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The map label for this gene is grxA [H]

Identifier: 126207542

GI number: 126207542

Start: 60795

End: 61058

Strand: Direct

Name: grxA [H]

Synonym: APL_0054

Alternate gene names: 126207542

Gene position: 60795-61058 (Clockwise)

Preceding gene: 126207541

Following gene: 126207544

Centisome position: 2.67

GC content: 39.39

Gene sequence:

>264_bases
ATGTTCGTAGAAATTTATGGTCGTATGACTTGCCCGTACTGCACACGTGCGAAAGCGTTAGCGGAAAAAATGAAAGGCGA
ATTAGCTGATTTCGATTTTAAATTTATCGATATGATTGCTGAAGGCATTTCAAAAGAAGATTTAGAACCGCGTGTCGGCA
AACCGGTTGCAACTGTGCCGCAAATTTTCTTAGATAACGTTCACGTTGGCGGTTGTACTGATTTCCAAGCGTTAGTGAAA
GAAAAATTTGGTATTGAAGTTTAA

Upstream 100 bases:

>100_bases
GGGTTTTTTGCAAAAAGCTGATAGAATTCGACCGCTTACCAGTCTATTGAAGCTGGCATTTATCACTGAATAATTAGCTT
AATTTTATAAGGAATGAATT

Downstream 100 bases:

>100_bases
TTACCAATCGTTAGAAACAAAAACGGCACAAGTATTTAATTTTAATTTACTTATGCCGTTTATTTTTATAAAGCCAATGC
TTTGCGTTGAGCATCTAACA

Product: glutaredoxin 1

Products: deoxyribonucleotides [C]

Alternate protein names: NA

Number of amino acids: Translated: 87; Mature: 87

Protein sequence:

>87_residues
MFVEIYGRMTCPYCTRAKALAEKMKGELADFDFKFIDMIAEGISKEDLEPRVGKPVATVPQIFLDNVHVGGCTDFQALVK
EKFGIEV

Sequences:

>Translated_87_residues
MFVEIYGRMTCPYCTRAKALAEKMKGELADFDFKFIDMIAEGISKEDLEPRVGKPVATVPQIFLDNVHVGGCTDFQALVK
EKFGIEV
>Mature_87_residues
MFVEIYGRMTCPYCTRAKALAEKMKGELADFDFKFIDMIAEGISKEDLEPRVGKPVATVPQIFLDNVHVGGCTDFQALVK
EKFGIEV

Specific function: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins [H]

COG id: COG0695

COG function: function code O; Glutaredoxin and related proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1787073, Length=79, Percent_Identity=59.4936708860759, Blast_Score=107, Evalue=2e-25,
Organism=Escherichia coli, GI1790039, Length=76, Percent_Identity=44.7368421052632, Blast_Score=60, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011767
- InterPro:   IPR002109
- InterPro:   IPR014025
- InterPro:   IPR011902
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin [H]

EC number: NA

Molecular weight: Translated: 9749; Mature: 9749

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00195 GLUTAREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
8.0 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
8.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVEIYGRMTCPYCTRAKALAEKMKGELADFDFKFIDMIAEGISKEDLEPRVGKPVATVP
CEEEECCCCCCCHHHHHHHHHHHHCCHHCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHH
QIFLDNVHVGGCTDFQALVKEKFGIEV
HHHHCCCCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MFVEIYGRMTCPYCTRAKALAEKMKGELADFDFKFIDMIAEGISKEDLEPRVGKPVATVP
CEEEECCCCCCCHHHHHHHHHHHHCCHHCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHH
QIFLDNVHVGGCTDFQALVKEKFGIEV
HHHHCCCCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ribonucleotides [C]

Specific reaction: ribonucleotides = deoxyribonucleotides [C]

General reaction: deoxyribonucleotide biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]