| Definition | Burkholderia mallei NCTC 10247 chromosome II, complete genome. |
|---|---|
| Accession | NC_009079 |
| Length | 2,352,693 |
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The map label for this gene is kduD [H]
Identifier: 126447175
GI number: 126447175
Start: 2006954
End: 2007724
Strand: Reverse
Name: kduD [H]
Synonym: BMA10247_A2073
Alternate gene names: 126447175
Gene position: 2007724-2006954 (Counterclockwise)
Preceding gene: 126447749
Following gene: 126446962
Centisome position: 85.34
GC content: 72.76
Gene sequence:
>771_bases ATGACGAATCTCTGGGATAGGGCGTTCGACCTGACGGGGCGCGTCGCACTCGTGACGGGCGGCGCGGCGGGCATCGGCCA TGCGTGCGCGCGGCTGCTCGCGCAGCGCGGCGCGAGCGTCGCGCTCGTCGATCGGCACCCCGAAACGGCGGGGATCGCCG CGACGCTCGAGGGCGGCGCCGCGCGCCACAGCGGGATGTCGCTCGACCTGCGCGACTGCTCCGCCGCGCAGGCGGGCGTC GCGCTCGCCGCGTCGCGCTTCGGCGGCGTCGACATGCTCGTCAACAGCGCGGGCGTCGCGCTGCTCGACAAGGCGCTCGA CGTCGGCGAAGCCGCGTGGGACGCGACGATGGCGATCAACGTGAAGGCGTCGTTCTTCGTCGCGCAGGCGGCCGCGCGGC AGATGATCGCGGGTGCGCGCGGCGGGCGGATCGTCAATCTCGCGTCGCAGGCGAGCGTTGTCGGGCTCGAGCGGCATGCC GCGTATTGCGCGAGCAAGGCCGCGATCGTCGGGATGACGAAGGCGCTCGCGCTCGAATGGGCGCCGCACGGCATTACCGT CAACGCGGTGTCGCCGACGATCGTCGAAACGGCGCTCGGCAAGCAGGCATGGGCGGGCGAGGCCGGCGAGCGCGCGAAGC GCGAGATTCCGGCCGGCCGCTTCGCGCAGCCGGACGAGATCGCCGCGCTCGTGCTGTATCTGCTGAGCGACGCGGCCGCG ATGATGACGGGCGAGAACGTCGTCATCGACGGCGGCTACACCGTGCGCTGA
Upstream 100 bases:
>100_bases GCGGCACCGCGAAGCGCTACATCCTGCCGTGGGTGCCCGTCACGCCGGCGAACGCCGATCAGCTGTACAAGCAGGTCACG GGCGGTTGAGGGCGGCGGCC
Downstream 100 bases:
>100_bases GGCGGCGGCCGCGCAATCATCGCCGCCCTCCCCGATCGACCGACACACAGCACAGGAGACAACGCATGCCACAGACAGCC GAAGCGCCGCCGCAACGCGC
Product: short chain dehydrogenase
Products: NA
Alternate protein names: 2-keto-3-deoxygluconate 5-dehydrogenase; 2-keto-3-deoxygluconate oxidoreductase; KDG oxidoreductase [H]
Number of amino acids: Translated: 256; Mature: 255
Protein sequence:
>256_residues MTNLWDRAFDLTGRVALVTGGAAGIGHACARLLAQRGASVALVDRHPETAGIAATLEGGAARHSGMSLDLRDCSAAQAGV ALAASRFGGVDMLVNSAGVALLDKALDVGEAAWDATMAINVKASFFVAQAAARQMIAGARGGRIVNLASQASVVGLERHA AYCASKAAIVGMTKALALEWAPHGITVNAVSPTIVETALGKQAWAGEAGERAKREIPAGRFAQPDEIAALVLYLLSDAAA MMTGENVVIDGGYTVR
Sequences:
>Translated_256_residues MTNLWDRAFDLTGRVALVTGGAAGIGHACARLLAQRGASVALVDRHPETAGIAATLEGGAARHSGMSLDLRDCSAAQAGV ALAASRFGGVDMLVNSAGVALLDKALDVGEAAWDATMAINVKASFFVAQAAARQMIAGARGGRIVNLASQASVVGLERHA AYCASKAAIVGMTKALALEWAPHGITVNAVSPTIVETALGKQAWAGEAGERAKREIPAGRFAQPDEIAALVLYLLSDAAA MMTGENVVIDGGYTVR >Mature_255_residues TNLWDRAFDLTGRVALVTGGAAGIGHACARLLAQRGASVALVDRHPETAGIAATLEGGAARHSGMSLDLRDCSAAQAGVA LAASRFGGVDMLVNSAGVALLDKALDVGEAAWDATMAINVKASFFVAQAAARQMIAGARGGRIVNLASQASVVGLERHAA YCASKAAIVGMTKALALEWAPHGITVNAVSPTIVETALGKQAWAGEAGERAKREIPAGRFAQPDEIAALVLYLLSDAAAM MTGENVVIDGGYTVR
Specific function: Catalyzes the reduction of 2,5-diketo-3-deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2-keto-3- deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH [H]
COG id: COG1028
COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI7705925, Length=249, Percent_Identity=37.7510040160643, Blast_Score=147, Evalue=7e-36, Organism=Homo sapiens, GI32483357, Length=253, Percent_Identity=35.1778656126482, Blast_Score=134, Evalue=7e-32, Organism=Homo sapiens, GI19923817, Length=255, Percent_Identity=31.7647058823529, Blast_Score=121, Evalue=5e-28, Organism=Homo sapiens, GI5031737, Length=256, Percent_Identity=34.765625, Blast_Score=111, Evalue=7e-25, Organism=Homo sapiens, GI126723750, Length=256, Percent_Identity=32.421875, Blast_Score=109, Evalue=2e-24, Organism=Homo sapiens, GI15277342, Length=247, Percent_Identity=31.1740890688259, Blast_Score=109, Evalue=3e-24, Organism=Homo sapiens, GI40254992, Length=239, Percent_Identity=34.3096234309623, Blast_Score=107, Evalue=7e-24, Organism=Homo sapiens, GI66933014, Length=251, Percent_Identity=32.6693227091633, Blast_Score=107, Evalue=2e-23, Organism=Homo sapiens, GI10190704, Length=248, Percent_Identity=31.8548387096774, Blast_Score=99, Evalue=3e-21, Organism=Homo sapiens, GI33667109, Length=223, Percent_Identity=36.322869955157, Blast_Score=95, Evalue=6e-20, Organism=Homo sapiens, GI31542939, Length=234, Percent_Identity=32.4786324786325, Blast_Score=92, Evalue=4e-19, Organism=Homo sapiens, GI126723191, Length=212, Percent_Identity=35.377358490566, Blast_Score=92, Evalue=6e-19, Organism=Homo sapiens, GI4758504, Length=258, Percent_Identity=31.3953488372093, Blast_Score=89, Evalue=4e-18, Organism=Homo sapiens, GI4503817, Length=196, Percent_Identity=33.6734693877551, Blast_Score=86, Evalue=4e-17, Organism=Homo sapiens, GI83715985, Length=257, Percent_Identity=30.3501945525292, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI224922801, Length=175, Percent_Identity=34.8571428571429, Blast_Score=79, Evalue=5e-15, Organism=Homo sapiens, GI7706318, Length=206, Percent_Identity=27.6699029126214, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI4504505, Length=241, Percent_Identity=28.2157676348548, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI109715829, Length=243, Percent_Identity=29.6296296296296, Blast_Score=74, Evalue=9e-14, Organism=Homo sapiens, GI59889578, Length=228, Percent_Identity=28.0701754385965, Blast_Score=73, Evalue=2e-13, Organism=Homo sapiens, GI4503301, Length=250, Percent_Identity=25.2, Blast_Score=72, Evalue=6e-13, Organism=Homo sapiens, GI225579078, Length=208, Percent_Identity=30.7692307692308, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI40807363, Length=200, Percent_Identity=28.5, Blast_Score=69, Evalue=5e-12, Organism=Homo sapiens, GI40254986, Length=202, Percent_Identity=28.7128712871287, Blast_Score=68, Evalue=9e-12, Organism=Homo sapiens, GI142976729, Length=204, Percent_Identity=28.921568627451, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI25282469, Length=243, Percent_Identity=27.5720164609054, Blast_Score=65, Evalue=7e-11, Organism=Escherichia coli, GI1789208, Length=251, Percent_Identity=37.4501992031873, Blast_Score=157, Evalue=8e-40, Organism=Escherichia coli, GI87082100, Length=253, Percent_Identity=37.5494071146245, Blast_Score=146, Evalue=1e-36, Organism=Escherichia coli, GI87082160, Length=249, Percent_Identity=33.7349397590361, Blast_Score=140, Evalue=1e-34, Organism=Escherichia coli, GI1788459, Length=245, Percent_Identity=34.2857142857143, Blast_Score=133, Evalue=9e-33, Organism=Escherichia coli, GI1787335, Length=244, Percent_Identity=34.0163934426229, Blast_Score=125, Evalue=2e-30, Organism=Escherichia coli, GI1790717, Length=250, Percent_Identity=30.4, Blast_Score=110, Evalue=7e-26, Organism=Escherichia coli, GI1786812, Length=259, Percent_Identity=32.4324324324324, Blast_Score=104, Evalue=7e-24, Organism=Escherichia coli, GI2367175, Length=252, Percent_Identity=34.5238095238095, Blast_Score=99, Evalue=4e-22, Organism=Escherichia coli, GI2367365, Length=247, Percent_Identity=31.5789473684211, Blast_Score=95, Evalue=4e-21, Organism=Escherichia coli, GI1789057, Length=258, Percent_Identity=29.0697674418605, Blast_Score=86, Evalue=3e-18, Organism=Escherichia coli, GI1789378, Length=243, Percent_Identity=32.5102880658436, Blast_Score=85, Evalue=5e-18, Organism=Escherichia coli, GI1787905, Length=243, Percent_Identity=28.8065843621399, Blast_Score=75, Evalue=4e-15, Organism=Escherichia coli, GI1787526, Length=241, Percent_Identity=29.045643153527, Blast_Score=72, Evalue=3e-14, Organism=Caenorhabditis elegans, GI115534694, Length=248, Percent_Identity=35.0806451612903, Blast_Score=142, Evalue=2e-34, Organism=Caenorhabditis elegans, GI17562910, Length=267, Percent_Identity=31.8352059925094, Blast_Score=117, Evalue=6e-27, Organism=Caenorhabditis elegans, GI25147288, Length=246, Percent_Identity=31.7073170731707, Blast_Score=117, Evalue=8e-27, Organism=Caenorhabditis elegans, GI17561402, Length=259, Percent_Identity=32.4324324324324, Blast_Score=116, Evalue=1e-26, Organism=Caenorhabditis elegans, GI17560676, Length=256, Percent_Identity=33.203125, Blast_Score=115, Evalue=2e-26, Organism=Caenorhabditis elegans, GI71994604, Length=249, Percent_Identity=32.5301204819277, Blast_Score=114, Evalue=5e-26, Organism=Caenorhabditis elegans, GI71994600, Length=248, Percent_Identity=31.4516129032258, Blast_Score=112, Evalue=3e-25, Organism=Caenorhabditis elegans, GI17562906, Length=269, Percent_Identity=31.5985130111524, Blast_Score=104, Evalue=4e-23, Organism=Caenorhabditis elegans, GI17555706, Length=243, Percent_Identity=30.0411522633745, Blast_Score=104, Evalue=5e-23, Organism=Caenorhabditis elegans, GI17559104, Length=261, Percent_Identity=31.0344827586207, Blast_Score=102, Evalue=2e-22, Organism=Caenorhabditis elegans, GI193204405, Length=268, Percent_Identity=31.3432835820896, Blast_Score=100, Evalue=8e-22, Organism=Caenorhabditis elegans, GI17536025, Length=254, Percent_Identity=32.2834645669291, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17538480, Length=265, Percent_Identity=29.0566037735849, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17536651, Length=261, Percent_Identity=31.0344827586207, Blast_Score=98, Evalue=5e-21, Organism=Caenorhabditis elegans, GI17560220, Length=267, Percent_Identity=29.9625468164794, Blast_Score=97, Evalue=6e-21, Organism=Caenorhabditis elegans, GI17531453, Length=267, Percent_Identity=30.7116104868914, Blast_Score=97, Evalue=6e-21, Organism=Caenorhabditis elegans, GI17560150, Length=267, Percent_Identity=29.9625468164794, Blast_Score=97, Evalue=9e-21, Organism=Caenorhabditis elegans, GI17562908, Length=264, Percent_Identity=31.0606060606061, Blast_Score=96, Evalue=1e-20, Organism=Caenorhabditis elegans, GI17562990, Length=265, Percent_Identity=28.6792452830189, Blast_Score=94, Evalue=7e-20, Organism=Caenorhabditis elegans, GI17560332, Length=266, Percent_Identity=30.4511278195489, Blast_Score=94, Evalue=8e-20, Organism=Caenorhabditis elegans, GI17538182, Length=255, Percent_Identity=32.9411764705882, Blast_Score=92, Evalue=3e-19, Organism=Caenorhabditis elegans, GI17551412, Length=265, Percent_Identity=27.5471698113208, Blast_Score=92, Evalue=3e-19, Organism=Caenorhabditis elegans, GI72000259, Length=271, Percent_Identity=29.520295202952, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17563726, Length=265, Percent_Identity=27.9245283018868, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17561272, Length=252, Percent_Identity=31.3492063492063, Blast_Score=87, Evalue=6e-18, Organism=Caenorhabditis elegans, GI17562904, Length=264, Percent_Identity=29.1666666666667, Blast_Score=87, Evalue=6e-18, Organism=Caenorhabditis elegans, GI17544670, Length=266, Percent_Identity=27.4436090225564, Blast_Score=86, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17568967, Length=245, Percent_Identity=29.3877551020408, Blast_Score=84, Evalue=7e-17, Organism=Caenorhabditis elegans, GI71982365, Length=192, Percent_Identity=26.5625, Blast_Score=77, Evalue=7e-15, Organism=Caenorhabditis elegans, GI17565030, Length=264, Percent_Identity=28.4090909090909, Blast_Score=77, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17538486, Length=269, Percent_Identity=27.5092936802974, Blast_Score=77, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17508651, Length=252, Percent_Identity=26.984126984127, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17508895, Length=195, Percent_Identity=30.2564102564103, Blast_Score=74, Evalue=9e-14, Organism=Caenorhabditis elegans, GI193203115, Length=198, Percent_Identity=27.7777777777778, Blast_Score=72, Evalue=4e-13, Organism=Caenorhabditis elegans, GI17564282, Length=193, Percent_Identity=27.979274611399, Blast_Score=71, Evalue=6e-13, Organism=Caenorhabditis elegans, GI193203117, Length=192, Percent_Identity=27.6041666666667, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17558628, Length=190, Percent_Identity=25.7894736842105, Blast_Score=64, Evalue=1e-10, Organism=Saccharomyces cerevisiae, GI6324126, Length=248, Percent_Identity=27.0161290322581, Blast_Score=86, Evalue=8e-18, Organism=Saccharomyces cerevisiae, GI6322861, Length=245, Percent_Identity=27.3469387755102, Blast_Score=73, Evalue=6e-14, Organism=Drosophila melanogaster, GI24643142, Length=247, Percent_Identity=36.8421052631579, Blast_Score=139, Evalue=2e-33, Organism=Drosophila melanogaster, GI21355319, Length=249, Percent_Identity=33.7349397590361, Blast_Score=124, Evalue=8e-29, Organism=Drosophila melanogaster, GI24639444, Length=244, Percent_Identity=34.0163934426229, Blast_Score=122, Evalue=2e-28, Organism=Drosophila melanogaster, GI23397609, Length=255, Percent_Identity=33.3333333333333, Blast_Score=103, Evalue=1e-22, Organism=Drosophila melanogaster, GI24644337, Length=256, Percent_Identity=32.421875, Blast_Score=100, Evalue=9e-22, Organism=Drosophila melanogaster, GI21357041, Length=248, Percent_Identity=30.6451612903226, Blast_Score=99, Evalue=3e-21, Organism=Drosophila melanogaster, GI28571526, Length=246, Percent_Identity=30.0813008130081, Blast_Score=91, Evalue=8e-19, Organism=Drosophila melanogaster, GI17737361, Length=249, Percent_Identity=32.5301204819277, Blast_Score=89, Evalue=2e-18, Organism=Drosophila melanogaster, GI24644339, Length=254, Percent_Identity=29.1338582677165, Blast_Score=85, Evalue=5e-17, Organism=Drosophila melanogaster, GI18859837, Length=194, Percent_Identity=31.4432989690722, Blast_Score=78, Evalue=5e-15, Organism=Drosophila melanogaster, GI161076933, Length=192, Percent_Identity=32.8125, Blast_Score=75, Evalue=4e-14, Organism=Drosophila melanogaster, GI24584748, Length=192, Percent_Identity=32.8125, Blast_Score=75, Evalue=5e-14, Organism=Drosophila melanogaster, GI24584744, Length=196, Percent_Identity=31.1224489795918, Blast_Score=72, Evalue=3e-13, Organism=Drosophila melanogaster, GI28574402, Length=196, Percent_Identity=31.1224489795918, Blast_Score=72, Evalue=4e-13, Organism=Drosophila melanogaster, GI21357673, Length=199, Percent_Identity=26.6331658291457, Blast_Score=72, Evalue=4e-13, Organism=Drosophila melanogaster, GI21358495, Length=246, Percent_Identity=26.0162601626016, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI221510726, Length=175, Percent_Identity=32, Blast_Score=65, Evalue=6e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR011286 - InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.127 [H]
Molecular weight: Translated: 26105; Mature: 25974
Theoretical pI: Translated: 7.04; Mature: 7.04
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.2 %Cys (Translated Protein) 3.1 %Met (Translated Protein) 4.3 %Cys+Met (Translated Protein) 1.2 %Cys (Mature Protein) 2.7 %Met (Mature Protein) 3.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTNLWDRAFDLTGRVALVTGGAAGIGHACARLLAQRGASVALVDRHPETAGIAATLEGGA CCCHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEECCCC ARHSGMSLDLRDCSAAQAGVALAASRFGGVDMLVNSAGVALLDKALDVGEAAWDATMAIN CCCCCCEEEHHCCCCHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHCCCHHCCEEEEEE VKASFFVAQAAARQMIAGARGGRIVNLASQASVVGLERHAAYCASKAAIVGMTKALALEW EHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEE APHGITVNAVSPTIVETALGKQAWAGEAGERAKREIPAGRFAQPDEIAALVLYLLSDAAA CCCCEEEECCCCHHHHHHHCCHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH MMTGENVVIDGGYTVR HCCCCEEEEECCEEEC >Mature Secondary Structure TNLWDRAFDLTGRVALVTGGAAGIGHACARLLAQRGASVALVDRHPETAGIAATLEGGA CCHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEECCCC ARHSGMSLDLRDCSAAQAGVALAASRFGGVDMLVNSAGVALLDKALDVGEAAWDATMAIN CCCCCCEEEHHCCCCHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHCCCHHCCEEEEEE VKASFFVAQAAARQMIAGARGGRIVNLASQASVVGLERHAAYCASKAAIVGMTKALALEW EHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEE APHGITVNAVSPTIVETALGKQAWAGEAGERAKREIPAGRFAQPDEIAALVLYLLSDAAA CCCCEEEECCCCHHHHHHHCCHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH MMTGENVVIDGGYTVR HCCCCEEEEECCEEEC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 1766386 [H]