Click here to switch to the map view.

The map label for this gene is ltaE [H]

Identifier: 126446603

GI number: 126446603

Start: 2031565

End: 2032941

Strand: Reverse

Name: ltaE [H]

Synonym: BMA10247_A2098

Alternate gene names: 126446603

Gene position: 2032941-2031565 (Counterclockwise)

Preceding gene: 262192877

Following gene: 126445911

Centisome position: 86.41

GC content: 71.82

Gene sequence:

>1377_bases
GTGACGCGCCTGCGGCAATTCACCGCGCCGCGGCAATGCGGGCGCGGGCGCGACGCGGCGCGCGCGGCGCCGCCCGGACG
AGCGCAGGGTACGACGCGGGCGACGGATCGCGCGCCGCGTCGATGGCGAATCCACAGCCGGATCGCGGCCGATTCGTCGC
CTGATCGCCGGCGGGGCGCCGCCGATGCGCCCGCGAACGGCTCACCGTATCGGCGCGCGAGCGCCGCGTCGCGCCCGCGC
TGCTCGGCCGCGTCAAGCGGCGCGACGCCGAATTGCGTACACTCGAAGCCTCCGCTTCACCGCGCGAGCGCGCCGGCGCA
CCGCGCAATCCTCCTCTTCGACGAGACTCCGACGGGAACCCAGATGATCGATTTACGCAGCGATACCGTGACGCGCCCGA
GCGCGCCGATGCTGGCCGCGATGACGGCCGCCGAAGTGGGCGACGACGTGTGGGGCGACGATCCCACCGTCGCGCGCCTG
CAGGCCGTGGTGGCCGAGCACGCGGGCAAGGAGGCGGCGCTGTTCTTTCCGAGCGGCACGCAGAGCAACCTCGCGGCGCT
GATGTCGCACTGCGAGCGCGGCGACGAGTACATCGTCGGCCAGGCCGCGCACACGTACAAATACGAGGGCGGCGGCGCGG
CGGTGCTCGGCAGCATTCAGCCGCAGCCGATCGAGAACGCCGCGGACGGCACGCTGCCGCTCGAGAAGATCGCGGCCGCG
ATCAAGCCGATCGACGATCACTTCGCCCGCTCGCGCCTGTTCACGCTTGAGAACACGATCGGCGGCAAGGTGCTGCCGGC
GGGCTATGTCGACGAAGCGGTCGCGCTCGCGCGCAGCCGCGGGCTCGCTGCGCATCTCGACGGCGCGCGCGTATGCAACG
CGGCCGTCGCGTCGGGCCGCGCGATCGCCGAGCTGTGCGCGCCGTTCGATTCGGTGTCGATCTGCTTTTCGAAGGGGCTC
GGCGCGCCGGTGGGCTCGGTGCTCGTCGGCAGCGGCGCGCTGATCGAGCGCGCGCACCGCTGGCGCAAGGTGCTCGGCGG
CGGCATGCGCCAGGCGGGCGTGCTCGCGGCCGCGTGCCTGTATGCGCTCGAGCACAACGTCGAGCGTCTCGCCGACGATC
ACGCGAACGCCGAGCGCCTCGCGCAGGGCCTCGCGCGCATCGAGCCGGTGAAGGTGCTGTCGCAGGCGACGAACATGGTG
TTCGCGCAATTTCCCGAAGCCGATTGCGCGCCGCTCGAAGCATGGCTCAAGGAGCGCGGGATTCTCACGCAGATGCTGTA
TGCGTCGCGCTTCGTCACGCACTGCGACGTGTCGCGCGACGACATCGACACGGCTGTCGCCGCGATCAGCGCGTATTTCG
CGCGTTCGCGCGCTTGA

Upstream 100 bases:

>100_bases
CGTCGCAGATGTCCAGCGTCTGCAAGCGGTTTGTCGACTTAAATCGTTGATTGGTATCAAGTTTGAAGCGCTTTTGTGTG
ATAGCGGCAGGCGCGGCGGG

Downstream 100 bases:

>100_bases
CGGGAGCGGGCGCCGCCGCGGCGCGCCCGCCCGCCGCGGCGGCGCCGCGCGGCGGCGGCGCGAGCAGTTGCTGCGCGGCC
TCGACGACCCGCGACGACAG

Product: L-allo-threonine aldolase

Products: NA

Alternate protein names: Low-specificity L-TA [H]

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MTRLRQFTAPRQCGRGRDAARAAPPGRAQGTTRATDRAPRRWRIHSRIAADSSPDRRRGAADAPANGSPYRRASAASRPR
CSAASSGATPNCVHSKPPLHRASAPAHRAILLFDETPTGTQMIDLRSDTVTRPSAPMLAAMTAAEVGDDVWGDDPTVARL
QAVVAEHAGKEAALFFPSGTQSNLAALMSHCERGDEYIVGQAAHTYKYEGGGAAVLGSIQPQPIENAADGTLPLEKIAAA
IKPIDDHFARSRLFTLENTIGGKVLPAGYVDEAVALARSRGLAAHLDGARVCNAAVASGRAIAELCAPFDSVSICFSKGL
GAPVGSVLVGSGALIERAHRWRKVLGGGMRQAGVLAAACLYALEHNVERLADDHANAERLAQGLARIEPVKVLSQATNMV
FAQFPEADCAPLEAWLKERGILTQMLYASRFVTHCDVSRDDIDTAVAAISAYFARSRA

Sequences:

>Translated_458_residues
MTRLRQFTAPRQCGRGRDAARAAPPGRAQGTTRATDRAPRRWRIHSRIAADSSPDRRRGAADAPANGSPYRRASAASRPR
CSAASSGATPNCVHSKPPLHRASAPAHRAILLFDETPTGTQMIDLRSDTVTRPSAPMLAAMTAAEVGDDVWGDDPTVARL
QAVVAEHAGKEAALFFPSGTQSNLAALMSHCERGDEYIVGQAAHTYKYEGGGAAVLGSIQPQPIENAADGTLPLEKIAAA
IKPIDDHFARSRLFTLENTIGGKVLPAGYVDEAVALARSRGLAAHLDGARVCNAAVASGRAIAELCAPFDSVSICFSKGL
GAPVGSVLVGSGALIERAHRWRKVLGGGMRQAGVLAAACLYALEHNVERLADDHANAERLAQGLARIEPVKVLSQATNMV
FAQFPEADCAPLEAWLKERGILTQMLYASRFVTHCDVSRDDIDTAVAAISAYFARSRA
>Mature_457_residues
TRLRQFTAPRQCGRGRDAARAAPPGRAQGTTRATDRAPRRWRIHSRIAADSSPDRRRGAADAPANGSPYRRASAASRPRC
SAASSGATPNCVHSKPPLHRASAPAHRAILLFDETPTGTQMIDLRSDTVTRPSAPMLAAMTAAEVGDDVWGDDPTVARLQ
AVVAEHAGKEAALFFPSGTQSNLAALMSHCERGDEYIVGQAAHTYKYEGGGAAVLGSIQPQPIENAADGTLPLEKIAAAI
KPIDDHFARSRLFTLENTIGGKVLPAGYVDEAVALARSRGLAAHLDGARVCNAAVASGRAIAELCAPFDSVSICFSKGLG
APVGSVLVGSGALIERAHRWRKVLGGGMRQAGVLAAACLYALEHNVERLADDHANAERLAQGLARIEPVKVLSQATNMVF
AQFPEADCAPLEAWLKERGILTQMLYASRFVTHCDVSRDDIDTAVAAISAYFARSRA

Specific function: Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates [H]

COG id: COG2008

COG function: function code E; Threonine aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1787095, Length=334, Percent_Identity=58.9820359281437, Blast_Score=384, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI193206520, Length=346, Percent_Identity=41.907514450867, Blast_Score=228, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI193206522, Length=346, Percent_Identity=41.907514450867, Blast_Score=228, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI193206524, Length=346, Percent_Identity=41.907514450867, Blast_Score=228, Evalue=5e-60,
Organism=Saccharomyces cerevisiae, GI6320789, Length=339, Percent_Identity=37.1681415929204, Blast_Score=186, Evalue=9e-48,
Organism=Drosophila melanogaster, GI21355439, Length=365, Percent_Identity=42.1917808219178, Blast_Score=255, Evalue=6e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001597
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01212 Beta_elim_lyase [H]

EC number: =4.1.2.5 [H]

Molecular weight: Translated: 48476; Mature: 48345

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRLRQFTAPRQCGRGRDAARAAPPGRAQGTTRATDRAPRRWRIHSRIAADSSPDRRRGA
CCCCHHHCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHCCCCCCHHHCCC
ADAPANGSPYRRASAASRPRCSAASSGATPNCVHSKPPLHRASAPAHRAILLFDETPTGT
CCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCC
QMIDLRSDTVTRPSAPMLAAMTAAEVGDDVWGDDPTVARLQAVVAEHAGKEAALFFPSGT
EEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCC
QSNLAALMSHCERGDEYIVGQAAHTYKYEGGGAAVLGSIQPQPIENAADGTLPLEKIAAA
HHHHHHHHHHHHCCCCEEEECCCEEEEECCCCEEEECCCCCCCCCCCCCCCCCHHHHHHH
IKPIDDHFARSRLFTLENTIGGKVLPAGYVDEAVALARSRGLAAHLDGARVCNAAVASGR
HCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEECCHHHHHHHHHHCCH
AIAELCAPFDSVSICFSKGLGAPVGSVLVGSGALIERAHRWRKVLGGGMRQAGVLAAACL
HHHHHHCCCHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
YALEHNVERLADDHANAERLAQGLARIEPVKVLSQATNMVFAQFPEADCAPLEAWLKERG
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHCC
ILTQMLYASRFVTHCDVSRDDIDTAVAAISAYFARSRA
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TRLRQFTAPRQCGRGRDAARAAPPGRAQGTTRATDRAPRRWRIHSRIAADSSPDRRRGA
CCCHHHCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHCCCCCCHHHCCC
ADAPANGSPYRRASAASRPRCSAASSGATPNCVHSKPPLHRASAPAHRAILLFDETPTGT
CCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCC
QMIDLRSDTVTRPSAPMLAAMTAAEVGDDVWGDDPTVARLQAVVAEHAGKEAALFFPSGT
EEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCC
QSNLAALMSHCERGDEYIVGQAAHTYKYEGGGAAVLGSIQPQPIENAADGTLPLEKIAAA
HHHHHHHHHHHHCCCCEEEECCCEEEEECCCCEEEECCCCCCCCCCCCCCCCCHHHHHHH
IKPIDDHFARSRLFTLENTIGGKVLPAGYVDEAVALARSRGLAAHLDGARVCNAAVASGR
HCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEECCHHHHHHHHHHCCH
AIAELCAPFDSVSICFSKGLGAPVGSVLVGSGALIERAHRWRKVLGGGMRQAGVLAAACL
HHHHHHCCCHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
YALEHNVERLADDHANAERLAQGLARIEPVKVLSQATNMVFAQFPEADCAPLEAWLKERG
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHCC
ILTQMLYASRFVTHCDVSRDDIDTAVAAISAYFARSRA
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]