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The map label for this gene is hemC [H]

Identifier: 126695860

GI number: 126695860

Start: 453661

End: 454611

Strand: Reverse

Name: hemC [H]

Synonym: P9301_05221

Alternate gene names: 126695860

Gene position: 454611-453661 (Counterclockwise)

Preceding gene: 126695861

Following gene: 126695857

Centisome position: 27.69

GC content: 35.23

Gene sequence:

>951_bases
ATGACTAATTTTAAGCTAAAAATAGCTAGTAGAAGAAGTAAGCTAGCAATGGTTCAAACTTTATGGGTTAAAGATCAACT
AGAAAGGAATATTCCCAATTTAGAGGTATCTATAGAAGCTATGGCAACTCAAGGTGACAAAATCCTTGATGTAGCCCTAG
CAAAAATAGGCGACAAAGGCTTATTTACAAAAGAACTTGAAGCACAAATGCTCGTGGGCCATGCTGATATAGCAGTACAT
TCTCTGAAAGATTTACCAACCAATTTGCCCAATGGCCTTAAATTAGGATGCATTACAAAAAGGGAGGATCCTGCAGATGC
TTTAGTAGTAAACAAAAAAAATGACTGTTATAAATTAGAAACCTTACCTGAAGGTTCGATTGTTGGAACAAGCTCTCTAA
GAAGACTTGCACAATTAAGAAATAAGTACCCACATCTTATTTTCAAAGACATCAGGGGTAATGTTATTACAAGAATTGAA
AAATTAGATGCAGGAGAATTTGATTGTATAATTCTCGCGGCCGCTGGCTTAAAGAGATTAGGCTTTGAATCAAGAATTCA
CCAGATTATCCCAAGCGAAATTTCCCTTCATGCCGTTGGCCAAGGAGCACTAGGCATTGAATGTAAATCTGATGATAAAA
AAGTTTTAGAAATTATAAATATTTTAGAAGATAAACCCACCAGTCAAAGATGTCTAGCAGAAAGGGCTTTTTTAAGAGAG
CTTGAAGGTGGATGCCAAGTCCCAATAGGTGTGAATAGTAATATTCAGAATGAAAAACTTTGCCTTACTGGTATGGTTGC
ATCTCTGGATGGAGAAAGGCTTATTAAAGATCAACATATTGGCAATATTAATGATCCCGAAGAAATAGGAAAAGAACTAG
CTAAAAAATTAAAGCAGCAAGGTGCCGAAGAAATACTAAGCGAAATATTTGAAAAATTTAGAGAAAAATAA

Upstream 100 bases:

>100_bases
TAAAAAAAGTTAAGTATATTATTCAGCTTTTAAAACTGGCAAAGTAATAGCTTAAAATACAGTCGACTTAATTTTTTATT
CAAACTCAAAACAATATTTA

Downstream 100 bases:

>100_bases
AATTAGTTAATTTACTAATTTAGGATCAATTTCTTTTTTGTATCTCTCTTCACAATCTTTAATCACTTTAACAGCTTCTT
CTATCCCAAAAAAACCATTG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MTNFKLKIASRRSKLAMVQTLWVKDQLERNIPNLEVSIEAMATQGDKILDVALAKIGDKGLFTKELEAQMLVGHADIAVH
SLKDLPTNLPNGLKLGCITKREDPADALVVNKKNDCYKLETLPEGSIVGTSSLRRLAQLRNKYPHLIFKDIRGNVITRIE
KLDAGEFDCIILAAAGLKRLGFESRIHQIIPSEISLHAVGQGALGIECKSDDKKVLEIINILEDKPTSQRCLAERAFLRE
LEGGCQVPIGVNSNIQNEKLCLTGMVASLDGERLIKDQHIGNINDPEEIGKELAKKLKQQGAEEILSEIFEKFREK

Sequences:

>Translated_316_residues
MTNFKLKIASRRSKLAMVQTLWVKDQLERNIPNLEVSIEAMATQGDKILDVALAKIGDKGLFTKELEAQMLVGHADIAVH
SLKDLPTNLPNGLKLGCITKREDPADALVVNKKNDCYKLETLPEGSIVGTSSLRRLAQLRNKYPHLIFKDIRGNVITRIE
KLDAGEFDCIILAAAGLKRLGFESRIHQIIPSEISLHAVGQGALGIECKSDDKKVLEIINILEDKPTSQRCLAERAFLRE
LEGGCQVPIGVNSNIQNEKLCLTGMVASLDGERLIKDQHIGNINDPEEIGKELAKKLKQQGAEEILSEIFEKFREK
>Mature_315_residues
TNFKLKIASRRSKLAMVQTLWVKDQLERNIPNLEVSIEAMATQGDKILDVALAKIGDKGLFTKELEAQMLVGHADIAVHS
LKDLPTNLPNGLKLGCITKREDPADALVVNKKNDCYKLETLPEGSIVGTSSLRRLAQLRNKYPHLIFKDIRGNVITRIEK
LDAGEFDCIILAAAGLKRLGFESRIHQIIPSEISLHAVGQGALGIECKSDDKKVLEIINILEDKPTSQRCLAERAFLREL
EGGCQVPIGVNSNIQNEKLCLTGMVASLDGERLIKDQHIGNINDPEEIGKELAKKLKQQGAEEILSEIFEKFREK

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=284, Percent_Identity=51.4084507042254, Blast_Score=286, Evalue=1e-77,
Organism=Homo sapiens, GI66933009, Length=284, Percent_Identity=51.4084507042254, Blast_Score=286, Evalue=2e-77,
Organism=Escherichia coli, GI48994974, Length=310, Percent_Identity=50.9677419354839, Blast_Score=296, Evalue=8e-82,
Organism=Saccharomyces cerevisiae, GI6319996, Length=316, Percent_Identity=45.253164556962, Blast_Score=246, Evalue=4e-66,
Organism=Drosophila melanogaster, GI20130425, Length=318, Percent_Identity=44.0251572327044, Blast_Score=255, Evalue=3e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 35062; Mature: 34931

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNFKLKIASRRSKLAMVQTLWVKDQLERNIPNLEVSIEAMATQGDKILDVALAKIGDKG
CCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCC
LFTKELEAQMLVGHADIAVHSLKDLPTNLPNGLKLGCITKREDPADALVVNKKNDCYKLE
CCHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCEEEE
TLPEGSIVGTSSLRRLAQLRNKYPHLIFKDIRGNVITRIEKLDAGEFDCIILAAAGLKRL
ECCCCCEECHHHHHHHHHHHHCCCCEEHHHHCCHHHHHHHHCCCCCCCEEEEEHHHHHHC
GFESRIHQIIPSEISLHAVGQGALGIECKSDDKKVLEIINILEDKPTSQRCLAERAFLRE
CHHHHHHHHCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LEGGCQVPIGVNSNIQNEKLCLTGMVASLDGERLIKDQHIGNINDPEEIGKELAKKLKQQ
HCCCCEEEECCCCCCCCCCEEHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
GAEEILSEIFEKFREK
HHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TNFKLKIASRRSKLAMVQTLWVKDQLERNIPNLEVSIEAMATQGDKILDVALAKIGDKG
CCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCC
LFTKELEAQMLVGHADIAVHSLKDLPTNLPNGLKLGCITKREDPADALVVNKKNDCYKLE
CCHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCEEEE
TLPEGSIVGTSSLRRLAQLRNKYPHLIFKDIRGNVITRIEKLDAGEFDCIILAAAGLKRL
ECCCCCEECHHHHHHHHHHHHCCCCEEHHHHCCHHHHHHHHCCCCCCCEEEEEHHHHHHC
GFESRIHQIIPSEISLHAVGQGALGIECKSDDKKVLEIINILEDKPTSQRCLAERAFLRE
CHHHHHHHHCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LEGGCQVPIGVNSNIQNEKLCLTGMVASLDGERLIKDQHIGNINDPEEIGKELAKKLKQQ
HCCCCEEEECCCCCCCCCCEEHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
GAEEILSEIFEKFREK
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA