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The map label for this gene is fhs [H]

Identifier: 125624396

GI number: 125624396

Start: 1568416

End: 1570083

Strand: Reverse

Name: fhs [H]

Synonym: llmg_1595

Alternate gene names: 125624396

Gene position: 1570083-1568416 (Counterclockwise)

Preceding gene: 125624397

Following gene: 125624395

Centisome position: 62.07

GC content: 40.17

Gene sequence:

>1668_bases
ATGAAAACAGATATTGAAATTGCCCAAGCTGCTGAAATTCAACCAATTACTAAAATTGCCGAAAAAATAGGATTATCTTT
TGACGATATTGAACTTTACGGAAAATATAAGGCTAAAATTCCCTTAGAAGTGTTAGAAAAGTTTGATGAACAAAACGATG
GGAAATTGGTTTTAGTGACATCTATTAACCCTACACCAGCGGGTGAGGGTAAATCGACGGTGACAGTGGGCCTTGCTGAT
GCCTTTGCCAGACAAGATAAAAATGTAATGGTTGCTCTACGGGAGCCTTCTCTTGGTCCGGTCATGGGAATTAAAGGTGG
AGCAGCTGGTGGTGGATTTGCTCAAGTTCTTCCAATGGAAGACATTAATCTTCATTTTACAGGAGATATTCATGCCATTA
CAACGGCTAATAATGCAATTTCGGCTTTTCTGGACAATTCGCTTCATCAAGGGAATCCTTTAAATATTGACCCACGAAGA
ATTATCTGGAAACGTGTGCTTGATTTGAACGACCGTGCTTTACGTCATGTAACGATTGGACTGGGTGGACCGCTTAATGG
GGTTCCTCGTGAGGATGGTTTTGATATTACGGTGGCTAGCGAAATTATGGCTGTTCTTTGTTTGGCGACTTCTATCAGTG
ATTTGAAAGAGCGCTTAGCAAGAATTGTCATCGCTCAAAATTATGACCGTAAACCTGTCAGTGTCGGAGATTTAGGGGTT
CAGGGGGCAATTGCAATGCTCTTAAAAGATGCCCTTAAACCAAACCTTGTTCAAACAATTGAAGGAACGCCAGCTTTAAT
TCACGGTGGACCTTTTGCTAATATTGCCCATGGATGTAATTCTGTTTTAGCAACAAAAACAGCACTTAAATTGGCTGATA
TTGTCATTACAGAGGCAGGATTTGGAGCTGACCTTGGTGGTGAAAAATTTTTGGATATCAAGACACGTCAGTTAGGGAAA
CAACCTGATGCTGTGGTAATTGTGGCTACGCTTCGTGCGCTTAAGATGCACGGTGGCGTTGATAAGAAAGAATTGACAAG
TGAAAATGTCGAGGCTGTTAAAAAAGGGTTTGCTAATTTGGAACGCCATATCAAAAACATGCAAAGTTATGGCCTGCCAG
TTATTGTAGCGATTAATCAATTTGCATCGGATACAGAGTCAGAAATTTCAACTTTAAAAGAACTGACAGAAGCTTTGGGA
GTTTCAGTTTCACTAACTCAAGTTTTTGCTAAAGGTGGCGAAGGTGGTTTAGATTTAGCTGAAAAACTGTCAGCAATGTT
ACAAGCAAAACCTGATTTCCGCTATCTTTATGAGCTAAATCAACCCTTGTCAGTAAAACTTGACAAAGTTGTGACAGAAA
TTTATGGCGGTTCCAAAGTTAATTTATCTCCGAAAGCTAAGCGTCAGATGAGAGAAATTGAAGAAAATGGTTGGAATAAC
TTACCAGTTTGTATGGCTAAAACGCAGTATTCATTTTCAGACCAAGCGAATCTTTTAGCAGCTCCCGAAGGCTTTGAGGT
TACAGTTCGTGAGCTGATTCCGAAAATCGGTGCTGGATTTATTGTTGCTCTTTTAGGAGATGTGATGACGATGCCAGGTC
TACCCAAAAATCCTGCTGCTTTAAAAATGGACGTGACTGATGATGGTAAAATCTCAGGATTATTTTAG

Upstream 100 bases:

>100_bases
TAAATATTTTTGAGAGTAAATTATAGAAAAATTTGTTAGAATAATATTAAAATTAGTATGATTTAAAGAAAATTTAAGCT
TATATTTTCAGAGGAGAATT

Downstream 100 bases:

>100_bases
AAATGGATTTCAAGGGGTTTGTTACTGTAAAATTAAGTGTAAATTTTTTTGGTAACAAATTTACAAAAAATTAAAAGCTT
GTAAAACCGCTTGTCAGGCG

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS [H]

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
MKTDIEIAQAAEIQPITKIAEKIGLSFDDIELYGKYKAKIPLEVLEKFDEQNDGKLVLVTSINPTPAGEGKSTVTVGLAD
AFARQDKNVMVALREPSLGPVMGIKGGAAGGGFAQVLPMEDINLHFTGDIHAITTANNAISAFLDNSLHQGNPLNIDPRR
IIWKRVLDLNDRALRHVTIGLGGPLNGVPREDGFDITVASEIMAVLCLATSISDLKERLARIVIAQNYDRKPVSVGDLGV
QGAIAMLLKDALKPNLVQTIEGTPALIHGGPFANIAHGCNSVLATKTALKLADIVITEAGFGADLGGEKFLDIKTRQLGK
QPDAVVIVATLRALKMHGGVDKKELTSENVEAVKKGFANLERHIKNMQSYGLPVIVAINQFASDTESEISTLKELTEALG
VSVSLTQVFAKGGEGGLDLAEKLSAMLQAKPDFRYLYELNQPLSVKLDKVVTEIYGGSKVNLSPKAKRQMREIEENGWNN
LPVCMAKTQYSFSDQANLLAAPEGFEVTVRELIPKIGAGFIVALLGDVMTMPGLPKNPAALKMDVTDDGKISGLF

Sequences:

>Translated_555_residues
MKTDIEIAQAAEIQPITKIAEKIGLSFDDIELYGKYKAKIPLEVLEKFDEQNDGKLVLVTSINPTPAGEGKSTVTVGLAD
AFARQDKNVMVALREPSLGPVMGIKGGAAGGGFAQVLPMEDINLHFTGDIHAITTANNAISAFLDNSLHQGNPLNIDPRR
IIWKRVLDLNDRALRHVTIGLGGPLNGVPREDGFDITVASEIMAVLCLATSISDLKERLARIVIAQNYDRKPVSVGDLGV
QGAIAMLLKDALKPNLVQTIEGTPALIHGGPFANIAHGCNSVLATKTALKLADIVITEAGFGADLGGEKFLDIKTRQLGK
QPDAVVIVATLRALKMHGGVDKKELTSENVEAVKKGFANLERHIKNMQSYGLPVIVAINQFASDTESEISTLKELTEALG
VSVSLTQVFAKGGEGGLDLAEKLSAMLQAKPDFRYLYELNQPLSVKLDKVVTEIYGGSKVNLSPKAKRQMREIEENGWNN
LPVCMAKTQYSFSDQANLLAAPEGFEVTVRELIPKIGAGFIVALLGDVMTMPGLPKNPAALKMDVTDDGKISGLF
>Mature_555_residues
MKTDIEIAQAAEIQPITKIAEKIGLSFDDIELYGKYKAKIPLEVLEKFDEQNDGKLVLVTSINPTPAGEGKSTVTVGLAD
AFARQDKNVMVALREPSLGPVMGIKGGAAGGGFAQVLPMEDINLHFTGDIHAITTANNAISAFLDNSLHQGNPLNIDPRR
IIWKRVLDLNDRALRHVTIGLGGPLNGVPREDGFDITVASEIMAVLCLATSISDLKERLARIVIAQNYDRKPVSVGDLGV
QGAIAMLLKDALKPNLVQTIEGTPALIHGGPFANIAHGCNSVLATKTALKLADIVITEAGFGADLGGEKFLDIKTRQLGK
QPDAVVIVATLRALKMHGGVDKKELTSENVEAVKKGFANLERHIKNMQSYGLPVIVAINQFASDTESEISTLKELTEALG
VSVSLTQVFAKGGEGGLDLAEKLSAMLQAKPDFRYLYELNQPLSVKLDKVVTEIYGGSKVNLSPKAKRQMREIEENGWNN
LPVCMAKTQYSFSDQANLLAAPEGFEVTVRELIPKIGAGFIVALLGDVMTMPGLPKNPAALKMDVTDDGKISGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family [H]

Homologues:

Organism=Homo sapiens, GI36796743, Length=618, Percent_Identity=44.336569579288, Blast_Score=477, Evalue=1e-134,
Organism=Homo sapiens, GI222136639, Length=619, Percent_Identity=43.7802907915994, Blast_Score=476, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17568737, Length=624, Percent_Identity=42.1474358974359, Blast_Score=444, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI17568739, Length=624, Percent_Identity=42.1474358974359, Blast_Score=444, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6319558, Length=630, Percent_Identity=41.5873015873016, Blast_Score=474, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6321643, Length=625, Percent_Identity=42.4, Blast_Score=470, Evalue=1e-133,
Organism=Drosophila melanogaster, GI62472483, Length=618, Percent_Identity=43.8511326860841, Blast_Score=489, Evalue=1e-138,
Organism=Drosophila melanogaster, GI45551871, Length=618, Percent_Identity=43.8511326860841, Blast_Score=489, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24645718, Length=618, Percent_Identity=43.8511326860841, Blast_Score=489, Evalue=1e-138,
Organism=Drosophila melanogaster, GI17137370, Length=618, Percent_Identity=43.8511326860841, Blast_Score=489, Evalue=1e-138,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000559
- InterPro:   IPR020628 [H]

Pfam domain/function: PF01268 FTHFS [H]

EC number: =6.3.4.3 [H]

Molecular weight: Translated: 59517; Mature: 59517

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTDIEIAQAAEIQPITKIAEKIGLSFDDIELYGKYKAKIPLEVLEKFDEQNDGKLVLVT
CCCCCCHHHHCCCCHHHHHHHHHCCCCCCEEEEECEECCCCHHHHHHHCCCCCCCEEEEE
SINPTPAGEGKSTVTVGLADAFARQDKNVMVALREPSLGPVMGIKGGAAGGGFAQVLPME
ECCCCCCCCCCCEEEEEHHHHHHCCCCCEEEEEECCCCCCEECCCCCCCCCCCEEEEECC
DINLHFTGDIHAITTANNAISAFLDNSLHQGNPLNIDPRRIIWKRVLDLNDRALRHVTIG
CCCEEEECCEEEEEECCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEE
LGGPLNGVPREDGFDITVASEIMAVLCLATSISDLKERLARIVIAQNYDRKPVSVGDLGV
CCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
QGAIAMLLKDALKPNLVQTIEGTPALIHGGPFANIAHGCNSVLATKTALKLADIVITEAG
HHHHHHHHHHHCCCCHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHEEECCC
FGADLGGEKFLDIKTRQLGKQPDAVVIVATLRALKMHGGVDKKELTSENVEAVKKGFANL
CCCCCCCCCEEEEHHHHCCCCCCCEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
ERHIKNMQSYGLPVIVAINQFASDTESEISTLKELTEALGVSVSLTQVFAKGGEGGLDLA
HHHHHHHHHCCCEEEEEEHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHH
EKLSAMLQAKPDFRYLYELNQPLSVKLDKVVTEIYGGSKVNLSPKAKRQMREIEENGWNN
HHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHCCCCC
LPVCMAKTQYSFSDQANLLAAPEGFEVTVRELIPKIGAGFIVALLGDVMTMPGLPKNPAA
CCEEEEECCCCCCCCCCEEECCCCCEEEHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCE
LKMDVTDDGKISGLF
EEEECCCCCCCCCCC
>Mature Secondary Structure
MKTDIEIAQAAEIQPITKIAEKIGLSFDDIELYGKYKAKIPLEVLEKFDEQNDGKLVLVT
CCCCCCHHHHCCCCHHHHHHHHHCCCCCCEEEEECEECCCCHHHHHHHCCCCCCCEEEEE
SINPTPAGEGKSTVTVGLADAFARQDKNVMVALREPSLGPVMGIKGGAAGGGFAQVLPME
ECCCCCCCCCCCEEEEEHHHHHHCCCCCEEEEEECCCCCCEECCCCCCCCCCCEEEEECC
DINLHFTGDIHAITTANNAISAFLDNSLHQGNPLNIDPRRIIWKRVLDLNDRALRHVTIG
CCCEEEECCEEEEEECCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEE
LGGPLNGVPREDGFDITVASEIMAVLCLATSISDLKERLARIVIAQNYDRKPVSVGDLGV
CCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
QGAIAMLLKDALKPNLVQTIEGTPALIHGGPFANIAHGCNSVLATKTALKLADIVITEAG
HHHHHHHHHHHCCCCHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHEEECCC
FGADLGGEKFLDIKTRQLGKQPDAVVIVATLRALKMHGGVDKKELTSENVEAVKKGFANL
CCCCCCCCCEEEEHHHHCCCCCCCEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
ERHIKNMQSYGLPVIVAINQFASDTESEISTLKELTEALGVSVSLTQVFAKGGEGGLDLA
HHHHHHHHHCCCEEEEEEHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHH
EKLSAMLQAKPDFRYLYELNQPLSVKLDKVVTEIYGGSKVNLSPKAKRQMREIEENGWNN
HHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHCCCCC
LPVCMAKTQYSFSDQANLLAAPEGFEVTVRELIPKIGAGFIVALLGDVMTMPGLPKNPAA
CCEEEEECCCCCCCCCCEEECCCCCEEEHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCE
LKMDVTDDGKISGLF
EEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]