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The map label for this gene is wecG [H]

Identifier: 126209007

GI number: 126209007

Start: 1764006

End: 1764731

Strand: Reverse

Name: wecG [H]

Synonym: APL_1543

Alternate gene names: 126209007

Gene position: 1764731-1764006 (Counterclockwise)

Preceding gene: 126209008

Following gene: 126209006

Centisome position: 77.59

GC content: 42.42

Gene sequence:

>726_bases
ATGATAGAAACGGTTGAAATTCGAGGGATTAATATCCTGACGGCAAAAACTAAGACCGAGTTTGTCGATTTCTTAACGGA
TAAAGGGCAACTCAAAACAGGCAAATTAATTGCAATGAATGCCGAAAAACTGGTGATGAGCGAGAAAGATCCTGAAATTC
GACAATTACTTAAGCAAGCGGAATATAACTATGCGGACGGTATTAGTATCGTTCGTTCGGTAAAACGCAAATATCCGCAT
ATTAAACAAATGGAACGGATTGCCGGTGCGGATTTATGGGAAGCGTTAATGCAAAAATCGGGAGAACTCGGCATTCCGGT
ATTTTTAATCGGCAGTACGGCGGATACCCTTGCAAAAACTCAGCAAAAATTGACCGCTTGGAATGTGGATATTGTCGGTC
TGCAGGATGGATATTTTGATAATAAGGAACAACGAGCCGTTATAGAACGTATAAAACGAAGCGGTGCAAAGCTTGTGACG
GTTGCAATGGGATCGCCGAAACAAGAAAAGTTTATTGCGGATGCCGCACGAGAATACCCCGACTGCTTATATATGGGAGT
CGGCGGAACTTATGACGTATTTATCGGTAAAGTGAAACGCGCGCCGAAAATTTGGCAGGATCTCGGTTTGGAATGGTTAT
ATCGCTTATTAAGTCAGCCGACCCGTTGGCGACGACAAGTTAATTTGCTACGTTTTCTATATTACTACTGCACAAAACAG
CTTTAA

Upstream 100 bases:

>100_bases
TGGATTTTCTTTAGCGTGATTTTCTTATTGTGTTGGTGCGTTGCCAAATTGATCGCGCTTAATTTTGAGCCGCTATTATC
GATGGAAAAGGTAGATAAAA

Downstream 100 bases:

>100_bases
AAATCAACGATTATGACAATTATTATTCATTTTGAATAAATTAAAAACAAATGAATGATTTTTTTAAACTTTTTTGCAAA
AAGTGCTAGACAACAAAAAG

Product: putative UDP-N-acetyl-D-mannosaminuronic acid transferase

Products: C55-PP-GlcNAc-ManNAcA; UDP [C]

Alternate protein names: UDP-ManNAcA transferase [H]

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MIETVEIRGINILTAKTKTEFVDFLTDKGQLKTGKLIAMNAEKLVMSEKDPEIRQLLKQAEYNYADGISIVRSVKRKYPH
IKQMERIAGADLWEALMQKSGELGIPVFLIGSTADTLAKTQQKLTAWNVDIVGLQDGYFDNKEQRAVIERIKRSGAKLVT
VAMGSPKQEKFIADAAREYPDCLYMGVGGTYDVFIGKVKRAPKIWQDLGLEWLYRLLSQPTRWRRQVNLLRFLYYYCTKQ
L

Sequences:

>Translated_241_residues
MIETVEIRGINILTAKTKTEFVDFLTDKGQLKTGKLIAMNAEKLVMSEKDPEIRQLLKQAEYNYADGISIVRSVKRKYPH
IKQMERIAGADLWEALMQKSGELGIPVFLIGSTADTLAKTQQKLTAWNVDIVGLQDGYFDNKEQRAVIERIKRSGAKLVT
VAMGSPKQEKFIADAAREYPDCLYMGVGGTYDVFIGKVKRAPKIWQDLGLEWLYRLLSQPTRWRRQVNLLRFLYYYCTKQ
L
>Mature_241_residues
MIETVEIRGINILTAKTKTEFVDFLTDKGQLKTGKLIAMNAEKLVMSEKDPEIRQLLKQAEYNYADGISIVRSVKRKYPH
IKQMERIAGADLWEALMQKSGELGIPVFLIGSTADTLAKTQQKLTAWNVDIVGLQDGYFDNKEQRAVIERIKRSGAKLVT
VAMGSPKQEKFIADAAREYPDCLYMGVGGTYDVFIGKVKRAPKIWQDLGLEWLYRLLSQPTRWRRQVNLLRFLYYYCTKQ
L

Specific function: Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in ECA synthesis [H]

COG id: COG1922

COG function: function code M; Teichoic acid biosynthesis proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 26 family [H]

Homologues:

Organism=Escherichia coli, GI2367289, Length=220, Percent_Identity=57.2727272727273, Blast_Score=263, Evalue=1e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023085
- InterPro:   IPR004629 [H]

Pfam domain/function: PF03808 Glyco_tran_WecB [H]

EC number: 2.4.1.- [C]

Molecular weight: Translated: 27633; Mature: 27633

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIETVEIRGINILTAKTKTEFVDFLTDKGQLKTGKLIAMNAEKLVMSEKDPEIRQLLKQA
CCCEEEECCEEEEEECHHHHHHHHHCCCCCCCCCCEEEECHHHHHHCCCCHHHHHHHHHH
EYNYADGISIVRSVKRKYPHIKQMERIAGADLWEALMQKSGELGIPVFLIGSTADTLAKT
CCCCCHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHCCCCCCCEEEEECCCHHHHHHH
QQKLTAWNVDIVGLQDGYFDNKEQRAVIERIKRSGAKLVTVAMGSPKQEKFIADAAREYP
HHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCC
DCLYMGVGGTYDVFIGKVKRAPKIWQDLGLEWLYRLLSQPTRWRRQVNLLRFLYYYCTKQ
CEEEECCCCCHHHHHHHHHHCHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
L
C
>Mature Secondary Structure
MIETVEIRGINILTAKTKTEFVDFLTDKGQLKTGKLIAMNAEKLVMSEKDPEIRQLLKQA
CCCEEEECCEEEEEECHHHHHHHHHCCCCCCCCCCEEEECHHHHHHCCCCHHHHHHHHHH
EYNYADGISIVRSVKRKYPHIKQMERIAGADLWEALMQKSGELGIPVFLIGSTADTLAKT
CCCCCHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHCCCCCCCEEEEECCCHHHHHHH
QQKLTAWNVDIVGLQDGYFDNKEQRAVIERIKRSGAKLVTVAMGSPKQEKFIADAAREYP
HHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCC
DCLYMGVGGTYDVFIGKVKRAPKIWQDLGLEWLYRLLSQPTRWRRQVNLLRFLYYYCTKQ
CEEEECCCCCHHHHHHHHHHCHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
L
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosaminuronic-acid; undecaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate [C]

Specific reaction: UDP-N-acetyl-D-mannosaminuronic-acid + undecaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate = C55-PP-GlcNAc-ManNAcA + UDP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA