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The map label for this gene is fkpA [H]

Identifier: 126696816

GI number: 126696816

Start: 1248160

End: 1248732

Strand: Direct

Name: fkpA [H]

Synonym: P9301_14781

Alternate gene names: 126696816

Gene position: 1248160-1248732 (Clockwise)

Preceding gene: 126696814

Following gene: 126696817

Centisome position: 76.02

GC content: 36.65

Gene sequence:

>573_bases
GTGAAAGAAGTATTTATTAGTTTTGCAATTTTTGTTTTTTGTGTTTCATTAACTATTTTCAGTCAATTTAATTCACCTCA
AGTTGTTAATGCTGCTGAATCAGAAACTCAGTCAGTTCAAAGAACACCTGTTGCAAAATCATCAAATGTCTCAAATAATA
ATTTATTTGAACTAGACCCATCAGATCCAAATCCTATACTTTTCGCTATGGCAGAAGAAACACCAATAGACATTAATTCA
AGGACAACAGAAAGTGGTCTAATTATTGCAGATATCGTAAACGGGGAAGGAGATGAGGCTAATGCTGGCCAAACAGTTAC
CGTAGATTACACAGGAACACTAGAAGACGGGACACAATTTGATACCAGTATAGGCAGAGCTCCATTCAGCTTTCCCTTGG
GTGCTGGACGAGTAATAAAAGGTTGGGACGAAGGTGTAGCAGGTATGAAAGTTGGAGGCAAAAGAAAATTAACAATACCT
CCGGAACTTGGATACGGGAAAAGAGGAGCTGGAAATGTAATACCTGCTAATGCGACATTAATATTTGAAGTTGAATTATT
AAAAGTCAATTAA

Upstream 100 bases:

>100_bases
TTTGGGATTAACAATCTAAAATTACGAAATTAAATTTATAATCACCCATTTATTGTACCTTCATTCTGTAGACTAAGTTT
TAGTAACTTTCAAAATTTAA

Downstream 100 bases:

>100_bases
ATTAAGTAAGAAAAATATCTAAGACTTTTCAATTTAGTTAATCTCCAAGTAATATATATACAACACCAAATATTTGAAAT
GTTAAGTAAATTCATCAATT

Product: FKBP-type peptidyl-prolyl cis-trans isomerase (PPIase)

Products: NA

Alternate protein names: Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase [H]

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MKEVFISFAIFVFCVSLTIFSQFNSPQVVNAAESETQSVQRTPVAKSSNVSNNNLFELDPSDPNPILFAMAEETPIDINS
RTTESGLIIADIVNGEGDEANAGQTVTVDYTGTLEDGTQFDTSIGRAPFSFPLGAGRVIKGWDEGVAGMKVGGKRKLTIP
PELGYGKRGAGNVIPANATLIFEVELLKVN

Sequences:

>Translated_190_residues
MKEVFISFAIFVFCVSLTIFSQFNSPQVVNAAESETQSVQRTPVAKSSNVSNNNLFELDPSDPNPILFAMAEETPIDINS
RTTESGLIIADIVNGEGDEANAGQTVTVDYTGTLEDGTQFDTSIGRAPFSFPLGAGRVIKGWDEGVAGMKVGGKRKLTIP
PELGYGKRGAGNVIPANATLIFEVELLKVN
>Mature_190_residues
MKEVFISFAIFVFCVSLTIFSQFNSPQVVNAAESETQSVQRTPVAKSSNVSNNNLFELDPSDPNPILFAMAEETPIDINS
RTTESGLIIADIVNGEGDEANAGQTVTVDYTGTLEDGTQFDTSIGRAPFSFPLGAGRVIKGWDEGVAGMKVGGKRKLTIP
PELGYGKRGAGNVIPANATLIFEVELLKVN

Specific function: PPIases accelerate the folding of proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm And Periplasmic Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI206725530, Length=93, Percent_Identity=58.0645161290323, Blast_Score=111, Evalue=5e-25,
Organism=Homo sapiens, GI17149844, Length=93, Percent_Identity=58.0645161290323, Blast_Score=111, Evalue=5e-25,
Organism=Homo sapiens, GI17149842, Length=93, Percent_Identity=58.0645161290323, Blast_Score=111, Evalue=5e-25,
Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=50.4672897196262, Blast_Score=100, Evalue=6e-22,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=50.4672897196262, Blast_Score=100, Evalue=6e-22,
Organism=Homo sapiens, GI4758380, Length=106, Percent_Identity=48.1132075471698, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI4503729, Length=87, Percent_Identity=54.0229885057471, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI4503727, Length=107, Percent_Identity=45.7943925233645, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI224809329, Length=113, Percent_Identity=47.787610619469, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI224809327, Length=113, Percent_Identity=47.787610619469, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI4758384, Length=113, Percent_Identity=47.787610619469, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI224809331, Length=121, Percent_Identity=45.4545454545455, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI8923659, Length=96, Percent_Identity=45.8333333333333, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI192448443, Length=92, Percent_Identity=45.6521739130435, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI33469985, Length=92, Percent_Identity=42.3913043478261, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI7706131, Length=91, Percent_Identity=41.7582417582418, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI206725547, Length=94, Percent_Identity=43.6170212765958, Blast_Score=70, Evalue=8e-13,
Organism=Homo sapiens, GI150010552, Length=117, Percent_Identity=35.042735042735, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI87082390, Length=109, Percent_Identity=51.3761467889908, Blast_Score=94, Evalue=5e-21,
Organism=Escherichia coli, GI1789745, Length=111, Percent_Identity=48.6486486486487, Blast_Score=83, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71993519, Length=99, Percent_Identity=59.5959595959596, Blast_Score=106, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17540882, Length=93, Percent_Identity=53.763440860215, Blast_Score=103, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17561782, Length=87, Percent_Identity=56.3218390804598, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17561778, Length=102, Percent_Identity=46.078431372549, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17506169, Length=112, Percent_Identity=38.3928571428571, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17506167, Length=112, Percent_Identity=38.3928571428571, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71993555, Length=81, Percent_Identity=53.0864197530864, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17561780, Length=111, Percent_Identity=41.4414414414414, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320727, Length=94, Percent_Identity=58.5106382978723, Blast_Score=105, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6323482, Length=120, Percent_Identity=44.1666666666667, Blast_Score=100, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6324194, Length=113, Percent_Identity=48.6725663716814, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323566, Length=112, Percent_Identity=44.6428571428571, Blast_Score=99, Evalue=5e-22,
Organism=Drosophila melanogaster, GI281363946, Length=89, Percent_Identity=62.9213483146067, Blast_Score=120, Evalue=5e-28,
Organism=Drosophila melanogaster, GI17352457, Length=89, Percent_Identity=62.9213483146067, Blast_Score=120, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24647110, Length=121, Percent_Identity=50.4132231404959, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24655568, Length=106, Percent_Identity=53.7735849056604, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI21356629, Length=94, Percent_Identity=58.5106382978723, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24583150, Length=120, Percent_Identity=45, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179 [H]

Pfam domain/function: PF00254 FKBP_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 20275; Mature: 20275

Theoretical pI: Translated: 4.23; Mature: 4.23

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEVFISFAIFVFCVSLTIFSQFNSPQVVNAAESETQSVQRTPVAKSSNVSNNNLFELDP
CCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCCCCCCCCCCCCEEEECC
SDPNPILFAMAEETPIDINSRTTESGLIIADIVNGEGDEANAGQTVTVDYTGTLEDGTQF
CCCCCEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCC
DTSIGRAPFSFPLGAGRVIKGWDEGVAGMKVGGKRKLTIPPELGYGKRGAGNVIPANATL
CHHCCCCCCCCCCCCCCEEECCCCCCCCEEECCCEEEECCCCCCCCCCCCCCEEECCEEE
IFEVELLKVN
EEEEEEEEEC
>Mature Secondary Structure
MKEVFISFAIFVFCVSLTIFSQFNSPQVVNAAESETQSVQRTPVAKSSNVSNNNLFELDP
CCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCCCCCCCCCCCCEEEECC
SDPNPILFAMAEETPIDINSRTTESGLIIADIVNGEGDEANAGQTVTVDYTGTLEDGTQF
CCCCCEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCC
DTSIGRAPFSFPLGAGRVIKGWDEGVAGMKVGGKRKLTIPPELGYGKRGAGNVIPANATL
CHHCCCCCCCCCCCCCCEEECCCCCCCCEEECCCEEEECCCCCCCCCCCCCCEEECCEEE
IFEVELLKVN
EEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]