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The map label for this gene is tyrA [H]

Identifier: 126207672

GI number: 126207672

Start: 203301

End: 204422

Strand: Reverse

Name: tyrA [H]

Synonym: APL_0184

Alternate gene names: 126207672

Gene position: 204422-203301 (Counterclockwise)

Preceding gene: 126207673

Following gene: 126207671

Centisome position: 8.99

GC content: 42.78

Gene sequence:

>1122_bases
ATGAATCCGCTCAATCCTTTACGAGAACAAATCGATCAAGTTGATCAACAATTAATCCGACTGTTTGCCGAACGTTTAAA
ATTAGTCGCCGAGGTGGGAAAAGTTAAATCGGAACACGGTATTCCCGTTTATGCGCCGGAACGCGAAACGGCGATGATAG
CCGCCCGCCGTCAAGAAGCGGAAAAGCAAGGCGTTCCCGCCGACTTAATCGAAGACGTATTAAGACGAGTAATGCGTGAA
TCTTATGTGAATGAAAACAAACACGGTTTTAAAACCACGAATCCGCATATTCATAAAATCGTAATTGTCGGCGGTAAAGG
AAAATTGGGCGGATTATTTGCACGTTTTCTAACACTTTCGGGCTATCGAGTAGAAACGTTAGGCAGTCAAGATTGGGAAC
AAGCGGAACACATTCTTAGCGATTGTGATTTGGTTATTGTTTGCGTACCGATTGTTAAAACGTTGGAAACGATCGAACGT
TTACAACCGTTTTTAACCGAAAATATGATCTTAGCGGATTTAACATCGGTTAAAGCGCAACCGCTTGAAAAAATGTTGGA
AGTGCATAGCGGCCCGGTGGTCGGTTTACATCCGATGTTCGGACCGGATATCGCTTCAATGGCAAAGCAAGTGGTAGCCT
GCTGCCACGGACGTTTTTCCGAAAAATACGAATGGCTTATCGAACAAATTAAAATTTGGGGCGCAAAAATCGAGGTAATC
GATGCGCACGAACACGATCATGCAATGACTTACATTCAAGCATTGCGCCACTTTTCAACTTTTACTTTCGGTTTGCACTT
ATCTCGACAATCGGTCAAATTATCGCAACTTTTGGCTCTGTCTTCACCGATTTACCGGTTAGAATTGGCAATGATCGGGC
GTTTATTTGCACAAGACGGCGGTTTATATGCGGATATTATTTCGGATAAGCCGGAAAATCTTGCCGTGATCGAATCGCTG
AAAGAGACTTTTACCAGCAGCCTGGATTTCTTTAAAAACAACGATAAAGCAGGCTTTATCCAAGCATTTGAAGACGTTCA
TCATTGGTTCGGTGATTATTCGGAACAATTTTTAAAAGAAAGCCGAGTCCTACTGCAACAAGCAAATGACAATCGGAAAT
AA

Upstream 100 bases:

>100_bases
AGGTTCGATATAAAACGAATAAGCGGGCACATTTTGCCAAAAAATTTAAAAATTTGACCGCTTATTTTATGAATCTTTCG
ATAGCATAAAGGACCCTTAT

Downstream 100 bases:

>100_bases
TAACAAGCGGTCTAATTTCCATACTTTTTTGCGAAAAGAAATAAAAATTAGGCCGCTTATAAAGCAAAGCGAAAGGCTCC
GTTATCGGAGCCTTTGTATC

Product: bifunctional chorismate mutase/prephenate dehydrogenase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydrogenase; PDH [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MNPLNPLREQIDQVDQQLIRLFAERLKLVAEVGKVKSEHGIPVYAPERETAMIAARRQEAEKQGVPADLIEDVLRRVMRE
SYVNENKHGFKTTNPHIHKIVIVGGKGKLGGLFARFLTLSGYRVETLGSQDWEQAEHILSDCDLVIVCVPIVKTLETIER
LQPFLTENMILADLTSVKAQPLEKMLEVHSGPVVGLHPMFGPDIASMAKQVVACCHGRFSEKYEWLIEQIKIWGAKIEVI
DAHEHDHAMTYIQALRHFSTFTFGLHLSRQSVKLSQLLALSSPIYRLELAMIGRLFAQDGGLYADIISDKPENLAVIESL
KETFTSSLDFFKNNDKAGFIQAFEDVHHWFGDYSEQFLKESRVLLQQANDNRK

Sequences:

>Translated_373_residues
MNPLNPLREQIDQVDQQLIRLFAERLKLVAEVGKVKSEHGIPVYAPERETAMIAARRQEAEKQGVPADLIEDVLRRVMRE
SYVNENKHGFKTTNPHIHKIVIVGGKGKLGGLFARFLTLSGYRVETLGSQDWEQAEHILSDCDLVIVCVPIVKTLETIER
LQPFLTENMILADLTSVKAQPLEKMLEVHSGPVVGLHPMFGPDIASMAKQVVACCHGRFSEKYEWLIEQIKIWGAKIEVI
DAHEHDHAMTYIQALRHFSTFTFGLHLSRQSVKLSQLLALSSPIYRLELAMIGRLFAQDGGLYADIISDKPENLAVIESL
KETFTSSLDFFKNNDKAGFIQAFEDVHHWFGDYSEQFLKESRVLLQQANDNRK
>Mature_373_residues
MNPLNPLREQIDQVDQQLIRLFAERLKLVAEVGKVKSEHGIPVYAPERETAMIAARRQEAEKQGVPADLIEDVLRRVMRE
SYVNENKHGFKTTNPHIHKIVIVGGKGKLGGLFARFLTLSGYRVETLGSQDWEQAEHILSDCDLVIVCVPIVKTLETIER
LQPFLTENMILADLTSVKAQPLEKMLEVHSGPVVGLHPMFGPDIASMAKQVVACCHGRFSEKYEWLIEQIKIWGAKIEVI
DAHEHDHAMTYIQALRHFSTFTFGLHLSRQSVKLSQLLALSSPIYRLELAMIGRLFAQDGGLYADIISDKPENLAVIESL
KETFTSSLDFFKNNDKAGFIQAFEDVHHWFGDYSEQFLKESRVLLQQANDNRK

Specific function: Tyrosine biosynthesis [C]

COG id: COG0287

COG function: function code E; Prephenate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate/arogenate dehydrogenase domain [H]

Homologues:

Organism=Escherichia coli, GI1788952, Length=370, Percent_Identity=58.3783783783784, Blast_Score=449, Evalue=1e-127,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR008244
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR011277
- InterPro:   IPR016040
- InterPro:   IPR003099 [H]

Pfam domain/function: PF01817 CM_2; PF02153 PDH [H]

EC number: =5.4.99.5; =1.3.1.12 [H]

Molecular weight: Translated: 42327; Mature: 42327

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPLNPLREQIDQVDQQLIRLFAERLKLVAEVGKVKSEHGIPVYAPERETAMIAARRQEA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHH
EKQGVPADLIEDVLRRVMRESYVNENKHGFKTTNPHIHKIVIVGGKGKLGGLFARFLTLS
HHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHC
GYRVETLGSQDWEQAEHILSDCDLVIVCVPIVKTLETIERLQPFLTENMILADLTSVKAQ
CCEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLEKMLEVHSGPVVGLHPMFGPDIASMAKQVVACCHGRFSEKYEWLIEQIKIWGAKIEVI
HHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEE
DAHEHDHAMTYIQALRHFSTFTFGLHLSRQSVKLSQLLALSSPIYRLELAMIGRLFAQDG
ECCCCHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
GLYADIISDKPENLAVIESLKETFTSSLDFFKNNDKAGFIQAFEDVHHWFGDYSEQFLKE
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SRVLLQQANDNRK
HHHHHHHCCCCCC
>Mature Secondary Structure
MNPLNPLREQIDQVDQQLIRLFAERLKLVAEVGKVKSEHGIPVYAPERETAMIAARRQEA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHH
EKQGVPADLIEDVLRRVMRESYVNENKHGFKTTNPHIHKIVIVGGKGKLGGLFARFLTLS
HHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHC
GYRVETLGSQDWEQAEHILSDCDLVIVCVPIVKTLETIERLQPFLTENMILADLTSVKAQ
CCEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLEKMLEVHSGPVVGLHPMFGPDIASMAKQVVACCHGRFSEKYEWLIEQIKIWGAKIEVI
HHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEE
DAHEHDHAMTYIQALRHFSTFTFGLHLSRQSVKLSQLLALSSPIYRLELAMIGRLFAQDG
ECCCCHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
GLYADIISDKPENLAVIESLKETFTSSLDFFKNNDKAGFIQAFEDVHHWFGDYSEQFLKE
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SRVLLQQANDNRK
HHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]