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The map label for this gene is degU [H]

Identifier: 124265671

GI number: 124265671

Start: 519259

End: 519906

Strand: Direct

Name: degU [H]

Synonym: Mpe_A0478

Alternate gene names: 124265671

Gene position: 519259-519906 (Clockwise)

Preceding gene: 124265670

Following gene: 124265673

Centisome position: 12.84

GC content: 67.28

Gene sequence:

>648_bases
TTGAGGGAGAAATGCTTGATACACGTCTTGCTGCTTGACGATCACGCGGTGGTGCGGGCGGGGTACCGGCAGCTCATCGA
TGCCGAGCCCGACATGTGCGTGGTCGCAGCCTGCGCCACCTCGGCTCAGGCCTGCGAGCAACTGCGCCTGCAGCAGATCG
ACGTCGCCGTCGTCGATCTCAGCCTGAAGGACGACAGCGGCCTGCAGGCCATCCAGAGATTGCGCGCCCGGCTGGCCTCG
CTGCGGATCCTGGTGTTCACGATGCACGCCCAGCAGAGCTATGCACTGCAGGCCTTGCGCGCCGGTGCGCTGGGCTACCT
GACCAAGGACTCCGACCCGCAGGCGATGCTGGATGCGGTGCGTCAGGTCGCTCAGGGCCGCCGGGTGTTTTCCAGCGAAC
TGGTCGAGGCGATGCTCGATCCCCTGGAAGTGGAGCGCGGCGGGCCGCTGCGGCAGCTCACGCCGCGCGAGTTCGATGTG
CTGCGGCTGGCCGCCCAGGGCCTCGCGACGCGTGCGATCGCCGAGGCCATGCACCTCGGCGACAAGACGGTGCTGAACTA
CATGTCGCTGATCCGGCAGAAGCTGGGTGCAGCGAACGACCTGCAATTGCTGCGGCTGGCGGCGCAGAACGGCCTGGTCG
AGCTCTGA

Upstream 100 bases:

>100_bases
GCCATGGTGGGTGGCGGATTGCGACTGGTCGACAACGCCGGTCCTGGCCTGTGCGTCGAAGTCTGGGTGCCGGTGCCGGC
CGTCGCCGTCACCGAGTCAC

Downstream 100 bases:

>100_bases
CCACGGCGCGGTGCCGGCGCCGACGCAGGTCCGTCCGGACCTGGTTTTCGCCGGCACTGCACCCGGTGGCGCTCAGCGGC
CCGCGCCTGGCGGCCAGTAG

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MREKCLIHVLLLDDHAVVRAGYRQLIDAEPDMCVVAACATSAQACEQLRLQQIDVAVVDLSLKDDSGLQAIQRLRARLAS
LRILVFTMHAQQSYALQALRAGALGYLTKDSDPQAMLDAVRQVAQGRRVFSSELVEAMLDPLEVERGGPLRQLTPREFDV
LRLAAQGLATRAIAEAMHLGDKTVLNYMSLIRQKLGAANDLQLLRLAAQNGLVEL

Sequences:

>Translated_215_residues
MREKCLIHVLLLDDHAVVRAGYRQLIDAEPDMCVVAACATSAQACEQLRLQQIDVAVVDLSLKDDSGLQAIQRLRARLAS
LRILVFTMHAQQSYALQALRAGALGYLTKDSDPQAMLDAVRQVAQGRRVFSSELVEAMLDPLEVERGGPLRQLTPREFDV
LRLAAQGLATRAIAEAMHLGDKTVLNYMSLIRQKLGAANDLQLLRLAAQNGLVEL
>Mature_215_residues
MREKCLIHVLLLDDHAVVRAGYRQLIDAEPDMCVVAACATSAQACEQLRLQQIDVAVVDLSLKDDSGLQAIQRLRARLAS
LRILVFTMHAQQSYALQALRAGALGYLTKDSDPQAMLDAVRQVAQGRRVFSSELVEAMLDPLEVERGGPLRQLTPREFDV
LRLAAQGLATRAIAEAMHLGDKTVLNYMSLIRQKLGAANDLQLLRLAAQNGLVEL

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=209, Percent_Identity=31.5789473684211, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1788521, Length=205, Percent_Identity=35.1219512195122, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1787473, Length=179, Percent_Identity=36.8715083798883, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1790102, Length=204, Percent_Identity=33.8235294117647, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1786747, Length=199, Percent_Identity=24.6231155778894, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1788546, Length=202, Percent_Identity=27.2277227722772, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788712, Length=206, Percent_Identity=23.7864077669903, Blast_Score=69, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23638; Mature: 23638

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREKCLIHVLLLDDHAVVRAGYRQLIDAEPDMCVVAACATSAQACEQLRLQQIDVAVVDL
CCCCEEEEEEEECCHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHCEEEEEE
SLKDDSGLQAIQRLRARLASLRILVFTMHAQQSYALQALRAGALGYLTKDSDPQAMLDAV
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
RQVAQGRRVFSSELVEAMLDPLEVERGGPLRQLTPREFDVLRLAAQGLATRAIAEAMHLG
HHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
DKTVLNYMSLIRQKLGAANDLQLLRLAAQNGLVEL
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MREKCLIHVLLLDDHAVVRAGYRQLIDAEPDMCVVAACATSAQACEQLRLQQIDVAVVDL
CCCCEEEEEEEECCHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHCEEEEEE
SLKDDSGLQAIQRLRARLASLRILVFTMHAQQSYALQALRAGALGYLTKDSDPQAMLDAV
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
RQVAQGRRVFSSELVEAMLDPLEVERGGPLRQLTPREFDVLRLAAQGLATRAIAEAMHLG
HHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
DKTVLNYMSLIRQKLGAANDLQLLRLAAQNGLVEL
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7765823 [H]