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The map label for this gene is mdtG [H]

Identifier: 138893957

GI number: 138893957

Start: 318801

End: 320039

Strand: Reverse

Name: mdtG [H]

Synonym: GTNG_0281

Alternate gene names: 138893957

Gene position: 320039-318801 (Counterclockwise)

Preceding gene: 138893958

Following gene: 138893954

Centisome position: 9.01

GC content: 53.03

Gene sequence:

>1239_bases
ATGGACTGGAAGCGAAGCGTCCGCATTTTATGGCTGTGCAATTTTATGGTTTCGGCTGGAATGACCATGGTCATTCCCTT
TTTATCGCTCTTCCTATGGCAAATGGGTGTCACTGAACATCATGCCTTAAGCATGTGGACAGGGCTCGTCTTTTCCGCCA
CCTTTTTATCGGCTGCGATTATGGCACCGATTTGGGGCATGTTTGCCGATAAATACGGCCAGCGCGCCAATTTGATTCGC
GCTGGAATCGGCATGGGCCTCCTCACCGCCTGCATGGCGTTTGCCGCATCGCCGATGGCACTGCTTGTGCTCCGATTTCT
TGTTGGCTTTTTCTCGGGATTCATCACCGTCTCGTTTTCCTATTTGGCCCGCATCGTTCCAAAAGACCATAGCGGCGAGG
CACTCGGAACACTGCAAACCGGAAGTATCGCCGGCAACATTATCGGACCGCTCATCGGCGGCGCTTTATCCGACCTATTT
GGCTTCCGTCCAGTGTTTTTGGTGACCGGGCTTTGCATTTTGCTTACGCTCTTGCCTGTAATGTTTTGGCTCGAAAAAGA
TCCGGTCGTGCCGCAGACGAAAAAGAACAAAGCGAGCTTCAAGGAAGTGTTCGAACATCGGCCGCTCATCATCTTGTTTA
TCGCTACGTTTCTTGTGCAAATCGCTGTTCTTGGCGTCAATTCGATGATGACCATTTTTGTCCAATCGTTAGTCGGCAAC
ACAAGCAATCTCGCATTTCTGTCCGGCCTCGCCTCATCCATCACCGGCATTGCGACGATCATCGGCGCGCCGTACTTAGG
AAAACTCGGCGACCGGATCGGGCAGGAGAAAACATTACCGATACTGCTTGTGCTGTCCGGTTTGTTCGCCTTGCCGCAAG
TATGGACAGACAATATTTACGCCCTGTACGTGTGGCGCTTCTTGCAAGGGCTGGTAGTCGGCGGCGTATGGCCAGCCATT
CAGGCACTCATCAATGTGCAAAGCCCACGCCGCATTCAAGGGCGGGTGTTCGGCGTCACCGCCAGCAGCCGCTTTCTCGG
CAACTTGACCGGTCCTACCGCTGCAGGTGCCATCGCCAGTCTATTTTCCATCGCCTACATTTTTGCCTTCTCCAGCCTCT
TGCTCATTGTCACCGGCGCCTTAGTCGGCTATGCCCATCGTCGTTCATCAAGCGTGTGGCGCAAAGAGATGAAAGAAAAA
CTCACCACTTGGACACATCGCCTTCATAGTCGGCACTAA

Upstream 100 bases:

>100_bases
CTAGTTGATTTCCCGCCATGGATGAGCAAAATCATTTCCTCTATTTTTCCATTGTAGTAGAATGATTAGAGAAACGAAAT
AATTCAGGAGATGACCTCCC

Downstream 100 bases:

>100_bases
GCGTCTTGTCGGAATCGAACGCAAAGAAGGTGTCCGTAAAGAAATGAGATGATCCCCTTATAGTAGACAGAAAAAGAAAG
CCCGCGAATCTGTTTACTAT

Product: multidrug resistance protein B-like protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MDWKRSVRILWLCNFMVSAGMTMVIPFLSLFLWQMGVTEHHALSMWTGLVFSATFLSAAIMAPIWGMFADKYGQRANLIR
AGIGMGLLTACMAFAASPMALLVLRFLVGFFSGFITVSFSYLARIVPKDHSGEALGTLQTGSIAGNIIGPLIGGALSDLF
GFRPVFLVTGLCILLTLLPVMFWLEKDPVVPQTKKNKASFKEVFEHRPLIILFIATFLVQIAVLGVNSMMTIFVQSLVGN
TSNLAFLSGLASSITGIATIIGAPYLGKLGDRIGQEKTLPILLVLSGLFALPQVWTDNIYALYVWRFLQGLVVGGVWPAI
QALINVQSPRRIQGRVFGVTASSRFLGNLTGPTAAGAIASLFSIAYIFAFSSLLLIVTGALVGYAHRRSSSVWRKEMKEK
LTTWTHRLHSRH

Sequences:

>Translated_412_residues
MDWKRSVRILWLCNFMVSAGMTMVIPFLSLFLWQMGVTEHHALSMWTGLVFSATFLSAAIMAPIWGMFADKYGQRANLIR
AGIGMGLLTACMAFAASPMALLVLRFLVGFFSGFITVSFSYLARIVPKDHSGEALGTLQTGSIAGNIIGPLIGGALSDLF
GFRPVFLVTGLCILLTLLPVMFWLEKDPVVPQTKKNKASFKEVFEHRPLIILFIATFLVQIAVLGVNSMMTIFVQSLVGN
TSNLAFLSGLASSITGIATIIGAPYLGKLGDRIGQEKTLPILLVLSGLFALPQVWTDNIYALYVWRFLQGLVVGGVWPAI
QALINVQSPRRIQGRVFGVTASSRFLGNLTGPTAAGAIASLFSIAYIFAFSSLLLIVTGALVGYAHRRSSSVWRKEMKEK
LTTWTHRLHSRH
>Mature_412_residues
MDWKRSVRILWLCNFMVSAGMTMVIPFLSLFLWQMGVTEHHALSMWTGLVFSATFLSAAIMAPIWGMFADKYGQRANLIR
AGIGMGLLTACMAFAASPMALLVLRFLVGFFSGFITVSFSYLARIVPKDHSGEALGTLQTGSIAGNIIGPLIGGALSDLF
GFRPVFLVTGLCILLTLLPVMFWLEKDPVVPQTKKNKASFKEVFEHRPLIILFIATFLVQIAVLGVNSMMTIFVQSLVGN
TSNLAFLSGLASSITGIATIIGAPYLGKLGDRIGQEKTLPILLVLSGLFALPQVWTDNIYALYVWRFLQGLVVGGVWPAI
QALINVQSPRRIQGRVFGVTASSRFLGNLTGPTAAGAIASLFSIAYIFAFSSLLLIVTGALVGYAHRRSSSVWRKEMKEK
LTTWTHRLHSRH

Specific function: Confers resistance to fosfomycin and deoxycholate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787291, Length=403, Percent_Identity=37.2208436724566, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI87082404, Length=392, Percent_Identity=24.7448979591837, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44983; Mature: 44983

Theoretical pI: Translated: 10.83; Mature: 10.83

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDWKRSVRILWLCNFMVSAGMTMVIPFLSLFLWQMGVTEHHALSMWTGLVFSATFLSAAI
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
MAPIWGMFADKYGQRANLIRAGIGMGLLTACMAFAASPMALLVLRFLVGFFSGFITVSFS
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
YLARIVPKDHSGEALGTLQTGSIAGNIIGPLIGGALSDLFGFRPVFLVTGLCILLTLLPV
HHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
MFWLEKDPVVPQTKKNKASFKEVFEHRPLIILFIATFLVQIAVLGVNSMMTIFVQSLVGN
HHHHCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TSNLAFLSGLASSITGIATIIGAPYLGKLGDRIGQEKTLPILLVLSGLFALPQVWTDNIY
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHH
ALYVWRFLQGLVVGGVWPAIQALINVQSPRRIQGRVFGVTASSRFLGNLTGPTAAGAIAS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEHHHHHCCCCCCHHHHHHHH
LFSIAYIFAFSSLLLIVTGALVGYAHRRSSSVWRKEMKEKLTTWTHRLHSRH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA