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The map label for this gene is trpR [H]

Identifier: 126207959

GI number: 126207959

Start: 547564

End: 547872

Strand: Direct

Name: trpR [H]

Synonym: APL_0475

Alternate gene names: 126207959

Gene position: 547564-547872 (Clockwise)

Preceding gene: 126207958

Following gene: 126207960

Centisome position: 24.07

GC content: 39.81

Gene sequence:

>309_bases
ATGAAAATTCTTTATAATCAACGAGAACCGCAAGAATGGCAACAATTTATGCGCTTACTGCAACAAGCGGTGGCAGAAGA
TAAATTGGAACAGTTTTTTACCTCGTTTTTAACCGCTGACGAGCGAGATTCTTTAGGATTACGTGTGCAAATTGTCAGAG
AATTATTAAAAGGCGACGTTCCGCAAAGAGAAATTCAGCAAAATCTCAATACCAGTGCCGCAACCATTACGCGAGGTTCT
AATATGCTTAAAACCTTAGAGCCGCAATTTATTGAGTGGTTAAACGAGAAACTGAATGGCAAGGCGTAA

Upstream 100 bases:

>100_bases
GCGGCGGTAAAAAATCTAAGAAATAATCTAATTTTACTAGCGGTTTTATTTTCGCAAAATTTTGCCAAAATCAGACCGCT
TTCCTTATTTTGGAGGTTCA

Downstream 100 bases:

>100_bases
ACGAAAGCGCAAAAAGAAGTCAGTTAGCATGTTTAGTTTGGTCAAACGTCTATGCCGTAGAATCATCAATTTTTTTATTC
CGCAGGCGATAAGTTCCCGA

Product: Trp operon repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 102; Mature: 102

Protein sequence:

>102_residues
MKILYNQREPQEWQQFMRLLQQAVAEDKLEQFFTSFLTADERDSLGLRVQIVRELLKGDVPQREIQQNLNTSAATITRGS
NMLKTLEPQFIEWLNEKLNGKA

Sequences:

>Translated_102_residues
MKILYNQREPQEWQQFMRLLQQAVAEDKLEQFFTSFLTADERDSLGLRVQIVRELLKGDVPQREIQQNLNTSAATITRGS
NMLKTLEPQFIEWLNEKLNGKA
>Mature_102_residues
MKILYNQREPQEWQQFMRLLQQAVAEDKLEQFFTSFLTADERDSLGLRVQIVRELLKGDVPQREIQQNLNTSAATITRGS
NMLKTLEPQFIEWLNEKLNGKA

Specific function: This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription [H]

COG id: COG2973

COG function: function code K; Trp operon repressor

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpR family [H]

Homologues:

Organism=Escherichia coli, GI1790854, Length=88, Percent_Identity=46.5909090909091, Blast_Score=76, Evalue=5e-16,

Paralogues:

None

Copy number: 250-750 50-300 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000831
- InterPro:   IPR013335
- InterPro:   IPR010921
- ProDom:   PD012582 [H]

Pfam domain/function: PF01371 Trp_repressor [H]

EC number: NA

Molecular weight: Translated: 11967; Mature: 11967

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILYNQREPQEWQQFMRLLQQAVAEDKLEQFFTSFLTADERDSLGLRVQIVRELLKGDV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCC
PQREIQQNLNTSAATITRGSNMLKTLEPQFIEWLNEKLNGKA
CHHHHHHHCCCHHHHHHCCHHHHHHCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKILYNQREPQEWQQFMRLLQQAVAEDKLEQFFTSFLTADERDSLGLRVQIVRELLKGDV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCC
PQREIQQNLNTSAATITRGSNMLKTLEPQFIEWLNEKLNGKA
CHHHHHHHCCCHHHHHHCCHHHHHHCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA