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The map label for this gene is etrA [H]

Identifier: 126174425

GI number: 126174425

Start: 2554384

End: 2555136

Strand: Direct

Name: etrA [H]

Synonym: Sbal_2209

Alternate gene names: 126174425

Gene position: 2554384-2555136 (Clockwise)

Preceding gene: 126174424

Following gene: 126174426

Centisome position: 49.82

GC content: 46.61

Gene sequence:

>753_bases
ATGACAATTGAACAAAATAAGAATCGTCGTCCTGCCGCTAGCGGATGCACAATCCATTGTCACGATTGCAGTATGGGTAC
CCTTTGTATTCCTTTTACCCTCAATGCAAGTGAGCTAGATCAGCTCGATGATATTATTGAGCGTAAAAAGCCGATCCAAA
AAGGCGAGCAAATTTTTAAATCGGGTGATGCGTTAAAGTCCCTGTTTGCGATCCGCTCTGGCACCATCAAAAGTTACACT
ATCACCGAGCAAGGCGATGAGCAGATCACCGGCTTTCACTTAGCGGGTGATGTGATTGGTTTTGACGGTATCCACGCCCA
GTTGCACCAGAGTTTTGCACAGGCACTCGAGACCTCCATGGTCTGTGAAATCCCCTTTAACATCCTCGATGAACTTTCAG
GCACTATGCCAAAATTGCGTCAGCAGATCATGCGCCTGATGAGCAATGAGATCATGAGCGATCAAGAAATGATCCTGCTA
CTCAGCAAGAAAAATGCCGAAGAACGTCTGGCAGCCTTTATCAGTAATCTGGCTAATCGTTTTGGTAGCCGTGGCTTCTC
GCCCAAAGAATTCCGCTTAACCATGACCCGCGGTGACATTGGTAATTATCTCGGTTTGACCGTAGAGACCATCAGTCGCT
TACTTGGGCGTTTCCAAAAATCAGGCTTGATTGAAGTTAAGGGAAAGTACATCACTATCCTCGACTCGCAAGAGCTGAAT
CTATTAGCGGGTAATTCGCGCATAGCGAGATAG

Upstream 100 bases:

>100_bases
TTTGGTGGTCAAACTTTATATATCGCACTCGCGCAGCTAAACTAGCCCAAGTGAGTGAATTGGTTTAACATGGCTGCAGT
GGATAAACTTGAGAATCAAC

Downstream 100 bases:

>100_bases
TTCACCGCAAGAGTGTTTGCTGCAATAAAGTTAAGCGCAGCATAATAGTTAAGTGCAAGAGAGTTACGCGCTAGGTCCTT
GCCATGAATGGCAAGAACAA

Product: fumarate/nitrate reduction transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MTIEQNKNRRPAASGCTIHCHDCSMGTLCIPFTLNASELDQLDDIIERKKPIQKGEQIFKSGDALKSLFAIRSGTIKSYT
ITEQGDEQITGFHLAGDVIGFDGIHAQLHQSFAQALETSMVCEIPFNILDELSGTMPKLRQQIMRLMSNEIMSDQEMILL
LSKKNAEERLAAFISNLANRFGSRGFSPKEFRLTMTRGDIGNYLGLTVETISRLLGRFQKSGLIEVKGKYITILDSQELN
LLAGNSRIAR

Sequences:

>Translated_250_residues
MTIEQNKNRRPAASGCTIHCHDCSMGTLCIPFTLNASELDQLDDIIERKKPIQKGEQIFKSGDALKSLFAIRSGTIKSYT
ITEQGDEQITGFHLAGDVIGFDGIHAQLHQSFAQALETSMVCEIPFNILDELSGTMPKLRQQIMRLMSNEIMSDQEMILL
LSKKNAEERLAAFISNLANRFGSRGFSPKEFRLTMTRGDIGNYLGLTVETISRLLGRFQKSGLIEVKGKYITILDSQELN
LLAGNSRIAR
>Mature_249_residues
TIEQNKNRRPAASGCTIHCHDCSMGTLCIPFTLNASELDQLDDIIERKKPIQKGEQIFKSGDALKSLFAIRSGTIKSYTI
TEQGDEQITGFHLAGDVIGFDGIHAQLHQSFAQALETSMVCEIPFNILDELSGTMPKLRQQIMRLMSNEIMSDQEMILLL
SKKNAEERLAAFISNLANRFGSRGFSPKEFRLTMTRGDIGNYLGLTVETISRLLGRFQKSGLIEVKGKYITILDSQELNL
LAGNSRIAR

Specific function: Regulates anaerobic growth on fumarate, nitrite, Fe(3+), TMAO, DMSO, thiosulfate and sulfite, but not on nitrate nor Mn(4+) [H]

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787595, Length=247, Percent_Identity=75.7085020242915, Blast_Score=384, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 27861; Mature: 27729

Theoretical pI: Translated: 7.46; Mature: 7.46

Prosite motif: PS50042 CNMP_BINDING_3 ; PS00042 HTH_CRP_1 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIEQNKNRRPAASGCTIHCHDCSMGTLCIPFTLNASELDQLDDIIERKKPIQKGEQIFK
CCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEEECHHHHHHHHHHHHHHCCHHHHHHHHH
SGDALKSLFAIRSGTIKSYTITEQGDEQITGFHLAGDVIGFDGIHAQLHQSFAQALETSM
CHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEECCHHCCCHHHHHHHHHHHHHHHHHE
VCEIPFNILDELSGTMPKLRQQIMRLMSNEIMSDQEMILLLSKKNAEERLAAFISNLANR
EEECCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHH
FGSRGFSPKEFRLTMTRGDIGNYLGLTVETISRLLGRFQKSGLIEVKGKYITILDSQELN
HCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCEEEEEECCCCE
LLAGNSRIAR
EEECCCCCCC
>Mature Secondary Structure 
TIEQNKNRRPAASGCTIHCHDCSMGTLCIPFTLNASELDQLDDIIERKKPIQKGEQIFK
CCCCCCCCCCCCCCCEEEEECCCCCCEEEEEEECHHHHHHHHHHHHHHCCHHHHHHHHH
SGDALKSLFAIRSGTIKSYTITEQGDEQITGFHLAGDVIGFDGIHAQLHQSFAQALETSM
CHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEECCHHCCCHHHHHHHHHHHHHHHHHE
VCEIPFNILDELSGTMPKLRQQIMRLMSNEIMSDQEMILLLSKKNAEERLAAFISNLANR
EEECCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHH
FGSRGFSPKEFRLTMTRGDIGNYLGLTVETISRLLGRFQKSGLIEVKGKYITILDSQELN
HCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCEEEEEECCCCE
LLAGNSRIAR
EEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8253682; 12368813 [H]