Definition Burkholderia mallei NCTC 10247 chromosome II, complete genome.
Accession NC_009079
Length 2,352,693

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The map label for this gene is gutB [H]

Identifier: 126446962

GI number: 126446962

Start: 2005752

End: 2006888

Strand: Reverse

Name: gutB [H]

Synonym: BMA10247_A2072

Alternate gene names: 126446962

Gene position: 2006888-2005752 (Counterclockwise)

Preceding gene: 126447175

Following gene: 126446413

Centisome position: 85.3

GC content: 68.34

Gene sequence:

>1137_bases
ATGCCACAGACAGCCGAAGCGCCGCCGCAACGCGCGGCCGAGCGCGGCGAGACGCCCGCGCTGCCCGCCACGATGCGCGC
CGTGGTTTGCCACGGCCCGCAAGACTACCGCCTCGAGCAGGTGCCGGTGCCGAAGCCGGGGCCGGACGAGATCCTGACCC
AGGTGGAGCGCGTGGGCATCTGCATGGGCGACATCAAGACGTTTCGCGGCGCGCCGTCGTTCTGGGGCGACGCGGTGCAG
CCGCGCTACGTGAAGCCGCCGATGATTCCCGGCCACGAATTCGTGTGCCGCGTCGTCGCGCTCGGCCCCGGCGCCGAGCG
GCGCGGCGTGAAGGTGGGCGATCGCGTGATCTCCGAGCAGATCGTGCCGTGCTGGAGCTGCCGCTTCTGCGGCCACGGCC
AGTACTGGATGTGCCAGAAGCACGATCTGTACGGATTCCAGAACAACGTGCACGGCGCGATGGCCGAATACATGATCTTC
ACGAAGGAGGCGATCGTGCACCGCGTGCCCGATTCGATCCCGACCGACGAGGCGATCCTGATCGAGCCGCTGTCGTGCTC
GCTGCACGCGGCCGATCGCGCGAACGTCGGCTTCGACGACGTGGTCGTCGTCGCCGGCGCGGGCACGCTCGGGCTCGGCA
TCATCGGCGCGGCGCGGCTGCGCCATCCGAAGCAACTGATCGTGCTCGACATGAAGCCCGAGCGCGCGGCGCTCGCGCGC
CGGATGGGCGCGGACGACGTGTGGAACCCGGCCGAGGAGAACGTGATCGAGAAGATCCGCGCGATCACGGGCGGCTACGG
CTGCGATATCTACATCGAGGCGACCGGCCACCATCGCGCGGTAGGCCAGGGGCTCGCGATGCTGCGCAAGCTCGGGCGCT
TCGTCGAGTTCAGCGTGTTCAACGACGAAGCGAGCGTCGACTGGTCGATCATCGGCGATCGCAAGGAGCTCGACGTGCTC
GGCTCGCATCTCGGCCCGTACATGTACCCGCGCGCGATCGAGTTCATCGCATCGCGCAGGATCGACGTGCGCGGCATCGT
CACGCACACGTTCCCGCTGTCGCGCTTCGCCGACGCGTTCGCGGTGATGGAGCGCGGCAAGCAATCGTTGAAGGTCGTTC
TGGATCCGCGAGGTTAA

Upstream 100 bases:

>100_bases
ACGTCGTCATCGACGGCGGCTACACCGTGCGCTGAGGCGGCGGCCGCGCAATCATCGCCGCCCTCCCCGATCGACCGACA
CACAGCACAGGAGACAACGC

Downstream 100 bases:

>100_bases
TTGCATGAATCGTGTCATCAATCATCCCGACTACGTCGTCGAGGACATGCTGCGCGGGATCGTCGCCGCGCATCCGGCGC
TCGCGCTCGACGCGGACAAC

Product: zinc-binding dehydrogenase family oxidoreductase

Products: NA

Alternate protein names: Glucitol dehydrogenase; L-iditol 2-dehydrogenase [H]

Number of amino acids: Translated: 378; Mature: 377

Protein sequence:

>378_residues
MPQTAEAPPQRAAERGETPALPATMRAVVCHGPQDYRLEQVPVPKPGPDEILTQVERVGICMGDIKTFRGAPSFWGDAVQ
PRYVKPPMIPGHEFVCRVVALGPGAERRGVKVGDRVISEQIVPCWSCRFCGHGQYWMCQKHDLYGFQNNVHGAMAEYMIF
TKEAIVHRVPDSIPTDEAILIEPLSCSLHAADRANVGFDDVVVVAGAGTLGLGIIGAARLRHPKQLIVLDMKPERAALAR
RMGADDVWNPAEENVIEKIRAITGGYGCDIYIEATGHHRAVGQGLAMLRKLGRFVEFSVFNDEASVDWSIIGDRKELDVL
GSHLGPYMYPRAIEFIASRRIDVRGIVTHTFPLSRFADAFAVMERGKQSLKVVLDPRG

Sequences:

>Translated_378_residues
MPQTAEAPPQRAAERGETPALPATMRAVVCHGPQDYRLEQVPVPKPGPDEILTQVERVGICMGDIKTFRGAPSFWGDAVQ
PRYVKPPMIPGHEFVCRVVALGPGAERRGVKVGDRVISEQIVPCWSCRFCGHGQYWMCQKHDLYGFQNNVHGAMAEYMIF
TKEAIVHRVPDSIPTDEAILIEPLSCSLHAADRANVGFDDVVVVAGAGTLGLGIIGAARLRHPKQLIVLDMKPERAALAR
RMGADDVWNPAEENVIEKIRAITGGYGCDIYIEATGHHRAVGQGLAMLRKLGRFVEFSVFNDEASVDWSIIGDRKELDVL
GSHLGPYMYPRAIEFIASRRIDVRGIVTHTFPLSRFADAFAVMERGKQSLKVVLDPRG
>Mature_377_residues
PQTAEAPPQRAAERGETPALPATMRAVVCHGPQDYRLEQVPVPKPGPDEILTQVERVGICMGDIKTFRGAPSFWGDAVQP
RYVKPPMIPGHEFVCRVVALGPGAERRGVKVGDRVISEQIVPCWSCRFCGHGQYWMCQKHDLYGFQNNVHGAMAEYMIFT
KEAIVHRVPDSIPTDEAILIEPLSCSLHAADRANVGFDDVVVVAGAGTLGLGIIGAARLRHPKQLIVLDMKPERAALARR
MGADDVWNPAEENVIEKIRAITGGYGCDIYIEATGHHRAVGQGLAMLRKLGRFVEFSVFNDEASVDWSIIGDRKELDVLG
SHLGPYMYPRAIEFIASRRIDVRGIVTHTFPLSRFADAFAVMERGKQSLKVVLDPRG

Specific function: Reduces glucitol to fructose [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=351, Percent_Identity=30.7692307692308, Blast_Score=158, Evalue=7e-39,
Organism=Homo sapiens, GI4501929, Length=370, Percent_Identity=22.7027027027027, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI34577061, Length=372, Percent_Identity=23.1182795698925, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1788073, Length=328, Percent_Identity=30.7926829268293, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1790045, Length=339, Percent_Identity=29.2035398230088, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1787863, Length=358, Percent_Identity=27.0949720670391, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI226510992, Length=339, Percent_Identity=27.4336283185841, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1788075, Length=367, Percent_Identity=26.9754768392371, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1788407, Length=363, Percent_Identity=24.7933884297521, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI87082125, Length=369, Percent_Identity=27.9132791327913, Blast_Score=104, Evalue=8e-24,
Organism=Escherichia coli, GI1786825, Length=411, Percent_Identity=26.2773722627737, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1790718, Length=330, Percent_Identity=24.5454545454545, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786552, Length=384, Percent_Identity=26.0416666666667, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562876, Length=343, Percent_Identity=30.9037900874636, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17562878, Length=343, Percent_Identity=29.1545189504373, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI71988145, Length=365, Percent_Identity=24.9315068493151, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562584, Length=379, Percent_Identity=24.802110817942, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562582, Length=379, Percent_Identity=25.065963060686, Blast_Score=68, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6323099, Length=344, Percent_Identity=27.906976744186, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6322619, Length=342, Percent_Identity=25.4385964912281, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6319955, Length=342, Percent_Identity=25.4385964912281, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319257, Length=387, Percent_Identity=25.5813953488372, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6320033, Length=298, Percent_Identity=25.8389261744966, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319258, Length=299, Percent_Identity=26.0869565217391, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323729, Length=374, Percent_Identity=25.4010695187166, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323961, Length=381, Percent_Identity=24.9343832020997, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6319621, Length=372, Percent_Identity=27.9569892473118, Blast_Score=73, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=382, Percent_Identity=25.6544502617801, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17737897, Length=343, Percent_Identity=30.6122448979592, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI17137530, Length=342, Percent_Identity=29.5321637426901, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI17737895, Length=367, Percent_Identity=22.8882833787466, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45550770, Length=335, Percent_Identity=25.0746268656716, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI221457811, Length=335, Percent_Identity=25.0746268656716, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI45551930, Length=335, Percent_Identity=25.0746268656716, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.14 [H]

Molecular weight: Translated: 41639; Mature: 41507

Theoretical pI: Translated: 7.31; Mature: 7.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQTAEAPPQRAAERGETPALPATMRAVVCHGPQDYRLEQVPVPKPGPDEILTQVERVGI
CCCCCCCCHHHHHHCCCCCCCCHHHHEEEECCCCCCCEEECCCCCCCHHHHHHHHHHHHH
CMGDIKTFRGAPSFWGDAVQPRYVKPPMIPGHEFVCRVVALGPGAERRGVKVGDRVISEQ
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHEEEEEECCCCCCCCCHHHHHHHHHH
IVPCWSCRFCGHGQYWMCQKHDLYGFQNNVHGAMAEYMIFTKEAIVHRVPDSIPTDEAIL
CCCCEEEEECCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
IEPLSCSLHAADRANVGFDDVVVVAGAGTLGLGIIGAARLRHPKQLIVLDMKPERAALAR
EECCCCEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHH
RMGADDVWNPAEENVIEKIRAITGGYGCDIYIEATGHHRAVGQGLAMLRKLGRFVEFSVF
HCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHEEEEEE
NDEASVDWSIIGDRKELDVLGSHLGPYMYPRAIEFIASRRIDVRGIVTHTFPLSRFADAF
CCCCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHH
AVMERGKQSLKVVLDPRG
HHHHCCCCEEEEEECCCC
>Mature Secondary Structure 
PQTAEAPPQRAAERGETPALPATMRAVVCHGPQDYRLEQVPVPKPGPDEILTQVERVGI
CCCCCCCHHHHHHCCCCCCCCHHHHEEEECCCCCCCEEECCCCCCCHHHHHHHHHHHHH
CMGDIKTFRGAPSFWGDAVQPRYVKPPMIPGHEFVCRVVALGPGAERRGVKVGDRVISEQ
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHEEEEEECCCCCCCCCHHHHHHHHHH
IVPCWSCRFCGHGQYWMCQKHDLYGFQNNVHGAMAEYMIFTKEAIVHRVPDSIPTDEAIL
CCCCEEEEECCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
IEPLSCSLHAADRANVGFDDVVVVAGAGTLGLGIIGAARLRHPKQLIVLDMKPERAALAR
EECCCCEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHH
RMGADDVWNPAEENVIEKIRAITGGYGCDIYIEATGHHRAVGQGLAMLRKLGRFVEFSVF
HCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHEEEEEE
NDEASVDWSIIGDRKELDVLGSHLGPYMYPRAIEFIASRRIDVRGIVTHTFPLSRFADAF
CCCCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHH
AVMERGKQSLKVVLDPRG
HHHHCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1460002; 9384377; 8195086 [H]