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The map label for this gene is hisS

Identifier: 126695987

GI number: 126695987

Start: 578199

End: 579479

Strand: Direct

Name: hisS

Synonym: P9301_06491

Alternate gene names: 126695987

Gene position: 578199-579479 (Clockwise)

Preceding gene: 126695985

Following gene: 126695988

Centisome position: 35.22

GC content: 31.77

Gene sequence:

>1281_bases
TTGAATAACTTAAAAAACCTAAGAGGAACAGTAGACCTATTTCCTGATCAATTAATAAAGTGGCAAAACGTTGAAAGAAT
TTTATTAGAACAGCTTTCTAGAGCATCCATCAAAGAAATAAGAACACCAATATTGGAAATGACCGAATTATTTATAAGAG
GAATTGGTGAAGGAACAGATGTTGTTAGCAAGGAAATGTATACATTTCTTGATAGGGGGGAGAGATCTTGCACTCTAAGA
CCTGAAGGAACAGCCTCAGTTGCACGAGCGTTAATACAAAATGGAATATCGTCTAATCCTCTTCAAAAACTTTGGTACAT
GGGTCCTATGTTTAGATACGAAAGACCTCAAGCAGGCAGGCAAAGACAATTTCATCAATTAGGTGTTGAGTTTATAGGAC
ATGATTCAGTTAGAAGTGATGTTGAAATTATTGCTTTAGCTTGGGATATCTTAAGTAAATTAGGAATAAAAGAACTCAAT
CTTGAAATAAATACGTTAGGTGATACTAATGACAGATCAAATTTTCAAAAATCTTTTTTAAAATGGTTACAAGCAAATAA
AGATTCTCTAGATTTAGATTCTCAGAATAGAATTTCTAAAAACCCTTTGAGGATTTTGGATTCAAAGAATATTCAAACTA
AAAAAGTTCTTGAAAATGCACCAAGATTATCTAATTTTTTATCTGAAAAAAGTCATAGCAGATATTTAGAATTAAAAAGA
CAATTAGAGGTTTTAAACATACCTTATGTAGAAAACTTTAATCTTGTAAGAGGTTTAGATTACTACACTCATACAGCTTT
TGAAATTACTAGTGGGGCTCTGGGCTCCCAAGCTACAGTTTGCGGAGGAGGGAGATACGACGATTTAATAAAACAAATGG
GAGGGCCAAACACTCCTGCAATTGGTTTCGCTATTGGTTTAGAAAGATTAATTTTACTCGCAGGAAAAGAGCTTGAAATT
CCAAGAAATACTGATATCTATATCATTAATAAAGGCTTAATTGCTGAATCATTCGCAATGGATTTATCTAGAAAATTAAG
AAATTACGATTTGTTAGTTGAGTTAGATTTAAGCGGAGCCTCATTCTCTAAGCAATTTAAAAAGGCAAATAAACTTAAAT
CTAAAAGTATTATTGTTATTGGTGATGATGAGGCAGTTAATGGGGAATTTATTATAAGGCTCTTTGGTCAATCAGGTAAT
GGGAATAAAGAGGAGGTTATATCTTTTGAGAATGATATTAAATTAGAAAATTGGATAAATAATAACTTACTTTTAAAGTG
A

Upstream 100 bases:

>100_bases
AATAGTTTTTCTAAATGTTAAATTAAAATTGTCTCACAAAATAACCAATCAAAGATTAATTTCTAGATGAATTAAAAATT
TTGAATTATTTTTTAGAACT

Downstream 100 bases:

>100_bases
TGTTCTTGAAGATAGTGATAATTTTTCTTTTTATATTTATTTTTTTTAATTTAAGGAATTTTCTTAAATTAAATAAAAAA
CAAAAAGTTTTTAATTCTAA

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MNNLKNLRGTVDLFPDQLIKWQNVERILLEQLSRASIKEIRTPILEMTELFIRGIGEGTDVVSKEMYTFLDRGERSCTLR
PEGTASVARALIQNGISSNPLQKLWYMGPMFRYERPQAGRQRQFHQLGVEFIGHDSVRSDVEIIALAWDILSKLGIKELN
LEINTLGDTNDRSNFQKSFLKWLQANKDSLDLDSQNRISKNPLRILDSKNIQTKKVLENAPRLSNFLSEKSHSRYLELKR
QLEVLNIPYVENFNLVRGLDYYTHTAFEITSGALGSQATVCGGGRYDDLIKQMGGPNTPAIGFAIGLERLILLAGKELEI
PRNTDIYIINKGLIAESFAMDLSRKLRNYDLLVELDLSGASFSKQFKKANKLKSKSIIVIGDDEAVNGEFIIRLFGQSGN
GNKEEVISFENDIKLENWINNNLLLK

Sequences:

>Translated_426_residues
MNNLKNLRGTVDLFPDQLIKWQNVERILLEQLSRASIKEIRTPILEMTELFIRGIGEGTDVVSKEMYTFLDRGERSCTLR
PEGTASVARALIQNGISSNPLQKLWYMGPMFRYERPQAGRQRQFHQLGVEFIGHDSVRSDVEIIALAWDILSKLGIKELN
LEINTLGDTNDRSNFQKSFLKWLQANKDSLDLDSQNRISKNPLRILDSKNIQTKKVLENAPRLSNFLSEKSHSRYLELKR
QLEVLNIPYVENFNLVRGLDYYTHTAFEITSGALGSQATVCGGGRYDDLIKQMGGPNTPAIGFAIGLERLILLAGKELEI
PRNTDIYIINKGLIAESFAMDLSRKLRNYDLLVELDLSGASFSKQFKKANKLKSKSIIVIGDDEAVNGEFIIRLFGQSGN
GNKEEVISFENDIKLENWINNNLLLK
>Mature_426_residues
MNNLKNLRGTVDLFPDQLIKWQNVERILLEQLSRASIKEIRTPILEMTELFIRGIGEGTDVVSKEMYTFLDRGERSCTLR
PEGTASVARALIQNGISSNPLQKLWYMGPMFRYERPQAGRQRQFHQLGVEFIGHDSVRSDVEIIALAWDILSKLGIKELN
LEINTLGDTNDRSNFQKSFLKWLQANKDSLDLDSQNRISKNPLRILDSKNIQTKKVLENAPRLSNFLSEKSHSRYLELKR
QLEVLNIPYVENFNLVRGLDYYTHTAFEITSGALGSQATVCGGGRYDDLIKQMGGPNTPAIGFAIGLERLILLAGKELEI
PRNTDIYIINKGLIAESFAMDLSRKLRNYDLLVELDLSGASFSKQFKKANKLKSKSIIVIGDDEAVNGEFIIRLFGQSGN
GNKEEVISFENDIKLENWINNNLLLK

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Escherichia coli, GI1788861, Length=397, Percent_Identity=45.3400503778337, Blast_Score=346, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI71993686, Length=443, Percent_Identity=25.9593679458239, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71993693, Length=443, Percent_Identity=25.9593679458239, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6325290, Length=479, Percent_Identity=22.964509394572, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYH_PROM0 (A3PBZ7)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001090873.1
- ProteinModelPortal:   A3PBZ7
- SMR:   A3PBZ7
- STRING:   A3PBZ7
- GeneID:   4911092
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_06491
- eggNOG:   COG0124
- HOGENOM:   HBG616575
- OMA:   VFEWVTT
- ProtClustDB:   PRK00037
- BioCyc:   PMAR167546:P9301ORF_0664-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00127
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR11476
- PIRSF:   PIRSF001549
- TIGRFAMs:   TIGR00442

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.21

Molecular weight: Translated: 48327; Mature: 48327

Theoretical pI: Translated: 8.57; Mature: 8.57

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNLKNLRGTVDLFPDQLIKWQNVERILLEQLSRASIKEIRTPILEMTELFIRGIGEGTD
CCCHHHHCCCHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
VVSKEMYTFLDRGERSCTLRPEGTASVARALIQNGISSNPLQKLWYMGPMFRYERPQAGR
HHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHCCCHHHCCCCCCHH
QRQFHQLGVEFIGHDSVRSDVEIIALAWDILSKLGIKELNLEINTLGDTNDRSNFQKSFL
HHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHCCCEEECEEEEECCCCCCHHHHHHHHH
KWLQANKDSLDLDSQNRISKNPLRILDSKNIQTKKVLENAPRLSNFLSEKSHSRYLELKR
HHHHCCCCCCCCCCCCCCCCCCHHEECCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
QLEVLNIPYVENFNLVRGLDYYTHTAFEITSGALGSQATVCGGGRYDDLIKQMGGPNTPA
HHHHCCCCCCCCCCHHHCCHHHHHHHEEEECCCCCCCCEEECCCCHHHHHHHCCCCCCCH
IGFAIGLERLILLAGKELEIPRNTDIYIINKGLIAESFAMDLSRKLRNYDLLVELDLSGA
HHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCEEEEEEECCCC
SFSKQFKKANKLKSKSIIVIGDDEAVNGEFIIRLFGQSGNGNKEEVISFENDIKLENWIN
HHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEEEECCCCCCCHHHEEECCCCCCHHHHCC
NNLLLK
CCCEEC
>Mature Secondary Structure
MNNLKNLRGTVDLFPDQLIKWQNVERILLEQLSRASIKEIRTPILEMTELFIRGIGEGTD
CCCHHHHCCCHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
VVSKEMYTFLDRGERSCTLRPEGTASVARALIQNGISSNPLQKLWYMGPMFRYERPQAGR
HHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHCCCHHHCCCCCCHH
QRQFHQLGVEFIGHDSVRSDVEIIALAWDILSKLGIKELNLEINTLGDTNDRSNFQKSFL
HHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHCCCEEECEEEEECCCCCCHHHHHHHHH
KWLQANKDSLDLDSQNRISKNPLRILDSKNIQTKKVLENAPRLSNFLSEKSHSRYLELKR
HHHHCCCCCCCCCCCCCCCCCCHHEECCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
QLEVLNIPYVENFNLVRGLDYYTHTAFEITSGALGSQATVCGGGRYDDLIKQMGGPNTPA
HHHHCCCCCCCCCCHHHCCHHHHHHHEEEECCCCCCCCEEECCCCHHHHHHHCCCCCCCH
IGFAIGLERLILLAGKELEIPRNTDIYIINKGLIAESFAMDLSRKLRNYDLLVELDLSGA
HHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCEEEEEEECCCC
SFSKQFKKANKLKSKSIIVIGDDEAVNGEFIIRLFGQSGNGNKEEVISFENDIKLENWIN
HHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEEEECCCCCCCHHHEEECCCCCCHHHHCC
NNLLLK
CCCEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA