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The map label for this gene is hemH2 [H]

Identifier: 126175223

GI number: 126175223

Start: 3545801

End: 3546814

Strand: Reverse

Name: hemH2 [H]

Synonym: Sbal_3021

Alternate gene names: 126175223

Gene position: 3546814-3545801 (Counterclockwise)

Preceding gene: 126175224

Following gene: 126175218

Centisome position: 69.17

GC content: 45.17

Gene sequence:

>1014_bases
TTGGCTAAATTTTCAGGCTTATCCAAAGAAGTTGGACACGGACAGCGCGGCAAAGTGGGCGTGCTGTTATTAAATTTAGG
TACGCCAGATGCACCCACAGCATCGGCTGTTAGGCGTTATCTTGCTGAGTTCTTAGCAGATCCCCGCGTAGTCGAAATCC
CTAAATTAGTGTGGATGATGATTTTACACGGGATAATTTTGCGGGTACGCCCAGCAAAATCGGCAGCGTTATACCAGAAG
GTATGGACAGCGGCCGGTTCACCGTTAATGGACATTAGTTTGCGTCAAACGGCGAAGTTAGCGGATAAACTTAACGCTGA
TAACCATGATGTTTCTGTCCATTTAGCAATGCGTTATGGCAGTCCATCGGTTGCCAGTACCTTGCAAACTATGCATCAAA
ATGGCATTGATAAAATCGTGGTGTTACCTCTGTATCCCCAATATGCGGCGCCCACTACGGGTTCTGCTTTTGATGCGATT
GCGGCTGAGTTGTCCAAGTGGCGCTATATTCCATCGTTGCATTTTATTAATACTTATCATGATAATGCTGATTTTATTAA
CGCGTTAGCCAGTTCGATCACGGCTGATTTTGAAGCCCATGGTAAACCGCAAAAATTGGTGTTGTCTTATCATGGTATGC
CTGAGCGTAATTTACATTTAGGCGATCCGTATTATTGCTTCTGCATGAAAACGACTCGACTGGTTACCGAAAAGCTTGGG
TTAGGTAAAGATGAGTTTGTGATGACATTTCAATCGCGTTTTGGTAAAGCCAAATGGCTACAACCTTATACCGATGCGAC
TTTGAAAGCGTTGCCGCAACAAGGCGTGCGCGATATTGCTATCGTTTGCCCGGCTTTTAGCGCCGATTGTTTAGAAACGC
TGGAAGAAATTGTTGGTGAGAATGGTCATCTCTTTGCCGAGGCGGGTGGTGAGAAGTTCCGCTACATTGCTGCACTAAAC
GATGATGATGCACACATTACTATGATGGCCAACTTAGTGAAGCCACATTTTTGA

Upstream 100 bases:

>100_bases
AACAGTTCAATTCTAAAGTGAAGCCAGATAGCGAAGAGCTTAAGCAAGCAATAGAATCTGTACTTTAATTTTATAAGTAT
TTATTAATTAAGAGGCTGTT

Downstream 100 bases:

>100_bases
TCCGGTAATTTATCGGGTTAAACATCAAACAGAAAAGGATAAGGCAACTTATCCTTTTCTTTTTTCTGTGGTTTTATTTA
TTGTGGCATTACTTGCTGAA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase 2; Protoheme ferro-lyase 2 [H]

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MAKFSGLSKEVGHGQRGKVGVLLLNLGTPDAPTASAVRRYLAEFLADPRVVEIPKLVWMMILHGIILRVRPAKSAALYQK
VWTAAGSPLMDISLRQTAKLADKLNADNHDVSVHLAMRYGSPSVASTLQTMHQNGIDKIVVLPLYPQYAAPTTGSAFDAI
AAELSKWRYIPSLHFINTYHDNADFINALASSITADFEAHGKPQKLVLSYHGMPERNLHLGDPYYCFCMKTTRLVTEKLG
LGKDEFVMTFQSRFGKAKWLQPYTDATLKALPQQGVRDIAIVCPAFSADCLETLEEIVGENGHLFAEAGGEKFRYIAALN
DDDAHITMMANLVKPHF

Sequences:

>Translated_337_residues
MAKFSGLSKEVGHGQRGKVGVLLLNLGTPDAPTASAVRRYLAEFLADPRVVEIPKLVWMMILHGIILRVRPAKSAALYQK
VWTAAGSPLMDISLRQTAKLADKLNADNHDVSVHLAMRYGSPSVASTLQTMHQNGIDKIVVLPLYPQYAAPTTGSAFDAI
AAELSKWRYIPSLHFINTYHDNADFINALASSITADFEAHGKPQKLVLSYHGMPERNLHLGDPYYCFCMKTTRLVTEKLG
LGKDEFVMTFQSRFGKAKWLQPYTDATLKALPQQGVRDIAIVCPAFSADCLETLEEIVGENGHLFAEAGGEKFRYIAALN
DDDAHITMMANLVKPHF
>Mature_336_residues
AKFSGLSKEVGHGQRGKVGVLLLNLGTPDAPTASAVRRYLAEFLADPRVVEIPKLVWMMILHGIILRVRPAKSAALYQKV
WTAAGSPLMDISLRQTAKLADKLNADNHDVSVHLAMRYGSPSVASTLQTMHQNGIDKIVVLPLYPQYAAPTTGSAFDAIA
AELSKWRYIPSLHFINTYHDNADFINALASSITADFEAHGKPQKLVLSYHGMPERNLHLGDPYYCFCMKTTRLVTEKLGL
GKDEFVMTFQSRFGKAKWLQPYTDATLKALPQQGVRDIAIVCPAFSADCLETLEEIVGENGHLFAEAGGEKFRYIAALND
DDAHITMMANLVKPHF

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=333, Percent_Identity=27.027027027027, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI60499025, Length=333, Percent_Identity=27.027027027027, Blast_Score=112, Evalue=7e-25,
Organism=Escherichia coli, GI1786681, Length=319, Percent_Identity=49.8432601880878, Blast_Score=311, Evalue=3e-86,
Organism=Saccharomyces cerevisiae, GI6324750, Length=342, Percent_Identity=26.0233918128655, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17864156, Length=346, Percent_Identity=24.8554913294798, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24651774, Length=277, Percent_Identity=23.4657039711191, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 37184; Mature: 37053

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKFSGLSKEVGHGQRGKVGVLLLNLGTPDAPTASAVRRYLAEFLADPRVVEIPKLVWMM
CCCCCCCCHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHHH
ILHGIILRVRPAKSAALYQKVWTAAGSPLMDISLRQTAKLADKLNADNHDVSVHLAMRYG
HHHHHHEEECCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCEEEEEEEECC
SPSVASTLQTMHQNGIDKIVVLPLYPQYAAPTTGSAFDAIAAELSKWRYIPSLHFINTYH
CCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECC
DNADFINALASSITADFEAHGKPQKLVLSYHGMPERNLHLGDPYYCFCMKTTRLVTEKLG
CCHHHHHHHHHHHHCCHHCCCCCCEEEEEECCCCCCCEECCCCEEEEEEHHHHHHHHHHC
LGKDEFVMTFQSRFGKAKWLQPYTDATLKALPQQGVRDIAIVCPAFSADCLETLEEIVGE
CCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCC
NGHLFAEAGGEKFRYIAALNDDDAHITMMANLVKPHF
CCEEEEECCCCEEEEEEEECCCCCEEEEEEHHHCCCC
>Mature Secondary Structure 
AKFSGLSKEVGHGQRGKVGVLLLNLGTPDAPTASAVRRYLAEFLADPRVVEIPKLVWMM
CCCCCCCHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHHH
ILHGIILRVRPAKSAALYQKVWTAAGSPLMDISLRQTAKLADKLNADNHDVSVHLAMRYG
HHHHHHEEECCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCEEEEEEEECC
SPSVASTLQTMHQNGIDKIVVLPLYPQYAAPTTGSAFDAIAAELSKWRYIPSLHFINTYH
CCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECC
DNADFINALASSITADFEAHGKPQKLVLSYHGMPERNLHLGDPYYCFCMKTTRLVTEKLG
CCHHHHHHHHHHHHCCHHCCCCCCEEEEEECCCCCCCEECCCCEEEEEEHHHHHHHHHHC
LGKDEFVMTFQSRFGKAKWLQPYTDATLKALPQQGVRDIAIVCPAFSADCLETLEEIVGE
CCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCC
NGHLFAEAGGEKFRYIAALNDDDAHITMMANLVKPHF
CCEEEEECCCCEEEEEEEECCCCCEEEEEEHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]