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The map label for this gene is cyoB [H]

Identifier: 126695807

GI number: 126695807

Start: 409075

End: 410700

Strand: Reverse

Name: cyoB [H]

Synonym: P9301_04691

Alternate gene names: 126695807

Gene position: 410700-409075 (Counterclockwise)

Preceding gene: 126695808

Following gene: 126695806

Centisome position: 25.01

GC content: 36.16

Gene sequence:

>1626_bases
ATGACAATATCAATTGATCCACAAAAAACTAATAATGAAAGCCTTCAACCTAAAGGCTGGCTTAGATACTTTAGTTTTAG
CCTTGATCATAAAGTAATTGGGATACAATATTTGGTTTGTGGTTTCCTCTTCTATTTAATAGGAGGAAGCTTAGCGAGCG
CTATAAGAATTGAACTAGCCAGTCCAATGTCTGATTTCATGCCAAGAGATGTTTATAACCAAGTTTTAACTTTACACGGA
ACAATAATGATATTCCTTTGGATAGTGCCAGTAGTAAACGGTGCTTTTGGAAATTATTTAATTCCATTTTATGTAGGCGC
GAGAGATATGGCATTCCCAAGATTAAATGCCGTAGCTTTTTGGTTAATTCCTCCTTCAGGTTTGATGTTGGTAGCAAGCT
ATTTTGTTGAGGGTGCTGCTCAGGCTGGATGGACGGCTTATCCACCTTTAAGCATAACTACTCCTCAATCTGGACAAATT
ATTTGGATTCTGAGCGTTCTATTACTTGGAGGCAGTTCTATATTTGGTGGAATAAACTTTATAGCCACCATTATCAAATT
AAGAAGGCCAGGATTAAAACTAATGCAATTGCCAATGTATTGTTGGGCAATGCTTGGAACAAGTCTATTAGTTGTTTTGT
CAACTCCTGTTTTAGCAGGCACTTTAATTCTTCTTAGCTTCGATATCATTGCTAATACTGGGTTTTTCAATCCTGTTTTA
GGAGGCAATGTCGTAGTTTATCAGCATTTATTTTGGTTTTATTCTCATCCAGCTGTATACATTATGGTCCTTCCAGCCTT
TGGTTTAGTTAGTGAAATACTTCCTGTACATGCTAGAAAACCACTTTTCGGATATACAACAATGGTTTTTTCAATAATGG
GGATAGTAGTTTTAGGTCTAGTTGTTTGGGCGCATCACATGTTTACAAGTGGAACGCCCCCTTGGATGAGATTGTTCTTT
ACAATTGCCACAGCATTTATCGCTGTTCCAACGGGTATAAAATTTTTTAATTGGGTTGCAACATTATGGGGAGGAAAAAT
TTCCATAAATAGTGCAATGTTATTCTCTTGTGGATTTATTATAAATTTCGTTTTTGGAGGTATTACAGGAGTTGCTTTGG
CACAGGTACCTTTCGATATTCACGTACATGATACCTATTTTGTTGTCGCCCATTTTCATTACATAGTTTATGGAGGGACT
GTCTTCATTATTTTCTCTTCAATTTATCATTGGTTCCCCAAAGTAACTGGAAAAATGCTCAATGAAAAATTAGGAATTTT
ACATTTTATCATTACTTTTATTGGATTTAACTTGTGCTTTGCTCCTCAACATTGGCTTGGTTTAAATGGAATGCCAAGAA
GAGTTGCAGAATATGATCCTCAATTCCAGTTCGTTAATCAAATTAGTAGCCTTGGGGCTCTTTTGATGGCTATAAGTACA
ATTCCTTTTTTAATTAATGTATTCCTTAGTGTGAGAAATGGAAAAGATGCTGGAGATAACCCTTGGAATGCTCTTACACC
TGAGTGGTTAACATCTTCTCCACCTCCAGTTGAAAATTGGGAAGGAGAAGCTCCATTAGTTGAAGAACCCTATGGTTATG
GTAAGGAAATTTCTGAACTAAAATAA

Upstream 100 bases:

>100_bases
GTGGCCCATATCATGGAGGGATGAGAGCCTCCATAATTGTTGAAGAAGAATCTGATTACAACGAATGGTTTAACAAAAAT
AAAAAACCTGAGGTAAATTT

Downstream 100 bases:

>100_bases
AAACATATGACAACTCTTGATAGCTCAAAAGAAATTCAAAAAAATAATTCTGAAGTCAACGAAACACATGAAGACTTCAG
AATGTTTGGTCTTATAACTT

Product: cytochrome c oxidase, subunit I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I; Oxidase aa(3) subunit 1 [H]

Number of amino acids: Translated: 541; Mature: 540

Protein sequence:

>541_residues
MTISIDPQKTNNESLQPKGWLRYFSFSLDHKVIGIQYLVCGFLFYLIGGSLASAIRIELASPMSDFMPRDVYNQVLTLHG
TIMIFLWIVPVVNGAFGNYLIPFYVGARDMAFPRLNAVAFWLIPPSGLMLVASYFVEGAAQAGWTAYPPLSITTPQSGQI
IWILSVLLLGGSSIFGGINFIATIIKLRRPGLKLMQLPMYCWAMLGTSLLVVLSTPVLAGTLILLSFDIIANTGFFNPVL
GGNVVVYQHLFWFYSHPAVYIMVLPAFGLVSEILPVHARKPLFGYTTMVFSIMGIVVLGLVVWAHHMFTSGTPPWMRLFF
TIATAFIAVPTGIKFFNWVATLWGGKISINSAMLFSCGFIINFVFGGITGVALAQVPFDIHVHDTYFVVAHFHYIVYGGT
VFIIFSSIYHWFPKVTGKMLNEKLGILHFIITFIGFNLCFAPQHWLGLNGMPRRVAEYDPQFQFVNQISSLGALLMAIST
IPFLINVFLSVRNGKDAGDNPWNALTPEWLTSSPPPVENWEGEAPLVEEPYGYGKEISELK

Sequences:

>Translated_541_residues
MTISIDPQKTNNESLQPKGWLRYFSFSLDHKVIGIQYLVCGFLFYLIGGSLASAIRIELASPMSDFMPRDVYNQVLTLHG
TIMIFLWIVPVVNGAFGNYLIPFYVGARDMAFPRLNAVAFWLIPPSGLMLVASYFVEGAAQAGWTAYPPLSITTPQSGQI
IWILSVLLLGGSSIFGGINFIATIIKLRRPGLKLMQLPMYCWAMLGTSLLVVLSTPVLAGTLILLSFDIIANTGFFNPVL
GGNVVVYQHLFWFYSHPAVYIMVLPAFGLVSEILPVHARKPLFGYTTMVFSIMGIVVLGLVVWAHHMFTSGTPPWMRLFF
TIATAFIAVPTGIKFFNWVATLWGGKISINSAMLFSCGFIINFVFGGITGVALAQVPFDIHVHDTYFVVAHFHYIVYGGT
VFIIFSSIYHWFPKVTGKMLNEKLGILHFIITFIGFNLCFAPQHWLGLNGMPRRVAEYDPQFQFVNQISSLGALLMAIST
IPFLINVFLSVRNGKDAGDNPWNALTPEWLTSSPPPVENWEGEAPLVEEPYGYGKEISELK
>Mature_540_residues
TISIDPQKTNNESLQPKGWLRYFSFSLDHKVIGIQYLVCGFLFYLIGGSLASAIRIELASPMSDFMPRDVYNQVLTLHGT
IMIFLWIVPVVNGAFGNYLIPFYVGARDMAFPRLNAVAFWLIPPSGLMLVASYFVEGAAQAGWTAYPPLSITTPQSGQII
WILSVLLLGGSSIFGGINFIATIIKLRRPGLKLMQLPMYCWAMLGTSLLVVLSTPVLAGTLILLSFDIIANTGFFNPVLG
GNVVVYQHLFWFYSHPAVYIMVLPAFGLVSEILPVHARKPLFGYTTMVFSIMGIVVLGLVVWAHHMFTSGTPPWMRLFFT
IATAFIAVPTGIKFFNWVATLWGGKISINSAMLFSCGFIINFVFGGITGVALAQVPFDIHVHDTYFVVAHFHYIVYGGTV
FIIFSSIYHWFPKVTGKMLNEKLGILHFIITFIGFNLCFAPQHWLGLNGMPRRVAEYDPQFQFVNQISSLGALLMAISTI
PFLINVFLSVRNGKDAGDNPWNALTPEWLTSSPPPVENWEGEAPLVEEPYGYGKEISELK

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=501, Percent_Identity=44.5109780439122, Blast_Score=380, Evalue=1e-105,
Organism=Escherichia coli, GI1786634, Length=511, Percent_Identity=41.0958904109589, Blast_Score=372, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6226519, Length=525, Percent_Identity=38.2857142857143, Blast_Score=372, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6226524, Length=318, Percent_Identity=39.937106918239, Blast_Score=243, Evalue=8e-65,
Organism=Saccharomyces cerevisiae, GI6226523, Length=246, Percent_Identity=36.5853658536585, Blast_Score=149, Evalue=8e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 60119; Mature: 59987

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTISIDPQKTNNESLQPKGWLRYFSFSLDHKVIGIQYLVCGFLFYLIGGSLASAIRIELA
CEEECCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SPMSDFMPRDVYNQVLTLHGTIMIFLWIVPVVNGAFGNYLIPFYVGARDMAFPRLNAVAF
CCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEEE
WLIPPSGLMLVASYFVEGAAQAGWTAYPPLSITTPQSGQIIWILSVLLLGGSSIFGGINF
EEECCCHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCHHHHHHHH
IATIIKLRRPGLKLMQLPMYCWAMLGTSLLVVLSTPVLAGTLILLSFDIIANTGFFNPVL
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GGNVVVYQHLFWFYSHPAVYIMVLPAFGLVSEILPVHARKPLFGYTTMVFSIMGIVVLGL
CCCHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
VVWAHHMFTSGTPPWMRLFFTIATAFIAVPTGIKFFNWVATLWGGKISINSAMLFSCGFI
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEECHHHHHHHHHH
INFVFGGITGVALAQVPFDIHVHDTYFVVAHFHYIVYGGTVFIIFSSIYHWFPKVTGKML
HHHHHHHHHHHHHHHCCEEEEECCCEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
NEKLGILHFIITFIGFNLCFAPQHWLGLNGMPRRVAEYDPQFQFVNQISSLGALLMAIST
HHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHH
IPFLINVFLSVRNGKDAGDNPWNALTPEWLTSSPPPVENWEGEAPLVEEPYGYGKEISEL
HHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHC
K
C
>Mature Secondary Structure 
TISIDPQKTNNESLQPKGWLRYFSFSLDHKVIGIQYLVCGFLFYLIGGSLASAIRIELA
EEECCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SPMSDFMPRDVYNQVLTLHGTIMIFLWIVPVVNGAFGNYLIPFYVGARDMAFPRLNAVAF
CCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEEE
WLIPPSGLMLVASYFVEGAAQAGWTAYPPLSITTPQSGQIIWILSVLLLGGSSIFGGINF
EEECCCHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCHHHHHHHH
IATIIKLRRPGLKLMQLPMYCWAMLGTSLLVVLSTPVLAGTLILLSFDIIANTGFFNPVL
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GGNVVVYQHLFWFYSHPAVYIMVLPAFGLVSEILPVHARKPLFGYTTMVFSIMGIVVLGL
CCCHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
VVWAHHMFTSGTPPWMRLFFTIATAFIAVPTGIKFFNWVATLWGGKISINSAMLFSCGFI
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEECHHHHHHHHHH
INFVFGGITGVALAQVPFDIHVHDTYFVVAHFHYIVYGGTVFIIFSSIYHWFPKVTGKML
HHHHHHHHHHHHHHHCCEEEEECCCEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
NEKLGILHFIITFIGFNLCFAPQHWLGLNGMPRRVAEYDPQFQFVNQISSLGALLMAIST
HHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHH
IPFLINVFLSVRNGKDAGDNPWNALTPEWLTSSPPPVENWEGEAPLVEEPYGYGKEISEL
HHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8387368; 8905231 [H]