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The map label for this gene is ribD [H]

Identifier: 126696788

GI number: 126696788

Start: 1222529

End: 1223623

Strand: Reverse

Name: ribD [H]

Synonym: P9301_14501

Alternate gene names: 126696788

Gene position: 1223623-1222529 (Counterclockwise)

Preceding gene: 126696789

Following gene: 126696787

Centisome position: 74.53

GC content: 33.88

Gene sequence:

>1095_bases
ATGTCTGAAAAAAGTTTAAGCCATACAAAATGGATGAAAAGAGCAATTTTTTTGGCTTCTTTAGGCAAAAATACAACGAG
TCCTAATCCGAGGGTGGGAGCAGTGATACTTGATAAGAATGGAAGCCTTATTTCAGAAGGGTTTCATTTCAAGGCAGGGA
TGCCTCATGCAGAGGCAATGGCTTTTAATAATTTAAAAAATGATGCTAAAGGTGGAACAATGTATGTGAATCTTGAACCT
TGTTGCCATCAAGGTAAAACACCTCCATGCGTAGATAAGGTGATATCCTCTGGGTTAAAAAAGGTATATATATCTATGGA
AGACCCTGATGAAAGAGTCTCTGGTAAAGGGATTAAGCTTCTAAAAGAAGCTGGAATACAAGTTAACTTAGGATTATGTA
AAAAAGAATCCTTAGATCTAAATAAGGCTTTTATTCATAGGAACACTACTAAAAAGGCATTTGGTGTTCTTAAATGGGCA
ATGAGTATAGATGGAAGAATAGCTTTAAAAAATGGGAAAAGTAAATGGATTACTAATGATGAATCAAGGTCATTAGTGCA
TTCTTTTAGAGCAGAATTTGACGCAATAATCATTGGTGGAAACACATTACGAAGAGACAACCCATTTTTGACTACTAGAG
GTTCCAAAAACCCTGAGCCTTTGCGAGTTGTTTTCACAAAAAGTTTAGATCTTCCTTCAAAATCTAATCTTTGGGATTGT
AGTAAGGCAAAAACTTTAGTTATTTATGATTCTTCTACAGCAAATGAAAGCTACCTCTCAAGGATTCCGAAATGTGTAGA
AGTTGAAAAGGTATTATCAGATAATCCAGAGTTAATTTCAAAAATTCTTGCAAAAAGAGGATGTAATAAAGTTCTGTGGG
AATGTGGTCCAAATTTGGCTACCGCCGCTATTCAATCTAACTGTATTCAGGAAATTATTACCTTTATCGCTCCAAAAATT
TTAGGTGGAGAAAATAGTATGCATCCTTTTGGAGATTTTGAATTTGAAGAAATGCATGAAGTTATTAAATTAAGTAATTC
TCAGGTTAGTTTGATTGGGAATGATATATGCGTTAAAAGTTTATGTAAAAATTAA

Upstream 100 bases:

>100_bases
ACCATTAAGATTATCTTTATCAGGAGTTTTTTCTGAGTTACCTGTTCCTCCCTTCCTTGTTAAAGAGTGGAGATCTATAA
ACTGAATTTGATTTCTGGAG

Downstream 100 bases:

>100_bases
TTTTTTCATGATCTTTTAAATGTGTAAAAGTACCGTACGGTACTTACCCAAAAAAAACAATACAGGTACGGAAACTCATC
GTTTAGTTTATAATAAGTTC

Product: putative diaminohydroxyphosphoribosylaminopyrimidine deaminase and 5-amino-6-(5-phosphoribosylamino)uracil reductase

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MSEKSLSHTKWMKRAIFLASLGKNTTSPNPRVGAVILDKNGSLISEGFHFKAGMPHAEAMAFNNLKNDAKGGTMYVNLEP
CCHQGKTPPCVDKVISSGLKKVYISMEDPDERVSGKGIKLLKEAGIQVNLGLCKKESLDLNKAFIHRNTTKKAFGVLKWA
MSIDGRIALKNGKSKWITNDESRSLVHSFRAEFDAIIIGGNTLRRDNPFLTTRGSKNPEPLRVVFTKSLDLPSKSNLWDC
SKAKTLVIYDSSTANESYLSRIPKCVEVEKVLSDNPELISKILAKRGCNKVLWECGPNLATAAIQSNCIQEIITFIAPKI
LGGENSMHPFGDFEFEEMHEVIKLSNSQVSLIGNDICVKSLCKN

Sequences:

>Translated_364_residues
MSEKSLSHTKWMKRAIFLASLGKNTTSPNPRVGAVILDKNGSLISEGFHFKAGMPHAEAMAFNNLKNDAKGGTMYVNLEP
CCHQGKTPPCVDKVISSGLKKVYISMEDPDERVSGKGIKLLKEAGIQVNLGLCKKESLDLNKAFIHRNTTKKAFGVLKWA
MSIDGRIALKNGKSKWITNDESRSLVHSFRAEFDAIIIGGNTLRRDNPFLTTRGSKNPEPLRVVFTKSLDLPSKSNLWDC
SKAKTLVIYDSSTANESYLSRIPKCVEVEKVLSDNPELISKILAKRGCNKVLWECGPNLATAAIQSNCIQEIITFIAPKI
LGGENSMHPFGDFEFEEMHEVIKLSNSQVSLIGNDICVKSLCKN
>Mature_363_residues
SEKSLSHTKWMKRAIFLASLGKNTTSPNPRVGAVILDKNGSLISEGFHFKAGMPHAEAMAFNNLKNDAKGGTMYVNLEPC
CHQGKTPPCVDKVISSGLKKVYISMEDPDERVSGKGIKLLKEAGIQVNLGLCKKESLDLNKAFIHRNTTKKAFGVLKWAM
SIDGRIALKNGKSKWITNDESRSLVHSFRAEFDAIIIGGNTLRRDNPFLTTRGSKNPEPLRVVFTKSLDLPSKSNLWDCS
KAKTLVIYDSSTANESYLSRIPKCVEVEKVLSDNPELISKILAKRGCNKVLWECGPNLATAAIQSNCIQEIITFIAPKIL
GGENSMHPFGDFEFEEMHEVIKLSNSQVSLIGNDICVKSLCKN

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG1985

COG function: function code H; Pyrimidine reductase, riboflavin biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=370, Percent_Identity=35.1351351351351, Blast_Score=219, Evalue=3e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 40159; Mature: 40028

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKSLSHTKWMKRAIFLASLGKNTTSPNPRVGAVILDKNGSLISEGFHFKAGMPHAEAM
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEECCCCEECCCCCHHHHH
AFNNLKNDAKGGTMYVNLEPCCHQGKTPPCVDKVISSGLKKVYISMEDPDERVSGKGIKL
HHHCCCCCCCCCEEEEEECHHHCCCCCCHHHHHHHHCCCCEEEEEECCCHHHHCCCCHHH
LKEAGIQVNLGLCKKESLDLNKAFIHRNTTKKAFGVLKWAMSIDGRIALKNGKSKWITND
HHHCCCEEEEECCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCC
ESRSLVHSFRAEFDAIIIGGNTLRRDNPFLTTRGSKNPEPLRVVFTKSLDLPSKSNLWDC
HHHHHHHHHHHCCCEEEECCCEEECCCCEEEECCCCCCCCEEEEEEECCCCCCCCCCCCC
SKAKTLVIYDSSTANESYLSRIPKCVEVEKVLSDNPELISKILAKRGCNKVLWECGPNLA
CCCCEEEEECCCCCCHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHCCCCHH
TAAIQSNCIQEIITFIAPKILGGENSMHPFGDFEFEEMHEVIKLSNSQVSLIGNDICVKS
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCHHHHHH
LCKN
HHCC
>Mature Secondary Structure 
SEKSLSHTKWMKRAIFLASLGKNTTSPNPRVGAVILDKNGSLISEGFHFKAGMPHAEAM
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEECCCCEECCCCCHHHHH
AFNNLKNDAKGGTMYVNLEPCCHQGKTPPCVDKVISSGLKKVYISMEDPDERVSGKGIKL
HHHCCCCCCCCCEEEEEECHHHCCCCCCHHHHHHHHCCCCEEEEEECCCHHHHCCCCHHH
LKEAGIQVNLGLCKKESLDLNKAFIHRNTTKKAFGVLKWAMSIDGRIALKNGKSKWITND
HHHCCCEEEEECCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCC
ESRSLVHSFRAEFDAIIIGGNTLRRDNPFLTTRGSKNPEPLRVVFTKSLDLPSKSNLWDC
HHHHHHHHHHHCCCEEEECCCEEECCCCEEEECCCCCCCCEEEEEEECCCCCCCCCCCCC
SKAKTLVIYDSSTANESYLSRIPKCVEVEKVLSDNPELISKILAKRGCNKVLWECGPNLA
CCCCEEEEECCCCCCHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHCCCCHH
TAAIQSNCIQEIITFIAPKILGGENSMHPFGDFEFEEMHEVIKLSNSQVSLIGNDICVKS
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCHHHHHH
LCKN
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]