAATGGCGTATATCG
ATGAGAGAGGTAGGTCAGCA

Downstream 100 bases:

>100_bases
GCAAACGAGGCATTGATTCCGATGAAGGAAAACGGAATTGGCCCACAGTCATTCAATGAAGCCTTGGAGCCAACTGCTCC
AAGGCTTCACTCTTCACCGT

Product: Mutator mutT protein/7,8-dihydro-8-oxoguanine-triphosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 133; Mature: 133

Protein sequence:

>133_residues
MKRVIHVVGAAICNEQGDVLCALRGPQMSLPNVWEFPGGKVEEGESSEAALVREIREELGCTISVGKLLADVFHKYEHAI
VHLQTYEARLIDGEPRAREHAELRWVPLSQLRTLAWAPADLPTVEALLAKSCS

Sequences:

>Translated_133_residues
MKRVIHVVGAAICNEQGDVLCALRGPQMSLPNVWEFPGGKVEEGESSEAALVREIREELGCTISVGKLLADVFHKYEHAI
VHLQTYEARLIDGEPRAREHAELRWVPLSQLRTLAWAPADLPTVEALLAKSCS
>Mature_133_residues
MKRVIHVVGAAICNEQGDVLCALRGPQMSLPNVWEFPGGKVEEGESSEAALVREIREELGCTISVGKLLADVFHKYEHAI
VHLQTYEARLIDGEPRAREHAELRWVPLSQLRTLAWAPADLPTVEALLAKSCS

Specific function: Specific for pyrimidine substrates. Acts on 5-methyl- dCTP, CTP and dCTP in decreasing order [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788056, Length=127, Percent_Identity=40.1574803149606, Blast_Score=83, Evalue=7e-18,
Organism=Escherichia coli, GI1786288, Length=127, Percent_Identity=31.496062992126, Blast_Score=65, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.-

Molecular weight: Translated: 14695; Mature: 14695

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVIHVVGAAICNEQGDVLCALRGPQMSLPNVWEFPGGKVEEGESSEAALVREIREELG
CCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
CTISVGKLLADVFHKYEHAIVHLQTYEARLIDGEPRAREHAELRWVPLSQLRTLAWAPAD
CEEEHHHHHHHHHHHHHHHEEEEEECCEEEECCCCCCCCCCEEEEECHHHHHHHHCCCCC
LPTVEALLAKSCS
CHHHHHHHHHCCC
>Mature Secondary Structure
MKRVIHVVGAAICNEQGDVLCALRGPQMSLPNVWEFPGGKVEEGESSEAALVREIREELG
CCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
CTISVGKLLADVFHKYEHAIVHLQTYEARLIDGEPRAREHAELRWVPLSQLRTLAWAPAD
CEEEHHHHHHHHHHHHHHHEEEEEECCEEEECCCCCCCCCCEEEEECHHHHHHHHCCCCC
LPTVEALLAKSCS
CHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 11053429 [H]