Click here to switch to the map view.

The map label for this gene is dnaA [H]

Identifier: 126207489

GI number: 126207489

Start: 63

End: 1547

Strand: Direct

Name: dnaA [H]

Synonym: APL_0001

Alternate gene names: 126207489

Gene position: 63-1547 (Clockwise)

Preceding gene: NA

Following gene: 126207490

Centisome position: 0.0

GC content: 40.94

Gene sequence:

>1485_bases
ATGACCGATTTACTAGCTAAATTTTTCGGATCTGTCAATCGGATAAGCGGCAAATTTTTCACAAAAATTTACAAGATTTC
CACAGGATTTTCAGGTATTATAACCAATCTTTTTCACTCATTTTATTCCTTGGAGCAAATCGTGTCTTCCCTTTGGTCCG
ATTGTCTTAATCACTTACAAACGAAAGTATCGCCGACTGATTACAGCACTTGGCTACGCCCTTTGCAGGCAAGTTTTGCA
AACGGGGAACTCACGCTTTACGCTCAAAACCAATTTGTTGAAAATTGGGTAAAAGATAAATTTTTGGCGGAGATCGTCGA
TCTTGCCCGTTTTTTATCGAAAAATAACGATTTAGCGGTTTCGATTCGCGTCGGGATTAAACCGGCGGAACATAGACCTG
TCTCTCCAAGTACGACAAGCAGCAATTCAAAAGAAGAAGTACCAGAAACCAATAAAAATTTCAGAACGGGTTTAAACGAA
TCGCTTACTTTTGAGAATTTCGTACAAGGTAAATCCAACCAATTAGCCAAAGCGGTTGCCCAACAAGTAGCGGATAATCC
GGGCGAAAGTCACTGTAATCCGTTTTCACTTTACGGTGGTACCGGTTTGGGTAAAACCCATTTATTACATGCGGTCGGTA
ATGAAATTCTAAAACGTAACCCGCAAGCGAGAGTGGTCTATATTCACTCCGAGCGTTTTGTGCAAGATATGGTAAAAGCG
TTGAAAGGCAATACGATTGAGAATTTTAAGAAATTCTACCGTTCGCTTGATGTGCTGATGATTGACGATATTCAATTCTT
TGCCAATAAAGAAGCCTCACAGGAAGAGTTTTTCCACACGTTTAATTCCTTATTCGAACGTAATAAACAGATTATTTTAG
CTTCGGATAACTTCCCAAAAAATATTGAGAATATCGAAGAACGCATTAAATCTCGACTAAGTTGGGGCGTGAGTACCGCA
ATCGAACCGCCTGAATTGGAAACTCGAGTGGCGATTTTGATGAAAAAGGCGGAAGAGCGTGGAGTAGAGTTACCAGAAGA
AGTAGCGTTTTTCATCGGGCAAAAATTGCGTACCAATGTACGTGAGTTGGAAGGGGCATTAAACCGTGTGATTGCGTGGC
GTAACTTTACTAAGCGTCAAATCACGATTGATGCGGTGCGTGAAGCGTTAAAAGATCTGATCGCGTCTTACGATCATTTA
ATTACGATTGAAAATATTCAAAAAACGGTTGCCGAATATTACAACATTAAAATGTCTGACTTAAAGTCAAAGAGTCGTAC
CCGTTCGGTCGCTCGCCCTCGGCAAATGGCGATGGCATTGGCAAAAGAATTAACCAATCACAGCTTACCGGAAATCGGTC
GAGAATTCGGCGGACGTGATCACACTACCGTGATGCACGCTTGCAAAACGATTAATGAATTACGTGATACCGATAGCGGT
ATTCAAGAAGATTATACCAACTTAACCAGAAAATTATCGTCATAG

Upstream 100 bases:

>100_bases
TAAACCTTAAACTATGTGAAAAATATGTTTATTATAAAGATGAAAATCAGTAAGCGGTAGGAATTTGTTAAAAATATGTG
ATCTATAACACAGAAAATTG

Downstream 100 bases:

>100_bases
GCGATAAGGGATTATTATGCAGTTTACGATAACCAGAGAACAGTTACTTAAGCCTTTACAACAGGTCTGTGGCGTATTAA
GCAGCCGCCCGACGTTGCCT

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MTDLLAKFFGSVNRISGKFFTKIYKISTGFSGIITNLFHSFYSLEQIVSSLWSDCLNHLQTKVSPTDYSTWLRPLQASFA
NGELTLYAQNQFVENWVKDKFLAEIVDLARFLSKNNDLAVSIRVGIKPAEHRPVSPSTTSSNSKEEVPETNKNFRTGLNE
SLTFENFVQGKSNQLAKAVAQQVADNPGESHCNPFSLYGGTGLGKTHLLHAVGNEILKRNPQARVVYIHSERFVQDMVKA
LKGNTIENFKKFYRSLDVLMIDDIQFFANKEASQEEFFHTFNSLFERNKQIILASDNFPKNIENIEERIKSRLSWGVSTA
IEPPELETRVAILMKKAEERGVELPEEVAFFIGQKLRTNVRELEGALNRVIAWRNFTKRQITIDAVREALKDLIASYDHL
ITIENIQKTVAEYYNIKMSDLKSKSRTRSVARPRQMAMALAKELTNHSLPEIGREFGGRDHTTVMHACKTINELRDTDSG
IQEDYTNLTRKLSS

Sequences:

