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The map label for this gene is ilvB [H]

Identifier: 126446508

GI number: 126446508

Start: 924211

End: 925884

Strand: Direct

Name: ilvB [H]

Synonym: BMA10247_A0978

Alternate gene names: 126446508

Gene position: 924211-925884 (Clockwise)

Preceding gene: 126447602

Following gene: 126447083

Centisome position: 39.28

GC content: 70.67

Gene sequence:

>1674_bases
ATGTCTAACCCAACCACGACCACGGTCGGCGAGCTGATTGCCGCCTTCCTCGAACAATGCGGCGTGAAGACCGCCTTCGG
CGTGATCTCGATTCACAACATGCCGATCCTCGACGCGATCCACACGCGCGGCAAGATCCGCTATGTCGGCGCGCGCGGCG
AGGCGGGCGCCGTCAACATGGCCGACGGCCTCGCGCGCGTGTCGGGCGGGCTCGGCGTCGCGTTCACGAGCACGGGCACC
GCGGCGGGCAACGCGGCGGGCGCGATGGTCGAGGCGCTGACGGCCGGCACCGCGCTCGTGCACATCACCGGGCAGATCGA
GACGCCGTACCTCGATCAGGACCTCGCGTACATCCACGAAGCGCCCGACCAACTGTCGATGCTCAACGCGATCTCGAAGG
CCGCGTATCGCGTGCGCACGGTCGAAGCCGTACTGCCGACGATCCGCGAGGCGGTGCGCGTCGCGATGACCGCGCCGAGC
GGGCCCGTGTCGGTCGAAATTCCGATCGACATCCAGGCGGCCGAAATCGAGTGGCCGGACGATCTCGCGCCGCCTCACGT
GGCGGTGCGCGAGCACGACGGCGCGCGCGTCGCGCAGCTCGCCGAGCGTCTGGCGGGCGCGCGCCGGCCGCTGCTGTGGC
TGGGCGGCGGCGCGCGGCACGCGCGCGCGGAAGTCGAGCGGCTCGTCGCACTCGGCTTCGGCGTGGTCACGAGCGTGCAG
GGGCGCGGCGTGCTGCCGGAGGATCACCCGGCGACGCTCGGCGCGTTCAACGTGCACGCGGCCGTCGAGCACTTCTACAA
GACGTGCGATGCGGTCGTCGTCGTCGGCTCGCGGCTGCGCGGCAACGAGGCGCTGAAGTACAAGCTCGCGCTGCCGCGTC
CGTTGTTCCGCGTCGACGCCGACGCGCTCGCCGACAACCGCGGCTACCGTAACGATCTGTTCGTGCACGGCGACGCGAAG
CGCGTGCTCGCGGAGCTCGCGGATCGGCTCGAAGGCCGGCTCGCGATCGACCCGCGCTTCGCCGACGATCTCGCGGCCGC
GCGCGCGGCGGCCGTCGCCGACGTCGGCAAGGGGCTCGGCCCGTACAAGCGCCTTGTCGACACGCTGCAGCAGGCGCTCG
GACGCGACTACAACTGGGTGCGCGACGTGACGATCTCGAACAGCACGTGGGGCAACCGCCTGCTCAGGATCTTCGAGCCG
CGCGCGGGCGTGCACGCGTTGGGCGGCGGAATCGGCCAGGGGATGCAGATGGCGATCGGCGCGGCGCTCGCCGGCAACGC
GGCGAAGACGGTGTGCCTCGTCGGCGACGGCGGCCTGATGGTCAACGTCGGCGAGCTCGCGACCGCCGTGCAGGAGAACG
CGAACGTGATGATCGTGCTGATGAACGACCAGTGCTACGGGGTGATCCGCAACATCCAGGACGCGCAGTACGGCGGGCGG
CGCTGTTACGTCGAGCTGCATCAGCCGGATTTCGCGCAGTTCTGCGCGAGCCTGAAACTCGCGCATCACCGGATCACGTC
GCTCGACGACGCGGAGCGCATCGTGCGCGAGGGGCTCGCGCACGAGGGGCCGGTGCTCGTCGAAGTCGACATGCTGTCGG
TCGGCTCGTTCGCAGCCGCGTTCGCCGGCCCCCCCGTCAAGAAGGACACGCCCGCGGAGCGCCAGTATGCGTAA

Upstream 100 bases:

>100_bases
CGGCCCGACGAGGCCGCGTGGGCGCTCTTTTATCTCGCAACGAATCTGTCGTCTTACACGACGGGCAGCCATATCGACGT
ATCAGGAGGCTTTGCACGCC

Downstream 100 bases:

>100_bases
CGCTCACGCTCCCGTCGACGTCGCGATGATCGGCTTCGGCGCGATCGGCGCGGCCGTCTATCGCGCGGTCGAGCACGACG
CCGCGCTGCGCGTCGCGCAC

Product: hypothetical protein

Products: NA

Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS [H]

Number of amino acids: Translated: 557; Mature: 556

Protein sequence:

>557_residues
MSNPTTTTVGELIAAFLEQCGVKTAFGVISIHNMPILDAIHTRGKIRYVGARGEAGAVNMADGLARVSGGLGVAFTSTGT
AAGNAAGAMVEALTAGTALVHITGQIETPYLDQDLAYIHEAPDQLSMLNAISKAAYRVRTVEAVLPTIREAVRVAMTAPS
GPVSVEIPIDIQAAEIEWPDDLAPPHVAVREHDGARVAQLAERLAGARRPLLWLGGGARHARAEVERLVALGFGVVTSVQ
GRGVLPEDHPATLGAFNVHAAVEHFYKTCDAVVVVGSRLRGNEALKYKLALPRPLFRVDADALADNRGYRNDLFVHGDAK
RVLAELADRLEGRLAIDPRFADDLAAARAAAVADVGKGLGPYKRLVDTLQQALGRDYNWVRDVTISNSTWGNRLLRIFEP
RAGVHALGGGIGQGMQMAIGAALAGNAAKTVCLVGDGGLMVNVGELATAVQENANVMIVLMNDQCYGVIRNIQDAQYGGR
RCYVELHQPDFAQFCASLKLAHHRITSLDDAERIVREGLAHEGPVLVEVDMLSVGSFAAAFAGPPVKKDTPAERQYA

Sequences:

>Translated_557_residues
MSNPTTTTVGELIAAFLEQCGVKTAFGVISIHNMPILDAIHTRGKIRYVGARGEAGAVNMADGLARVSGGLGVAFTSTGT
AAGNAAGAMVEALTAGTALVHITGQIETPYLDQDLAYIHEAPDQLSMLNAISKAAYRVRTVEAVLPTIREAVRVAMTAPS
GPVSVEIPIDIQAAEIEWPDDLAPPHVAVREHDGARVAQLAERLAGARRPLLWLGGGARHARAEVERLVALGFGVVTSVQ
GRGVLPEDHPATLGAFNVHAAVEHFYKTCDAVVVVGSRLRGNEALKYKLALPRPLFRVDADALADNRGYRNDLFVHGDAK
RVLAELADRLEGRLAIDPRFADDLAAARAAAVADVGKGLGPYKRLVDTLQQALGRDYNWVRDVTISNSTWGNRLLRIFEP
RAGVHALGGGIGQGMQMAIGAALAGNAAKTVCLVGDGGLMVNVGELATAVQENANVMIVLMNDQCYGVIRNIQDAQYGGR
RCYVELHQPDFAQFCASLKLAHHRITSLDDAERIVREGLAHEGPVLVEVDMLSVGSFAAAFAGPPVKKDTPAERQYA
>Mature_556_residues
SNPTTTTVGELIAAFLEQCGVKTAFGVISIHNMPILDAIHTRGKIRYVGARGEAGAVNMADGLARVSGGLGVAFTSTGTA
AGNAAGAMVEALTAGTALVHITGQIETPYLDQDLAYIHEAPDQLSMLNAISKAAYRVRTVEAVLPTIREAVRVAMTAPSG
PVSVEIPIDIQAAEIEWPDDLAPPHVAVREHDGARVAQLAERLAGARRPLLWLGGGARHARAEVERLVALGFGVVTSVQG
RGVLPEDHPATLGAFNVHAAVEHFYKTCDAVVVVGSRLRGNEALKYKLALPRPLFRVDADALADNRGYRNDLFVHGDAKR
VLAELADRLEGRLAIDPRFADDLAAARAAAVADVGKGLGPYKRLVDTLQQALGRDYNWVRDVTISNSTWGNRLLRIFEPR
AGVHALGGGIGQGMQMAIGAALAGNAAKTVCLVGDGGLMVNVGELATAVQENANVMIVLMNDQCYGVIRNIQDAQYGGRR
CYVELHQPDFAQFCASLKLAHHRITSLDDAERIVREGLAHEGPVLVEVDMLSVGSFAAAFAGPPVKKDTPAERQYA

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21361361, Length=590, Percent_Identity=25.4237288135593, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI93004078, Length=481, Percent_Identity=25.1559251559252, Blast_Score=95, Evalue=2e-19,
Organism=Escherichia coli, GI1790104, Length=540, Percent_Identity=28.5185185185185, Blast_Score=175, Evalue=7e-45,
Organism=Escherichia coli, GI87081685, Length=549, Percent_Identity=26.4116575591985, Blast_Score=165, Evalue=8e-42,
Organism=Escherichia coli, GI1786717, Length=476, Percent_Identity=27.3109243697479, Blast_Score=132, Evalue=7e-32,
Organism=Escherichia coli, GI1788716, Length=562, Percent_Identity=23.4875444839858, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1787096, Length=543, Percent_Identity=23.2044198895028, Blast_Score=73, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17542570, Length=571, Percent_Identity=24.3432574430823, Blast_Score=92, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6323755, Length=559, Percent_Identity=24.865831842576, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI19922626, Length=483, Percent_Identity=23.3954451345756, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 59129; Mature: 58998

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPTTTTVGELIAAFLEQCGVKTAFGVISIHNMPILDAIHTRGKIRYVGARGEAGAVNM
CCCCCCHHHHHHHHHHHHHCCCCHHEEEEEECCCCHHHHHHCCCEEEEEECCCCCCCEEH
ADGLARVSGGLGVAFTSTGTAAGNAAGAMVEALTAGTALVHITGQIETPYLDQDLAYIHE
HHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHCCEEEEEEEECCCCCCCCCHHHHHHC
APDQLSMLNAISKAAYRVRTVEAVLPTIREAVRVAMTAPSGPVSVEIPIDIQAAEIEWPD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEEEEEEEEEECCCC
DLAPPHVAVREHDGARVAQLAERLAGARRPLLWLGGGARHARAEVERLVALGFGVVTSVQ
CCCCCCEEEECCCCHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHEECC
GRGVLPEDHPATLGAFNVHAAVEHFYKTCDAVVVVGSRLRGNEALKYKLALPRPLFRVDA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCEEEEEEECCCCHHHCCH
DALADNRGYRNDLFVHGDAKRVLAELADRLEGRLAIDPRFADDLAAARAAAVADVGKGLG
HHHHCCCCCCCCEEEECCHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHCCCC
PYKRLVDTLQQALGRDYNWVRDVTISNSTWGNRLLRIFEPRAGVHALGGGIGQGMQMAIG
HHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHEEECCCCCHHHHCCCCCCCHHHHHH
AALAGNAAKTVCLVGDGGLMVNVGELATAVQENANVMIVLMNDQCYGVIRNIQDAQYGGR
HHHCCCCCEEEEEEECCCEEEEHHHHHHHHHCCCCEEEEEECCCHHHHHHCCHHHCCCCC
RCYVELHQPDFAQFCASLKLAHHRITSLDDAERIVREGLAHEGPVLVEVDMLSVGSFAAA
EEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHH
FAGPPVKKDTPAERQYA
HCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SNPTTTTVGELIAAFLEQCGVKTAFGVISIHNMPILDAIHTRGKIRYVGARGEAGAVNM
CCCCCHHHHHHHHHHHHHCCCCHHEEEEEECCCCHHHHHHCCCEEEEEECCCCCCCEEH
ADGLARVSGGLGVAFTSTGTAAGNAAGAMVEALTAGTALVHITGQIETPYLDQDLAYIHE
HHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHCCEEEEEEEECCCCCCCCCHHHHHHC
APDQLSMLNAISKAAYRVRTVEAVLPTIREAVRVAMTAPSGPVSVEIPIDIQAAEIEWPD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEEEEEEEEEECCCC
DLAPPHVAVREHDGARVAQLAERLAGARRPLLWLGGGARHARAEVERLVALGFGVVTSVQ
CCCCCCEEEECCCCHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHEECC
GRGVLPEDHPATLGAFNVHAAVEHFYKTCDAVVVVGSRLRGNEALKYKLALPRPLFRVDA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCEEEEEEECCCCHHHCCH
DALADNRGYRNDLFVHGDAKRVLAELADRLEGRLAIDPRFADDLAAARAAAVADVGKGLG
HHHHCCCCCCCCEEEECCHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHCCCC
PYKRLVDTLQQALGRDYNWVRDVTISNSTWGNRLLRIFEPRAGVHALGGGIGQGMQMAIG
HHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHEEECCCCCHHHHCCCCCCCHHHHHH
AALAGNAAKTVCLVGDGGLMVNVGELATAVQENANVMIVLMNDQCYGVIRNIQDAQYGGR
HHHCCCCCEEEEEEECCCEEEEHHHHHHHHHCCCCEEEEEECCCHHHHHHCCHHHCCCCC
RCYVELHQPDFAQFCASLKLAHHRITSLDDAERIVREGLAHEGPVLVEVDMLSVGSFAAA
EEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHH
FAGPPVKKDTPAERQYA
HCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]