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The map label for this gene is murC

Identifier: 126207507

GI number: 126207507

Start: 21880

End: 23307

Strand: Direct

Name: murC

Synonym: APL_0019

Alternate gene names: 126207507

Gene position: 21880-23307 (Clockwise)

Preceding gene: 126207506

Following gene: 126207508

Centisome position: 0.96

GC content: 46.99

Gene sequence:

>1428_bases
ATGAAAAATTTCCAAGATAAAATTAAAAAATTAGTGCCGGAAATGCGCCGTGTAAATCAGATCCATTTTATCGGTATCGG
CGGTGCGGGTATGAGCGGTATCGCTGAAGTGTTATTAAATGAAGGCTATCAAATTTCCGGTTCCGATATTGCCGAAGGTC
CTGTGACTAAACGTTTAGCGGAAGCCGGTGCAAAAGTGTTTATCGGTCATCAAGCGGAGAATGTTGCCGGTGCGAGCGTA
GTGGTTGCTTCCAGTGCGATTGACGACAGCAATCCGGAAGTGCGTGCGGCAAAAGAAGCGCGTATTCCTGTGATTCAGCG
TGCGCAAATGTTGGCGGAAATTATGCGTTTTCGTCACGGTATTGCGGTTGCGGGAACGCATGGTAAAACAACGACTACCG
CAATGATTTCGATGATCTATACCGAAGCGAAATTAGACCCGACCTTTGTAAACGGCGGTTTGGTTAAATCGGCGGGGAAA
AATGCGCATTTGGGTGCAAGCCGTTATTTAATTGCGGAAGCGGATGAAAGTGATGCGTCGTTCTTACACTTACAACCGAT
GGTTTCGGTGGTGACTAATATCGAACCGGATCATATGGACACTTACGGCGGCGATTTCGAGCAGATGAAAGCGACTTACG
TAAAATTCCTACGCAACTTACCGTTCTACGGTTTAGCGGTGATGTGTGCCGATGATGAAACGGTAATAGAAATTGCGCCG
CAAGTCGGTCGCCAAGTATTAACTTACGGCTTTAGTGAAAAAGCGGATTACCGTATCGAAGATTATCAACAAACCGGTTT
CCAAGGTCATTACACTGTGGTTTGCCCGAACGGCGAGCGTATTGACGTATTGTTGAATGTGCCGGGTAAACACAATGCAC
TGAATGCAACAGCCGCACTGGCGGTCGCAAAAGAAGAAGGAATTGCTAACGAAGCGATTTTAGCCGCGCTTGCCGATTTC
CAAGGTGCAGGTCGTCGTTTTGACCAATTGGGTTCATTTATTCGTCCGAACGGTAAAGTGATGTTGGTTGATGACTACGG
TCATCACCCGACCGAAGTGGACGTAACAATTAAAGCTGCTCGTTCAGGTTGGGAAAACAAACGTGTTGTGATGATTTTCC
AACCGCACCGTTATTCGCGTACCCGTGATTTATTTGATGATTTCGTACAAGTGTTATCGCAAGTCGATGCGTTAATTATG
CTCGAAGTGTATGCGGCGGGCGAAGCGCCGATTGTCGGAGCGGATAGTAAAGCGTTATGCCGCTCAATCCGTAATTTGGG
TAAAGTGGATCCGATTTTAGTTTCGGATACCGATCAGCTCGGTGAAGTATTAGATCAAATTATCCAAGACGGCGATTTAA
TTCTTGCACAAGGTGCCGGTAGCGTAAGCCGCATTTCTCGTGGCTTGGCGGAAAGCTGGAAAGCCTAA

Upstream 100 bases:

>100_bases
TACCGCAGCACAACGTGTGGCGGAAGTGATTATCGAACAAGCTAAATAGTTTTAAATGCAATCAACAAAAATATTTGGTT
GCACAGATAGGAAAACAACA

Downstream 100 bases:

>100_bases
CAAGCGGTAAGATTTGCAAAAAATTTTGTAAAATTGACCGCTTGTGAATCTCCAATCGGTCAGTAGGGATACGAGACCTC
GTGTCCATAATAAGAAAGGA

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MKNFQDKIKKLVPEMRRVNQIHFIGIGGAGMSGIAEVLLNEGYQISGSDIAEGPVTKRLAEAGAKVFIGHQAENVAGASV
VVASSAIDDSNPEVRAAKEARIPVIQRAQMLAEIMRFRHGIAVAGTHGKTTTTAMISMIYTEAKLDPTFVNGGLVKSAGK
NAHLGASRYLIAEADESDASFLHLQPMVSVVTNIEPDHMDTYGGDFEQMKATYVKFLRNLPFYGLAVMCADDETVIEIAP
QVGRQVLTYGFSEKADYRIEDYQQTGFQGHYTVVCPNGERIDVLLNVPGKHNALNATAALAVAKEEGIANEAILAALADF
QGAGRRFDQLGSFIRPNGKVMLVDDYGHHPTEVDVTIKAARSGWENKRVVMIFQPHRYSRTRDLFDDFVQVLSQVDALIM
LEVYAAGEAPIVGADSKALCRSIRNLGKVDPILVSDTDQLGEVLDQIIQDGDLILAQGAGSVSRISRGLAESWKA

Sequences:

>Translated_475_residues
MKNFQDKIKKLVPEMRRVNQIHFIGIGGAGMSGIAEVLLNEGYQISGSDIAEGPVTKRLAEAGAKVFIGHQAENVAGASV
VVASSAIDDSNPEVRAAKEARIPVIQRAQMLAEIMRFRHGIAVAGTHGKTTTTAMISMIYTEAKLDPTFVNGGLVKSAGK
NAHLGASRYLIAEADESDASFLHLQPMVSVVTNIEPDHMDTYGGDFEQMKATYVKFLRNLPFYGLAVMCADDETVIEIAP
QVGRQVLTYGFSEKADYRIEDYQQTGFQGHYTVVCPNGERIDVLLNVPGKHNALNATAALAVAKEEGIANEAILAALADF
QGAGRRFDQLGSFIRPNGKVMLVDDYGHHPTEVDVTIKAARSGWENKRVVMIFQPHRYSRTRDLFDDFVQVLSQVDALIM
LEVYAAGEAPIVGADSKALCRSIRNLGKVDPILVSDTDQLGEVLDQIIQDGDLILAQGAGSVSRISRGLAESWKA
>Mature_475_residues
MKNFQDKIKKLVPEMRRVNQIHFIGIGGAGMSGIAEVLLNEGYQISGSDIAEGPVTKRLAEAGAKVFIGHQAENVAGASV
VVASSAIDDSNPEVRAAKEARIPVIQRAQMLAEIMRFRHGIAVAGTHGKTTTTAMISMIYTEAKLDPTFVNGGLVKSAGK
NAHLGASRYLIAEADESDASFLHLQPMVSVVTNIEPDHMDTYGGDFEQMKATYVKFLRNLPFYGLAVMCADDETVIEIAP
QVGRQVLTYGFSEKADYRIEDYQQTGFQGHYTVVCPNGERIDVLLNVPGKHNALNATAALAVAKEEGIANEAILAALADF
QGAGRRFDQLGSFIRPNGKVMLVDDYGHHPTEVDVTIKAARSGWENKRVVMIFQPHRYSRTRDLFDDFVQVLSQVDALIM
LEVYAAGEAPIVGADSKALCRSIRNLGKVDPILVSDTDQLGEVLDQIIQDGDLILAQGAGSVSRISRGLAESWKA

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=470, Percent_Identity=68.0851063829787, Blast_Score=601, Evalue=1e-173,
Organism=Escherichia coli, GI1790680, Length=476, Percent_Identity=28.3613445378151, Blast_Score=154, Evalue=8e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_ACTP2 (A3MY91)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001052732.1
- ProteinModelPortal:   A3MY91
- SMR:   A3MY91
- STRING:   A3MY91
- GeneID:   4849865
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0019
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- PhylomeDB:   A3MY91
- ProtClustDB:   PRK00421
- BioCyc:   APLE416269:APL_0019-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 51502; Mature: 51502

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNFQDKIKKLVPEMRRVNQIHFIGIGGAGMSGIAEVLLNEGYQISGSDIAEGPVTKRLA
CCCHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHCCCCEECCCCCCCCHHHHHHH
EAGAKVFIGHQAENVAGASVVVASSAIDDSNPEVRAAKEARIPVIQRAQMLAEIMRFRHG
HCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCEEEHHHCCCHHHHHHHHHHHHHHHHCC
IAVAGTHGKTTTTAMISMIYTEAKLDPTFVNGGLVKSAGKNAHLGASRYLIAEADESDAS
EEEEECCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCCCCCCCCCCEEEEEECCCCCCC
FLHLQPMVSVVTNIEPDHMDTYGGDFEQMKATYVKFLRNLPFYGLAVMCADDETVIEIAP
EEEHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEECCH
QVGRQVLTYGFSEKADYRIEDYQQTGFQGHYTVVCPNGERIDVLLNVPGKHNALNATAAL
HHHHHHHHCCCCCCCCCCCHHHHHCCCCCCEEEECCCCCEEEEEEECCCCCCCCCHHHHE
AVAKEEGIANEAILAALADFQGAGRRFDQLGSFIRPNGKVMLVDDYGHHPTEVDVTIKAA
EEHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEEEC
RSGWENKRVVMIFQPHRYSRTRDLFDDFVQVLSQVDALIMLEVYAAGEAPIVGADSKALC
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCEECCCHHHHH
RSIRNLGKVDPILVSDTDQLGEVLDQIIQDGDLILAQGAGSVSRISRGLAESWKA
HHHHHCCCCCCEEECCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MKNFQDKIKKLVPEMRRVNQIHFIGIGGAGMSGIAEVLLNEGYQISGSDIAEGPVTKRLA
CCCHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHCCCCEECCCCCCCCHHHHHHH
EAGAKVFIGHQAENVAGASVVVASSAIDDSNPEVRAAKEARIPVIQRAQMLAEIMRFRHG
HCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCEEEHHHCCCHHHHHHHHHHHHHHHHCC
IAVAGTHGKTTTTAMISMIYTEAKLDPTFVNGGLVKSAGKNAHLGASRYLIAEADESDAS
EEEEECCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCCCCCCCCCCEEEEEECCCCCCC
FLHLQPMVSVVTNIEPDHMDTYGGDFEQMKATYVKFLRNLPFYGLAVMCADDETVIEIAP
EEEHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEECCH
QVGRQVLTYGFSEKADYRIEDYQQTGFQGHYTVVCPNGERIDVLLNVPGKHNALNATAAL
HHHHHHHHCCCCCCCCCCCHHHHHCCCCCCEEEECCCCCEEEEEEECCCCCCCCCHHHHE
AVAKEEGIANEAILAALADFQGAGRRFDQLGSFIRPNGKVMLVDDYGHHPTEVDVTIKAA
EEHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEEEC
RSGWENKRVVMIFQPHRYSRTRDLFDDFVQVLSQVDALIMLEVYAAGEAPIVGADSKALC
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCEECCCHHHHH
RSIRNLGKVDPILVSDTDQLGEVLDQIIQDGDLILAQGAGSVSRISRGLAESWKA
HHHHHCCCCCCEEECCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA