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The map label for this gene is hisB

Identifier: 126695643

GI number: 126695643

Start: 280754

End: 281359

Strand: Reverse

Name: hisB

Synonym: P9301_03051

Alternate gene names: 126695643

Gene position: 281359-280754 (Counterclockwise)

Preceding gene: 126695644

Following gene: 126695642

Centisome position: 17.14

GC content: 33.66

Gene sequence:

>606_bases
ATGTCATCTCTAAGGCAATCTGAAATCAAAAGAAAAACGAATGAAACAGATATTTCTGTATTTATAAACTTAGATGGAAA
TGGAATTTCTGAGATTGATACCGGGATACCATTCTTAGATCATATGCTTCATCAAATATCCAGTCATGGTTTGTTCGATT
TAAAAATAAGAGCAATTGGAGATACCCATATTGATGATCATCATACAAATGAAGATGTAGGAATTGCGTTAGGAAAAGCA
TTTTCAAAAGCCTTGGGAGAAAGAAAAGGAATATGTAGATTTGGGCATTTCTTTGCCCCATTAGATGAAGCATTAGTTCA
AGTTACTTTGGACTGTTCTGGCAGACCGCATCTATCTTATGACCTTCAATTAAAAGCTCCTAGAATTGGTAATTATGATA
CTGAACTAGTAAAAGAGTTTTTTATCGCCTTTGTAAATAACAGTGGTATTACTCTGCATATTAATCAAATAAGAGGTAGC
AATTCACATCATATAGTTGAAGCTTGCTTTAAAGCTTTTTCACGAGCAATGAGAATGGCTACCGAAATAGATCTTAGAAG
ATCTGGTTCAATTCCAAGCAGCAAAGGAATGCTAGAAAATCAATAA

Upstream 100 bases:

>100_bases
TTTTATTAAGTGATCTCTCTAGCGGCATTTCAGGCCAAACAATTTATGTTGATGCGGGTTACTGCATTAATGGAATGTAA
ACTAAGTTTTTTGCATAAAA

Downstream 100 bases:

>100_bases
ATAGAAATTTTTCGAATCAGCCACAATTCAGTTGATTTTTGGCGAAGATAGATAGAGCTCTTAATTTGTTGTGACTAATT
TACAAGATAAAAAAATTGAT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 201; Mature: 200

Protein sequence:

>201_residues
MSSLRQSEIKRKTNETDISVFINLDGNGISEIDTGIPFLDHMLHQISSHGLFDLKIRAIGDTHIDDHHTNEDVGIALGKA
FSKALGERKGICRFGHFFAPLDEALVQVTLDCSGRPHLSYDLQLKAPRIGNYDTELVKEFFIAFVNNSGITLHINQIRGS
NSHHIVEACFKAFSRAMRMATEIDLRRSGSIPSSKGMLENQ

Sequences:

>Translated_201_residues
MSSLRQSEIKRKTNETDISVFINLDGNGISEIDTGIPFLDHMLHQISSHGLFDLKIRAIGDTHIDDHHTNEDVGIALGKA
FSKALGERKGICRFGHFFAPLDEALVQVTLDCSGRPHLSYDLQLKAPRIGNYDTELVKEFFIAFVNNSGITLHINQIRGS
NSHHIVEACFKAFSRAMRMATEIDLRRSGSIPSSKGMLENQ
>Mature_200_residues
SSLRQSEIKRKTNETDISVFINLDGNGISEIDTGIPFLDHMLHQISSHGLFDLKIRAIGDTHIDDHHTNEDVGIALGKAF
SKALGERKGICRFGHFFAPLDEALVQVTLDCSGRPHLSYDLQLKAPRIGNYDTELVKEFFIAFVNNSGITLHINQIRGSN
SHHIVEACFKAFSRAMRMATEIDLRRSGSIPSSKGMLENQ

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=47.4226804123711, Blast_Score=186, Evalue=8e-49,
Organism=Saccharomyces cerevisiae, GI6324776, Length=218, Percent_Identity=40.3669724770642, Blast_Score=167, Evalue=8e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_PROM0 (A3PB03)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001090529.1
- ProteinModelPortal:   A3PB03
- SMR:   A3PB03
- STRING:   A3PB03
- GeneID:   4911589
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_03051
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- ProtClustDB:   PRK00951
- BioCyc:   PMAR167546:P9301ORF_0310-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 22405; Mature: 22274

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLRQSEIKRKTNETDISVFINLDGNGISEIDTGIPFLDHMLHQISSHGLFDLKIRAIG
CCCHHHHHHHHHCCCCEEEEEEEECCCCCHHHHCCCHHHHHHHHHHHCCCEEEEEEEEEC
DTHIDDHHTNEDVGIALGKAFSKALGERKGICRFGHFFAPLDEALVQVTLDCSGRPHLSY
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHEEEEECCCCCCCCEE
DLQLKAPRIGNYDTELVKEFFIAFVNNSGITLHINQIRGSNSHHIVEACFKAFSRAMRMA
EEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
TEIDLRRSGSIPSSKGMLENQ
HHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SSLRQSEIKRKTNETDISVFINLDGNGISEIDTGIPFLDHMLHQISSHGLFDLKIRAIG
CCHHHHHHHHHCCCCEEEEEEEECCCCCHHHHCCCHHHHHHHHHHHCCCEEEEEEEEEC
DTHIDDHHTNEDVGIALGKAFSKALGERKGICRFGHFFAPLDEALVQVTLDCSGRPHLSY
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHEEEEECCCCCCCCEE
DLQLKAPRIGNYDTELVKEFFIAFVNNSGITLHINQIRGSNSHHIVEACFKAFSRAMRMA
EEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
TEIDLRRSGSIPSSKGMLENQ
HHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA