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The map label for this gene is pncB [H]

Identifier: 125624279

GI number: 125624279

Start: 1446079

End: 1447551

Strand: Reverse

Name: pncB [H]

Synonym: llmg_1472

Alternate gene names: 125624279

Gene position: 1447551-1446079 (Counterclockwise)

Preceding gene: 125624281

Following gene: 125624278

Centisome position: 57.23

GC content: 37.81

Gene sequence:

>1473_bases
ATGCCACATCTATATCAAGACGACAGTCTTACATTACATACGGACTTATATCAAATTAATATGATGCAAACTTACTTTGA
GCTTGGAAGACACCAGCGCCATGCAGTCTTTGAAGTTTTTTTCCGTGAGATGCCTTTTAAAAATGGTTATGCTGTTTTTG
CTGGTTTAGAGCGAATGGTTGAATATTTAAAGAATCTCAAATTCTCGGAAACAGATATCGCCTATTTGCGTGAATTAGAC
TATCCAGAAGATTTTCTAAATTATTTAAAAGAATTACGCTTTACAGGAACAGTCAGAGCCATGCAAGAAGGTCAACTTGC
CTTTGCAAATGAACCTTTGGTTCAGGTTGAAGGTTCACTTGCGGAATGCCAGTTGGTAGAAACAGCTATTTTAAATATTA
TTAATTTCCAAACTCTGATAGCAACAAAAGCCGCCCGTATCAAATCTGTAATTGGGGAAGACCCTTTGTTGGAATTTGGG
ACAAGAAGAGCTCAAGAAATGGATGCAGCAATTTGGGGAACAAGAGCTGCGGTTATTGGCGGCGCTGATGCGACATCAAA
TGTTCGGGCGGCTAAAATCTTTGGCTTGAAAGCAAGTGGAACACATGCGCATGCTTTAGTTCAATCTTATGGTAATGACT
ATGAAGCTTTTAAGGCTTATGCTCAAACGCATAAAGATTGTGTTTTCCTCGTTGATACTTATGATACTTTAAGAGTAGGA
GTTCCTTCAGCGATTAAAGTGGCGCGTGAATTTGGCGATAAAATTAATTTTCAAGGTGTCCGAATTGATTCAGGAGATAT
GGCTTATATCTCGAAAAAAGTTCGTCAGCAACTTGATGAAGCTGGCTTTACTGACGCAAAGATTTATGCTTCAAATGACT
TAGATGAAAATACTATTTTAAGTTTGAAAATGCAAAAAGCAAAAATTGATGTTTGGGGAGTCGGAACAAAATTAATTACC
GCCTACGACCAACCAGCGCTTGGTGCGGTTTATAAATTAGTATCTATGGAAGATGAACACGGAGAAATGCAAGATACGAT
TAAGCTTTCAAGTAATGCGGAAAAAGTATCGACACCGGGTAAAAAGCAAGTTTGGCGCATCACCAAAAAAGCAGATGGAA
AATCAGAGGGAGATTATATCACTTTTTCTGACGAGCGTCCAGATGTAGCAGAAGAAATCTACATGTTCCACCCGCTCTAT
ACATACATTAATAAAAATGTTCGGGATTTCAATGCTAATCCACTTTTAAAAGATATTTTTATTGATGGTGAACTTATTTA
TCAACTTCCAGAACTACAGGAAATTAAAGCATTTGCCCATGAAAACTTGGAAGAGCTTTGGGATGAATACAAGCGAGATT
TAAATCCACAGCCTTACCCAGTGGATTTGTCTCAAGAATTATGGAATCATAAAATGCGTCTGATTTCACAAGTACGCACA
ACAGTATCAATGACCAGATTGGATGATGAATGA

Upstream 100 bases:

>100_bases
GGGTTCCCAGTACAAATTTAGGGCAAAATTTGATAAAATAAAGATTAGAATTGCGTTAAAATCGGTGTGATTAGCGAAAG
TGAATATGGGAGAAAAAATT

Downstream 100 bases:

