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The map label for this gene is hmuU [H]

Identifier: 126447293

GI number: 126447293

Start: 2025293

End: 2026309

Strand: Direct

Name: hmuU [H]

Synonym: BMA10247_A2093

Alternate gene names: 126447293

Gene position: 2025293-2026309 (Clockwise)

Preceding gene: 126447939

Following gene: 126445718

Centisome position: 86.08

GC content: 75.32

Gene sequence:

>1017_bases
ATGAGCCTCGCCGCCCGCCGCCATTCGGCCCGCCCGATATCCGCCGAGCGCGGTTCGACCTGCGCGTCGCGCGCCCTCGC
CGCACTGCGCCGGCGACGCGCGCGATGGACGCTCGCCACGCTGATCGCCGCGCTCGCCGCCGCGTCGATCGCCGCACTCT
GCATCGGCGCGTACCGGCTCTCGCCCGCGCAGTTGCTCGGCGCGCTCACCGCCACCGATGCGCAGCTCGCGGGCGACGCG
GCGCTGCGCCAGGCGCGCGCGGTGCTCGTCGACATCCGCGCGCCGCGCGTCGTGCTCGCGCTCTTCGTCGGCGCGGGCTT
CGGCGCGGCCGGCGCCGCGATGCAAGCGCTCTTTCGCAATCCGCTCGCCGATCCGGGCCTGATCGGCGTATCGAGCGGCG
CGGCGCTCGTCTACCGGCTCGCCGTCGCGCGCGGCCGGCTCGCGCTGCCGCTGCTGCTGCTCGCCGGCATCGCGATCAAC
GCGCTCGCCGGCGCGGGGATCGGGCTTCTCACCTACCTCGCCGACGATGCGCAACTGCGGTCGCTGACGTTCTGGAGCCT
CGGCAGCGTCGGCGGCGCGCAATGGCGCACGATCGCCGCCGTCGCGCCGTTCGCGCTCGCCGGCTGCGTGCTGCTCGCGC
GCGAGCGACACGCGCTGAACGCGCTGCAGCTCGGCGAAGCCGAAGCGATGCATCTCGGGGTGCCGGTGCCGCGCGTGAAG
CGGCGCGTGCTCGTCGGCACCGCGATGTGCGTCGGCGCGCTCGTGTCGTGCACCGGCGCGATCGGTTTCATCGGGCTCGT
CGCACCGCATTGCGTGCGGCTCGCGGCGGGCGCCGATCAGCGCATCGTGATACCGGGCGCGGCGCTTTTCGGCGCGCTGC
TCGCGGTGGCCGCCGATCTCGCCGCGCGCACGCTCGCCGCGCCGGCCGAGATTCCGCTCGGCATCCTGACCGCGCTGATC
GGCGCGCCGTTCTTTCTAGCGCTGCTCTGGAAGCGGCGCGGCGCGCTGGGAGGATGA

Upstream 100 bases:

>100_bases
TCGCGCGCGGCGCGGCGACCGTCGCCGCCGCGCGCGCACCGCAGGCCGGGTGCCGCGCATACGCCTCGAGCGCGCCACCC
CTCCCGTTCGACTTCACGCG

Downstream 100 bases:

>100_bases
CGTTGCGCACGCGCCTTCGGCGCCGACCTGCCGGACAGGCCGACGACGTTCGCGCGCGGCGAGCGTGCCGCCGCATCGGC
ACGCTCGCCGCCGCGATGCC

Product: hemin ABC transporter, permease protein

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MSLAARRHSARPISAERGSTCASRALAALRRRRARWTLATLIAALAAASIAALCIGAYRLSPAQLLGALTATDAQLAGDA
ALRQARAVLVDIRAPRVVLALFVGAGFGAAGAAMQALFRNPLADPGLIGVSSGAALVYRLAVARGRLALPLLLLAGIAIN
ALAGAGIGLLTYLADDAQLRSLTFWSLGSVGGAQWRTIAAVAPFALAGCVLLARERHALNALQLGEAEAMHLGVPVPRVK
RRVLVGTAMCVGALVSCTGAIGFIGLVAPHCVRLAAGADQRIVIPGAALFGALLAVAADLAARTLAAPAEIPLGILTALI
GAPFFLALLWKRRGALGG

Sequences:

>Translated_338_residues
MSLAARRHSARPISAERGSTCASRALAALRRRRARWTLATLIAALAAASIAALCIGAYRLSPAQLLGALTATDAQLAGDA
ALRQARAVLVDIRAPRVVLALFVGAGFGAAGAAMQALFRNPLADPGLIGVSSGAALVYRLAVARGRLALPLLLLAGIAIN
ALAGAGIGLLTYLADDAQLRSLTFWSLGSVGGAQWRTIAAVAPFALAGCVLLARERHALNALQLGEAEAMHLGVPVPRVK
RRVLVGTAMCVGALVSCTGAIGFIGLVAPHCVRLAAGADQRIVIPGAALFGALLAVAADLAARTLAAPAEIPLGILTALI
GAPFFLALLWKRRGALGG
>Mature_337_residues
SLAARRHSARPISAERGSTCASRALAALRRRRARWTLATLIAALAAASIAALCIGAYRLSPAQLLGALTATDAQLAGDAA
LRQARAVLVDIRAPRVVLALFVGAGFGAAGAAMQALFRNPLADPGLIGVSSGAALVYRLAVARGRLALPLLLLAGIAINA
LAGAGIGLLTYLADDAQLRSLTFWSLGSVGGAQWRTIAAVAPFALAGCVLLARERHALNALQLGEAEAMHLGVPVPRVKR
RVLVGTAMCVGALVSCTGAIGFIGLVAPHCVRLAAGADQRIVIPGAALFGALLAVAADLAARTLAAPAEIPLGILTALIG
APFFLALLWKRRGALGG

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=287, Percent_Identity=37.6306620209059, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1790740, Length=294, Percent_Identity=37.0748299319728, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI1790741, Length=282, Percent_Identity=32.9787234042553, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1786805, Length=291, Percent_Identity=37.4570446735395, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786804, Length=331, Percent_Identity=31.4199395770393, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786347, Length=281, Percent_Identity=29.5373665480427, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 34315; Mature: 34184

Theoretical pI: Translated: 12.05; Mature: 12.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLAARRHSARPISAERGSTCASRALAALRRRRARWTLATLIAALAAASIAALCIGAYRL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SPAQLLGALTATDAQLAGDAALRQARAVLVDIRAPRVVLALFVGAGFGAAGAAMQALFRN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHCCCCHHHHHHHHHHHC
PLADPGLIGVSSGAALVYRLAVARGRLALPLLLLAGIAINALAGAGIGLLTYLADDAQLR
CCCCCCCEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHH
SLTFWSLGSVGGAQWRTIAAVAPFALAGCVLLARERHALNALQLGEAEAMHLGVPVPRVK
HEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHH
RRVLVGTAMCVGALVSCTGAIGFIGLVAPHCVRLAAGADQRIVIPGAALFGALLAVAADL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHH
AARTLAAPAEIPLGILTALIGAPFFLALLWKRRGALGG
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SLAARRHSARPISAERGSTCASRALAALRRRRARWTLATLIAALAAASIAALCIGAYRL
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SPAQLLGALTATDAQLAGDAALRQARAVLVDIRAPRVVLALFVGAGFGAAGAAMQALFRN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHCCCCHHHHHHHHHHHC
PLADPGLIGVSSGAALVYRLAVARGRLALPLLLLAGIAINALAGAGIGLLTYLADDAQLR
CCCCCCCEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHH
SLTFWSLGSVGGAQWRTIAAVAPFALAGCVLLARERHALNALQLGEAEAMHLGVPVPRVK
HEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHH
RRVLVGTAMCVGALVSCTGAIGFIGLVAPHCVRLAAGADQRIVIPGAALFGALLAVAADL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHH
AARTLAAPAEIPLGILTALIGAPFFLALLWKRRGALGG
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]