Click here to switch to the map view.

The map label for this gene is panB [H]

Identifier: 126175691

GI number: 126175691

Start: 4094411

End: 4095205

Strand: Direct

Name: panB [H]

Synonym: Sbal_3494

Alternate gene names: 126175691

Gene position: 4094411-4095205 (Clockwise)

Preceding gene: 126175690

Following gene: 126175692

Centisome position: 79.85

GC content: 49.69

Gene sequence:

>795_bases
ATGTCTAAAATTACTAGCTCAACCCTGTTGAAATACAAACAGGAAGGTAGAAAATTCACGGCACTGACAGCCTATGATGC
CAGTTTTGCCAGCGCGTTCGATAGCGAAGGTGTAGATGTGCTGCTCGTCGGCGATTCTCTAGGAATGGTTCTCCAAGGCC
ATGACGATACCCTGCCAGTCTCTACGGCGGATATCGCTTACCATACTCGCTGTGTCCGTCGCGGTATCGAACGTGCCCTG
CTGATCGCCGATATGCCCTTTATGAGTTACGCCACACCAGAACAAGCTATGGTTAATGCCACTGAGTTAATGCAGGCTGG
CGCGAACATGGTAAAAGTCGAAGGTGGCCACTGGTTACTCGAAACGGTCACTAAGCTAACCGAACGCGGTATTCCCGTGT
GTGCTCACTTAGGGCTAACGCCTCAGTCAGTCCATGTGTTTGGTGGTTTTAAAGTGCAAGGCCGCGACGCCGAAAATGCC
CAGCGCATCCTCGACGAAGCAAAAGCATTAGAAGCAGCCGGTGCTCAACTATTGGTTGTGGAATGCATTCCAGCGCCACT
CGCAGCGGCGATCACTCAAGCCTTAACAATTCCAGTTATTGGGATTGGCGCGGGCGCATCGACCGATGGCCAAATTTTGG
TTATGCATGATGTGTTAGGTATTTCAAGTGGTTATATTCCACGTTTCTCGAAAAACTACCTAAAACAAACCGGTGAAATT
CGTTCTGCCGTGCGTGCTTATATCGACGAAGTTGCCCAAGGAACATTCCCTGGCGAAGAACACACTTTTAACTAA

Upstream 100 bases:

>100_bases
CAAAAATGTTGGCCGAGTTACAACAACTGGGCATTGATCATTGAAGTCCGTCCCCAGTTAGCTTATAACACCACTTCTAT
TTGGTTTGAAGATCATCCAT

Downstream 100 bases:

>100_bases
TAACCGATTTATGCAAGGTAAGGCTCAATGATCACTAGCGCCCATATTGATGATATTCGCACCCAAGTGCGTGCATGGCG
TGCCAAGGGCGAAACCGTCG

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MSKITSSTLLKYKQEGRKFTALTAYDASFASAFDSEGVDVLLVGDSLGMVLQGHDDTLPVSTADIAYHTRCVRRGIERAL
LIADMPFMSYATPEQAMVNATELMQAGANMVKVEGGHWLLETVTKLTERGIPVCAHLGLTPQSVHVFGGFKVQGRDAENA
QRILDEAKALEAAGAQLLVVECIPAPLAAAITQALTIPVIGIGAGASTDGQILVMHDVLGISSGYIPRFSKNYLKQTGEI
RSAVRAYIDEVAQGTFPGEEHTFN

Sequences:

>Translated_264_residues
MSKITSSTLLKYKQEGRKFTALTAYDASFASAFDSEGVDVLLVGDSLGMVLQGHDDTLPVSTADIAYHTRCVRRGIERAL
LIADMPFMSYATPEQAMVNATELMQAGANMVKVEGGHWLLETVTKLTERGIPVCAHLGLTPQSVHVFGGFKVQGRDAENA
QRILDEAKALEAAGAQLLVVECIPAPLAAAITQALTIPVIGIGAGASTDGQILVMHDVLGISSGYIPRFSKNYLKQTGEI
RSAVRAYIDEVAQGTFPGEEHTFN
>Mature_263_residues
SKITSSTLLKYKQEGRKFTALTAYDASFASAFDSEGVDVLLVGDSLGMVLQGHDDTLPVSTADIAYHTRCVRRGIERALL
IADMPFMSYATPEQAMVNATELMQAGANMVKVEGGHWLLETVTKLTERGIPVCAHLGLTPQSVHVFGGFKVQGRDAENAQ
RILDEAKALEAAGAQLLVVECIPAPLAAAITQALTIPVIGIGAGASTDGQILVMHDVLGISSGYIPRFSKNYLKQTGEIR
SAVRAYIDEVAQGTFPGEEHTFN

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=264, Percent_Identity=65.1515151515152, Blast_Score=368, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6319653, Length=258, Percent_Identity=36.8217054263566, Blast_Score=171, Evalue=1e-43,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 28224; Mature: 28092

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKITSSTLLKYKQEGRKFTALTAYDASFASAFDSEGVDVLLVGDSLGMVLQGHDDTLPV
CCCCHHHHHHHHHHCCCEEEEEEEECCHHHHHHCCCCCEEEEECCCCCEEEECCCCCCCC
STADIAYHTRCVRRGIERALLIADMPFMSYATPEQAMVNATELMQAGANMVKVEGGHWLL
CHHHHHHHHHHHHHHHHHEEHHCCCCCHHCCCCHHHHHHHHHHHHCCCCEEEEECCCHHH
ETVTKLTERGIPVCAHLGLTPQSVHVFGGFKVQGRDAENAQRILDEAKALEAAGAQLLVV
HHHHHHHHCCCCEEEECCCCCCEEEEEECEEEECCCHHHHHHHHHHHHHHHHCCCEEEEE
ECIPAPLAAAITQALTIPVIGIGAGASTDGQILVMHDVLGISSGYIPRFSKNYLKQTGEI
EECCCHHHHHHHHHHHHCEEEECCCCCCCCCEEEEEEHHCCCCCCCCCHHHHHHHHHHHH
RSAVRAYIDEVAQGTFPGEEHTFN
HHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SKITSSTLLKYKQEGRKFTALTAYDASFASAFDSEGVDVLLVGDSLGMVLQGHDDTLPV
CCCHHHHHHHHHHCCCEEEEEEEECCHHHHHHCCCCCEEEEECCCCCEEEECCCCCCCC
STADIAYHTRCVRRGIERALLIADMPFMSYATPEQAMVNATELMQAGANMVKVEGGHWLL
CHHHHHHHHHHHHHHHHHEEHHCCCCCHHCCCCHHHHHHHHHHHHCCCCEEEEECCCHHH
ETVTKLTERGIPVCAHLGLTPQSVHVFGGFKVQGRDAENAQRILDEAKALEAAGAQLLVV
HHHHHHHHCCCCEEEECCCCCCEEEEEECEEEECCCHHHHHHHHHHHHHHHHCCCEEEEE
ECIPAPLAAAITQALTIPVIGIGAGASTDGQILVMHDVLGISSGYIPRFSKNYLKQTGEI
EECCCHHHHHHHHHHHHCEEEECCCCCCCCCEEEEEEHHCCCCCCCCCHHHHHHHHHHHH
RSAVRAYIDEVAQGTFPGEEHTFN
HHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]