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The map label for this gene is cssS [H]

Identifier: 126698598

GI number: 126698598

Start: 1181794

End: 1183185

Strand: Direct

Name: cssS [H]

Synonym: CD1014

Alternate gene names: 126698598

Gene position: 1181794-1183185 (Clockwise)

Preceding gene: 126698597

Following gene: 126698599

Centisome position: 27.55

GC content: 27.87

Gene sequence:

>1392_bases
TTGTTGAGTATACTTTGTTTGATAATTATAGTATTTATGATAATATTAGTATCTTTTAATGTATTTCTTGATACATATAT
AAAAACAACTGCGAATGAAGAATTGACAAAGTCTACAGAAATAGTAGAACATATGGATAGTAATTTTAGACCTATTAAGC
CACCACAAGATGATGGAAAGCTTCCTCCCAAAGTATTATCTAATTTTATGAGAAATGTACAAGATAAAGTTAGGATGGCA
GAAACACAATCAGATGCTGATGCTATGGTAGTTGATTCTAAGTATAACCTGATATTTCCAACAAGAGAGGATGATTTCTT
AAAAAATGTTGATGAGATGGAGCTGATTAGGGAGTGTATTCAAAATGAAAAATTAGATTTAAATTCAGATGCAAATACAC
GGATATCTACCAGAAATAAGGATTATTATATTTCAACTGTAAAAATTACCAGTATATATGGTGAACAAGACAAGTATCTT
ATACTTTTTATAGACATATCAAAAACTCTAAATCTAGCACAAAAGATAAATATTGTATTAATATCTGTAATGTGTTTTGC
TGGAATATTAGCAATATTTACAGCTGTGATTTTATCTGAGAAAATTGCTAAACCGATAAAAGAGTTGTGTGAGTTTGCAA
AAAAAATGGGTCAAGGAGATTTCAAAAGAACCTACTTTGACTTTTCAGATAAAGAATTAGTAGAGCTCTCAACTGTTATG
AATAAGAGTGCTGAGTATCTGGATAAGTATGATAATGAACAAAAAATATTTTTTCAAAATGCATCTCATGAATTAAGGAC
ACCACTTATGTCTATTAAAGGTTATGCAGAAGCTATAAAATATAATGTTATAGATAGTAAACATGCAAGTGATATAATTC
TTGAAGAAAGTGATAGGTTAAGTGATATGGTTGAAGATTTATTATACATTTCTAAAATAGATAATATAACTAAAGATTTT
GAACTTGTAGAATGTGATTTAAGAGAAGTACTTTCAAATTGTGGAGCTAGGCAAAATGTAAGAGCTATAAATAAGGGGAT
AAAATTTATTTATGAATTTGATGAAGAAATGGTTTTATTTGAATGTGATGAAAAAAACATTTCCAAAGCATTTATGAATC
TTATAGAAAATGCTTTGAGATACGCTAAGAGTGAAATAAAAATAGTGTGTAAGTATAATCAAAAAAATATAGTTGTGATA
ATAGAAGATGATGGAATTGGAATCAAGAAAGAAGATTTACCTCATGTTTTTGAAAGATTCTATAAGGGAGTAGGGGGAAA
TCATGGAATTGGATTATCAATAGTTAAATCTATTGTAAATAAGCATGGTGGGCGTATATACGTAGAAAATGGCAAAAAAG
GAGCTAAATTTACTATATTATTTAAATTGTAA

Upstream 100 bases:

>100_bases
TAAGATGAAGAATGGAAATGACAAGAATAGAATTGGAAAGATTAAATCCAAATTTAAATTAAAGTTCTCAAAGAAAAATA
TAAGCATAAAAACTAGGATT

Downstream 100 bases:

>100_bases
AAAAATTAGAGAAAATATAGAGATGTTTGAAGTTGTTTTTTATATATATCTGTTGTATACTGTTGAAAAAAGAACAATAT
TAAGCTGACATATATTACGA

Product: two-component system sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MLSILCLIIIVFMIILVSFNVFLDTYIKTTANEELTKSTEIVEHMDSNFRPIKPPQDDGKLPPKVLSNFMRNVQDKVRMA
ETQSDADAMVVDSKYNLIFPTREDDFLKNVDEMELIRECIQNEKLDLNSDANTRISTRNKDYYISTVKITSIYGEQDKYL
ILFIDISKTLNLAQKINIVLISVMCFAGILAIFTAVILSEKIAKPIKELCEFAKKMGQGDFKRTYFDFSDKELVELSTVM
NKSAEYLDKYDNEQKIFFQNASHELRTPLMSIKGYAEAIKYNVIDSKHASDIILEESDRLSDMVEDLLYISKIDNITKDF
ELVECDLREVLSNCGARQNVRAINKGIKFIYEFDEEMVLFECDEKNISKAFMNLIENALRYAKSEIKIVCKYNQKNIVVI
IEDDGIGIKKEDLPHVFERFYKGVGGNHGIGLSIVKSIVNKHGGRIYVENGKKGAKFTILFKL

Sequences:

>Translated_463_residues
MLSILCLIIIVFMIILVSFNVFLDTYIKTTANEELTKSTEIVEHMDSNFRPIKPPQDDGKLPPKVLSNFMRNVQDKVRMA
ETQSDADAMVVDSKYNLIFPTREDDFLKNVDEMELIRECIQNEKLDLNSDANTRISTRNKDYYISTVKITSIYGEQDKYL
ILFIDISKTLNLAQKINIVLISVMCFAGILAIFTAVILSEKIAKPIKELCEFAKKMGQGDFKRTYFDFSDKELVELSTVM
NKSAEYLDKYDNEQKIFFQNASHELRTPLMSIKGYAEAIKYNVIDSKHASDIILEESDRLSDMVEDLLYISKIDNITKDF
ELVECDLREVLSNCGARQNVRAINKGIKFIYEFDEEMVLFECDEKNISKAFMNLIENALRYAKSEIKIVCKYNQKNIVVI
IEDDGIGIKKEDLPHVFERFYKGVGGNHGIGLSIVKSIVNKHGGRIYVENGKKGAKFTILFKL
>Mature_463_residues
MLSILCLIIIVFMIILVSFNVFLDTYIKTTANEELTKSTEIVEHMDSNFRPIKPPQDDGKLPPKVLSNFMRNVQDKVRMA
ETQSDADAMVVDSKYNLIFPTREDDFLKNVDEMELIRECIQNEKLDLNSDANTRISTRNKDYYISTVKITSIYGEQDKYL
ILFIDISKTLNLAQKINIVLISVMCFAGILAIFTAVILSEKIAKPIKELCEFAKKMGQGDFKRTYFDFSDKELVELSTVM
NKSAEYLDKYDNEQKIFFQNASHELRTPLMSIKGYAEAIKYNVIDSKHASDIILEESDRLSDMVEDLLYISKIDNITKDF
ELVECDLREVLSNCGARQNVRAINKGIKFIYEFDEEMVLFECDEKNISKAFMNLIENALRYAKSEIKIVCKYNQKNIVVI
IEDDGIGIKKEDLPHVFERFYKGVGGNHGIGLSIVKSIVNKHGGRIYVENGKKGAKFTILFKL

Specific function: Member of the two-component regulatory system CssS/CssR required to control the cellular response to secretion stress. Required for the transcription of htrA. Could detect misfolded proteins at the membrane-cell wall interface and then activate CssR by ph

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=260, Percent_Identity=30, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1786783, Length=294, Percent_Identity=28.5714285714286, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1790346, Length=270, Percent_Identity=24.8148148148148, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1786600, Length=227, Percent_Identity=28.1938325991189, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1787894, Length=365, Percent_Identity=23.8356164383562, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1788549, Length=213, Percent_Identity=23.943661971831, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1789808, Length=280, Percent_Identity=25, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790436, Length=208, Percent_Identity=24.5192307692308, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789403, Length=287, Percent_Identity=25.0871080139373, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1786912, Length=207, Percent_Identity=27.0531400966184, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI48994928, Length=238, Percent_Identity=25.2100840336134, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87081816, Length=241, Percent_Identity=24.4813278008299, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1790861, Length=207, Percent_Identity=25.1207729468599, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1787374, Length=291, Percent_Identity=20.6185567010309, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788279, Length=293, Percent_Identity=24.5733788395904, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53125; Mature: 53125

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSILCLIIIVFMIILVSFNVFLDTYIKTTANEELTKSTEIVEHMDSNFRPIKPPQDDGK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC
LPPKVLSNFMRNVQDKVRMAETQSDADAMVVDSKYNLIFPTREDDFLKNVDEMELIRECI
CCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEECCCCCHHHHCCHHHHHHHHHH
QNEKLDLNSDANTRISTRNKDYYISTVKITSIYGEQDKYLILFIDISKTLNLAQKINIVL
CCCCCCCCCCCCCEEECCCCCEEEEEEEEEEEECCCCCEEEEEEECCHHHHHHHHHHHHH
ISVMCFAGILAIFTAVILSEKIAKPIKELCEFAKKMGQGDFKRTYFDFSDKELVELSTVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHH
NKSAEYLDKYDNEQKIFFQNASHELRTPLMSIKGYAEAIKYNVIDSKHASDIILEESDRL
HHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHH
SDMVEDLLYISKIDNITKDFELVECDLREVLSNCGARQNVRAINKGIKFIYEFDEEMVLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEECCCCEEEE
ECDEKNISKAFMNLIENALRYAKSEIKIVCKYNQKNIVVIIEDDGIGIKKEDLPHVFERF
ECCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCEEEEEEECCCCCCCCCHHHHHHHHH
YKGVGGNHGIGLSIVKSIVNKHGGRIYVENGKKGAKFTILFKL
HHCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEC
>Mature Secondary Structure
MLSILCLIIIVFMIILVSFNVFLDTYIKTTANEELTKSTEIVEHMDSNFRPIKPPQDDGK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC
LPPKVLSNFMRNVQDKVRMAETQSDADAMVVDSKYNLIFPTREDDFLKNVDEMELIRECI
CCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEECCCCCHHHHCCHHHHHHHHHH
QNEKLDLNSDANTRISTRNKDYYISTVKITSIYGEQDKYLILFIDISKTLNLAQKINIVL
CCCCCCCCCCCCCEEECCCCCEEEEEEEEEEEECCCCCEEEEEEECCHHHHHHHHHHHHH
ISVMCFAGILAIFTAVILSEKIAKPIKELCEFAKKMGQGDFKRTYFDFSDKELVELSTVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHH
NKSAEYLDKYDNEQKIFFQNASHELRTPLMSIKGYAEAIKYNVIDSKHASDIILEESDRL
HHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHH
SDMVEDLLYISKIDNITKDFELVECDLREVLSNCGARQNVRAINKGIKFIYEFDEEMVLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEECCCCEEEE
ECDEKNISKAFMNLIENALRYAKSEIKIVCKYNQKNIVVIIEDDGIGIKKEDLPHVFERF
ECCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCEEEEEEECCCCCCCCCHHHHHHHHH
YKGVGGNHGIGLSIVKSIVNKHGGRIYVENGKKGAKFTILFKL
HHCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9353931; 9639930; 9384377; 11555295 [H]