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The map label for this gene is frdA [H]

Identifier: 126208993

GI number: 126208993

Start: 1742294

End: 1744093

Strand: Reverse

Name: frdA [H]

Synonym: APL_1529

Alternate gene names: 126208993

Gene position: 1744093-1742294 (Counterclockwise)

Preceding gene: 126208995

Following gene: 126208992

Centisome position: 76.68

GC content: 45.44

Gene sequence:

>1800_bases
ATGCAAAGTGTTAATTTTGATGTCGCGATTATCGGTGCTGGCGGCGGCGGTTTACGTGCAGCTATCGCAGCAGCGGAAGC
AAATCCAAATCTTAAAATTGCTTTAATTTCAAAAGTTTACCCGATGCGTAGCCATACCGTGGCGGCAGAAGGCGGTTCAG
CGGCAGTCATTAAAGATACAGACTCTTTCGATAACCACTTTAACGACACCGTTGGCGGCGGCGACTGGTTATGCGAACAA
GATATCGTAGAATATTTCGTGGAACATTCACCGATTGAAATGACCCAATTAGAACGTTGGGGTTGTCCTTGGTCACGTCG
CGAAGACGGTGAAGTAAACGTGCGTCGTTTCGGCGGGATGAAAATCGAACGTACGTGGTTTGCGGCGGATAAAACCGGTT
TCCACTTATTACACACCCTTTTCCAAACTTCTATCAAATATCCTAACATTGTCCGTTTTGACGAACATTTCGTGTTAGAT
ATTCTGACCGACAACGGCGAAGCGCGCGGTTGTGTGGCGATGAATATGATGGAAGGCACGCTTGTTCAAATCAATGCGAA
TGCGGTGGTTATCGCAACGGGCGGCGGCTGCCGTACTTATCGTTTCAATACCAACGGCGGTATCGTAACCGGTGACGGTT
TATCAATGGCGTATCGTCACGGCGTAGCATTACGTGATATGGAATTCGTGCAATATCACCCGACCGGCTTACCTAATACC
GGTATCTTAATGACTGAAGGTTGTCGCGGTGAAGGCGGTATCTTAGTCAATAAAGACGGTTACCGTTACTTACAAGATTA
TGGTCTAGGCCCTGAAACGCCAATCGGCAAACCTGAAAACAAATATATGGAATTAGGTCCGCGTGACAAAGTTTCACAAG
CATTCTGGCAAGAATGGAAAAAAGGTAACACCTTAAAAACCGCAAAAGGCGTAGATGTGGTGCATTTAGACTTACGTCAC
TTAGGAGAAAAACACTTAACCGAGCGTTTACCGTTTATCTGCGAATTAGCACGTGCTTATGAAGGTGTTGATCCGGTAAC
TTCGCCAATCCCAGTTCGTCCGGTTGTACACTACACCATGGGTGGTATTGAAGTGGATATGCACGCAGAAACTTCAATTA
AAGGTTTATTTGCAGTCGGTGAATGTGCTTCTTCAGGCTTACACGGTGCAAACCGCTTAGGTTCTAACTCATTAGCGGAA
TTAGTGGTATTCGGTAAAGTTGCCGGTGAAAATGCCGCTCGTCGTGCTCAAGAAGCCGGTCCTCGTAATCAAGCGCAAAT
TGATGCGCAAGCACAAGATGTGGTGGCACGCTTACACGCTTTAGCTCGTCAAGAGGGTAATGAATCTTGGTCTGACATTC
GTAACCAAATGGGTGATGCAATGGAAGAAGGTTGCGGTATCTATCGTACGCAAGAAAGTATGGAAGGTGCGGTAAACAAA
ATCCATGAGTTAAGAGAGCGTTACAAAAATATCAGCGTGAAAGATAAATCAAGCGTATTTAATACCGATTTACTCTACAA
AATCGAATTAGGCTTCATTTTAGATGTGGCGCAATCAATCGCTTGCTCGGCTGTTGAACGTAAAGAATCTCGCGGTGCGC
ATCAACGTTTAGACTATACCGAACGTGACGATGTGAATTATTTAAAACACACTCAAGCGTTCTATAACGCGGACGGCACA
CCGACCATTAAATATTCGGATGTGAAAATTACTAAATCACAACCGGCGAAACGTGTATATGGTGCGGAAGCCGAAGCGCA
AGAAAAAGCGAAAAAAGCCGCAGAACAGGCACAAAAATAG

Upstream 100 bases:

>100_bases
GTCCCCTTAAAAATACAAAATATGCTTATCTTGCATAAAAAATAGTGGCACAATAAAAATGAGTTATATTGATTAATATC
TATTATTTTTGGAGTGCATT

Downstream 100 bases:

>100_bases
GAGAGCGATAATATGGCAAATTTAAGCAAAATGACCATCGAAGTGCTTCGCTACAACCCGGAAACAGATAGCGAACCACA
TTTAGATAAATATGAAGTGC

Product: fumarate reductase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 599; Mature: 599

Protein sequence:

>599_residues
MQSVNFDVAIIGAGGGGLRAAIAAAEANPNLKIALISKVYPMRSHTVAAEGGSAAVIKDTDSFDNHFNDTVGGGDWLCEQ
DIVEYFVEHSPIEMTQLERWGCPWSRREDGEVNVRRFGGMKIERTWFAADKTGFHLLHTLFQTSIKYPNIVRFDEHFVLD
ILTDNGEARGCVAMNMMEGTLVQINANAVVIATGGGCRTYRFNTNGGIVTGDGLSMAYRHGVALRDMEFVQYHPTGLPNT
GILMTEGCRGEGGILVNKDGYRYLQDYGLGPETPIGKPENKYMELGPRDKVSQAFWQEWKKGNTLKTAKGVDVVHLDLRH
LGEKHLTERLPFICELARAYEGVDPVTSPIPVRPVVHYTMGGIEVDMHAETSIKGLFAVGECASSGLHGANRLGSNSLAE
LVVFGKVAGENAARRAQEAGPRNQAQIDAQAQDVVARLHALARQEGNESWSDIRNQMGDAMEEGCGIYRTQESMEGAVNK
IHELRERYKNISVKDKSSVFNTDLLYKIELGFILDVAQSIACSAVERKESRGAHQRLDYTERDDVNYLKHTQAFYNADGT
PTIKYSDVKITKSQPAKRVYGAEAEAQEKAKKAAEQAQK

Sequences:

>Translated_599_residues
MQSVNFDVAIIGAGGGGLRAAIAAAEANPNLKIALISKVYPMRSHTVAAEGGSAAVIKDTDSFDNHFNDTVGGGDWLCEQ
DIVEYFVEHSPIEMTQLERWGCPWSRREDGEVNVRRFGGMKIERTWFAADKTGFHLLHTLFQTSIKYPNIVRFDEHFVLD
ILTDNGEARGCVAMNMMEGTLVQINANAVVIATGGGCRTYRFNTNGGIVTGDGLSMAYRHGVALRDMEFVQYHPTGLPNT
GILMTEGCRGEGGILVNKDGYRYLQDYGLGPETPIGKPENKYMELGPRDKVSQAFWQEWKKGNTLKTAKGVDVVHLDLRH
LGEKHLTERLPFICELARAYEGVDPVTSPIPVRPVVHYTMGGIEVDMHAETSIKGLFAVGECASSGLHGANRLGSNSLAE
LVVFGKVAGENAARRAQEAGPRNQAQIDAQAQDVVARLHALARQEGNESWSDIRNQMGDAMEEGCGIYRTQESMEGAVNK
IHELRERYKNISVKDKSSVFNTDLLYKIELGFILDVAQSIACSAVERKESRGAHQRLDYTERDDVNYLKHTQAFYNADGT
PTIKYSDVKITKSQPAKRVYGAEAEAQEKAKKAAEQAQK
>Mature_599_residues
MQSVNFDVAIIGAGGGGLRAAIAAAEANPNLKIALISKVYPMRSHTVAAEGGSAAVIKDTDSFDNHFNDTVGGGDWLCEQ
DIVEYFVEHSPIEMTQLERWGCPWSRREDGEVNVRRFGGMKIERTWFAADKTGFHLLHTLFQTSIKYPNIVRFDEHFVLD
ILTDNGEARGCVAMNMMEGTLVQINANAVVIATGGGCRTYRFNTNGGIVTGDGLSMAYRHGVALRDMEFVQYHPTGLPNT
GILMTEGCRGEGGILVNKDGYRYLQDYGLGPETPIGKPENKYMELGPRDKVSQAFWQEWKKGNTLKTAKGVDVVHLDLRH
LGEKHLTERLPFICELARAYEGVDPVTSPIPVRPVVHYTMGGIEVDMHAETSIKGLFAVGECASSGLHGANRLGSNSLAE
LVVFGKVAGENAARRAQEAGPRNQAQIDAQAQDVVARLHALARQEGNESWSDIRNQMGDAMEEGCGIYRTQESMEGAVNK
IHELRERYKNISVKDKSSVFNTDLLYKIELGFILDVAQSIACSAVERKESRGAHQRLDYTERDDVNYLKHTQAFYNADGT
PTIKYSDVKITKSQPAKRVYGAEAEAQEKAKKAAEQAQK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=546, Percent_Identity=39.010989010989, Blast_Score=358, Evalue=7e-99,
Organism=Escherichia coli, GI1790597, Length=583, Percent_Identity=75.1286449399657, Blast_Score=876, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=541, Percent_Identity=40.8502772643253, Blast_Score=351, Evalue=8e-98,
Organism=Escherichia coli, GI1788928, Length=559, Percent_Identity=32.5581395348837, Blast_Score=254, Evalue=8e-69,
Organism=Caenorhabditis elegans, GI17550100, Length=546, Percent_Identity=36.996336996337, Blast_Score=337, Evalue=1e-92,
Organism=Caenorhabditis elegans, GI17505833, Length=535, Percent_Identity=36.6355140186916, Blast_Score=333, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI71986328, Length=430, Percent_Identity=26.5116279069767, Blast_Score=112, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6322416, Length=564, Percent_Identity=40.2482269503546, Blast_Score=387, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6322701, Length=585, Percent_Identity=40.5128205128205, Blast_Score=384, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6320788, Length=490, Percent_Identity=25.7142857142857, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322511, Length=383, Percent_Identity=28.9817232375979, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17137288, Length=595, Percent_Identity=37.4789915966387, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24655642, Length=595, Percent_Identity=37.4789915966387, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24655647, Length=595, Percent_Identity=37.4789915966387, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24663005, Length=602, Percent_Identity=34.3853820598007, Blast_Score=330, Evalue=2e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005884
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 65995; Mature: 65995

