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The map label for this gene is proP [H]

Identifier: 126447753

GI number: 126447753

Start: 826941

End: 828233

Strand: Reverse

Name: proP [H]

Synonym: BMA10247_A0875

Alternate gene names: 126447753

Gene position: 828233-826941 (Counterclockwise)

Preceding gene: 126447824

Following gene: 126447640

Centisome position: 35.2

GC content: 68.37

Gene sequence:

>1293_bases
ATGCCCGCTTCCGAACTGAGCGCCGTCTCGAGCGCCCCGCCCCGCGCCCTGACGGGCCGCGACTACAAGACGCTCGGCCT
CGCCGCACTGGGCGGCGCGCTGGAGTTCTACGATTTCATCATCTTCGTGTTCTTCGCGCCCGCGATCGGCCAGTTGTTCT
TTCCGCACGACATTCCCGACTGGCTGCGCCAACTGCAGACGTTCGGCATCTTCGCGGCCGGCTATCTCGCGCGGCCGCTC
GGCGGCATCGTGATGGCGCACTTCGGCGACCTCGTCGGCCGCAAGCGGATGTTCACGTTGAGCGTGCTGCTGATGTCGGT
GCCGACGCTCCTGATGGGCCTGCTGCCCACCTACGACAGCGTCGGCATCCTCGCGCCCGTCGTGCTGCTGCTGTTGCGCG
TGCTGCAAGGCGCGGCGGTGGGCGGCGAAGTGCCGGGCGCGTGGGTGTTCGTCTCCGAGCACGTGCCGCCGCAACGCATC
GGCTATGCGTGCGGCACGCTGACGGCGGGCCTGACCATCGGCATCCTGCTCGGCTCGCTCGTCGCGACGGCCGTCAACAG
CCGCTTCTCGACGGCCGAGGTTGCCGCGTTCGCGTGGCGCATCCCGTTCCTGCTCGGCGGCGTGTTCGGCCTGTTCTCCG
TCTACCTGCGCCGCTGGCTGCACGAGACGCCCGTGTTCGCCGAAATGAAGGCGCGCAAGACGCTCGCGGCCGAAATCCCG
CTGAAGGCCGTGATCCGCGACCACGGCCGCGCGGTGATCGTATCGATGCTGATCACGTGGATGCTGTCGGCGGCAATCGT
CGTCGTGATCCTGATGACGCCGACGCTGCTGCAAAAGCAGTTCCACATCGCGCCCGCGACCGCGCTGTTCGCGAACAGCA
TCGCGACGCTGTGCCTCACGGCCGGCTGCATCACCGCCGGCTCGCTCGCCGACCGCTTCGGCGCGAAGGCGGTGCTGTCG
ATCGGCGGCGTCGCGCTCGCCGCGTGCTACTACGCGATGTACACGCAGATCGCCGTCGACGCGGCGCGCCTCGTGCCGCT
CTACGGGCTCGCGGGCTTCACCGTCGGCACGATCGGCGCGGTGCCGTTCGTGCTGGTGAAGAGCTTTCCGGCCGTCGTGC
GCTTCTCGGGCATCTCGTTCTCGTACAACGTCGCGTACGCGGTGTTCGGCGGGCTCACGCCGGTAATCGTGTCGCTGCTG
ATGAAATCGCACTCGCTCGCGCCGGCGCACTATGTCGCGGCGATCTGCGTGCTCGGCGCGGTCGCGATGCTGTTCTCGAA
GGACGCCGAATAA

Upstream 100 bases:

>100_bases
CCACCCCGCGCGTTGCACCGTCTGTTCGACAACGAGGCCCGCCGCCCGGCCCCGTTTTTTCGCGCGGTACACAACCATTC
GAACCAAGATCGCCCTGACC

Downstream 100 bases:

>100_bases
CGCCGGTTGCGCGCGCGGCGCGGCACGCGTCGTGCTTGGGTGCTTCGGCGTTCCGGTGCTTTGGGTGCTTTGGGGGCTTC
CCGCGTTTCGGCGCTTTCGG

Product: major facilitator family transporter

Products: betaine [Cytoplasm]; Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MPASELSAVSSAPPRALTGRDYKTLGLAALGGALEFYDFIIFVFFAPAIGQLFFPHDIPDWLRQLQTFGIFAAGYLARPL
GGIVMAHFGDLVGRKRMFTLSVLLMSVPTLLMGLLPTYDSVGILAPVVLLLLRVLQGAAVGGEVPGAWVFVSEHVPPQRI
GYACGTLTAGLTIGILLGSLVATAVNSRFSTAEVAAFAWRIPFLLGGVFGLFSVYLRRWLHETPVFAEMKARKTLAAEIP
LKAVIRDHGRAVIVSMLITWMLSAAIVVVILMTPTLLQKQFHIAPATALFANSIATLCLTAGCITAGSLADRFGAKAVLS
IGGVALAACYYAMYTQIAVDAARLVPLYGLAGFTVGTIGAVPFVLVKSFPAVVRFSGISFSYNVAYAVFGGLTPVIVSLL
MKSHSLAPAHYVAAICVLGAVAMLFSKDAE