>Translated_494_residues
MTDLLAKFFGSVNRISGKFFTKIYKISTGFSGIITNLFHSFYSLEQIVSSLWSDCLNHLQTKVSPTDYSTWLRPLQASFA
NGELTLYAQNQFVENWVKDKFLAEIVDLARFLSKNNDLAVSIRVGIKPAEHRPVSPSTTSSNSKEEVPETNKNFRTGLNE
SLTFENFVQGKSNQLAKAVAQQVADNPGESHCNPFSLYGGTGLGKTHLLHAVGNEILKRNPQARVVYIHSERFVQDMVKA
LKGNTIENFKKFYRSLDVLMIDDIQFFANKEASQEEFFHTFNSLFERNKQIILASDNFPKNIENIEERIKSRLSWGVSTA
IEPPELETRVAILMKKAEERGVELPEEVAFFIGQKLRTNVRELEGALNRVIAWRNFTKRQITIDAVREALKDLIASYDHL
ITIENIQKTVAEYYNIKMSDLKSKSRTRSVARPRQMAMALAKELTNHSLPEIGREFGGRDHTTVMHACKTINELRDTDSG
IQEDYTNLTRKLSS
>Mature_493_residues
TDLLAKFFGSVNRISGKFFTKIYKISTGFSGIITNLFHSFYSLEQIVSSLWSDCLNHLQTKVSPTDYSTWLRPLQASFAN
GELTLYAQNQFVENWVKDKFLAEIVDLARFLSKNNDLAVSIRVGIKPAEHRPVSPSTTSSNSKEEVPETNKNFRTGLNES
LTFENFVQGKSNQLAKAVAQQVADNPGESHCNPFSLYGGTGLGKTHLLHAVGNEILKRNPQARVVYIHSERFVQDMVKAL
KGNTIENFKKFYRSLDVLMIDDIQFFANKEASQEEFFHTFNSLFERNKQIILASDNFPKNIENIEERIKSRLSWGVSTAI
EPPELETRVAILMKKAEERGVELPEEVAFFIGQKLRTNVRELEGALNRVIAWRNFTKRQITIDAVREALKDLIASYDHLI
TIENIQKTVAEYYNIKMSDLKSKSRTRSVARPRQMAMALAKELTNHSLPEIGREFGGRDHTTVMHACKTINELRDTDSGI
QEDYTNLTRKLSS

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=465, Percent_Identity=60, Blast_Score=570, Evalue=1e-164,
Organism=Escherichia coli, GI226510964, Length=236, Percent_Identity=25.8474576271186, Blast_Score=81, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 56219; Mature: 56087

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLLAKFFGSVNRISGKFFTKIYKISTGFSGIITNLFHSFYSLEQIVSSLWSDCLNHLQ
CHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TKVSPTDYSTWLRPLQASFANGELTLYAQNQFVENWVKDKFLAEIVDLARFLSKNNDLAV
HCCCCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
SIRVGIKPAEHRPVSPSTTSSNSKEEVPETNKNFRTGLNESLTFENFVQGKSNQLAKAVA
EEEECCCCCCCCCCCCCCCCCCCHHHCCCCCCHHHCCCCCCCCHHHHHCCCHHHHHHHHH
QQVADNPGESHCNPFSLYGGTGLGKTHLLHAVGNEILKRNPQARVVYIHSERFVQDMVKA
HHHHCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHH
LKGNTIENFKKFYRSLDVLMIDDIQFFANKEASQEEFFHTFNSLFERNKQIILASDNFPK
HCCCCHHHHHHHHHHCCHHEEHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCC
NIENIEERIKSRLSWGVSTAIEPPELETRVAILMKKAEERGVELPEEVAFFIGQKLRTNV
HHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
RELEGALNRVIAWRNFTKRQITIDAVREALKDLIASYDHLITIENIQKTVAEYYNIKMSD
HHHHHHHHHHHHHHCCCHHHEEHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHCCHHHH
LKSKSRTRSVARPRQMAMALAKELTNHSLPEIGREFGGRDHTTVMHACKTINELRDTDSG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCH
IQEDYTNLTRKLSS
HHHHHHHHHHHHCC
>Mature Secondary Structure 
TDLLAKFFGSVNRISGKFFTKIYKISTGFSGIITNLFHSFYSLEQIVSSLWSDCLNHLQ
HHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TKVSPTDYSTWLRPLQASFANGELTLYAQNQFVENWVKDKFLAEIVDLARFLSKNNDLAV
HCCCCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
SIRVGIKPAEHRPVSPSTTSSNSKEEVPETNKNFRTGLNESLTFENFVQGKSNQLAKAVA
EEEECCCCCCCCCCCCCCCCCCCHHHCCCCCCHHHCCCCCCCCHHHHHCCCHHHHHHHHH
QQVADNPGESHCNPFSLYGGTGLGKTHLLHAVGNEILKRNPQARVVYIHSERFVQDMVKA
HHHHCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHH
LKGNTIENFKKFYRSLDVLMIDDIQFFANKEASQEEFFHTFNSLFERNKQIILASDNFPK
HCCCCHHHHHHHHHHCCHHEEHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCC
NIENIEERIKSRLSWGVSTAIEPPELETRVAILMKKAEERGVELPEEVAFFIGQKLRTNV
HHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
RELEGALNRVIAWRNFTKRQITIDAVREALKDLIASYDHLITIENIQKTVAEYYNIKMSD
HHHHHHHHHHHHHHCCCHHHEEHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHCCHHHH
LKSKSRTRSVARPRQMAMALAKELTNHSLPEIGREFGGRDHTTVMHACKTINELRDTDSG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCH
IQEDYTNLTRKLSS
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA