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The map label for this gene is map [H]

Identifier: 138893806

GI number: 138893806

Start: 136597

End: 137337

Strand: Direct

Name: map [H]

Synonym: GTNG_0127

Alternate gene names: 138893806

Gene position: 136597-137337 (Clockwise)

Preceding gene: 138893805

Following gene: 138893807

Centisome position: 3.85

GC content: 48.99

Gene sequence:

>741_bases
ATGATTATTTATAAAACCGAGCATGAAATTGCCCTTATGCGTGAGGCGGGAAAAATTGTTTCCCTTACCTTAGAAGAGCT
GAAAAAGCATATTCGTCCCGGGATAACGACAAAGGAACTGGACGCCATTGCGGAGGAAGTAATTCGTTCCCATGGCGCCA
TTCCGTCGTTTAAAGGGTATCAAGGGTTTCCAGGAAGCATTTGCGCCTCAGTAAATGAGGAACTCGTGCACGGAATTCCC
GGCAATCGCATGCTACGCGAGGGCGACATTATTACGGTCGATGTGGGAGCACAGTATGAAGGCTACCATGCTGACTCAGC
TTGGACATATCCAGTTGGGGAGATCGACGCTGAGACGAAGCGGTTGCTTGACGTGACGGAACAATCGTTGTATGTTGGAC
TCGCAGAGGCGAAGCCAGGTGCCCGCTTGACAAACATTTCTCATGCGATTCAAACATACGTCGAAGCGCACCATTTTTCC
GTCGTCCGCGAGTATGTCGGGCACGGAATTGGTCAACACTTACATGAAGACCCACAAGTCCCTCATTATGGTCCACCGAA
TAGAGGACCAATTTTGCGGCCAGGCATGACGCTGTGCATTGAGCCGATGGTCAATGCTGGAAGTCGTCATGTGAAAACAT
TGGCTGACGATTGGACTGTTGTCACGGTGGACGGAAAACGGTGTGCTCATTTCGAACATACGATTGTTATTACAGAGCAA
GGCTATGAAATCTTAACATGA

Upstream 100 bases:

>100_bases
ATTTCTATGAGCAAAAAGGCTATTTGCGCCACATTAACGGCGAACAAGAAATGGAAAAAGTGTTTAGCGACATTCGCGAA
TTGCTCGGGGGACTTACTCG

Downstream 100 bases:

>100_bases
ACGGATGCAGGCAGCGCAGTCTCTAAGCGTCGGGGCAGGTCAGCAAGCTTTTCTTCAGAGTTTGCGGTGGCCTTAGACCA
CTCAACTGATTCAGCGATCA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP 1; Peptidase M [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MIIYKTEHEIALMREAGKIVSLTLEELKKHIRPGITTKELDAIAEEVIRSHGAIPSFKGYQGFPGSICASVNEELVHGIP
GNRMLREGDIITVDVGAQYEGYHADSAWTYPVGEIDAETKRLLDVTEQSLYVGLAEAKPGARLTNISHAIQTYVEAHHFS
VVREYVGHGIGQHLHEDPQVPHYGPPNRGPILRPGMTLCIEPMVNAGSRHVKTLADDWTVVTVDGKRCAHFEHTIVITEQ
GYEILT

Sequences:

>Translated_246_residues
MIIYKTEHEIALMREAGKIVSLTLEELKKHIRPGITTKELDAIAEEVIRSHGAIPSFKGYQGFPGSICASVNEELVHGIP
GNRMLREGDIITVDVGAQYEGYHADSAWTYPVGEIDAETKRLLDVTEQSLYVGLAEAKPGARLTNISHAIQTYVEAHHFS
VVREYVGHGIGQHLHEDPQVPHYGPPNRGPILRPGMTLCIEPMVNAGSRHVKTLADDWTVVTVDGKRCAHFEHTIVITEQ
GYEILT
>Mature_246_residues
MIIYKTEHEIALMREAGKIVSLTLEELKKHIRPGITTKELDAIAEEVIRSHGAIPSFKGYQGFPGSICASVNEELVHGIP
GNRMLREGDIITVDVGAQYEGYHADSAWTYPVGEIDAETKRLLDVTEQSLYVGLAEAKPGARLTNISHAIQTYVEAHHFS
VVREYVGHGIGQHLHEDPQVPHYGPPNRGPILRPGMTLCIEPMVNAGSRHVKTLADDWTVVTVDGKRCAHFEHTIVITEQ
GYEILT

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=241, Percent_Identity=39.8340248962656, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI40385867, Length=242, Percent_Identity=39.6694214876033, Blast_Score=183, Evalue=1e-46,
Organism=Homo sapiens, GI260593665, Length=286, Percent_Identity=24.1258741258741, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI149589008, Length=286, Percent_Identity=24.1258741258741, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1786364, Length=247, Percent_Identity=44.9392712550607, Blast_Score=227, Evalue=5e-61,
Organism=Escherichia coli, GI1788728, Length=247, Percent_Identity=26.7206477732794, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1789275, Length=267, Percent_Identity=25.8426966292135, Blast_Score=74, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71996291, Length=242, Percent_Identity=41.7355371900826, Blast_Score=196, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6323273, Length=246, Percent_Identity=43.0894308943089, Blast_Score=201, Evalue=1e-52,
Organism=Drosophila melanogaster, GI21355531, Length=240, Percent_Identity=41.25, Blast_Score=191, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24583427, Length=242, Percent_Identity=39.6694214876033, Blast_Score=186, Evalue=8e-48,
Organism=Drosophila melanogaster, GI19920384, Length=230, Percent_Identity=24.7826086956522, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27217; Mature: 27217

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIYKTEHEIALMREAGKIVSLTLEELKKHIRPGITTKELDAIAEEVIRSHGAIPSFKGY
CEEEECCCHHHHHHHCCCCEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
QGFPGSICASVNEELVHGIPGNRMLREGDIITVDVGAQYEGYHADSAWTYPVGEIDAETK
CCCCHHHHHHHHHHHHHCCCCCCEEECCCEEEEECCCCCCCEECCCCEECCCCCCCHHHH
RLLDVTEQSLYVGLAEAKPGARLTNISHAIQTYVEAHHFSVVREYVGHGIGQHLHEDPQV
HHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PHYGPPNRGPILRPGMTLCIEPMVNAGSRHVKTLADDWTVVTVDGKRCAHFEHTIVITEQ
CCCCCCCCCCEECCCHHEEEHHHHCCCCHHHHHHCCCEEEEEECCCEEECEEEEEEEEEC
GYEILT
CCEECC
>Mature Secondary Structure
MIIYKTEHEIALMREAGKIVSLTLEELKKHIRPGITTKELDAIAEEVIRSHGAIPSFKGY
CEEEECCCHHHHHHHCCCCEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
QGFPGSICASVNEELVHGIPGNRMLREGDIITVDVGAQYEGYHADSAWTYPVGEIDAETK
CCCCHHHHHHHHHHHHHCCCCCCEEECCCEEEEECCCCCCCEECCCCEECCCCCCCHHHH
RLLDVTEQSLYVGLAEAKPGARLTNISHAIQTYVEAHHFSVVREYVGHGIGQHLHEDPQV
HHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PHYGPPNRGPILRPGMTLCIEPMVNAGSRHVKTLADDWTVVTVDGKRCAHFEHTIVITEQ
CCCCCCCCCCEECCCHHEEEHHHHCCCCHHHHHHCCCEEEEEECCCEEECEEEEEEEEEC
GYEILT
CCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2113521; 8635744; 9384377 [H]