Click here to switch to the map view.

The map label for this gene is prpD1 [H]

Identifier: 126447346

GI number: 126447346

Start: 2171474

End: 2172952

Strand: Direct

Name: prpD1 [H]

Synonym: BMA10247_A2231

Alternate gene names: 126447346

Gene position: 2171474-2172952 (Clockwise)

Preceding gene: 126446105

Following gene: 126446765

Centisome position: 92.3

GC content: 71.33

Gene sequence:

>1479_bases
ATGAATCGACGCCATTTCCTCGCCGCCGCCGTCGCGGCGAGCCTGCCGCTCGCCGCGACGCTCGCGCCGCGCGGCGCGCG
CGCACAGCCGAACGCAACGCAGGCCGCCGCGCCCACGCTCGCGCGCCAACTCGCCGAATACGCGGCGGGGCTGCGCTACG
AGGATCTCGACTCGGCGACGATCGACATCGTCAAATCGCATCTGATCGACGCGCTCGGTTGCGCGCTCGCCGCGCTCGAC
GAGCCGCCCGTGCGCATCGCGCGCGACGCGGCGCGCAGCGCCGGCGGCGGCGGCGGACCGTCGACGATCATCGGAACGGC
CGAGCGAACGAGCCCCGATCTCGCGACGTTCGCCACGGGCACCGCGCTGCGCTACTTCGATTTCAACGACGCATACGCGG
GCCGCGAAATCGGCCATCCGAGCGACAACATCGCCGCGTGCGTCGCGGTGGCCGAGGCGCAGCATGCGAGCGGCCGCGAG
CTGATCCTGTCGATCGCGCTCGCCTACGAGATCGCATGCCGGCTGATGGACGCGGCCGCGATCAGCCCGCGCGGCTGGGA
CCACACGTGCTACTCGCTGCCCGCCGCCGCGCTCGCGGCGGGCAAGCTGATGCGCATGCCGGTCGAAGCGCTCACGCAGG
CCGTGAACCTGTCGCTCAACAGCCATCTCGCGCTGAACCAGACGCGCGTGCAGCAGCTATCGAACTGGAAGGCGCTCGCC
GACGCGGACGCCGCGCGCAACGCGGTGTTCTCGACGCAGCTCGCCCGTGCGGGGCTCACCGGGCCGTCGCCGATCTTCGA
GGGCGAGGCGGGCTTCTTCCGCCAGGTATCGGGGCCGTTCGAGCTCGAGACGAGCCGTTTCGGCGGGCGCGGCGAGCCGT
TCAGGATCGCGCGCTGCTTCGTCAAATACTACCCGGCGCAAGGCTTCACGCAGACCGCGATTCCGGCCGCGCTCGACGTC
GCGTCGCAAGCGGGCGACCTGAGCCGCATCCGCCGCATCGATGTGCACACGACGCGCGTCGGCTACGTAACGGCCGGCAG
CGAGCCGGAGAAATGGAAGCCGTCGACGCGCGAAACGGCCGACCACAGCCTGCCGTACATCGTCGCGCGCGCGATGCTCG
ACGGCGACATCCGGACCACGAGCTTCTCGGACGCCGCGCTGCGCGATCCGGTGCTGCACGCGCTGATCGCGAAGATTCGC
GTCGAAGAGGATCCGGCGCTGACGGCGGGCTACCCCGCGCGCGCGGCGAATCGCGTGACCGCGCATTGCCGCGACGGCGC
GGTGTATGCGAAGCAGGTCGACGATCTGCCCGGCTCGCCGACGCGGCCGATGCGCCGTGAGGATTTCGAAGCGAAATTCG
TGAAGAACGGCGGCGCGCGCCTGAGCGAGCAGCGCATGCGCGCGGCGCTCGACAGGTTGTGGCGGCTCGACGAGCTGCAG
GATGTCGCCGCGCTGCCGCCGCTGTTCGTCGCGGGCTGA

Upstream 100 bases:

>100_bases
TCGCCGGCGCGCGCGCCGGCAGCGCGGGCGTCGCCGTCGGCGTGCGCAAGTTGTTCTGAGCCGCGCGCCCCGATCCTTTC
GTCACAGGAGCCTCATCACC

Downstream 100 bases:

>100_bases
GCAAGGCGGGCCCAGCGGACCAAGGGGGGGGCCGAACGCGCGCGGCGCGGGCCCGCGGCGCGCCGCGCTCGCCCGCCTCA
CGTGGCGGCGGCGGCGGCGG

Product: MmgE/PrpD family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 492; Mature: 492

Protein sequence:

>492_residues
MNRRHFLAAAVAASLPLAATLAPRGARAQPNATQAAAPTLARQLAEYAAGLRYEDLDSATIDIVKSHLIDALGCALAALD
EPPVRIARDAARSAGGGGGPSTIIGTAERTSPDLATFATGTALRYFDFNDAYAGREIGHPSDNIAACVAVAEAQHASGRE
LILSIALAYEIACRLMDAAAISPRGWDHTCYSLPAAALAAGKLMRMPVEALTQAVNLSLNSHLALNQTRVQQLSNWKALA
DADAARNAVFSTQLARAGLTGPSPIFEGEAGFFRQVSGPFELETSRFGGRGEPFRIARCFVKYYPAQGFTQTAIPAALDV
ASQAGDLSRIRRIDVHTTRVGYVTAGSEPEKWKPSTRETADHSLPYIVARAMLDGDIRTTSFSDAALRDPVLHALIAKIR
VEEDPALTAGYPARAANRVTAHCRDGAVYAKQVDDLPGSPTRPMRREDFEAKFVKNGGARLSEQRMRAALDRLWRLDELQ
DVAALPPLFVAG

Sequences:

>Translated_492_residues
MNRRHFLAAAVAASLPLAATLAPRGARAQPNATQAAAPTLARQLAEYAAGLRYEDLDSATIDIVKSHLIDALGCALAALD
EPPVRIARDAARSAGGGGGPSTIIGTAERTSPDLATFATGTALRYFDFNDAYAGREIGHPSDNIAACVAVAEAQHASGRE
LILSIALAYEIACRLMDAAAISPRGWDHTCYSLPAAALAAGKLMRMPVEALTQAVNLSLNSHLALNQTRVQQLSNWKALA
DADAARNAVFSTQLARAGLTGPSPIFEGEAGFFRQVSGPFELETSRFGGRGEPFRIARCFVKYYPAQGFTQTAIPAALDV
ASQAGDLSRIRRIDVHTTRVGYVTAGSEPEKWKPSTRETADHSLPYIVARAMLDGDIRTTSFSDAALRDPVLHALIAKIR
VEEDPALTAGYPARAANRVTAHCRDGAVYAKQVDDLPGSPTRPMRREDFEAKFVKNGGARLSEQRMRAALDRLWRLDELQ
DVAALPPLFVAG
>Mature_492_residues
MNRRHFLAAAVAASLPLAATLAPRGARAQPNATQAAAPTLARQLAEYAAGLRYEDLDSATIDIVKSHLIDALGCALAALD
EPPVRIARDAARSAGGGGGPSTIIGTAERTSPDLATFATGTALRYFDFNDAYAGREIGHPSDNIAACVAVAEAQHASGRE
LILSIALAYEIACRLMDAAAISPRGWDHTCYSLPAAALAAGKLMRMPVEALTQAVNLSLNSHLALNQTRVQQLSNWKALA
DADAARNAVFSTQLARAGLTGPSPIFEGEAGFFRQVSGPFELETSRFGGRGEPFRIARCFVKYYPAQGFTQTAIPAALDV
ASQAGDLSRIRRIDVHTTRVGYVTAGSEPEKWKPSTRETADHSLPYIVARAMLDGDIRTTSFSDAALRDPVLHALIAKIR
VEEDPALTAGYPARAANRVTAHCRDGAVYAKQVDDLPGSPTRPMRREDFEAKFVKNGGARLSEQRMRAALDRLWRLDELQ
DVAALPPLFVAG