>100_bases
TGAGAATAAGACGAATAGATCTCAGTGATGCACGACTTTTTTGGGATGTCCAAAAGCAATTGGATATTGAAAGTAAGTTT
ATGATGCTTGAGCCAGATGA

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MPHLYQDDSLTLHTDLYQINMMQTYFELGRHQRHAVFEVFFREMPFKNGYAVFAGLERMVEYLKNLKFSETDIAYLRELD
YPEDFLNYLKELRFTGTVRAMQEGQLAFANEPLVQVEGSLAECQLVETAILNIINFQTLIATKAARIKSVIGEDPLLEFG
TRRAQEMDAAIWGTRAAVIGGADATSNVRAAKIFGLKASGTHAHALVQSYGNDYEAFKAYAQTHKDCVFLVDTYDTLRVG
VPSAIKVAREFGDKINFQGVRIDSGDMAYISKKVRQQLDEAGFTDAKIYASNDLDENTILSLKMQKAKIDVWGVGTKLIT
AYDQPALGAVYKLVSMEDEHGEMQDTIKLSSNAEKVSTPGKKQVWRITKKADGKSEGDYITFSDERPDVAEEIYMFHPLY
TYINKNVRDFNANPLLKDIFIDGELIYQLPELQEIKAFAHENLEELWDEYKRDLNPQPYPVDLSQELWNHKMRLISQVRT
TVSMTRLDDE

Sequences:

>Translated_490_residues
MPHLYQDDSLTLHTDLYQINMMQTYFELGRHQRHAVFEVFFREMPFKNGYAVFAGLERMVEYLKNLKFSETDIAYLRELD
YPEDFLNYLKELRFTGTVRAMQEGQLAFANEPLVQVEGSLAECQLVETAILNIINFQTLIATKAARIKSVIGEDPLLEFG
TRRAQEMDAAIWGTRAAVIGGADATSNVRAAKIFGLKASGTHAHALVQSYGNDYEAFKAYAQTHKDCVFLVDTYDTLRVG
VPSAIKVAREFGDKINFQGVRIDSGDMAYISKKVRQQLDEAGFTDAKIYASNDLDENTILSLKMQKAKIDVWGVGTKLIT
AYDQPALGAVYKLVSMEDEHGEMQDTIKLSSNAEKVSTPGKKQVWRITKKADGKSEGDYITFSDERPDVAEEIYMFHPLY
TYINKNVRDFNANPLLKDIFIDGELIYQLPELQEIKAFAHENLEELWDEYKRDLNPQPYPVDLSQELWNHKMRLISQVRT
TVSMTRLDDE
>Mature_489_residues
PHLYQDDSLTLHTDLYQINMMQTYFELGRHQRHAVFEVFFREMPFKNGYAVFAGLERMVEYLKNLKFSETDIAYLRELDY
PEDFLNYLKELRFTGTVRAMQEGQLAFANEPLVQVEGSLAECQLVETAILNIINFQTLIATKAARIKSVIGEDPLLEFGT
RRAQEMDAAIWGTRAAVIGGADATSNVRAAKIFGLKASGTHAHALVQSYGNDYEAFKAYAQTHKDCVFLVDTYDTLRVGV
PSAIKVAREFGDKINFQGVRIDSGDMAYISKKVRQQLDEAGFTDAKIYASNDLDENTILSLKMQKAKIDVWGVGTKLITA
YDQPALGAVYKLVSMEDEHGEMQDTIKLSSNAEKVSTPGKKQVWRITKKADGKSEGDYITFSDERPDVAEEIYMFHPLYT
YINKNVRDFNANPLLKDIFIDGELIYQLPELQEIKAFAHENLEELWDEYKRDLNPQPYPVDLSQELWNHKMRLISQVRTT
VSMTRLDDE

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=518, Percent_Identity=31.6602316602317, Blast_Score=246, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI71997952, Length=534, Percent_Identity=36.5168539325843, Blast_Score=309, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI71997947, Length=529, Percent_Identity=36.6729678638941, Blast_Score=307, Evalue=9e-84,
Organism=Caenorhabditis elegans, GI71997955, Length=216, Percent_Identity=43.5185185185185, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24581587, Length=519, Percent_Identity=35.4527938342967, Blast_Score=272, Evalue=5e-73,
Organism=Drosophila melanogaster, GI161076680, Length=227, Percent_Identity=40.0881057268723, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24581595, Length=227, Percent_Identity=40.0881057268723, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI28574709, Length=227, Percent_Identity=40.0881057268723, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24581593, Length=227, Percent_Identity=40.0881057268723, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24581591, Length=227, Percent_Identity=40.0881057268723, Blast_Score=147, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 55914; Mature: 55783

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHLYQDDSLTLHTDLYQINMMQTYFELGRHQRHAVFEVFFREMPFKNGYAVFAGLERMV
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
EYLKNLKFSETDIAYLRELDYPEDFLNYLKELRFTGTVRAMQEGQLAFANEPLVQVEGSL
HHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEECCCH
AECQLVETAILNIINFQTLIATKAARIKSVIGEDPLLEFGTRRAQEMDAAIWGTRAAVIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEE
GADATSNVRAAKIFGLKASGTHAHALVQSYGNDYEAFKAYAQTHKDCVFLVDTYDTLRVG
CCCCCCCCEEEEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEECCCHHHCC
VPSAIKVAREFGDKINFQGVRIDSGDMAYISKKVRQQLDEAGFTDAKIYASNDLDENTIL
CCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEE
SLKMQKAKIDVWGVGTKLITAYDQPALGAVYKLVSMEDEHGEMQDTIKLSSNAEKVSTPG
EEEEEEEEEEEEECCCEEEEECCCCHHHHHHHHHHCCCCCCCHHHHEEECCCCHHHCCCC
KKQVWRITKKADGKSEGDYITFSDERPDVAEEIYMFHPLYTYINKNVRDFNANPLLKDIF
HHHHEEHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHE
IDGELIYQLPELQEIKAFAHENLEELWDEYKRDLNPQPYPVDLSQELWNHKMRLISQVRT
ECCHHHHCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
TVSMTRLDDE
HHHHHHCCCC
>Mature Secondary Structure 
PHLYQDDSLTLHTDLYQINMMQTYFELGRHQRHAVFEVFFREMPFKNGYAVFAGLERMV
CCCCCCCCEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
EYLKNLKFSETDIAYLRELDYPEDFLNYLKELRFTGTVRAMQEGQLAFANEPLVQVEGSL
HHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEECCCH
AECQLVETAILNIINFQTLIATKAARIKSVIGEDPLLEFGTRRAQEMDAAIWGTRAAVIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEE
GADATSNVRAAKIFGLKASGTHAHALVQSYGNDYEAFKAYAQTHKDCVFLVDTYDTLRVG
CCCCCCCCEEEEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEECCCHHHCC
VPSAIKVAREFGDKINFQGVRIDSGDMAYISKKVRQQLDEAGFTDAKIYASNDLDENTIL
CCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEE
SLKMQKAKIDVWGVGTKLITAYDQPALGAVYKLVSMEDEHGEMQDTIKLSSNAEKVSTPG
EEEEEEEEEEEEECCCEEEEECCCCHHHHHHHHHHCCCCCCCHHHHEEECCCCHHHCCCC
KKQVWRITKKADGKSEGDYITFSDERPDVAEEIYMFHPLYTYINKNVRDFNANPLLKDIF
HHHHEEHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHE
IDGELIYQLPELQEIKAFAHENLEELWDEYKRDLNPQPYPVDLSQELWNHKMRLISQVRT
ECCHHHHCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
TVSMTRLDDE
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]