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The map label for this gene is pan [H]

Identifier: 126173584

GI number: 126173584

Start: 1543275

End: 1544159

Strand: Reverse

Name: pan [H]

Synonym: Sbal_1346

Alternate gene names: 126173584

Gene position: 1544159-1543275 (Counterclockwise)

Preceding gene: 126173585

Following gene: 126173579

Centisome position: 30.12

GC content: 42.15

Gene sequence:

>885_bases
ATGAGTTACGACGGGCGTGTCAGTGTTAAGTCTATCGGCTACGGTATGCACCTGTTTAAATACCATGGTTGTATCATGTT
GGCGACCCGTACTAAGGTCGATAGTACGATGGCATACGATACTATTACTGTAAGTGCACCATGGTGGGCAAAAGATAAAC
TACATAGTTTTTTAGAAGATACTCGTGGAGACATCTCTACTGAGCCGAAAGTTAATATTTTCGAAGAAACCGAATGGTGT
CGCTATGGCATATTGAAATCATCGGGTTTTAGTGAATTAGTGCTTGATGAAGGGTTTAAGCAGGAGTTGATGGGGGAAGT
TGATAACTTCGCAAGTAGGGGGGAATCGGTTGTAAGTAAGCTAACCATACTGTTACATGGAAAAACGGGTACGGGTAAGA
CGGGTATAGCGAGAGCCTTAGCCGTTGAGTATCATCGCGATCTATACATATTGAATCTATCGACTGTAAATGATGCCACT
ATTCATAAGGCTATTAGAAAAGTACCGCCCGGAGCTATGTTGTTAATCGAGGACTGTGACTGTGTAAAGGCTACTGTATC
ACGAACTGCTGAAAGCAATGCAGATAACCCACCACTCACTTTAGGTGGCGTTCTAAACGCGTTAGACGGAATCATTCCTC
TTGATGACTGCCTTGTAATAATGACCACAAATCATCCTGATAATCTTGACCCCGCGTTAATACGTAAAGGTCGTGTAGAT
GTCAGTATTGAAGTACCACTTATTAGTGCAAAACAAGTTAATGAAGACTACTTTGAACGTTTTGGCGCAGTTCTTAATAG
AACTGAGCCATTGTTAGGTTGTGAAGTCTATGAACTCCATCGCAGAGCGAACTTAAGATATGGTGTGTGTTGTAAGCCAG
TGTAA

Upstream 100 bases:

>100_bases
AGACCCCATCAATATAATGGTGGGTTAACGCCAAATGAGTCAGAACGTTTATATTGGAATGACTCTAAAACCGTGGCCAA
TTTTACTTGACCACTACAGT

Downstream 100 bases:

>100_bases
ACCTCTTCCTCTGTAATAGACGGGAGTGTCTTCAACACTTATCTGAGTTCTGCGAGGGTGCGGCATACAAACCTCCTTGT
TTAATGCTTAACCCAAGCAT

Product: ATPase central domain-containing protein

Products: NA

Alternate protein names: PAN; Proteasomal ATPase; Proteasome regulatory ATPase; Proteasome regulatory particle [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MSYDGRVSVKSIGYGMHLFKYHGCIMLATRTKVDSTMAYDTITVSAPWWAKDKLHSFLEDTRGDISTEPKVNIFEETEWC
RYGILKSSGFSELVLDEGFKQELMGEVDNFASRGESVVSKLTILLHGKTGTGKTGIARALAVEYHRDLYILNLSTVNDAT
IHKAIRKVPPGAMLLIEDCDCVKATVSRTAESNADNPPLTLGGVLNALDGIIPLDDCLVIMTTNHPDNLDPALIRKGRVD
VSIEVPLISAKQVNEDYFERFGAVLNRTEPLLGCEVYELHRRANLRYGVCCKPV

Sequences:

>Translated_294_residues
MSYDGRVSVKSIGYGMHLFKYHGCIMLATRTKVDSTMAYDTITVSAPWWAKDKLHSFLEDTRGDISTEPKVNIFEETEWC
RYGILKSSGFSELVLDEGFKQELMGEVDNFASRGESVVSKLTILLHGKTGTGKTGIARALAVEYHRDLYILNLSTVNDAT
IHKAIRKVPPGAMLLIEDCDCVKATVSRTAESNADNPPLTLGGVLNALDGIIPLDDCLVIMTTNHPDNLDPALIRKGRVD
VSIEVPLISAKQVNEDYFERFGAVLNRTEPLLGCEVYELHRRANLRYGVCCKPV
>Mature_293_residues
SYDGRVSVKSIGYGMHLFKYHGCIMLATRTKVDSTMAYDTITVSAPWWAKDKLHSFLEDTRGDISTEPKVNIFEETEWCR
YGILKSSGFSELVLDEGFKQELMGEVDNFASRGESVVSKLTILLHGKTGTGKTGIARALAVEYHRDLYILNLSTVNDATI
HKAIRKVPPGAMLLIEDCDCVKATVSRTAESNADNPPLTLGGVLNALDGIIPLDDCLVIMTTNHPDNLDPALIRKGRVDV
SIEVPLISAKQVNEDYFERFGAVLNRTEPLLGCEVYELHRRANLRYGVCCKPV

Specific function: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereb

COG id: COG0465

COG function: function code O; ATP-dependent Zn proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AAA ATPase family [H]

Homologues:

Organism=Homo sapiens, GI4757852, Length=288, Percent_Identity=28.4722222222222, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI119964730, Length=288, Percent_Identity=28.4722222222222, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71990340, Length=181, Percent_Identity=35.3591160220994, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71990335, Length=181, Percent_Identity=35.3591160220994, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17508701, Length=157, Percent_Identity=32.484076433121, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320583, Length=280, Percent_Identity=30.7142857142857, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6324833, Length=134, Percent_Identity=31.3432835820896, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20129417, Length=305, Percent_Identity=28.8524590163934, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24583262, Length=305, Percent_Identity=28.8524590163934, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24640100, Length=133, Percent_Identity=33.0827067669173, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24663015, Length=133, Percent_Identity=32.3308270676692, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005937
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR003960 [H]

Pfam domain/function: PF00004 AAA [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 32570; Mature: 32439

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYDGRVSVKSIGYGMHLFKYHGCIMLATRTKVDSTMAYDTITVSAPWWAKDKLHSFLED
CCCCCEEEEECCCCCHHEEECCCEEEEEECCCCCCEEEEEEEEECCCCCCHHHHHHHHHH
TRGDISTEPKVNIFEETEWCRYGILKSSGFSELVLDEGFKQELMGEVDNFASRGESVVSK
HCCCCCCCCCEEEECCCCHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHE
LTILLHGKTGTGKTGIARALAVEYHRDLYILNLSTVNDATIHKAIRKVPPGAMLLIEDCD
EEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCC
CVKATVSRTAESNADNPPLTLGGVLNALDGIIPLDDCLVIMTTNHPDNLDPALIRKGRVD
HHHHHHHHHHHCCCCCCCEEHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHCCCEE
VSIEVPLISAKQVNEDYFERFGAVLNRTEPLLGCEVYELHRRANLRYGVCCKPV
EEEEEEEECHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEEECCC
>Mature Secondary Structure 
SYDGRVSVKSIGYGMHLFKYHGCIMLATRTKVDSTMAYDTITVSAPWWAKDKLHSFLED
CCCCEEEEECCCCCHHEEECCCEEEEEECCCCCCEEEEEEEEECCCCCCHHHHHHHHHH
TRGDISTEPKVNIFEETEWCRYGILKSSGFSELVLDEGFKQELMGEVDNFASRGESVVSK
HCCCCCCCCCEEEECCCCHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHE
LTILLHGKTGTGKTGIARALAVEYHRDLYILNLSTVNDATIHKAIRKVPPGAMLLIEDCD
EEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCC
CVKATVSRTAESNADNPPLTLGGVLNALDGIIPLDDCLVIMTTNHPDNLDPALIRKGRVD
HHHHHHHHHHHCCCCCCCEEHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHCCCEE
VSIEVPLISAKQVNEDYFERFGAVLNRTEPLLGCEVYELHRRANLRYGVCCKPV
EEEEEEEECHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Metalloendopeptidases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014 [H]