Sequences:

>Translated_430_residues
MPASELSAVSSAPPRALTGRDYKTLGLAALGGALEFYDFIIFVFFAPAIGQLFFPHDIPDWLRQLQTFGIFAAGYLARPL
GGIVMAHFGDLVGRKRMFTLSVLLMSVPTLLMGLLPTYDSVGILAPVVLLLLRVLQGAAVGGEVPGAWVFVSEHVPPQRI
GYACGTLTAGLTIGILLGSLVATAVNSRFSTAEVAAFAWRIPFLLGGVFGLFSVYLRRWLHETPVFAEMKARKTLAAEIP
LKAVIRDHGRAVIVSMLITWMLSAAIVVVILMTPTLLQKQFHIAPATALFANSIATLCLTAGCITAGSLADRFGAKAVLS
IGGVALAACYYAMYTQIAVDAARLVPLYGLAGFTVGTIGAVPFVLVKSFPAVVRFSGISFSYNVAYAVFGGLTPVIVSLL
MKSHSLAPAHYVAAICVLGAVAMLFSKDAE
>Mature_429_residues
PASELSAVSSAPPRALTGRDYKTLGLAALGGALEFYDFIIFVFFAPAIGQLFFPHDIPDWLRQLQTFGIFAAGYLARPLG
GIVMAHFGDLVGRKRMFTLSVLLMSVPTLLMGLLPTYDSVGILAPVVLLLLRVLQGAAVGGEVPGAWVFVSEHVPPQRIG
YACGTLTAGLTIGILLGSLVATAVNSRFSTAEVAAFAWRIPFLLGGVFGLFSVYLRRWLHETPVFAEMKARKTLAAEIPL
KAVIRDHGRAVIVSMLITWMLSAAIVVVILMTPTLLQKQFHIAPATALFANSIATLCLTAGCITAGSLADRFGAKAVLSI
GGVALAACYYAMYTQIAVDAARLVPLYGLAGFTVGTIGAVPFVLVKSFPAVVRFSGISFSYNVAYAVFGGLTPVIVSLLM
KSHSLAPAHYVAAICVLGAVAMLFSKDAE

Specific function: May be a proton symporter invoved in the uptake of osmolytes such as proline and glycine betaine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Escherichia coli, GI1790550, Length=423, Percent_Identity=28.1323877068558, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1788292, Length=417, Percent_Identity=29.4964028776978, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1789941, Length=423, Percent_Identity=31.6784869976359, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1788942, Length=427, Percent_Identity=30.4449648711944, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI87082231, Length=461, Percent_Identity=21.9088937093275, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45489; Mature: 45357

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHCCCC
>Mature Secondary Structure 
PASELSAVSSAPPRALTGRDYKTLGLAALGGALEFYDFIIFVFFAPAIGQLFFPHDIPD
CCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
WLRQLQTFGIFAAGYLARPLGGIVMAHFGDLVGRKRMFTLSVLLMSVPTLLMGLLPTYDS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VGILAPVVLLLLRVLQGAAVGGEVPGAWVFVSEHVPPQRIGYACGTLTAGLTIGILLGSL
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
VATAVNSRFSTAEVAAFAWRIPFLLGGVFGLFSVYLRRWLHETPVFAEMKARKTLAAEIP
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
LKAVIRDHGRAVIVSMLITWMLSAAIVVVILMTPTLLQKQFHIAPATALFANSIATLCLT
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
AGCITAGSLADRFGAKAVLSIGGVALAACYYAMYTQIAVDAARLVPLYGLAGFTVGTIGA
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPFVLVKSFPAVVRFSGISFSYNVAYAVFGGLTPVIVSLLMKSHSLAPAHYVAAICVLGA
HHHHHHHHCHHHHEECCCCEEHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
VAMLFSKDAE
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: betaine [Periplasm]; Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + betaine [Periplasm] = Proton [Cytoplasm] + betaine [Cytoplasm] Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10708580 [H]