Specific function: Catalyzes the dehydration of 2-methylcitrate to 2- methyl-cis-aconitate [H]

COG id: COG2079

COG function: function code R; Uncharacterized protein involved in propionate catabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prpD family [H]

Homologues:

Organism=Homo sapiens, GI310123058, Length=459, Percent_Identity=23.9651416122004, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI310129732, Length=470, Percent_Identity=23.6170212765957, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI310110533, Length=470, Percent_Identity=23.6170212765957, Blast_Score=90, Evalue=5e-18,
Organism=Escherichia coli, GI1786528, Length=474, Percent_Identity=26.1603375527426, Blast_Score=114, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6325258, Length=380, Percent_Identity=25.2631578947368, Blast_Score=99, Evalue=1e-21,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005656 [H]

Pfam domain/function: PF03972 MmgE_PrpD [H]

EC number: =4.2.1.79 [H]

Molecular weight: Translated: 52565; Mature: 52565

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRRHFLAAAVAASLPLAATLAPRGARAQPNATQAAAPTLARQLAEYAAGLRYEDLDSAT
CCCHHHHHHHHHHHCCHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHH
IDIVKSHLIDALGCALAALDEPPVRIARDAARSAGGGGGPSTIIGTAERTSPDLATFATG
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCCCCHHHHHCC
TALRYFDFNDAYAGREIGHPSDNIAACVAVAEAQHASGRELILSIALAYEIACRLMDAAA
CEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHC
ISPRGWDHTCYSLPAAALAAGKLMRMPVEALTQAVNLSLNSHLALNQTRVQQLSNWKALA
CCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEECHHHHHHHHCCHHHH
DADAARNAVFSTQLARAGLTGPSPIFEGEAGFFRQVSGPFELETSRFGGRGEPFRIARCF
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCEEECCCCCCCCCHHHHHHHH
VKYYPAQGFTQTAIPAALDVASQAGDLSRIRRIDVHTTRVGYVTAGSEPEKWKPSTRETA
HHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHEEEEEEEEEEEEECCCCCCCCCCCCCCHH
DHSLPYIVARAMLDGDIRTTSFSDAALRDPVLHALIAKIRVEEDPALTAGYPARAANRVT
HCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCE
AHCRDGAVYAKQVDDLPGSPTRPMRREDFEAKFVKNGGARLSEQRMRAALDRLWRLDELQ
EECCCCCEEHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
DVAALPPLFVAG
HHHHCCCCCCCC
>Mature Secondary Structure
MNRRHFLAAAVAASLPLAATLAPRGARAQPNATQAAAPTLARQLAEYAAGLRYEDLDSAT
CCCHHHHHHHHHHHCCHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHH
IDIVKSHLIDALGCALAALDEPPVRIARDAARSAGGGGGPSTIIGTAERTSPDLATFATG
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCCCCHHHHHCC
TALRYFDFNDAYAGREIGHPSDNIAACVAVAEAQHASGRELILSIALAYEIACRLMDAAA
CEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHC
ISPRGWDHTCYSLPAAALAAGKLMRMPVEALTQAVNLSLNSHLALNQTRVQQLSNWKALA
CCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEECHHHHHHHHCCHHHH
DADAARNAVFSTQLARAGLTGPSPIFEGEAGFFRQVSGPFELETSRFGGRGEPFRIARCF
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCEEECCCCCCCCCHHHHHHHH
VKYYPAQGFTQTAIPAALDVASQAGDLSRIRRIDVHTTRVGYVTAGSEPEKWKPSTRETA
HHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHEEEEEEEEEEEEECCCCCCCCCCCCCCHH
DHSLPYIVARAMLDGDIRTTSFSDAALRDPVLHALIAKIRVEEDPALTAGYPARAANRVT
HCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCE
AHCRDGAVYAKQVDDLPGSPTRPMRREDFEAKFVKNGGARLSEQRMRAALDRLWRLDELQ
EECCCCCEEHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
DVAALPPLFVAG
HHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11976302; 12948626 [H]