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSVNFDVAIIGAGGGGLRAAIAAAEANPNLKIALISKVYPMRSHTVAAEGGSAAVIKDT
CCCCCEEEEEEECCCCCHHHEEEEECCCCCEEEEEEECCCCCCCCEEEECCCCEEEEECC
DSFDNHFNDTVGGGDWLCEQDIVEYFVEHSPIEMTQLERWGCPWSRREDGEVNVRRFGGM
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCEEEEEECCE
KIERTWFAADKTGFHLLHTLFQTSIKYPNIVRFDEHFVLDILTDNGEARGCVAMNMMEGT
EEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCEEEEEEEECCCCCCCEEEEEECCCE
LVQINANAVVIATGGGCRTYRFNTNGGIVTGDGLSMAYRHGVALRDMEFVQYHPTGLPNT
EEEEECCEEEEECCCCEEEEEEECCCCEEECCCCHHHHHCCCEEECCCEEEECCCCCCCC
GILMTEGCRGEGGILVNKDGYRYLQDYGLGPETPIGKPENKYMELGPRDKVSQAFWQEWK
CEEEECCCCCCCCEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
KGNTLKTAKGVDVVHLDLRHLGEKHLTERLPFICELARAYEGVDPVTSPIPVRPVVHYTM
CCCCEEECCCCEEEEECHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEE
GGIEVDMHAETSIKGLFAVGECASSGLHGANRLGSNSLAELVVFGKVAGENAARRAQEAG
CCEEEEEECCCCCCHHEEEHHHHHCCCCCHHHCCCCHHHHHHEEEHHCCCHHHHHHHHCC
PRNQAQIDAQAQDVVARLHALARQEGNESWSDIRNQMGDAMEEGCGIYRTQESMEGAVNK
CCCCCEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHH
IHELRERYKNISVKDKSSVFNTDLLYKIELGFILDVAQSIACSAVERKESRGAHQRLDYT
HHHHHHHHHCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCC
ERDDVNYLKHTQAFYNADGTPTIKYSDVKITKSQPAKRVYGAEAEAQEKAKKAAEQAQK
CCCCCHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCHHHHCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQSVNFDVAIIGAGGGGLRAAIAAAEANPNLKIALISKVYPMRSHTVAAEGGSAAVIKDT
CCCCCEEEEEEECCCCCHHHEEEEECCCCCEEEEEEECCCCCCCCEEEECCCCEEEEECC
DSFDNHFNDTVGGGDWLCEQDIVEYFVEHSPIEMTQLERWGCPWSRREDGEVNVRRFGGM
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCEEEEEECCE
KIERTWFAADKTGFHLLHTLFQTSIKYPNIVRFDEHFVLDILTDNGEARGCVAMNMMEGT
EEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCEEEEEEEECCCCCCCEEEEEECCCE
LVQINANAVVIATGGGCRTYRFNTNGGIVTGDGLSMAYRHGVALRDMEFVQYHPTGLPNT
EEEEECCEEEEECCCCEEEEEEECCCCEEECCCCHHHHHCCCEEECCCEEEECCCCCCCC
GILMTEGCRGEGGILVNKDGYRYLQDYGLGPETPIGKPENKYMELGPRDKVSQAFWQEWK
CEEEECCCCCCCCEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
KGNTLKTAKGVDVVHLDLRHLGEKHLTERLPFICELARAYEGVDPVTSPIPVRPVVHYTM
CCCCEEECCCCEEEEECHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEE
GGIEVDMHAETSIKGLFAVGECASSGLHGANRLGSNSLAELVVFGKVAGENAARRAQEAG
CCEEEEEECCCCCCHHEEEHHHHHCCCCCHHHCCCCHHHHHHEEEHHCCCHHHHHHHHCC
PRNQAQIDAQAQDVVARLHALARQEGNESWSDIRNQMGDAMEEGCGIYRTQESMEGAVNK
CCCCCEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHH
IHELRERYKNISVKDKSSVFNTDLLYKIELGFILDVAQSIACSAVERKESRGAHQRLDYT
HHHHHHHHHCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCC
ERDDVNYLKHTQAFYNADGTPTIKYSDVKITKSQPAKRVYGAEAEAQEKAKKAAEQAQK
CCCCCHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCHHHHCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]