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The map label for this gene is nhoA [H]

Identifier: 126447313

GI number: 126447313

Start: 942185

End: 943057

Strand: Direct

Name: nhoA [H]

Synonym: BMA10247_A0998

Alternate gene names: 126447313

Gene position: 942185-943057 (Clockwise)

Preceding gene: 126447943

Following gene: 126446160

Centisome position: 40.05

GC content: 66.9

Gene sequence:

>873_bases
ATGCGCGACGCAGTCGATCTTTCCCGTTATTTCGCCCGCATCGGTTATCGCGGCCCCGCCGAGCCGACGCTCGACGTCCT
TCGCCAGTTGCAACTGCTGCATCCGCAGTCGATTCCGTTCGAGAACCTCAACCCGTTCACCGGCGCGCGCGTCGCGCTCG
AACTCGAATCGGTCGTCGATAAGCTGGTCGGGCAGCGCCGCGGCGGTTACTGCTTCGAGCAGAACAAGCTCTTCTACACG
GTGCTCGTGCAGCTCGGCTTTCGCGTGACGCCGCTGATCGCGCGCGTGCGCTGGCAGCGTCCGCCGGAACAGTCGACGCC
GCAGACGCACATGCTGCTGCGGATCGATCTGGACGGCGACACCTGGTTCGCCGACGTCGGCTTCGGTTCGACGACGCTGA
CCGCGCCGCTGCGCCATGACCCGAACGTCGCACAGCCGACGCCGCACGGCACGTTTCGCGTCGTCGACGCGCCCGTCGCT
GGCGAGTTCGAGATCGAATGCGAAACGCCGAACGGTTGGCATCCGCTGTATCGTTTTTCGCTGAAGCCCGTCGAGTGGGT
CGATTACGAGGTCGCGAACTGGTATACGTCGCGGCACCCCGATTCGTTCTTCACGCACGATTTCATCGCGTGCCGAATCC
TGCCGGATGCGCGTGCGCTGCTTTTCAACGATGCGTTGACGCTGCGAACGGCCGACGGCGCGGCGCACACCACCCGGCTG
ACGGATGCCGACGCATGGGCGGCGTGCGTGCGCGAGCGCTTCGGTCTCGACCTGGACGGATTCGATGCGGCGGCGCTTTA
TGCACGGGCAGTGGCGCGTGCCGACGAGGCGGCGGCTGCCGCCGAGCGGCGCGACGGCAGCGCGGCGCGCTGA

Upstream 100 bases:

>100_bases
GCGCGCCGATATGGCCGCCGGCGCGCGCTTTCCCTTGTGTCGAATGGGGTTATCCGCGTAATGCTATGGTGATGCGTTCC
GTCACCATCAGATTGTCCCC

Downstream 100 bases:

>100_bases
GGCCGCGTGAGGCATGCGTCGCGAAGCGCCGCTCGAGCCGGCGCGCTCGGCGGGGCGGCGGTTGAGCTTGGCGCGCATGC
GGCGATACGGCGAGACCGTG

Product: N-hydroxyarylamine O-acetyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MRDAVDLSRYFARIGYRGPAEPTLDVLRQLQLLHPQSIPFENLNPFTGARVALELESVVDKLVGQRRGGYCFEQNKLFYT
VLVQLGFRVTPLIARVRWQRPPEQSTPQTHMLLRIDLDGDTWFADVGFGSTTLTAPLRHDPNVAQPTPHGTFRVVDAPVA
GEFEIECETPNGWHPLYRFSLKPVEWVDYEVANWYTSRHPDSFFTHDFIACRILPDARALLFNDALTLRTADGAAHTTRL
TDADAWAACVRERFGLDLDGFDAAALYARAVARADEAAAAAERRDGSAAR

Sequences:

>Translated_290_residues
MRDAVDLSRYFARIGYRGPAEPTLDVLRQLQLLHPQSIPFENLNPFTGARVALELESVVDKLVGQRRGGYCFEQNKLFYT
VLVQLGFRVTPLIARVRWQRPPEQSTPQTHMLLRIDLDGDTWFADVGFGSTTLTAPLRHDPNVAQPTPHGTFRVVDAPVA
GEFEIECETPNGWHPLYRFSLKPVEWVDYEVANWYTSRHPDSFFTHDFIACRILPDARALLFNDALTLRTADGAAHTTRL
TDADAWAACVRERFGLDLDGFDAAALYARAVARADEAAAAAERRDGSAAR
>Mature_290_residues
MRDAVDLSRYFARIGYRGPAEPTLDVLRQLQLLHPQSIPFENLNPFTGARVALELESVVDKLVGQRRGGYCFEQNKLFYT
VLVQLGFRVTPLIARVRWQRPPEQSTPQTHMLLRIDLDGDTWFADVGFGSTTLTAPLRHDPNVAQPTPHGTFRVVDAPVA
GEFEIECETPNGWHPLYRFSLKPVEWVDYEVANWYTSRHPDSFFTHDFIACRILPDARALLFNDALTLRTADGAAHTTRL
TDADAWAACVRERFGLDLDGFDAAALYARAVARADEAAAAAERRDGSAAR

Specific function: Could have a role in acetylating, and hence inactivating, the antitubercular drug isoniazid [H]

COG id: COG2162

COG function: function code Q; Arylamine N-acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arylamine N-acetyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI237649132, Length=246, Percent_Identity=30.4878048780488, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI237649130, Length=246, Percent_Identity=30.4878048780488, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI237649128, Length=243, Percent_Identity=30.8641975308642, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI237649126, Length=243, Percent_Identity=30.8641975308642, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI237649124, Length=243, Percent_Identity=30.8641975308642, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI237649122, Length=243, Percent_Identity=30.8641975308642, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI237649119, Length=243, Percent_Identity=30.8641975308642, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI42741671, Length=243, Percent_Identity=30.8641975308642, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI237649009, Length=243, Percent_Identity=30.8641975308642, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI116295260, Length=252, Percent_Identity=29.3650793650794, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1787736, Length=254, Percent_Identity=39.7637795275591, Blast_Score=171, Evalue=8e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001447 [H]

Pfam domain/function: PF00797 Acetyltransf_2 [H]

EC number: =2.3.1.5 [H]

Molecular weight: Translated: 32557; Mature: 32557

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDAVDLSRYFARIGYRGPAEPTLDVLRQLQLLHPQSIPFENLNPFTGARVALELESVVD
CCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEHHHHHH
KLVGQRRGGYCFEQNKLFYTVLVQLGFRVTPLIARVRWQRPPEQSTPQTHMLLRIDLDGD
HHHHCCCCCEEEECCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCC
TWFADVGFGSTTLTAPLRHDPNVAQPTPHGTFRVVDAPVAGEFEIECETPNGWHPLYRFS
EEEEECCCCCCEEEECCCCCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCEEEEE
LKPVEWVDYEVANWYTSRHPDSFFTHDFIACRILPDARALLFNDALTLRTADGAAHTTRL
CCCCCCCCHHHHHHCCCCCCCCHHCCCEEEEEECCCCCEEHCCCCEEEEECCCCCCEEEC
TDADAWAACVRERFGLDLDGFDAAALYARAVARADEAAAAAERRDGSAAR
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRDAVDLSRYFARIGYRGPAEPTLDVLRQLQLLHPQSIPFENLNPFTGARVALELESVVD
CCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEHHHHHH
KLVGQRRGGYCFEQNKLFYTVLVQLGFRVTPLIARVRWQRPPEQSTPQTHMLLRIDLDGD
HHHHCCCCCEEEECCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCC
TWFADVGFGSTTLTAPLRHDPNVAQPTPHGTFRVVDAPVAGEFEIECETPNGWHPLYRFS
EEEEECCCCCCEEEECCCCCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCEEEEE
LKPVEWVDYEVANWYTSRHPDSFFTHDFIACRILPDARALLFNDALTLRTADGAAHTTRL
CCCCCCCCHHHHHHCCCCCCCCHHCCCEEEEEECCCCCEEHCCCCEEEEECCCCCCEEEC
TDADAWAACVRERFGLDLDGFDAAALYARAVARADEAAAAAERRDGSAAR
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]