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The map label for this gene is ilvD

Identifier: 126207585

GI number: 126207585

Start: 102119

End: 103954

Strand: Reverse

Name: ilvD

Synonym: APL_0097

Alternate gene names: 126207585

Gene position: 103954-102119 (Counterclockwise)

Preceding gene: 126207586

Following gene: 126207584

Centisome position: 4.57

GC content: 47.33

Gene sequence:

>1836_bases
ATGCCTATTTTACGTTCTGCAACCTCAACGCAAGGTCGCAATATGGCAGGCGCACGTGCATTATGGCGTGCAACAGGAAT
GAAAGAAAACGACTTCGGCAAACCGATTATTGCCGTAGTAAACTCCTTTACCCAATTTGTACCGGGTCACGTCCACTTAC
GTGATATGGGTAAACTGGTTGCCGAACAAATCGAAGCAGCCGGCGGTGTCGCAAAAGAATTTAATACGATTGCGGTGGAC
GACGGTATCGCAATGGGTCACGGCGGTATGCTTTATTCCTTACCAAGCCGTGATTTAATCGCCGACTCGGTGGAATATAT
GGTTAATGCGCACTGTGCCGATGCGATGGTGTGTATTTCAAACTGTGACAAAATCACCCCGGGAATGTTAATGGCGGCAA
TGCGCTTAAATATTCCGGCGGTATTTGTGTCAGGCGGTCCGATGGAAGCGGGTAAAACCAAATTATCCGATCAGCTCATC
AAATTAGACTTAGTTGATGCAATGATGAAAAGCGCCGACAAAACCGTGTGTGACGATGACGTAGATGCGATTGAAAAATC
CGCTTGCCCGACTTGCGGTTCATGCTCAGGTATGTTTACCGCCAACTCAATGAACTGCTTAACCGAAGCGTTAGGTTTAT
CTTTACCGGGTAACGGTTCAATGTTAGCCACCCACGCCGACCGTAAAGAATTATTCTTAACTGCCGGCCGTCAAATCGTT
GAGCTTTGCAAACGTTATTACGAACAAGACGATGCGAGCGTATTACCGCGTTCAATCGCAACCAAAGCGGCATTTGAAAA
CGCAATGAGCTTAGATATCGCAATGGGCGGTTCAACCAATACGGTTTTACACTTATTAGCCGCAGCACAAGAAGCGGAAG
TGGATTTCACTATGGCGGATATCGACCGCTTATCACGTAAAGTGCCGTGTTTATCGAAAGTTGCACCGAATACCAATAAA
TACCATATGGAAGACGTACACCGTGCCGGCGGTATTATGGCGATTTTAGGCGAACTTGAGCGTGCCGATTTATTACATTC
TGATACTCGTACCGTATTAGGTATGACGATCGGCGAACAGATTGCGAAATACGACATAACCTTAACCAAAGACGAAGCGG
TGCATAAATTCTTCCGTGCCGGCCCGGCGGGGATTCGTACCACTAAAGCATTCTCACAAGATTGCCGTTGGGATACGGTA
GATGACGACCGTCAAAACGGTTGTATCCGTTCAAAAGAATTTGCTTATAGCCAAGACGGCGGTTTAGCAATGCTGACCGG
TAATATCGCTCTGGACGGCTGTATCGTAAAAACTGCCGGTGTAGATGAATCCATCTTAAAATTCACCGGTGATGCGATTG
TGTTTGAAAGCCAAGAAGAAGCGGTGGAAGGTATTTTAGGCGGTAAAGTGCGCGCCGGTCACGTAGTAATTATTCGTTAC
GAAGGCCCGAAAGGCGGCCCGGGTATGCAAGAAATGTTGTATCCGACCACTTACTTAAAATCCATCGGTTTAGGTAAAGA
ATGTGCGCTATTAACCGACGGTCGTTTCTCCGGCGGTACATCGGGTTTATCTATCGGACACTGTTCACCGGAAGCGGCTT
CCGGCGGTACCATCGGTTTAGTCCGTGACGGTGATAAAATTGCGATCGATATTCCGAACCGCTCAATTCAACTTTTAGTT
TCGGATGAAGAATTAGCGGTACGCAGAGCGGAACAAGATACGAAAGGCTGGAAACCGGCAAATCGCCAACGTGAAGTTTC
GATGGCGTTAAAAATGTTCGGTCACTTCGCAACCTCTGCCGACAAAGGTGCGGTACGTGATAAAACCAAACTGTAA

Upstream 100 bases:

>100_bases
AAATAAGCGGTCTGATTTTATCCGTTTTTTACAAATTCATTGAGAAATCGAACCGCTTACCGAATAACGAAACACAACAT
ACCCTAATTTGGAGAAATAT

Downstream 100 bases:

>100_bases
AGGTCATTCATCAAAACTTATAAAATCTATTGATTAAAACTAATAAAAGCGGTCAAATTTCGCTAGAAAATTGCAAAATA
ATTTGCAAAAATTCGAGCAA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 611; Mature: 610

Protein sequence:

>611_residues
MPILRSATSTQGRNMAGARALWRATGMKENDFGKPIIAVVNSFTQFVPGHVHLRDMGKLVAEQIEAAGGVAKEFNTIAVD
DGIAMGHGGMLYSLPSRDLIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPAVFVSGGPMEAGKTKLSDQLI
KLDLVDAMMKSADKTVCDDDVDAIEKSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRKELFLTAGRQIV
ELCKRYYEQDDASVLPRSIATKAAFENAMSLDIAMGGSTNTVLHLLAAAQEAEVDFTMADIDRLSRKVPCLSKVAPNTNK
YHMEDVHRAGGIMAILGELERADLLHSDTRTVLGMTIGEQIAKYDITLTKDEAVHKFFRAGPAGIRTTKAFSQDCRWDTV
DDDRQNGCIRSKEFAYSQDGGLAMLTGNIALDGCIVKTAGVDESILKFTGDAIVFESQEEAVEGILGGKVRAGHVVIIRY
EGPKGGPGMQEMLYPTTYLKSIGLGKECALLTDGRFSGGTSGLSIGHCSPEAASGGTIGLVRDGDKIAIDIPNRSIQLLV
SDEELAVRRAEQDTKGWKPANRQREVSMALKMFGHFATSADKGAVRDKTKL

Sequences:

>Translated_611_residues
MPILRSATSTQGRNMAGARALWRATGMKENDFGKPIIAVVNSFTQFVPGHVHLRDMGKLVAEQIEAAGGVAKEFNTIAVD
DGIAMGHGGMLYSLPSRDLIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPAVFVSGGPMEAGKTKLSDQLI
KLDLVDAMMKSADKTVCDDDVDAIEKSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRKELFLTAGRQIV
ELCKRYYEQDDASVLPRSIATKAAFENAMSLDIAMGGSTNTVLHLLAAAQEAEVDFTMADIDRLSRKVPCLSKVAPNTNK
YHMEDVHRAGGIMAILGELERADLLHSDTRTVLGMTIGEQIAKYDITLTKDEAVHKFFRAGPAGIRTTKAFSQDCRWDTV
DDDRQNGCIRSKEFAYSQDGGLAMLTGNIALDGCIVKTAGVDESILKFTGDAIVFESQEEAVEGILGGKVRAGHVVIIRY
EGPKGGPGMQEMLYPTTYLKSIGLGKECALLTDGRFSGGTSGLSIGHCSPEAASGGTIGLVRDGDKIAIDIPNRSIQLLV
SDEELAVRRAEQDTKGWKPANRQREVSMALKMFGHFATSADKGAVRDKTKL
>Mature_610_residues
PILRSATSTQGRNMAGARALWRATGMKENDFGKPIIAVVNSFTQFVPGHVHLRDMGKLVAEQIEAAGGVAKEFNTIAVDD
GIAMGHGGMLYSLPSRDLIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPAVFVSGGPMEAGKTKLSDQLIK
LDLVDAMMKSADKTVCDDDVDAIEKSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRKELFLTAGRQIVE
LCKRYYEQDDASVLPRSIATKAAFENAMSLDIAMGGSTNTVLHLLAAAQEAEVDFTMADIDRLSRKVPCLSKVAPNTNKY
HMEDVHRAGGIMAILGELERADLLHSDTRTVLGMTIGEQIAKYDITLTKDEAVHKFFRAGPAGIRTTKAFSQDCRWDTVD
DDRQNGCIRSKEFAYSQDGGLAMLTGNIALDGCIVKTAGVDESILKFTGDAIVFESQEEAVEGILGGKVRAGHVVIIRYE
GPKGGPGMQEMLYPTTYLKSIGLGKECALLTDGRFSGGTSGLSIGHCSPEAASGGTIGLVRDGDKIAIDIPNRSIQLLVS
DEELAVRRAEQDTKGWKPANRQREVSMALKMFGHFATSADKGAVRDKTKL

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=614, Percent_Identity=79.6416938110749, Blast_Score=1025, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=545, Percent_Identity=29.5412844036697, Blast_Score=183, Evalue=3e-47,
Organism=Escherichia coli, GI2367371, Length=558, Percent_Identity=29.5698924731183, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI1786464, Length=524, Percent_Identity=30.7251908396947, Blast_Score=175, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6322476, Length=605, Percent_Identity=37.8512396694215, Blast_Score=358, Evalue=1e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_ACTP2 (A3MYG9)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001052810.1
- STRING:   A3MYG9
- GeneID:   4849997
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0097
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- PhylomeDB:   A3MYG9
- ProtClustDB:   PRK12448
- BioCyc:   APLE416269:APL_0097-MONOMER
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 65440; Mature: 65309

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPILRSATSTQGRNMAGARALWRATGMKENDFGKPIIAVVNSFTQFVPGHVHLRDMGKLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AEQIEAAGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRDLIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAAMRLNIPAVFVSGGPMEAGKTKLSDQLIKLDLVDAMMKSADKTVCDDD
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCH
VDAIEKSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRKELFLTAGRQIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHCCHHHH
ELCKRYYEQDDASVLPRSIATKAAFENAMSLDIAMGGSTNTVLHLLAAAQEAEVDFTMAD
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEHHH
IDRLSRKVPCLSKVAPNTNKYHMEDVHRAGGIMAILGELERADLLHSDTRTVLGMTIGEQ
HHHHHHCCCHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
IAKYDITLTKDEAVHKFFRAGPAGIRTTKAFSQDCRWDTVDDDRQNGCIRSKEFAYSQDG
HHHEEEEECCHHHHHHHHHCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
GLAMLTGNIALDGCIVKTAGVDESILKFTGDAIVFESQEEAVEGILGGKVRAGHVVIIRY
CEEEEECCEEECCEEEEECCCCHHHHHHCCCEEEECCHHHHHHHHHCCCEECCEEEEEEE
EGPKGGPGMQEMLYPTTYLKSIGLGKECALLTDGRFSGGTSGLSIGHCSPEAASGGTIGL
CCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEECCCCCCCCCCCEEEE
VRDGDKIAIDIPNRSIQLLVSDEELAVRRAEQDTKGWKPANRQREVSMALKMFGHFATSA
EECCCEEEEECCCCEEEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCC
DKGAVRDKTKL
CCCCCCCCCCC
>Mature Secondary Structure 
PILRSATSTQGRNMAGARALWRATGMKENDFGKPIIAVVNSFTQFVPGHVHLRDMGKLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AEQIEAAGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRDLIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAAMRLNIPAVFVSGGPMEAGKTKLSDQLIKLDLVDAMMKSADKTVCDDD
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCH
VDAIEKSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRKELFLTAGRQIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHCCHHHH
ELCKRYYEQDDASVLPRSIATKAAFENAMSLDIAMGGSTNTVLHLLAAAQEAEVDFTMAD
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEHHH
IDRLSRKVPCLSKVAPNTNKYHMEDVHRAGGIMAILGELERADLLHSDTRTVLGMTIGEQ
HHHHHHCCCHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
IAKYDITLTKDEAVHKFFRAGPAGIRTTKAFSQDCRWDTVDDDRQNGCIRSKEFAYSQDG
HHHEEEEECCHHHHHHHHHCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
GLAMLTGNIALDGCIVKTAGVDESILKFTGDAIVFESQEEAVEGILGGKVRAGHVVIIRY
CEEEEECCEEECCEEEEECCCCHHHHHHCCCEEEECCHHHHHHHHHCCCEECCEEEEEEE
EGPKGGPGMQEMLYPTTYLKSIGLGKECALLTDGRFSGGTSGLSIGHCSPEAASGGTIGL
CCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEECCCCCCCCCCCEEEE
VRDGDKIAIDIPNRSIQLLVSDEELAVRRAEQDTKGWKPANRQREVSMALKMFGHFATSA
EECCCEEEEECCCCEEEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCC
DKGAVRDKTKL
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA