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The map label for this gene is cirA [C]

Identifier: 126446338

GI number: 126446338

Start: 2020572

End: 2022875

Strand: Direct

Name: cirA [C]

Synonym: BMA10247_A2089

Alternate gene names: 126446338

Gene position: 2020572-2022875 (Clockwise)

Preceding gene: 126446299

Following gene: 126446611

Centisome position: 85.88

GC content: 68.62

Gene sequence:

>2304_bases
TTGGCGCGGCGGCCGCTTCGCGCCGCGCTGTTCGGGGCCTTCGGCCTCTATGCGGCGGCCGCGCGCGCCGCCGGCCCCGC
TTCCGAACCCGCGGCCGCCGCGCCGCCGGCCGCCGCATCCGCCGCATCCGCCGCATCCACGTCGCAGGTGCGGCACGCGG
CGATCGCCGCCGCGCGCAAGGACGCGCCGGCACTCGATCCGATCACCGTCACCGCGACGCGCACCGCGTCGGCCGCGAGC
CGCACCGCGGCGAGCGTATCGGTGATCACCGATTCAGACCTCGAGGAGCAGCAGGCCGACAACATCAAGGACGCGCTGCG
CTACGAGCCGGGCGTCACCGTGCGACGCACCGCGTACCGCCCGGCGAACGCCGCGCTCGGCGGCGGCCGCGACGGCGATT
CGAGCATCAACATCCGCGGCCTCGAAGGCAACCGCGTGCTGCTGATGGAAGACGGCATCCGGCTGCCGAGCGCGTTCTCG
TTCGGCCCGCTCGAAGCCGGCCGCGGCGATTACGCCGATCTCGACACGCTCGCGCGCATCGAGATCCTGCGCGGTCCGGC
GTCCGCGCTGTATGGCAGCGACGGCCTGACGGGCGCCGTCAACTTCATCACGAAAGATCCGTCCGATCTGCTGTCGATCC
ATCGAAAAAAGACCTATTTCTCGTTCCGGCCGAGCTACGACTCGGTCGACCGCAGCATCGGCGCGACCGTGACGGCGGCG
GGCGGCAACGATCGCGTGCAGGCGATGCTGATCGCGTCCGGCCGCCGCGGCCACGAACTCGACACGCACGGCGACGACAA
TTCCGCGAGCACGCGGCGCACGCGCGCGAATCCTCAGGATGTCTACACGGAATCGCTGCTCGGCAAGCTGACGATCACGC
CGACCGCGCGCGACACGATCAAGCTCGCCGCCGAAACGGTGCGGCGGCGGATCGACACGAACGTGCTGTCGGCGATCAAT
CCGCCGACAACGCTCGGCCTCACCGCGAACGACAGGCTCGAGCGCAACCGCTTCAGTATCGACTACGATTTGCGCGACGC
CGCCGCGCGCGGGTTCCAGACCGCGCACGTGCAGTTCTACTATCAGGAGTCGACGCAGGATCAGGACGCGTTCGAGACGC
GCGGCGGGCGGCTCCAATCGCGTTCGCGCTCGAACCACTACAGCGAGCGCGCGCTCGGCGGCTCCGCGTTCGCCGAGAGC
GGCTTCGCGACCGGGCCGCTCGCGCACAAGCTGCTGTACGGCGTCGACGGCAGCATCGACCGCATCAAGAGCCTGCGCGA
GGGCACCGTCGCGAGCCCCGGCGAATCGTTCCCGAACAAGGCGTTTCCGGACACCGACTACTCGCTGTTCGGCGCGTTCG
TGCAGGATCAGATCGGCTTCGGCAAGCTGCTCGTCACGCCGGGCCTGCGCTTCGACGCGTATCGGCTCAGCCCGAGCTCG
GGCGATCCGCTGTTCACCGGCAAGACGGTCAGCTCGAGCGATCACGAGCTGTCGCCGCGCGTCGCGATGCTCTATGAAGC
GTCGCCCGCGCTGATTCCCTACGCGCAGTATGCGCACGGCTTTCGCACGCCGACGCCCGATCAGGTCAACAACAGCTTCT
CGAATCCGATCTATGGCTATACATCGATCGGCAATCCGAACCTGAAGCCCGAGACGAGCGACACGCTCGAAGCGGGCCTG
CGCGGCACGCTCGGCACCGGCTACGGGCCGCTGCGCTACAGCGTCGCCGCGTTCGCCGGCCGCTATCGCAACTTCATCTC
GCAGCGCACGGTAGGCGGCAGTGGCCGGCCGAACGATCCGCTCGTGTTCCAGTACGTAAACTTCGCGAACGCGCGCATTC
ACGGCTTCGAGGGACGCGCCGAATGGGTGATGCCGAATGGCTTCACGCTGAAGACGGCGATGGCGTTCACGAAGGGCACG
ACGCAGGACAACGGCGCGGCGAGCGAGCCGCTCGATACGGTCAACCCGTTCTCCGCCGTGTTCGGCGTGCGCTACGAGCC
GAGCGAGCGCTGGTTCGCGCAGGCGGACCTGCTGTGGCAGGCGGGCAAGCGCGGCCGCGACGTGTCGTCGGCCGCGTGCC
AGAAAAAGACCTGCTTCACGCCGCCGTCGTCGTTCGTCGTCGATCTGCGCGGCGGCTACCGCTTCAACAAGCACGTGAGC
GCCTACCTCGGCATTCACAACCTGTTCGACCGCAAGTACTGGAACTGGTCGGACGTGCGCGGCATCGCCGCCGATTCGAA
CGTGCTCGACGCATACACCGCCCCGGGCCGCAGCGTCGCGGTCAGCATGAAGGTGGATTTCTGA

Upstream 100 bases:

>100_bases
CGCCGTCCAGACGCGCGGGCGCCAGCCAGGTGCACGCGTCACCCAGCCAGCCTCCGGGCTCAAACGTCACTGGGAGACCA
ACACCGTGCATCAACCTCTG

Downstream 100 bases:

>100_bases
TGCGGCCCGCACGCTTTTTTCCCAACCCGACCGCCCGGCAATCGAGGATCTCCGACATGATGAACACCGCCGCCCCCGCC
GCTTCGCCCGCCCGCGCGCT

Product: TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 767; Mature: 766

Protein sequence:

>767_residues
MARRPLRAALFGAFGLYAAAARAAGPASEPAAAAPPAAASAASAASTSQVRHAAIAAARKDAPALDPITVTATRTASAAS
RTAASVSVITDSDLEEQQADNIKDALRYEPGVTVRRTAYRPANAALGGGRDGDSSINIRGLEGNRVLLMEDGIRLPSAFS
FGPLEAGRGDYADLDTLARIEILRGPASALYGSDGLTGAVNFITKDPSDLLSIHRKKTYFSFRPSYDSVDRSIGATVTAA
GGNDRVQAMLIASGRRGHELDTHGDDNSASTRRTRANPQDVYTESLLGKLTITPTARDTIKLAAETVRRRIDTNVLSAIN
PPTTLGLTANDRLERNRFSIDYDLRDAAARGFQTAHVQFYYQESTQDQDAFETRGGRLQSRSRSNHYSERALGGSAFAES
GFATGPLAHKLLYGVDGSIDRIKSLREGTVASPGESFPNKAFPDTDYSLFGAFVQDQIGFGKLLVTPGLRFDAYRLSPSS
GDPLFTGKTVSSSDHELSPRVAMLYEASPALIPYAQYAHGFRTPTPDQVNNSFSNPIYGYTSIGNPNLKPETSDTLEAGL
RGTLGTGYGPLRYSVAAFAGRYRNFISQRTVGGSGRPNDPLVFQYVNFANARIHGFEGRAEWVMPNGFTLKTAMAFTKGT
TQDNGAASEPLDTVNPFSAVFGVRYEPSERWFAQADLLWQAGKRGRDVSSAACQKKTCFTPPSSFVVDLRGGYRFNKHVS
AYLGIHNLFDRKYWNWSDVRGIAADSNVLDAYTAPGRSVAVSMKVDF

Sequences:

>Translated_767_residues
MARRPLRAALFGAFGLYAAAARAAGPASEPAAAAPPAAASAASAASTSQVRHAAIAAARKDAPALDPITVTATRTASAAS
RTAASVSVITDSDLEEQQADNIKDALRYEPGVTVRRTAYRPANAALGGGRDGDSSINIRGLEGNRVLLMEDGIRLPSAFS
FGPLEAGRGDYADLDTLARIEILRGPASALYGSDGLTGAVNFITKDPSDLLSIHRKKTYFSFRPSYDSVDRSIGATVTAA
GGNDRVQAMLIASGRRGHELDTHGDDNSASTRRTRANPQDVYTESLLGKLTITPTARDTIKLAAETVRRRIDTNVLSAIN
PPTTLGLTANDRLERNRFSIDYDLRDAAARGFQTAHVQFYYQESTQDQDAFETRGGRLQSRSRSNHYSERALGGSAFAES
GFATGPLAHKLLYGVDGSIDRIKSLREGTVASPGESFPNKAFPDTDYSLFGAFVQDQIGFGKLLVTPGLRFDAYRLSPSS
GDPLFTGKTVSSSDHELSPRVAMLYEASPALIPYAQYAHGFRTPTPDQVNNSFSNPIYGYTSIGNPNLKPETSDTLEAGL
RGTLGTGYGPLRYSVAAFAGRYRNFISQRTVGGSGRPNDPLVFQYVNFANARIHGFEGRAEWVMPNGFTLKTAMAFTKGT
TQDNGAASEPLDTVNPFSAVFGVRYEPSERWFAQADLLWQAGKRGRDVSSAACQKKTCFTPPSSFVVDLRGGYRFNKHVS
AYLGIHNLFDRKYWNWSDVRGIAADSNVLDAYTAPGRSVAVSMKVDF
>Mature_766_residues
ARRPLRAALFGAFGLYAAAARAAGPASEPAAAAPPAAASAASAASTSQVRHAAIAAARKDAPALDPITVTATRTASAASR
TAASVSVITDSDLEEQQADNIKDALRYEPGVTVRRTAYRPANAALGGGRDGDSSINIRGLEGNRVLLMEDGIRLPSAFSF
GPLEAGRGDYADLDTLARIEILRGPASALYGSDGLTGAVNFITKDPSDLLSIHRKKTYFSFRPSYDSVDRSIGATVTAAG
GNDRVQAMLIASGRRGHELDTHGDDNSASTRRTRANPQDVYTESLLGKLTITPTARDTIKLAAETVRRRIDTNVLSAINP
PTTLGLTANDRLERNRFSIDYDLRDAAARGFQTAHVQFYYQESTQDQDAFETRGGRLQSRSRSNHYSERALGGSAFAESG
FATGPLAHKLLYGVDGSIDRIKSLREGTVASPGESFPNKAFPDTDYSLFGAFVQDQIGFGKLLVTPGLRFDAYRLSPSSG
DPLFTGKTVSSSDHELSPRVAMLYEASPALIPYAQYAHGFRTPTPDQVNNSFSNPIYGYTSIGNPNLKPETSDTLEAGLR
GTLGTGYGPLRYSVAAFAGRYRNFISQRTVGGSGRPNDPLVFQYVNFANARIHGFEGRAEWVMPNGFTLKTAMAFTKGTT
QDNGAASEPLDTVNPFSAVFGVRYEPSERWFAQADLLWQAGKRGRDVSSAACQKKTCFTPPSSFVVDLRGGYRFNKHVSA
YLGIHNLFDRKYWNWSDVRGIAADSNVLDAYTAPGRSVAVSMKVDF

Specific function: Acts as a receptor for hemoglobin or the hemoglobin/haptoglobin complex of the human host and is required for heme uptake [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family. Hemoglobin/haptoglobin binding protein subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788478, Length=703, Percent_Identity=25.0355618776671, Blast_Score=109, Evalue=6e-25,
Organism=Escherichia coli, GI1790405, Length=166, Percent_Identity=34.9397590361446, Blast_Score=76, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR006970
- InterPro:   IPR000531
- InterPro:   IPR010949
- InterPro:   IPR010917 [H]

Pfam domain/function: PF07715 Plug; PF04886 PT; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 82521; Mature: 82390

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARRPLRAALFGAFGLYAAAARAAGPASEPAAAAPPAAASAASAASTSQVRHAAIAAARK
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
DAPALDPITVTATRTASAASRTAASVSVITDSDLEEQQADNIKDALRYEPGVTVRRTAYR
CCCCCCCEEEEEECCHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEECCC
PANAALGGGRDGDSSINIRGLEGNRVLLMEDGIRLPSAFSFGPLEAGRGDYADLDTLARI
CCCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
EILRGPASALYGSDGLTGAVNFITKDPSDLLSIHRKKTYFSFRPSYDSVDRSIGATVTAA
HHHCCCHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHEEEEECCCHHHHHHHCCCEEEEC
GGNDRVQAMLIASGRRGHELDTHGDDNSASTRRTRANPQDVYTESLLGKLTITPTARDTI
CCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCEEEECCCCHHHH
KLAAETVRRRIDTNVLSAINPPTTLGLTANDRLERNRFSIDYDLRDAAARGFQTAHVQFY
HHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEEECHHHHHHCCCEEEEEEEE
YQESTQDQDAFETRGGRLQSRSRSNHYSERALGGSAFAESGFATGPLAHKLLYGVDGSID
ECCCCCCHHHHHHCCCCCCCCCCCCCHHHHHCCCHHHHCCCCCCCHHHHHHHHCCCCCHH
RIKSLREGTVASPGESFPNKAFPDTDYSLFGAFVQDQIGFGKLLVTPGLRFDAYRLSPSS
HHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCEEEEEEECCCC
GDPLFTGKTVSSSDHELSPRVAMLYEASPALIPYAQYAHGFRTPTPDQVNNSFSNPIYGY
CCCEEECCCCCCCCCCCCCCEEEEEECCCCEECHHHHHCCCCCCCCHHHCCCCCCCCEEE
TSIGNPNLKPETSDTLEAGLRGTLGTGYGPLRYSVAAFAGRYRNFISQRTVGGSGRPNDP
ECCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
LVFQYVNFANARIHGFEGRAEWVMPNGFTLKTAMAFTKGTTQDNGAASEPLDTVNPFSAV
EEEEEECCCCCEEECCCCCEEEECCCCEEEEEEHHHHCCCCCCCCCCCCCCCCCCHHHHH
FGVRYEPSERWFAQADLLWQAGKRGRDVSSAACQKKTCFTPPSSFVVDLRGGYRFNKHVS
HCCEECCCHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCEEEECCCCEEECCHHH
AYLGIHNLFDRKYWNWSDVRGIAADSNVLDAYTAPGRSVAVSMKVDF
HHHHHHHHHHCCCCCHHHCCCEECCCCEEECCCCCCCEEEEEEEECC
>Mature Secondary Structure 
ARRPLRAALFGAFGLYAAAARAAGPASEPAAAAPPAAASAASAASTSQVRHAAIAAARK
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
DAPALDPITVTATRTASAASRTAASVSVITDSDLEEQQADNIKDALRYEPGVTVRRTAYR
CCCCCCCEEEEEECCHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEECCC
PANAALGGGRDGDSSINIRGLEGNRVLLMEDGIRLPSAFSFGPLEAGRGDYADLDTLARI
CCCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
EILRGPASALYGSDGLTGAVNFITKDPSDLLSIHRKKTYFSFRPSYDSVDRSIGATVTAA
HHHCCCHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHEEEEECCCHHHHHHHCCCEEEEC
GGNDRVQAMLIASGRRGHELDTHGDDNSASTRRTRANPQDVYTESLLGKLTITPTARDTI
CCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCEEEECCCCHHHH
KLAAETVRRRIDTNVLSAINPPTTLGLTANDRLERNRFSIDYDLRDAAARGFQTAHVQFY
HHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEEECHHHHHHCCCEEEEEEEE
YQESTQDQDAFETRGGRLQSRSRSNHYSERALGGSAFAESGFATGPLAHKLLYGVDGSID
ECCCCCCHHHHHHCCCCCCCCCCCCCHHHHHCCCHHHHCCCCCCCHHHHHHHHCCCCCHH
RIKSLREGTVASPGESFPNKAFPDTDYSLFGAFVQDQIGFGKLLVTPGLRFDAYRLSPSS
HHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCEEEEEEECCCC
GDPLFTGKTVSSSDHELSPRVAMLYEASPALIPYAQYAHGFRTPTPDQVNNSFSNPIYGY
CCCEEECCCCCCCCCCCCCCEEEEEECCCCEECHHHHHCCCCCCCCHHHCCCCCCCCEEE
TSIGNPNLKPETSDTLEAGLRGTLGTGYGPLRYSVAAFAGRYRNFISQRTVGGSGRPNDP
ECCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
LVFQYVNFANARIHGFEGRAEWVMPNGFTLKTAMAFTKGTTQDNGAASEPLDTVNPFSAV
EEEEEECCCCCEEECCCCCEEEECCCCEEEEEEHHHHCCCCCCCCCCCCCCCCCCHHHHH
FGVRYEPSERWFAQADLLWQAGKRGRDVSSAACQKKTCFTPPSSFVVDLRGGYRFNKHVS
HCCEECCCHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCEEEECCCCEEECCHHH
AYLGIHNLFDRKYWNWSDVRGIAADSNVLDAYTAPGRSVAVSMKVDF
HHHHHHHHHHCCCCCHHHCCCEECCCCEEECCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]