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The map label for this gene is gyrA [H]

Identifier: 126207774

GI number: 126207774

Start: 315604

End: 318294

Strand: Direct

Name: gyrA [H]

Synonym: APL_0286

Alternate gene names: 126207774

Gene position: 315604-318294 (Clockwise)

Preceding gene: 126207772

Following gene: 126207775

Centisome position: 13.88

GC content: 44.82

Gene sequence:

>2691_bases
ATGAGCGAATTAGCCAAAGATATTACCCCCGTCAGTATCGAAGACGAGTTAAAAACGTCTTATCTCGACTATGCGATGTC
CGTTATTGTCGGACGTGCGCTTCCCGATGTGCGTGATGGTTTAAAACCGGTACACCGCCGCGTGTTATTCTCAATGGATC
AAAACAGCAATACCTTTAACCGCCCGCACGTAAAATCTGCACGTGTGGTGGGTGACGTAATCGGTAAATATCACCCGCAC
GGTGACTCTGCTGTGTATGACACCATTGTACGTATGGCACAGCCGTTCTCACTTCGTTATATGTTGGTTGACGGTCAAGG
TAACTTTGGTTCGATTGACGGCGATGCGCCGGCGGCAATGCGTTATACCGAAGTGCGTATGCAAAAAATTACGCAGGAAT
TATTAACGGACTTAGATAAAGAAACCGTAGATTACTCGCCGAACTATGACGGCAAAGAGATGATTCCTGATGTATTACCG
ACCAAAATCCCAGCGTTATTAGTAAACGGTTCATCCGGTATTGCGGTGGGTATGGCGACTAATATTCCGCCGCATAACTT
AAATGAAGTGTTGGACGGTTGCTTAGCCTACATTGAAAACGAGCAAATCGGCATTGAAGAATTAATGCGTTTTATCCCAG
GGCCGGATTTCCCGACAGGGGCGATTATTAACGGTCGTAAGGGGATTGAAGAAGCGTATCGTACCGGTCGTGGTAAAGTT
TATGTGCGTGCTAAAGCAAGCGTAGAAACCACGGAAAAAGGGCGTGAGCAAATTGTGGTAACTGAGCTTCCGTACCAAGT
AAACAAAGCGAAGTTGATCGAGAAAATTGCCGAGTTAGTGAAAGATAAGAAAATCGAAGGCATTAGCGGTATTCAAGATC
ACTCGGACAAAAAAGGTATCTCAATCGTTATTGAAGTAAAACGTGATGCGGTGGGTGAAGTGGTGTTAAACCATCTTTAT
TCATTGACACAAATGCAAGTCACGTTTGGTATCAATATGGTTGCACTTGATCACGGTCAGCCGAAAGTATTGAACTTAAA
GCAAATTATCGAAGCGTTCGTCAAACACCGCCGTGAAGTGGTAACACGCCGCACCATTTTTGAATTGCGTAAAGCACGTG
AACGTGCGCATATCTTAGAAGGTTTGGCGATTGCGTTAGCCAATATCGATCCGGTTATCGAATTAATCCGTAACTCAAAA
ACAGCGGACGAAGCGCGTGAAGGTTTATTAGCACGAGCATGGGCATTAGGTAATGTCGCACCAATGTTAGAAGCTGCCGG
TGTTGATGCGTCACGTCCGGAAGATTTACCGGAAAACTTAGGCGTACGTGACGGTCAATACTATCTTTCCGAAGCGCAAG
CACGTGCAATTTTAGAATTACGTTTACACCGTTTAACCGGTTTAGAGCATGAAAAAATTGTGGATGAATACAAAGCATTG
CTCACTGAAATCGGCGAATTGTTACGTATTCTAAGCAGTGCAGAACGCTTAATGGAAGTGATTCGTGAAGAATTAGAAAA
AGTGAAAGCAGAATTCGGTGACGAACGTCGTACTGAAATTACAGCGGCTTCGGGCGATATTAATATGGAAGATTTAATCG
CTCAAGAAGACGTGGTTGTCACACTTTCTCATGCTGGCTATGTGAAATACCAACCGCTTTCAGATTACGAAGCACAACGT
CGTGGCGGTAAAGGTAAATCGGCGACTAAGATGAAAGAAGACGATTTCATCGAGAAATTATTAGTAGCAAACACGCACGA
TACGATTTTATGTTTCTCAAGCCGTGGTCGTTTATATCAATTGAAAGTGTATCAATTACCGCAAGCAAGTCGTGGCGCAC
GTGGTACGCCAATCGTGAACATTCTGCCGTTAGTGAAAGAAGAAAACGAGCGTATTACGGCGATTCTACCGATTCCGAAC
GGTGAATTTAGTGCGGATAAATTTATCTTTATGGCAACCGCAAGCGGTGTGGTGAAGAAAGTGAGTTTAGATGCGTTCAG
CAACGTGCGTTCAAGCGGTCTGATTGCATTAAAACTTCGTGAAGGCGATGAGTTAATCGGCGTTGATATTACTGATGGCG
AGAGCGAGATTATGTTATTCTCGGCACAAGGTCGAGTAGTACGTTTTGCAGAAAAAGCCGTGCGTGCAATGGGACGTACC
GCAACCGGTGTTCGAGGCATTAAACTTGCTACGACAGACATTTCAAGTGAAGAAATTGAAGAAGCGGAGATCGTAGAAAT
TGAAAACGAGGAAGCGGATGAGTCTTCAGTAAGTCTTGATACCGACCGTGTGGTTTCACTTGTGATTCCTCGTACGGAAG
GCGATATTCTAACTGTAACGCAAAACGGTTTCGGTAAACGTACCGTGATTGGCGAATATCCGGTTAAATCTCGTGCAACC
AAAGGTGTGGTTTCTATCAAAGTGAATGAGCGTAACGGTAAAGTAGTTGCGGCAGTTCAAGTTGAAGAAGCGGATCAAAT
TATGTTGATTACCGATGCCGGAACGCTAGTACGAACCCGAGTTGCAGAAGTTAGCCTCGTTGGTCGTAACACCCAAGGCG
TCCGCATTATCCGCACCGCAGATGATGAAAGCGTAGTAAGCGTAGAACGAGTTTGCGAACCTGATGATGAAGACGAAAAC
AGCGAAGCGTTAGACAACGTAGAAAGCACAGAAACTTCAACAGAAGCCTAA

Upstream 100 bases:

>100_bases
TTTCAAAATCCAACTTTCAACTGTTTTTTGTGCTATAATTGACTGAATTTTTCGCCCTAACGAATAGGGCTACTTCTTTA
AACGTGATTAGGAAATTTCA

Downstream 100 bases:

>100_bases
ACAAAGGGTGTAAGACCCTAAACAAGCGGTCGGATTTTGGTAAAATTTTGCAAAAATCCGACCGCTTTTGATTATAAGCA
AAGAGAGGAAGATAAGATGA

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 896; Mature: 895

Protein sequence:

>896_residues
MSELAKDITPVSIEDELKTSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFSMDQNSNTFNRPHVKSARVVGDVIGKYHPH
GDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDAPAAMRYTEVRMQKITQELLTDLDKETVDYSPNYDGKEMIPDVLP
TKIPALLVNGSSGIAVGMATNIPPHNLNEVLDGCLAYIENEQIGIEELMRFIPGPDFPTGAIINGRKGIEEAYRTGRGKV
YVRAKASVETTEKGREQIVVTELPYQVNKAKLIEKIAELVKDKKIEGISGIQDHSDKKGISIVIEVKRDAVGEVVLNHLY
SLTQMQVTFGINMVALDHGQPKVLNLKQIIEAFVKHRREVVTRRTIFELRKARERAHILEGLAIALANIDPVIELIRNSK
TADEAREGLLARAWALGNVAPMLEAAGVDASRPEDLPENLGVRDGQYYLSEAQARAILELRLHRLTGLEHEKIVDEYKAL
LTEIGELLRILSSAERLMEVIREELEKVKAEFGDERRTEITAASGDINMEDLIAQEDVVVTLSHAGYVKYQPLSDYEAQR
RGGKGKSATKMKEDDFIEKLLVANTHDTILCFSSRGRLYQLKVYQLPQASRGARGTPIVNILPLVKEENERITAILPIPN
GEFSADKFIFMATASGVVKKVSLDAFSNVRSSGLIALKLREGDELIGVDITDGESEIMLFSAQGRVVRFAEKAVRAMGRT
ATGVRGIKLATTDISSEEIEEAEIVEIENEEADESSVSLDTDRVVSLVIPRTEGDILTVTQNGFGKRTVIGEYPVKSRAT
KGVVSIKVNERNGKVVAAVQVEEADQIMLITDAGTLVRTRVAEVSLVGRNTQGVRIIRTADDESVVSVERVCEPDDEDEN
SEALDNVESTETSTEA

Sequences:

>Translated_896_residues
MSELAKDITPVSIEDELKTSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFSMDQNSNTFNRPHVKSARVVGDVIGKYHPH
GDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDAPAAMRYTEVRMQKITQELLTDLDKETVDYSPNYDGKEMIPDVLP
TKIPALLVNGSSGIAVGMATNIPPHNLNEVLDGCLAYIENEQIGIEELMRFIPGPDFPTGAIINGRKGIEEAYRTGRGKV
YVRAKASVETTEKGREQIVVTELPYQVNKAKLIEKIAELVKDKKIEGISGIQDHSDKKGISIVIEVKRDAVGEVVLNHLY
SLTQMQVTFGINMVALDHGQPKVLNLKQIIEAFVKHRREVVTRRTIFELRKARERAHILEGLAIALANIDPVIELIRNSK
TADEAREGLLARAWALGNVAPMLEAAGVDASRPEDLPENLGVRDGQYYLSEAQARAILELRLHRLTGLEHEKIVDEYKAL
LTEIGELLRILSSAERLMEVIREELEKVKAEFGDERRTEITAASGDINMEDLIAQEDVVVTLSHAGYVKYQPLSDYEAQR
RGGKGKSATKMKEDDFIEKLLVANTHDTILCFSSRGRLYQLKVYQLPQASRGARGTPIVNILPLVKEENERITAILPIPN
GEFSADKFIFMATASGVVKKVSLDAFSNVRSSGLIALKLREGDELIGVDITDGESEIMLFSAQGRVVRFAEKAVRAMGRT
ATGVRGIKLATTDISSEEIEEAEIVEIENEEADESSVSLDTDRVVSLVIPRTEGDILTVTQNGFGKRTVIGEYPVKSRAT
KGVVSIKVNERNGKVVAAVQVEEADQIMLITDAGTLVRTRVAEVSLVGRNTQGVRIIRTADDESVVSVERVCEPDDEDEN
SEALDNVESTETSTEA
>Mature_895_residues
SELAKDITPVSIEDELKTSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFSMDQNSNTFNRPHVKSARVVGDVIGKYHPHG
DSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDAPAAMRYTEVRMQKITQELLTDLDKETVDYSPNYDGKEMIPDVLPT
KIPALLVNGSSGIAVGMATNIPPHNLNEVLDGCLAYIENEQIGIEELMRFIPGPDFPTGAIINGRKGIEEAYRTGRGKVY
VRAKASVETTEKGREQIVVTELPYQVNKAKLIEKIAELVKDKKIEGISGIQDHSDKKGISIVIEVKRDAVGEVVLNHLYS
LTQMQVTFGINMVALDHGQPKVLNLKQIIEAFVKHRREVVTRRTIFELRKARERAHILEGLAIALANIDPVIELIRNSKT
ADEAREGLLARAWALGNVAPMLEAAGVDASRPEDLPENLGVRDGQYYLSEAQARAILELRLHRLTGLEHEKIVDEYKALL
TEIGELLRILSSAERLMEVIREELEKVKAEFGDERRTEITAASGDINMEDLIAQEDVVVTLSHAGYVKYQPLSDYEAQRR
GGKGKSATKMKEDDFIEKLLVANTHDTILCFSSRGRLYQLKVYQLPQASRGARGTPIVNILPLVKEENERITAILPIPNG
EFSADKFIFMATASGVVKKVSLDAFSNVRSSGLIALKLREGDELIGVDITDGESEIMLFSAQGRVVRFAEKAVRAMGRTA
TGVRGIKLATTDISSEEIEEAEIVEIENEEADESSVSLDTDRVVSLVIPRTEGDILTVTQNGFGKRTVIGEYPVKSRATK
GVVSIKVNERNGKVVAAVQVEEADQIMLITDAGTLVRTRVAEVSLVGRNTQGVRIIRTADDESVVSVERVCEPDDEDENS
EALDNVESTETSTEA

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=320, Percent_Identity=25.3125, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI19913406, Length=321, Percent_Identity=24.2990654205607, Blast_Score=76, Evalue=2e-13,
Organism=Escherichia coli, GI1788562, Length=891, Percent_Identity=70.7070707070707, Blast_Score=1276, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=725, Percent_Identity=34.4827586206897, Blast_Score=388, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17535065, Length=283, Percent_Identity=28.2685512367491, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI212645657, Length=282, Percent_Identity=28.0141843971631, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI212645845, Length=543, Percent_Identity=22.4677716390424, Blast_Score=74, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=350, Percent_Identity=26.2857142857143, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17136538, Length=363, Percent_Identity=26.1707988980716, Blast_Score=83, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 98879; Mature: 98748

