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The map label for this gene is htpX2 [H]

Identifier: 124485472

GI number: 124485472

Start: 621959

End: 622873

Strand: Reverse

Name: htpX2 [H]

Synonym: Mlab_0648

Alternate gene names: 124485472

Gene position: 622873-621959 (Counterclockwise)

Preceding gene: 124485474

Following gene: 124485466

Centisome position: 34.51

GC content: 53.22

Gene sequence:

>915_bases
ATGATTTGGAAACGTGACTGGGGGCTGGTTGGTCGTCAGGTTATAGCCTGGCTGATCATGCTCCTGTTGTATATGGTAAT
ACTGACAGTGATCATGGTGTTCCTGAAAGGAACGATGATGTACTTCCTGGTCGGTCTGGTATTTATCATGGCGTTTGTAC
AGTACTTCTTCTCCGATAAGCTTGTGCAGAGGAGTATGCAGGTGATGCTGGTCGATGAGGACGAGGAGCCGCAGTTGTAT
GCAATGGTCCGGCGGCTGGCCGATGAAGCGGGCCTTCCGATGCCCAAAGTAGGGATTATCCAGCACAAAGCAATGGCAAA
TATTCCCAACGCCTTTGCGACCGGCAGAAGCCCGAGAAAGGCTGTTGTGGCCGTAACCCCGAAGATCCGGTATCTTCTGA
CCGATGACGAACTGGAGGCCGTTCTGGCACATGAAATGGCTCATGTAAAGAACCGGGACATGCTTACGATGACGGTCGGC
AGTTTCGCGGTGATGATCGCTTCGATCATTTTGAACAATGCGTTCCTCATGGCCCTCTTTGGAGGGAGCAGGGACAGTGA
AAACGGCGGCGGGATCATCATATTCATTCTGGCGATGCTCCTGACCTTTGTCGTGTACATCGTTGGAACGATCGTGACCA
TGGCGATTTCCCGGTACCGGGAGTTCTCGGCAGACCGCGGGAGTGCCTATCTCACCCGTGATCCGGATGCGCTTATCCGC
GCTCTGAGAAAAATCAGCAGCGGCGTGAATGCAGCGTCTCCCGATGCAAAACGGGCGGTTTCCGGGACGAACTCGTTCTT
CATCATCCCGGCGATCTCCGGCGAGTCGGTTATGGAGTTATTTTCCACCCACCCGTCACTTGAGAAGAGGATTGCCAATC
TGGAAAAAGTCCGTGCAGAGATCAGAGGATACTGA

Upstream 100 bases:

>100_bases
AGTCATTATTCATTATTGTATCCTTCATGTAGTTTATATTTCGGATTGAATATGCGGGGTCAGGAAACCTATTATTCCGG
CATTATCCATACTAAGTACA

Downstream 100 bases:

>100_bases
TCATCCAATATTTTTTCGACAGGTTTAATTAGATCAAAGAGAAACATAAGTGACGCAAAGACTGCACTGATGGTCTAGAG
GTATGACTTTGGCCTTCCAA

Product: HtpX-2 peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MIWKRDWGLVGRQVIAWLIMLLLYMVILTVIMVFLKGTMMYFLVGLVFIMAFVQYFFSDKLVQRSMQVMLVDEDEEPQLY
AMVRRLADEAGLPMPKVGIIQHKAMANIPNAFATGRSPRKAVVAVTPKIRYLLTDDELEAVLAHEMAHVKNRDMLTMTVG
SFAVMIASIILNNAFLMALFGGSRDSENGGGIIIFILAMLLTFVVYIVGTIVTMAISRYREFSADRGSAYLTRDPDALIR
ALRKISSGVNAASPDAKRAVSGTNSFFIIPAISGESVMELFSTHPSLEKRIANLEKVRAEIRGY

Sequences:

>Translated_304_residues
MIWKRDWGLVGRQVIAWLIMLLLYMVILTVIMVFLKGTMMYFLVGLVFIMAFVQYFFSDKLVQRSMQVMLVDEDEEPQLY
AMVRRLADEAGLPMPKVGIIQHKAMANIPNAFATGRSPRKAVVAVTPKIRYLLTDDELEAVLAHEMAHVKNRDMLTMTVG
SFAVMIASIILNNAFLMALFGGSRDSENGGGIIIFILAMLLTFVVYIVGTIVTMAISRYREFSADRGSAYLTRDPDALIR
ALRKISSGVNAASPDAKRAVSGTNSFFIIPAISGESVMELFSTHPSLEKRIANLEKVRAEIRGY
>Mature_304_residues
MIWKRDWGLVGRQVIAWLIMLLLYMVILTVIMVFLKGTMMYFLVGLVFIMAFVQYFFSDKLVQRSMQVMLVDEDEEPQLY
AMVRRLADEAGLPMPKVGIIQHKAMANIPNAFATGRSPRKAVVAVTPKIRYLLTDDELEAVLAHEMAHVKNRDMLTMTVG
SFAVMIASIILNNAFLMALFGGSRDSENGGGIIIFILAMLLTFVVYIVGTIVTMAISRYREFSADRGSAYLTRDPDALIR
ALRKISSGVNAASPDAKRAVSGTNSFFIIPAISGESVMELFSTHPSLEKRIANLEKVRAEIRGY

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family [H]

Homologues:

Organism=Escherichia coli, GI1788133, Length=270, Percent_Identity=35.9259259259259, Blast_Score=117, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022919
- InterPro:   IPR001915 [H]

Pfam domain/function: PF01435 Peptidase_M48 [H]

EC number: 3.4.24.-

Molecular weight: Translated: 33901; Mature: 33901

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.6 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.6 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIWKRDWGLVGRQVIAWLIMLLLYMVILTVIMVFLKGTMMYFLVGLVFIMAFVQYFFSDK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVQRSMQVMLVDEDEEPQLYAMVRRLADEAGLPMPKVGIIQHKAMANIPNAFATGRSPRK
HHHHHHHEEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHCCCCCCC
AVVAVTPKIRYLLTDDELEAVLAHEMAHVKNRDMLTMTVGSFAVMIASIILNNAFLMALF
EEEEECCCEEEEECCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHEEEE
GGSRDSENGGGIIIFILAMLLTFVVYIVGTIVTMAISRYREFSADRGSAYLTRDPDALIR
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHH
ALRKISSGVNAASPDAKRAVSGTNSFFIIPAISGESVMELFSTHPSLEKRIANLEKVRAE
HHHHHHCCCCCCCCCHHHHHCCCCCEEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHH
IRGY
HCCC
>Mature Secondary Structure
MIWKRDWGLVGRQVIAWLIMLLLYMVILTVIMVFLKGTMMYFLVGLVFIMAFVQYFFSDK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVQRSMQVMLVDEDEEPQLYAMVRRLADEAGLPMPKVGIIQHKAMANIPNAFATGRSPRK
HHHHHHHEEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHCCCCCCC
AVVAVTPKIRYLLTDDELEAVLAHEMAHVKNRDMLTMTVGSFAVMIASIILNNAFLMALF
EEEEECCCEEEEECCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHEEEE
GGSRDSENGGGIIIFILAMLLTFVVYIVGTIVTMAISRYREFSADRGSAYLTRDPDALIR
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHH
ALRKISSGVNAASPDAKRAVSGTNSFFIIPAISGESVMELFSTHPSLEKRIANLEKVRAE
HHHHHHCCCCCCCCCHHHHHCCCCCEEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHH
IRGY
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12125824 [H]