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The map label for this gene is apt

Identifier: 126696779

GI number: 126696779

Start: 1211525

End: 1212043

Strand: Reverse

Name: apt

Synonym: P9301_14411

Alternate gene names: 126696779

Gene position: 1212043-1211525 (Counterclockwise)

Preceding gene: 126696781

Following gene: 126696778

Centisome position: 73.82

GC content: 27.55

Gene sequence:

>519_bases
ATGCTTGAAAAAAATCTTAAAAATACTATTAAAAGTTATCCAGATTTTCCTAAAAAGGGAATTTTATTTAGGGATATACT
TCCGGTTTTTCAAAATCCAAGTATTTTTAATAAACTGATTGAATCAATGATAGATAAAAAAATTTATCGAAAATCTGAAG
CTATTTTAGCAATTGATGCTAGAGGTTTTTTATTTGGATCTGTTATCGCATATAAGCTATCAAAACCACTTATCTTGGCA
AGAAAGCCTGGTAAATTACCAGGCAAACTATCAACTTATAAATATGATCTAGAGTATGGTTCTAATTCTCTTTCTCTTCA
AGATGATTCCATAAGAAATCTTGATAATTTTGTCATTGTTGACGACTTATTAGCTACAGGAGGCACAGTAAATAGTGTAA
GCAAAATTTTAAAAGATAAAGATAAAAATGTTTTAGGTTTAAGTGTTGTTGTTGAATTAAAAGATTTAAATGGAAGATCC
AAACTTAATTTCCCTGTAGAATCAGAAATTATTTACTAG

Upstream 100 bases:

>100_bases
TTTCCTATTTCTTCTTGCATTGCTCCAAGAATGCCTATATGCAAAATTTCAGCATATTGATTTTTCAATTATTTAAAAAA
CTCTTCACTAATCTTACATA

Downstream 100 bases:

>100_bases
ATTTGGATTTTTCTAAAAGTACATTATTGACAGCGATAAAAATAGATAATATGATATCAAAAAAAAAAGTGAAAAAAATA
CTTGTAGACCAGAATGTATC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 172; Mature: 172

Protein sequence:

>172_residues
MLEKNLKNTIKSYPDFPKKGILFRDILPVFQNPSIFNKLIESMIDKKIYRKSEAILAIDARGFLFGSVIAYKLSKPLILA
RKPGKLPGKLSTYKYDLEYGSNSLSLQDDSIRNLDNFVIVDDLLATGGTVNSVSKILKDKDKNVLGLSVVVELKDLNGRS
KLNFPVESEIIY

Sequences:

>Translated_172_residues
MLEKNLKNTIKSYPDFPKKGILFRDILPVFQNPSIFNKLIESMIDKKIYRKSEAILAIDARGFLFGSVIAYKLSKPLILA
RKPGKLPGKLSTYKYDLEYGSNSLSLQDDSIRNLDNFVIVDDLLATGGTVNSVSKILKDKDKNVLGLSVVVELKDLNGRS
KLNFPVESEIIY
>Mature_172_residues
MLEKNLKNTIKSYPDFPKKGILFRDILPVFQNPSIFNKLIESMIDKKIYRKSEAILAIDARGFLFGSVIAYKLSKPLILA
RKPGKLPGKLSTYKYDLEYGSNSLSLQDDSIRNLDNFVIVDDLLATGGTVNSVSKILKDKDKNVLGLSVVVELKDLNGRS
KLNFPVESEIIY

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=160, Percent_Identity=40.625, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=40.8, Blast_Score=99, Evalue=2e-21,
Organism=Escherichia coli, GI1786675, Length=158, Percent_Identity=37.9746835443038, Blast_Score=120, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17509087, Length=159, Percent_Identity=40.251572327044, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323619, Length=167, Percent_Identity=40.1197604790419, Blast_Score=118, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6320649, Length=169, Percent_Identity=32.5443786982249, Blast_Score=87, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17136334, Length=169, Percent_Identity=38.4615384615385, Blast_Score=112, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_PROM0 (A3PE89)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001091665.1
- ProteinModelPortal:   A3PE89
- SMR:   A3PE89
- STRING:   A3PE89
- GeneID:   4911280
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_14411
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   PMAR167546:P9301ORF_1464-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19329; Mature: 19329

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKNLKNTIKSYPDFPKKGILFRDILPVFQNPSIFNKLIESMIDKKIYRKSEAILAIDA
CCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEEC
RGFLFGSVIAYKLSKPLILARKPGKLPGKLSTYKYDLEYGSNSLSLQDDSIRNLDNFVIV
CHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEEECCCCCCEECCCHHHCCCCEEEE
DDLLATGGTVNSVSKILKDKDKNVLGLSVVVELKDLNGRSKLNFPVESEIIY
HHHHHCCCCHHHHHHHHHCCCCCEEEEEEEEEEECCCCCCEECCCCCCCCCC
>Mature Secondary Structure
MLEKNLKNTIKSYPDFPKKGILFRDILPVFQNPSIFNKLIESMIDKKIYRKSEAILAIDA
CCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEEC
RGFLFGSVIAYKLSKPLILARKPGKLPGKLSTYKYDLEYGSNSLSLQDDSIRNLDNFVIV
CHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEEECCCCCCEECCCHHHCCCCEEEE
DDLLATGGTVNSVSKILKDKDKNVLGLSVVVELKDLNGRSKLNFPVESEIIY
HHHHHCCCCHHHHHHHHHCCCCCEEEEEEEEEEECCCCCCEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA