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The map label for this gene is copA [H]

Identifier: 126447165

GI number: 126447165

Start: 2052362

End: 2053024

Strand: Direct

Name: copA [H]

Synonym: BMA10247_A2119

Alternate gene names: 126447165

Gene position: 2052362-2053024 (Clockwise)

Preceding gene: 126445962

Following gene: 126447719

Centisome position: 87.23

GC content: 72.7

Gene sequence:

>663_bases
GTGCCCGACGGCGTCGCGCGCCGCGCGGCGGCGCTCGAAGCGGCGGGCAACACGGTATCGTGGCTGATGCGCGCCGACGC
GCCGCGCGAGGCGCTCGCACTCGTCGCGTTCGGTGACACGGTCAAGCCGAACGCGCGGCGCGCGATCGAGCGGCTCGCCG
CGCGCGGCATCAGGAGCGCGCTCGTGACGGGCGACAACCGCGGCAGCGCGACAGCCGTCGCCGCGTCGCTCGGCATCGAC
GAAGTGCACGCGCAGGTGCTGCCGGACGACAAGGCGCGCGTCGTCGCGCAATTGAAGGCGACGGCGGGCGACGGCGCGGT
CGCGATGGTCGGCGACGGCATCAACGATGCGCCCGCGCTCGCCGCGGCCGACGTCGGCATCGCGATGGCGACGGGCACCG
ACGTCGCGATGCACACCGCCGGCATCACGCTGATGCGCGGCGATCCGGCGCTCGTCGCGGACGCGGTCGACATCTCGCGC
CGCACGTACCGGAAGATTCAGCAGAACCTGTTCTGGGCGTTCGTCTACAACCTGGTGGGGATTCCGCTCGCGGCGCTCGG
CTGGCTGAACCCGATGATCGCGGGCGCGGCGATGGCGTTCTCCAGCGTGAGCGTCGTGACGAACGCACTGTTGCTGCGGC
GCTGGAAGGGCGACGCGCGCTAA

Upstream 100 bases:

>100_bases
TACGCCGCGCGCGGTCGCGGGTCGCGGCGTCGAGGCGCGCGTCGACGCTCGCCTGCTCGCGCTCGGCAGCACGCGCTGGC
GCGATGAACTCGGCATCGCC

Downstream 100 bases:

>100_bases
AGCCGGAACGCGCGCGAACCGCGCGCGGCGCTTGGGCGGTATGCGATGCGGCGTGCGGTTCGTTGTTCGTTGGTCGTTGG
TCGTTGGTCGTTGGTCGTTG

Product: copper-translocating P-type ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MPDGVARRAAALEAAGNTVSWLMRADAPREALALVAFGDTVKPNARRAIERLAARGIRSALVTGDNRGSATAVAASLGID
EVHAQVLPDDKARVVAQLKATAGDGAVAMVGDGINDAPALAAADVGIAMATGTDVAMHTAGITLMRGDPALVADAVDISR
RTYRKIQQNLFWAFVYNLVGIPLAALGWLNPMIAGAAMAFSSVSVVTNALLLRRWKGDAR

Sequences:

>Translated_220_residues
MPDGVARRAAALEAAGNTVSWLMRADAPREALALVAFGDTVKPNARRAIERLAARGIRSALVTGDNRGSATAVAASLGID
EVHAQVLPDDKARVVAQLKATAGDGAVAMVGDGINDAPALAAADVGIAMATGTDVAMHTAGITLMRGDPALVADAVDISR
RTYRKIQQNLFWAFVYNLVGIPLAALGWLNPMIAGAAMAFSSVSVVTNALLLRRWKGDAR
>Mature_219_residues
PDGVARRAAALEAAGNTVSWLMRADAPREALALVAFGDTVKPNARRAIERLAARGIRSALVTGDNRGSATAVAASLGIDE
VHAQVLPDDKARVVAQLKATAGDGAVAMVGDGINDAPALAAADVGIAMATGTDVAMHTAGITLMRGDPALVADAVDISRR
TYRKIQQNLFWAFVYNLVGIPLAALGWLNPMIAGAAMAFSSVSVVTNALLLRRWKGDAR

