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The map label for this gene is dfrA [H]

Identifier: 126446765

GI number: 126446765

Start: 2175904

End: 2176911

Strand: Direct

Name: dfrA [H]

Synonym: BMA10247_A2237

Alternate gene names: 126446765

Gene position: 2175904-2176911 (Clockwise)

Preceding gene: 126447346

Following gene: 126447144

Centisome position: 92.49

GC content: 71.13

Gene sequence:

>1008_bases
ATGACTGACATACAACGCGATCTCGTTCTGGTGACCGGCGCATCCGGTTTTGTCGGCTCCGCCGTCGCGCGCGCCGCGCG
GCGGCAGGGCTATCGGGTGCGCGTGCTCGTGCGGCTGACGAGCCCGCGCACGAACGTCGCGGATCTCGACGCCGAGATCG
CCACCGGCGACATGCGCGACGAGGCATCGATGCGCGCCGCGCTGCGCGGCGTGCGCCATCTGCTGCACGTCGCCGCCGAC
TACCGGCTGTGGGCGCCCGATCCGCTCGAGATCGAGCGCGCGAATCTCGAAGGCGCGGTCGCGACGATGCGCGCGGCGCT
CGCCGAGGGCGTCGAGCGGATCGTCTACACGAGCAGCGTCGCCACGCTGAAGGTGACGCCGTCGGGCGCCTCGGCCGACG
AATCGTCGCCGCTCGCCGCCGGGCAGGCGATCGGCGTATACAAGCGCAGCAAGGTGCTCGCCGAGCGCGCGGTCGAGCGG
ATGATCGCCGAGGACGGGCTGCCCGCGGTGATCGTCAATCCGTCGACGCCGATCGGCCCGCGCGACGTGAAGCCGACGCC
GACCGGCCGGATCATCGTCGAGGCGGCGCTCGGCAAGATCCCGGCGTTCGTCGACACGGGGCTGAACCTCGTGCACGTCG
ACGACGTCGCGCAGGGCCACCTGCTCGCGCTCGAGCGCGGGCGCGTCGGCGAGCGCTACATCCTCGGCGGCGAGAACCTG
CCGCTGCAGGCGATGCTCGCCGACATCGCGCAATCGACGGGACGCAAGCCGCCGACGATCGCGCTGCCGCGCTGGCCGCT
GTATCCGATCGCGCTCGGCGCGGAGGCGGTGGCGAAGCTGACGAAGCGCGAGCCGTTCGTGACGGTCGACGGGCTCAGGA
TGTCGAAGAACAAGATGTATTTCACGTCCGCGAAAGCCGAGCGCGAGCTCGGCTACCGCGCGCGGCCGTACCGCGAAGGC
ATTCGCGACGCGCTCGACTGGTTCAGGCAGGCGGGCTATCTGCGCTGA

Upstream 100 bases:

>100_bases
TGCTCGATGCAGCCCGCGCGCCGCGCATCCCGGGCGAGCACGTACAATCTCGCACGACGTACAACACGCCGCGCCGCACG
GCCGCGCGGCCATGAGGACC

Downstream 100 bases:

>100_bases
GCGCCAACCGCGCGGGGCGTCCGGACGCGAGCGGGCGCAGACCGCGCGGGCGGGCCGGTTCGTTCGATGCGGCCCGCCCG
CGCGCACCGGCGCCGCCGGA

Product: dihydroflavonol-4-reductase family protein

Products: NA

Alternate protein names: DFR; Dihydrokaempferol 4-reductase [H]

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MTDIQRDLVLVTGASGFVGSAVARAARRQGYRVRVLVRLTSPRTNVADLDAEIATGDMRDEASMRAALRGVRHLLHVAAD
YRLWAPDPLEIERANLEGAVATMRAALAEGVERIVYTSSVATLKVTPSGASADESSPLAAGQAIGVYKRSKVLAERAVER
MIAEDGLPAVIVNPSTPIGPRDVKPTPTGRIIVEAALGKIPAFVDTGLNLVHVDDVAQGHLLALERGRVGERYILGGENL
PLQAMLADIAQSTGRKPPTIALPRWPLYPIALGAEAVAKLTKREPFVTVDGLRMSKNKMYFTSAKAERELGYRARPYREG
IRDALDWFRQAGYLR

Sequences:

>Translated_335_residues
MTDIQRDLVLVTGASGFVGSAVARAARRQGYRVRVLVRLTSPRTNVADLDAEIATGDMRDEASMRAALRGVRHLLHVAAD
YRLWAPDPLEIERANLEGAVATMRAALAEGVERIVYTSSVATLKVTPSGASADESSPLAAGQAIGVYKRSKVLAERAVER
MIAEDGLPAVIVNPSTPIGPRDVKPTPTGRIIVEAALGKIPAFVDTGLNLVHVDDVAQGHLLALERGRVGERYILGGENL
PLQAMLADIAQSTGRKPPTIALPRWPLYPIALGAEAVAKLTKREPFVTVDGLRMSKNKMYFTSAKAERELGYRARPYREG
IRDALDWFRQAGYLR
>Mature_334_residues
TDIQRDLVLVTGASGFVGSAVARAARRQGYRVRVLVRLTSPRTNVADLDAEIATGDMRDEASMRAALRGVRHLLHVAADY
RLWAPDPLEIERANLEGAVATMRAALAEGVERIVYTSSVATLKVTPSGASADESSPLAAGQAIGVYKRSKVLAERAVERM
IAEDGLPAVIVNPSTPIGPRDVKPTPTGRIIVEAALGKIPAFVDTGLNLVHVDDVAQGHLLALERGRVGERYILGGENLP
LQAMLADIAQSTGRKPPTIALPRWPLYPIALGAEAVAKLTKREPFVTVDGLRMSKNKMYFTSAKAERELGYRARPYREGI
RDALDWFRQAGYLR

Specific function: Galactose metabolism; third step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroflavonol-4-reductase family [H]

Homologues:

Organism=Homo sapiens, GI116268111, Length=357, Percent_Identity=26.3305322128852, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI193211614, Length=323, Percent_Identity=24.4582043343653, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI8393516, Length=323, Percent_Identity=24.4582043343653, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI310132178, Length=359, Percent_Identity=25.6267409470752, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI310113012, Length=359, Percent_Identity=25.6267409470752, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI239745448, Length=359, Percent_Identity=25.6267409470752, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71987463, Length=334, Percent_Identity=27.8443113772455, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR017829
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =1.1.1.219 [H]

Molecular weight: Translated: 36307; Mature: 36176

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDIQRDLVLVTGASGFVGSAVARAARRQGYRVRVLVRLTSPRTNVADLDAEIATGDMRD
CCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHCCCHHCCCCCHH
EASMRAALRGVRHLLHVAADYRLWAPDPLEIERANLEGAVATMRAALAEGVERIVYTSSV
HHHHHHHHHHHHHHHHHHHCCEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHEEECCE
ATLKVTPSGASADESSPLAAGQAIGVYKRSKVLAERAVERMIAEDGLPAVIVNPSTPIGP
EEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCC
RDVKPTPTGRIIVEAALGKIPAFVDTGLNLVHVDDVAQGHLLALERGRVGERYILGGENL
CCCCCCCCCCEEEEEHHCCCCHHHHCCCCEEEECCCCCCCEEEEECCCCCCEEEECCCCC
PLQAMLADIAQSTGRKPPTIALPRWPLYPIALGAEAVAKLTKREPFVTVDGLRMSKNKMY
CHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHCHHHHHHHHCCCCEEEECCCEECCCEEE
FTSAKAERELGYRARPYREGIRDALDWFRQAGYLR
EECCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TDIQRDLVLVTGASGFVGSAVARAARRQGYRVRVLVRLTSPRTNVADLDAEIATGDMRD
CCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHCCCHHCCCCCHH
EASMRAALRGVRHLLHVAADYRLWAPDPLEIERANLEGAVATMRAALAEGVERIVYTSSV
HHHHHHHHHHHHHHHHHHHCCEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHEEECCE
ATLKVTPSGASADESSPLAAGQAIGVYKRSKVLAERAVERMIAEDGLPAVIVNPSTPIGP
EEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCC
RDVKPTPTGRIIVEAALGKIPAFVDTGLNLVHVDDVAQGHLLALERGRVGERYILGGENL
CCCCCCCCCCEEEEEHHCCCCHHHHCCCCEEEECCCCCCCEEEEECCCCCCEEEECCCCC
PLQAMLADIAQSTGRKPPTIALPRWPLYPIALGAEAVAKLTKREPFVTVDGLRMSKNKMY
CHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHCHHHHHHHHCCCCEEEECCCEECCCEEE
FTSAKAERELGYRARPYREGIRDALDWFRQAGYLR
EECCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]