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00018 EF_HAND_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELAKDITPVSIEDELKTSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFSMDQNSNTFN
CCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEECCCCCCCC
RPHVKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDAPAAM
CCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCHHH
RYTEVRMQKITQELLTDLDKETVDYSPNYDGKEMIPDVLPTKIPALLVNGSSGIAVGMAT
HHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCHHHCHHHCCCCCCEEEEECCCCEEEEEEC
NIPPHNLNEVLDGCLAYIENEQIGIEELMRFIPGPDFPTGAIINGRKGIEEAYRTGRGKV
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCEECCCHHHHHHHHCCCCEE
YVRAKASVETTEKGREQIVVTELPYQVNKAKLIEKIAELVKDKKIEGISGIQDHSDKKGI
EEEEECCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCE
SIVIEVKRDAVGEVVLNHLYSLTQMQVTFGINMVALDHGQPKVLNLKQIIEAFVKHRREV
EEEEEECHHHHHHHHHHHHHHHHHEEEEECEEEEEEECCCCCEECHHHHHHHHHHHHHHH
VTRRTIFELRKARERAHILEGLAIALANIDPVIELIRNSKTADEAREGLLARAWALGNVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHH
PMLEAAGVDASRPEDLPENLGVRDGQYYLSEAQARAILELRLHRLTGLEHEKIVDEYKAL
HHHHHCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LTEIGELLRILSSAERLMEVIREELEKVKAEFGDERRTEITAASGDINMEDLIAQEDVVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCEEEECCCCCCHHHHHCCCCEEE
TLSHAGYVKYQPLSDYEAQRRGGKGKSATKMKEDDFIEKLLVANTHDTILCFSSRGRLYQ
EEECCCEEEECCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCEEE
LKVYQLPQASRGARGTPIVNILPLVKEENERITAILPIPNGEFSADKFIFMATASGVVKK
EEEEECCCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCEEEEEECCCHHHH
VSLDAFSNVRSSGLIALKLREGDELIGVDITDGESEIMLFSAQGRVVRFAEKAVRAMGRT
HHHHHHHCCCCCCEEEEEEECCCEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHCCC
ATGVRGIKLATTDISSEEIEEAEIVEIENEEADESSVSLDTDRVVSLVIPRTEGDILTVT
CCCCCCEEEEECCCCHHHCCCCEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEE
QNGFGKRTVIGEYPVKSRATKGVVSIKVNERNGKVVAAVQVEEADQIMLITDAGTLVRTR
CCCCCCCEEEECCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCEEEEEECCCHHHHHH
VAEVSLVGRNTQGVRIIRTADDESVVSVERVCEPDDEDENSEALDNVESTETSTEA
HHEEEEECCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SELAKDITPVSIEDELKTSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFSMDQNSNTFN
CCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEECCCCCCCC
RPHVKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDAPAAM
CCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCHHH
RYTEVRMQKITQELLTDLDKETVDYSPNYDGKEMIPDVLPTKIPALLVNGSSGIAVGMAT
HHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCHHHCHHHCCCCCCEEEEECCCCEEEEEEC
NIPPHNLNEVLDGCLAYIENEQIGIEELMRFIPGPDFPTGAIINGRKGIEEAYRTGRGKV
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCEECCCHHHHHHHHCCCCEE
YVRAKASVETTEKGREQIVVTELPYQVNKAKLIEKIAELVKDKKIEGISGIQDHSDKKGI
EEEEECCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCE
SIVIEVKRDAVGEVVLNHLYSLTQMQVTFGINMVALDHGQPKVLNLKQIIEAFVKHRREV
EEEEEECHHHHHHHHHHHHHHHHHEEEEECEEEEEEECCCCCEECHHHHHHHHHHHHHHH
VTRRTIFELRKARERAHILEGLAIALANIDPVIELIRNSKTADEAREGLLARAWALGNVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHH
PMLEAAGVDASRPEDLPENLGVRDGQYYLSEAQARAILELRLHRLTGLEHEKIVDEYKAL
HHHHHCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LTEIGELLRILSSAERLMEVIREELEKVKAEFGDERRTEITAASGDINMEDLIAQEDVVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCEEEECCCCCCHHHHHCCCCEEE
TLSHAGYVKYQPLSDYEAQRRGGKGKSATKMKEDDFIEKLLVANTHDTILCFSSRGRLYQ
EEECCCEEEECCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCEEE
LKVYQLPQASRGARGTPIVNILPLVKEENERITAILPIPNGEFSADKFIFMATASGVVKK
EEEEECCCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCEEEEEECCCHHHH
VSLDAFSNVRSSGLIALKLREGDELIGVDITDGESEIMLFSAQGRVVRFAEKAVRAMGRT
HHHHHHHCCCCCCEEEEEEECCCEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHCCC
ATGVRGIKLATTDISSEEIEEAEIVEIENEEADESSVSLDTDRVVSLVIPRTEGDILTVT
CCCCCCEEEEECCCCHHHCCCCEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEE
QNGFGKRTVIGEYPVKSRATKGVVSIKVNERNGKVVAAVQVEEADQIMLITDAGTLVRTR
CCCCCCCEEEECCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCEEEEEECCCHHHHHH
VAEVSLVGRNTQGVRIIRTADDESVVSVERVCEPDDEDENSEALDNVESTETSTEA
HHEEEEECCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]