Specific function: Involved in copper export [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI115529486, Length=156, Percent_Identity=49.3589743589744, Blast_Score=147, Evalue=8e-36,
Organism=Homo sapiens, GI55743071, Length=153, Percent_Identity=47.0588235294118, Blast_Score=137, Evalue=7e-33,
Organism=Homo sapiens, GI55743073, Length=153, Percent_Identity=47.0588235294118, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI48762685, Length=195, Percent_Identity=29.2307692307692, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI48762691, Length=195, Percent_Identity=29.2307692307692, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI48762689, Length=195, Percent_Identity=29.2307692307692, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI48762687, Length=195, Percent_Identity=29.2307692307692, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI209413709, Length=190, Percent_Identity=31.5789473684211, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI24638454, Length=190, Percent_Identity=31.5789473684211, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI4502285, Length=190, Percent_Identity=31.5789473684211, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI118498343, Length=162, Percent_Identity=30.8641975308642, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI83700225, Length=206, Percent_Identity=28.1553398058252, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI297374799, Length=206, Percent_Identity=28.1553398058252, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1786691, Length=194, Percent_Identity=52.5773195876289, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI1789879, Length=204, Percent_Identity=39.7058823529412, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1786914, Length=130, Percent_Identity=36.9230769230769, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI2367363, Length=154, Percent_Identity=31.1688311688312, Blast_Score=65, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17556548, Length=156, Percent_Identity=48.0769230769231, Blast_Score=132, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71997262, Length=195, Percent_Identity=29.7435897435897, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71997269, Length=163, Percent_Identity=30.6748466257669, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71997275, Length=195, Percent_Identity=29.7435897435897, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6320475, Length=214, Percent_Identity=40.6542056074766, Blast_Score=140, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6319772, Length=239, Percent_Identity=25.9414225941423, Blast_Score=86, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6321271, Length=184, Percent_Identity=29.3478260869565, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6321432, Length=184, Percent_Identity=29.3478260869565, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221329854, Length=177, Percent_Identity=46.3276836158192, Blast_Score=138, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24668704, Length=163, Percent_Identity=31.2883435582822, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24668708, Length=163, Percent_Identity=31.2883435582822, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI281366617, Length=163, Percent_Identity=31.2883435582822, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI161085803, Length=163, Percent_Identity=31.2883435582822, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24668696, Length=163, Percent_Identity=31.2883435582822, Blast_Score=74, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR001366
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000150 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 22796; Mature: 22664

Theoretical pI: Translated: 10.14; Mature: 10.14

Prosite motif: PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDGVARRAAALEAAGNTVSWLMRADAPREALALVAFGDTVKPNARRAIERLAARGIRSA
CCCHHHHHHHHHHHCCCHHHHHHCCCCCHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHH
LVTGDNRGSATAVAASLGIDEVHAQVLPDDKARVVAQLKATAGDGAVAMVGDGINDAPAL
HEECCCCCCHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCHH
AAADVGIAMATGTDVAMHTAGITLMRGDPALVADAVDISRRTYRKIQQNLFWAFVYNLVG
HHHHCCEEEECCCCEEEHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPLAALGWLNPMIAGAAMAFSSVSVVTNALLLRRWKGDAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PDGVARRAAALEAAGNTVSWLMRADAPREALALVAFGDTVKPNARRAIERLAARGIRSA
CCHHHHHHHHHHHCCCHHHHHHCCCCCHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHH
LVTGDNRGSATAVAASLGIDEVHAQVLPDDKARVVAQLKATAGDGAVAMVGDGINDAPAL
HEECCCCCCHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCHH
AAADVGIAMATGTDVAMHTAGITLMRGDPALVADAVDISRRTYRKIQQNLFWAFVYNLVG
HHHHCCEEEECCCCEEEHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPLAALGWLNPMIAGAAMAFSSVSVVTNALLLRRWKGDAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA