Definition Burkholderia mallei NCTC 10247 chromosome II, complete genome.
Accession NC_009079
Length 2,352,693

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The map label for this gene is hmuV

Identifier: 126447694

GI number: 126447694

Start: 2026788

End: 2027606

Strand: Direct

Name: hmuV

Synonym: BMA10247_A2096

Alternate gene names: 126447694

Gene position: 2026788-2027606 (Clockwise)

Preceding gene: 126445718

Following gene: 126446391

Centisome position: 86.15

GC content: 75.82

Gene sequence:

>819_bases
ATGCTGAATGCCGACCATCTTCACGTCGCGCGCGACGGCCGCGCGATCCTGAACGACCTGTCGATCCGGATCGCGCCCGG
CTGCGTCACCGCGCTGCTCGGCCGCAACGGCGCGGGCAAGAGCACGCTGCTCGGCGTGCTCGCGGGCGACCTGCCGGCCG
GCGGCCTCGCGCGCGGCGCGACGGTGCGCGGCGGCGTCGCGCTGAACGGCGAGCCGCTTCACGCGATCGACGCGCCGCGC
CTCGCACGGCTGCGGGCGGTGCTGCCGCAGGCGTCGCGGCCCGCGTTCGCGTTCAGCGCGCGCGAGATCGTGCTGCTCGG
GCGCTACCCGCACGCGCGCCGCGCGGGCGCGCTCACGCATGCGGACGGCGAGATCGCGTCGCAGGCGCTCGCGCTCGCCG
GCGCAACGGCGCTCGATGCGCGCGACGTGACGACGCTCTCGGGCGGCGAGCTTGCCCGCGTGCAGTTCGCGCGCGTGCTC
GCGCAGCTCTGGCCGCCGCCCGGCGCGGCGCAGCCGCCGCGCTACCTGCTGCTCGACGAGCCGACCGCCGCGCTCGACCT
CGCGCATCAGCATCAATTGCTCGACACGGTTCGACGCCTGTCGCGCGACTGGAACCTCGGCGTGCTGACGATCGTCCACG
ATCCGAATCTCGCCGCGCGCCACGCGGATCGCATCGCGATGCTCGCGGACGGCGCGATCGTCGCGCAAGGCGCGCCCGCC
GACGTGCTGCGCCCCGAGCCGATCGCGCGGTGCTACGGCTTTCGCGTGCGGCTCGTCGACGCGGGCGACGGCGTCGCGCC
CGTCATCGTGCCCGCGTGA

Upstream 100 bases:

>100_bases
ATCTGACTCATCGAGTTCATCGAACCCGAACCCGAACCCGAACCCATCGAGAGCCTCATCGAAAACCCATCGATAGTCCA
CCCATAGCCCATCGAACGCC

Downstream 100 bases:

>100_bases
ACGACGCGCGAGCGGCACATGAGCGGCCGCCGCGCCCGCGGCGACGTGTCACCCGGCGTCGGCCGCCTGAAACGCCTTCA
GCCGCCAGCCGCGCCGCACG

Product: hemin importer ATP-binding subunit

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MLNADHLHVARDGRAILNDLSIRIAPGCVTALLGRNGAGKSTLLGVLAGDLPAGGLARGATVRGGVALNGEPLHAIDAPR
LARLRAVLPQASRPAFAFSAREIVLLGRYPHARRAGALTHADGEIASQALALAGATALDARDVTTLSGGELARVQFARVL
AQLWPPPGAAQPPRYLLLDEPTAALDLAHQHQLLDTVRRLSRDWNLGVLTIVHDPNLAARHADRIAMLADGAIVAQGAPA
DVLRPEPIARCYGFRVRLVDAGDGVAPVIVPA

Sequences:

>Translated_272_residues
MLNADHLHVARDGRAILNDLSIRIAPGCVTALLGRNGAGKSTLLGVLAGDLPAGGLARGATVRGGVALNGEPLHAIDAPR
LARLRAVLPQASRPAFAFSAREIVLLGRYPHARRAGALTHADGEIASQALALAGATALDARDVTTLSGGELARVQFARVL
AQLWPPPGAAQPPRYLLLDEPTAALDLAHQHQLLDTVRRLSRDWNLGVLTIVHDPNLAARHADRIAMLADGAIVAQGAPA
DVLRPEPIARCYGFRVRLVDAGDGVAPVIVPA
>Mature_272_residues
MLNADHLHVARDGRAILNDLSIRIAPGCVTALLGRNGAGKSTLLGVLAGDLPAGGLARGATVRGGVALNGEPLHAIDAPR
LARLRAVLPQASRPAFAFSAREIVLLGRYPHARRAGALTHADGEIASQALALAGATALDARDVTTLSGGELARVQFARVL
AQLWPPPGAAQPPRYLLLDEPTAALDLAHQHQLLDTVRRLSRDWNLGVLTIVHDPNLAARHADRIAMLADGAIVAQGAPA
DVLRPEPIARCYGFRVRLVDAGDGVAPVIVPA

Specific function: Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system

COG id: COG4559

COG function: function code P; ABC-type hemin transport system, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain

Homologues:

Organism=Homo sapiens, GI11967969, Length=234, Percent_Identity=29.0598290598291, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI1786345, Length=256, Percent_Identity=39.453125, Blast_Score=160, Evalue=7e-41,
Organism=Escherichia coli, GI1786803, Length=271, Percent_Identity=33.9483394833948, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1790739, Length=244, Percent_Identity=33.6065573770492, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1788002, Length=247, Percent_Identity=35.2226720647773, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1789891, Length=243, Percent_Identity=29.2181069958848, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87081791, Length=271, Percent_Identity=28.7822878228782, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87081834, Length=233, Percent_Identity=30.9012875536481, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1786563, Length=233, Percent_Identity=29.1845493562232, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI48994997, Length=246, Percent_Identity=28.4552845528455, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787712, Length=240, Percent_Identity=27.9166666666667, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787029, Length=240, Percent_Identity=27.9166666666667, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790544, Length=228, Percent_Identity=30.2631578947368, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1786398, Length=245, Percent_Identity=25.3061224489796, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786703, Length=224, Percent_Identity=31.25, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789864, Length=268, Percent_Identity=23.5074626865672, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1786253, Length=225, Percent_Identity=31.1111111111111, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI48994883, Length=230, Percent_Identity=24.7826086956522, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787759, Length=236, Percent_Identity=26.6949152542373, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789890, Length=230, Percent_Identity=29.1304347826087, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788506, Length=237, Percent_Identity=24.8945147679325, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI48995001, Length=220, Percent_Identity=27.2727272727273, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1788450, Length=257, Percent_Identity=25.2918287937743, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1786872, Length=243, Percent_Identity=26.7489711934156, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1789586, Length=266, Percent_Identity=26.6917293233083, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1787112, Length=246, Percent_Identity=29.6747967479675, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI145693107, Length=257, Percent_Identity=26.0700389105058, Blast_Score=61, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322640, Length=253, Percent_Identity=26.0869565217391, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI23397593, Length=240, Percent_Identity=30.8333333333333, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17136592, Length=245, Percent_Identity=27.3469387755102, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HMUV_BURMA (Q62A98)

Other databases:

- EMBL:   CP000011
- RefSeq:   YP_106381.1
- HSSP:   P06611
- ProteinModelPortal:   Q62A98
- GeneID:   3086206
- GenomeReviews:   CP000011_GR
- KEGG:   bma:BMAA1830
- TIGR:   BMAA1830
- HOGENOM:   HBG758042
- OMA:   EDHMISA
- PhylomeDB:   Q62A98
- ProtClustDB:   PRK13547
- BioCyc:   BMAL243160:BMA_A1830-MONOMER
- HAMAP:   MF_01718
- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR015863
- InterPro:   IPR003593
- SMART:   SM00382

Pfam domain/function: PF00005 ABC_tran

EC number: NA

Molecular weight: Translated: 28401; Mature: 28401

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS00211 ABC_TRANSPORTER_1; PS50893 ABC_TRANSPORTER_2; PS51261 HMUV

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNADHLHVARDGRAILNDLSIRIAPGCVTALLGRNGAGKSTLLGVLAGDLPAGGLARGA
CCCCCCEEEECCCHHHHHCCEEEECCHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCC
TVRGGVALNGEPLHAIDAPRLARLRAVLPQASRPAFAFSAREIVLLGRYPHARRAGALTH
EEECCEEECCCCCCCCCCHHHHHHHHHCCCCCCCEEEECCEEEEEEECCCCHHHCCCEEC
ADGEIASQALALAGATALDARDVTTLSGGELARVQFARVLAQLWPPPGAAQPPRYLLLDE
CCHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEC
PTAALDLAHQHQLLDTVRRLSRDWNLGVLTIVHDPNLAARHADRIAMLADGAIVAQGAPA
CHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHCEEEEEECCEEEECCCCC
DVLRPEPIARCYGFRVRLVDAGDGVAPVIVPA
CCCCCCHHHHHCCEEEEEEECCCCCCEEEECC
>Mature Secondary Structure
MLNADHLHVARDGRAILNDLSIRIAPGCVTALLGRNGAGKSTLLGVLAGDLPAGGLARGA
CCCCCCEEEECCCHHHHHCCEEEECCHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCC
TVRGGVALNGEPLHAIDAPRLARLRAVLPQASRPAFAFSAREIVLLGRYPHARRAGALTH
EEECCEEECCCCCCCCCCHHHHHHHHHCCCCCCCEEEECCEEEEEEECCCCHHHCCCEEC
ADGEIASQALALAGATALDARDVTTLSGGELARVQFARVLAQLWPPPGAAQPPRYLLLDE
CCHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEC
PTAALDLAHQHQLLDTVRRLSRDWNLGVLTIVHDPNLAARHADRIAMLADGAIVAQGAPA
CHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHCEEEEEECCEEEECCCCC
DVLRPEPIARCYGFRVRLVDAGDGVAPVIVPA
CCCCCCHHHHHCCEEEEEEECCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA